当前位置： SCI文献检索 > PEDIATRIC DIABETES期刊下所有文献 > Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

Gene CNVs and protein levels of complement C4A and C4B as novel biomarkers for partial disease remissions in new-onset type 1 diabetes patients.

Abstract：

OBJECTIVE:To determine the roles of complement C4A and C4B gene copy-number variations and their plasma protein concentrations in residual insulin secretion and loss of pancreatic β-cell function in new-onset type 1 diabetes (T1D) patients. METHODS:We studied 34 patients of European ancestry with new-onset T1D, aged between 3 and 17 yr (10.7 ± 3.45), at Nationwide Children's Hospital in Columbus, Ohio. Gene copy-number and size variations of complement C4A and C4B were determined by genomic Southern blot analyses. C4A and C4B protein phenotypes were elucidated by immunofixation and radial immunodiffusion. Two-digit human leukocyte antigen (HLA)-DRB1 genotypes were determined by sequence-specific polymerase chain reaction. At 1- and 9-month post diagnosis, stimulated C-peptide levels were measured after a standardized mixed-meal tolerance test. RESULTS:The diploid gene copy-numbers of C4A varied from 0 to 4, and those of C4B from 0 to 3. Patients with higher copy-number of C4A or higher C4A plasma protein concentrations at diagnosis had higher C-peptide levels at 1-month post diagnosis (p = 0.008; p = 0.008). When controlled by the Z-score of body mass index, C4A copy-numbers, C4A protein concentrations, the age of disease onset, and the number of HLA-DR3 but not DR4 alleles were significant parameters in determining C-peptide levels. At 9-month post diagnosis, 42.3% of patients remained in partial remission, and these patients were characterized by lower total C4B copy-numbers or lower C4B protein concentrations (p = 0.02; p = 0.0004). CONCLUSIONS:C4A appears to associate with the protection of residual β-cell function in new-onset T1D; C4B is correlated with the end of disease remission at 9-month post diagnosis.

journal_name

Pediatr Diabetes

journal_title

Pediatric diabetes

authors

Kingery SE,Wu YL,Zhou B,Hoffman RP,Yu CY

doi

10.1111/j.1399-5448.2011.00836.x

subject

Has Abstract

pub_date

2012-08-01 00:00:00

pages

408-18

issue

5

eissn

1399-543X

issn

1399-5448

journal_volume

13

pub_type

杂志文章

相关文献

PEDIATRIC DIABETES文献大全
  • Sweet dreams?--nocturnal hypoglycemia in children with type 1 diabetes.

    abstract：:Hypoglycemia is an inevitable consequence of the treatment of type 1 diabetes in childhood. Nocturnal hypoglycemia is often considered as merely the submerged part of this serious complication yet there are reasons to believe that hypoglycemia occurring during sleep may be different in physiological terms. Glucose hom...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1034/j.1399-5448.2002.30203.x

    authors： Matyka KA

    更新日期：2002-06-01 00:00:00

  • An Egyptian family with H syndrome due to a novel mutation in SLC29A3 illustrating overlapping features with pigmented hypertrichotic dermatosis with insulin-dependent diabetes and Faisalabad histiocytosis.

    abstract：:The SLC29A3 gene, encoding hENT3, a member of the equilibrative nucleoside transporter family, has recently been found mutated in Faisalabad histiocytosis, pigmented hypertrichotic dermatosis with insulin-dependent diabetes, familial sinus histiocytosis with massive lymphadenopathy (SHML), and H syndromes. We here rep...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2012.00925.x

    authors： Elbarbary NS,Tjora E,Molnes J,Lie BA,Habib MA,Salem MA,Njølstad PR

    更新日期：2013-09-01 00:00:00

  • Screening for cystic fibrosis-related diabetes and prediabetes: Evaluating 1,5-anhydroglucitol, fructosamine, glycated albumin, and hemoglobin A1c.

