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Predictive hyperglycemia and hypoglycemia minimization: In-home double-blind randomized controlled evaluation in children and young adolescents.

Abstract：

OBJECTIVE:The primary objective of this trial was to evaluate the feasibility, safety, and efficacy of a predictive hyperglycemia and hypoglycemia minimization (PHHM) system vs predictive low glucose suspension (PLGS) alone in optimizing overnight glucose control in children 6 to 14 years old. RESEARCH DESIGN AND METHODS:Twenty-eight participants 6 to 14 years old with T1D duration ≥1 year with daily insulin therapy ≥12 months and on insulin pump therapy for ≥6 months were randomized per night into PHHM mode or PLGS-only mode for 42 nights. The primary outcome was percentage of time in sensor-measured range 70 to 180 mg/dL in the overnight period. RESULTS:The addition of automated insulin delivery with PHHM increased time in target range (70-180 mg/dL) from 66 ± 11% during PLGS nights to 76 ± 9% during PHHM nights (P<.001), without increasing hypoglycemia as measured by time below various thresholds. Average morning blood glucose improved from 176 ± 28 mg/dL following PLGS nights to 154 ± 19 mg/dL following PHHM nights (P<.001). CONCLUSIONS:The PHHM system was effective in optimizing overnight glycemic control, significantly increasing time in range, lowering mean glucose, and decreasing glycemic variability compared to PLGS alone in children 6 to 14 years old.

journal_name

Pediatr Diabetes

journal_title

Pediatric diabetes

authors

Forlenza GP,Raghinaru D,Cameron F,Wayne Bequette B,Peter Chase H,Paul Wadwa R,Maahs DM,Jost E,Ly TT,Wilson DM,Norlander L,Ekhlaspour L,Min H,Clinton P,Njeru N,Lum JW,Kollman C,Beck RW,Buckingham BA,In-Home Closed-Lo

doi

10.1111/pedi.12603

subject

Has Abstract

pub_date

2018-05-01 00:00:00

pages

420-428

issue

3

eissn

1399-543X

issn

1399-5448

journal_volume

19

pub_type

杂志文章,随机对照试验

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