Abstract:
OBJECTIVES:The aim of the study was to determine the influence of regular physical activity on ghrelin and IGF-1/IGFBP-3 levels during a diabetes camp. METHODS:Twenty-eight children and adolescents (14 boys; mean age 12.1 yr) with type 1 diabetes mellitus (T1DM, mean duration of diabetes 4.8 yr) attending a 2-wk diabetes camp that features increased regular physical activities have been studied. Serum levels of ghrelin (total and acylated), growth hormone (GH), insulin-like growth factor-1 (IGF-1), insulin-like growth factor-bindng protein-3 (IGFBP-3) and insulin were measured in fasting state on day 1 and day 14. Improvement of metabolic control was documented by haemoglobin A1c (HbA1c). Glucose levels and insulin doses were determined daily. RESULTS:Mean insulin dosage decreased from 0.87 to 0.78 U/kg/d, mean HbA1c levels decreased from 8.6 to 8.3%, but the changes were not statistical. There was a significant decline in total ghrelin. IGFBP-3 and IGF-1 decreased also significantly. Total basal ghrelin was inversely related to the change in IGFBP-3. CONCLUSIONS:We hypothesize an association between ghrelin and metabolic control in T1DM. Higher ghrelin levels might be associated with poor metabolic control. The dynamic of IGFBP-3 levels appears to be under the influence of basal ghrelin concentrations in T1DM.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Huber J,Fröhlich-Reiterer EE,Sudi K,Suppan E,Weinhandl G,Jasser-Nitsche H,Aigner R,Borkenstein MHdoi
10.1111/j.1399-5448.2009.00604.xsubject
Has Abstractpub_date
2010-09-01 00:00:00pages
383-5issue
6eissn
1399-543Xissn
1399-5448pii
PDI604journal_volume
11pub_type
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更新日期:2017-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-04-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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journal_title:Pediatric diabetes
pub_type: 杂志文章,评审
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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doi:10.1111/pedi.12109
更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12462
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:To investigate the changes of peripheral nerve conduction in children with insulin-dependent diabetes mellitus (IDDM) prospectively from diagnosis and to know how those results were related to clinical risk factors. METHODS:A total of 37 patients (14 males and 23 females) aged 3-19 yr (mean 12.0 ± 3.7) with ...
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doi:10.1111/j.1399-5448.2009.00636.x
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVE:To explore the outcomes of monthly video consultations for children with diabetes. METHODS:The Virtual Outpatient Diabetes Clinic for Children and Youth (VIDIKI) was a 6-month multicenter controlled clinical trial followed by an extension phase. The 240 participants (1-16 years), all using a CGM, were quasi-...
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pub_type: 杂志文章
doi:10.1111/j.1399-5448.2011.00823.x
更新日期:2012-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00438.x
更新日期:2009-02-01 00:00:00
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更新日期:2019-11-01 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the effectiveness of directly integrating self-monitoring blood glucose (BG) information with insulin pump therapy on overall glycemic control. METHODS:In this randomized trial, 34 youth with type 1 diabetes using insulin pump therapy were trained on the use of the ...
journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5448.2007.00268.x
更新日期:2008-04-01 00:00:00
abstract:AIMS:To design, develop, and evaluate the feasibility of delivering a multi-component community based intervention to parents and primary health care professionals to raise awareness of the symptoms of Type 1 diabetes (T1D) in childhood in 3 adjoining borough counties of South Wales. MATERIALS AND METHODS:Parent and p...
journal_title:Pediatric diabetes
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doi:10.1111/pedi.12516
更新日期:2017-12-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-543X.2006.00140.x
更新日期:2006-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12914
更新日期:2019-12-01 00:00:00
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journal_title:Pediatric diabetes
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更新日期:2020-12-01 00:00:00
abstract:AIMS:Children with type 1 diabetes (T1D) risk and islet autoantibodies are recruited to a secondary prevention study. The aims were to determine metabolic control in relation to human leukocyte antigen (HLA) genetic risk and islet autoantibodies in prepubertal children. METHODS:In 47 healthy children with GADA and at ...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12023
更新日期:2013-08-01 00:00:00