    abstract：OBJECTIVE:Dysglycemia is prevalent in cystic fibrosis (CF) but screening with annual oral glucose tolerance tests (OGTT) can be burdensome. We investigated alternate glycemic markers-hemoglobin A1c (HbA1c), 1,5-anhydroglucitol (1,5AG), fructosamine (FA), and glycated albumin (GA)-as screening tests for CF-related diabe...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12914

    authors： Tommerdahl KL,Brinton JT,Vigers T,Nadeau KJ,Zeitler PS,Chan CL

    更新日期：2019-12-01 00:00:00

  • Metformin treatment to reduce central adiposity after prenatal growth restraint: a placebo-controlled pilot study in prepubertal children.

    abstract：BACKGROUND:Children born small-for-gestational-age (SGA) who experience rapid postnatal catch-up in weight are at risk for central adiposity and hyperinsulinemia. OBJECTIVES:To study the effects of prepubertal metformin intervention over 24 months on the body composition and endocrine-metabolic profile of catch-up SGA...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1111/pedi.12220

    authors： Díaz M,Bassols J,López-Bermejo A,de Zegher F,Ibáñez L

    更新日期：2015-11-01 00:00:00

  • A 5-yr follow-up nerve conduction study for the detection of subclinical diabetic neuropathy in children with newly diagnosed insulin-dependent diabetes mellitus.

    abstract：OBJECTIVE:To investigate the changes of peripheral nerve conduction in children with insulin-dependent diabetes mellitus (IDDM) prospectively from diagnosis and to know how those results were related to clinical risk factors. METHODS:A total of 37 patients (14 males and 23 females) aged 3-19 yr (mean 12.0 ± 3.7) with ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2009.00636.x

    authors： Lee SS,Han HS,Kim H

    更新日期：2010-12-01 00:00:00

  • Fluid management in pediatric patients with DKA and rates of suspected clinical cerebral edema.

    abstract：OBJECTIVE:To compare outcomes of diabetic ketoacidosis (DKA) 6 yrs before and 6 yrs after changing rehydration fluids from ½ normal saline to Lactated Ringer's and decreasing the total intended fluid volume administered in the first 24 hrs from 3500 mL/m(2) /d to ≤ 2500 mL/m(2) /d at Texas Children's Hospital (TCH) in ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12268

    authors： Hsia DS,Tarai SG,Alimi A,Coss-Bu JA,Haymond MW

    更新日期：2015-08-01 00:00:00

  • Detection and treatment efficacy of hypoglycemic events in the everyday life of children younger than 7 yr.

    abstract：BACKGROUND:Mild hypoglycemia is commonly observed in children treated for type 1 diabetes mellitus (T1DM). Hypoglycemia disturbs cognition and learning. OBJECTIVE:To describe how and to what extent hypoglycemia in young children with T1DM is detected in everyday life. To learn how parents and caregivers treat hypoglyc...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12057

    authors： Sundberg F,Forsander G

    更新日期：2014-02-01 00:00:00

  • DNA methylation and its role in the pathogenesis of diabetes.

    abstract：:Although the factors responsible for the recent increase in the prevalence of diabetes worldwide are not entirely known, the morbidity associated with this disease results in substantial health and economic burden on society. Epigenetic modifications, including DNA methylation have been identified as one mechanism by ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,评审

    doi：10.1111/pedi.12521

    authors： Bansal A,Pinney SE

    更新日期：2017-05-01 00:00:00

  • The influence of physical activity on ghrelin and IGF-1/IGFBP-3 levels in children and adolescents with type 1 diabetes mellitus.

    abstract：OBJECTIVES:The aim of the study was to determine the influence of regular physical activity on ghrelin and IGF-1/IGFBP-3 levels during a diabetes camp. METHODS:Twenty-eight children and adolescents (14 boys; mean age 12.1 yr) with type 1 diabetes mellitus (T1DM, mean duration of diabetes 4.8 yr) attending a 2-wk diabe...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2009.00604.x

    authors： Huber J,Fröhlich-Reiterer EE,Sudi K,Suppan E,Weinhandl G,Jasser-Nitsche H,Aigner R,Borkenstein MH

    更新日期：2010-09-01 00:00:00

  • First test effect in intravenous glucose tolerance testing.

    abstract：AIMS:Intravenous glucose tolerance testing (IVGTT) is a common test of β-cell function in which a glucose load is administered and insulin and/or C-peptide responses are monitored. Since the first IVGTT may be more stressful and stress may alter β-cell secretion or hepatic insulin extraction, we asked whether there was...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12064

    authors： Ismail HM,White KS,Krischer JP,Chase HP,Cuthbertson D,Palmer JP,DPT-1 Study Group.

    更新日期：2015-03-01 00:00:00

  • C-peptide in the classification of diabetes in children and adolescents.

    abstract：AIM:To report C-peptide results in newly diagnosed patients and the relation to clinical diagnosis of diabetes. METHODS:A nation-wide cohort, the Better Diabetes Diagnosis study was used to determine serum C-peptide at diagnosis in 2734 children and adolescents. Clinical data were collected at diagnosis and follow-up....

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2011.00807.x

    authors： Ludvigsson J,Carlsson A,Forsander G,Ivarsson S,Kockum I,Lernmark A,Lindblad B,Marcus C,Samuelsson U

    更新日期：2012-02-01 00:00:00

  • Blood pressure measurement methodology and technology in the SWEET diabetes centers: An international SWEET database survey.

    abstract：INTRODUCTION:The accuracy of blood pressure (BP) measurement is a prerequisite for the reliable diagnosis and management of hypertension. OBJECTIVES:This survey evaluated the use of office and out-of-office BP measurements and the antihypertensive pharmacological treatment in expert pediatric diabetes centers. METHOD...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.13114

    authors： Gerasimidi-Vazeou A,Birkebaek NH,Iotova V,Cherubini V,Piccini B,Biester T,Stipancic G,Jefferies C,Maffeis C,Stergiou GS,SWEET study group.

    更新日期：2020-12-01 00:00:00

  • Treatment adherence and BMI reduction are key predictors of HbA1c 1 year after diagnosis of childhood type 2 diabetes in the United Kingdom.

    abstract：BACKGROUND/OBJECTIVE:Type 2 Diabetes (T2DM) is increasing in childhood especially among females and South-Asians. Our objective was to report outcomes from a national cohort of children and adolescents with T2DM 1 year following diagnosis. METHODS:Clinician reported, 1-year follow-up of a cohort of children (<17 years...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12761

    authors： Candler TP,Mahmoud O,Lynn RM,Majbar AA,Barrett TG,Shield JPH

    更新日期：2018-12-01 00:00:00

  • Outcomes of monthly video consultations as an add-on to regular care for children with type 1 diabetes: A 6-month quasi-randomized clinical trial followed by an extension phase.

    abstract：OBJECTIVE:To explore the outcomes of monthly video consultations for children with diabetes. METHODS:The Virtual Outpatient Diabetes Clinic for Children and Youth (VIDIKI) was a 6-month multicenter controlled clinical trial followed by an extension phase. The 240 participants (1-16 years), all using a CGM, were quasi-...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.13133

    authors： von Sengbusch S,Eisemann N,Mueller-Godeffroy E,Lange K,Doerdelmann J,Erdem A,Menrath I,Bokelmann J,Krasmann M,Kaczmarczyk P,Bertram B,Hiort O,Katalinic A,Frielitz FS

    更新日期：2020-12-01 00:00:00

  • Can the metabolic syndrome identify children with insulin resistance?

    abstract：OBJECTIVE:The metabolic syndrome is associated with insulin resistance in adults. We defined pediatric metabolic syndrome using criteria analogous to Adult Treatment Panel III. The purpose of this study was to determine whether these criteria are reliable for insulin resistance in children. RESEARCH DESIGN AND METHODS...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2007.00282.x

    authors： Hirschler V,Calcagno ML,Aranda C,Maccallini G,Jadzinsky M

    更新日期：2007-10-01 00:00:00

  • Islet/pancreas transplantation: challenges for pediatrics.

    abstract：:Beta cell replacement is a valid alternative to exogenous insulin injections to treat type 1 diabetic patients. The rate of success obtained after whole-pancreas transplantation, performed alone or in combination with kidney, and, as shown recently, by islet transplantation, justifies optimism and sets the stage for a...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1034/j.1399-5448.2002.30408.x

    authors： Bottino R,Balamurugan AN,Giannoukakis N,Trucco M

    更新日期：2002-12-01 00:00:00

  • Changes in body composition after a 12-wk aerobic exercise program in obese boys.

    abstract：UNLABELLED:Previous studies have shown that vigorous aerobic training programs for obese children result in minimal weight changes, and concluded that they may not be beneficial. Weight change alone may not detect important beneficial changes in body composition associated with vigorous training in these children. Fift...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1034/j.1399-5448.2000.010202.x

    authors： DeStefano RA,Caprio S,Fahey JT,Tamborlane WV,Goldberg B

    更新日期：2000-06-01 00:00:00

  • Care delivery in youth with type 2 diabetes - are we meeting clinical practice guidelines?

    abstract：BACKGROUND:Studies indicate high rates of treatment failure and early onset diabetes-related complications in youth-onset type 2 diabetes (T2D). We aim to describe the quality of care provided to children and youth with T2D. METHODS:This prospective cohort study used administrative datasets to describe individuals age...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12147

    authors： Amed S,Nuernberger K,Reimer K,Krueger H,Aydede SK,Ayers D,Collet JP

    更新日期：2014-11-01 00:00:00

  • Measurement of diabetes stress in older children and adolescents with type 1 diabetes mellitus.

    abstract：OBJECTIVE:Studies indicate general psychological stress plays a role in the glycemic control of individuals with type 1 diabetes mellitus (T1DM). Disease-specific rather than general measures may be more closely related to measures of health outcomes. Therefore, measurement of diabetes-related stress is needed to advan...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2012.00894.x

    authors： Delamater AM,Patiño-Fernández AM,Smith KE,Bubb J

    更新日期：2013-02-01 00:00:00

  • Acute chorea and type 1 diabetes mellitus: clinical and neuroimaging findings.

    abstract：:The association of type 1 diabetes mellitus (T1DM) and acute chorea is rare. We report an 8-yr-old boy with T1DM who developed acute hemichorea-hemiballism of the right arm in whom magnetic resonance imaging (MRI) of the brain revealed hyperintense signal in putamen and considerable atrophy and focal area of gliosis i...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,评审

    doi：10.1111/j.1399-5448.2012.00856.x

    authors： Alves C,Sampaio S,Barbosa V,Machado M

    更新日期：2012-09-01 00:00:00

  • Skin and subcutaneous thickness at injecting sites in children with diabetes: ultrasound findings and recommendations for giving injection.

    abstract：BACKGROUND:Children who inject insulin need clear guidelines as to the length of needle best for them. We studied the distance from surface to muscle in children in order to make needle choices which are evidence-based. METHODS:One hundred one children with type 1 diabetes were divided into three groups according to a...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2012.00865.x

    authors： Lo Presti D,Ingegnosi C,Strauss K

    更新日期：2012-11-01 00:00:00

  • Impaired beta-cell sensitivity to glucose and maximal insulin secretory capacity in adolescents with type 2 diabetes.

    abstract：BACKGROUND:Adults with type 2 diabetes mellitus (T2DM) have broad impairments in beta-cell function, including severe attenuation of the first-phase insulin response to glucose, and reduced beta-cell mass. In adolescents with T2DM, there is some evidence that beta-cell dysfunction may be less severe. Our objective was ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2009.00601.x

    authors： Elder DA,Woo JG,D'Alessio DA

    更新日期：2010-08-01 00:00:00

  • Long-term metabolic consequences of being born small for gestational age.

    abstract：:This review highlights the evidence of linking small for gestational age (SGA) with metabolic/cardiovascular disturbances (dysmetabolic syndrome) in later life. The metabolic and cardiovascular complications associated with in utero undernutrition have been identified during the past 10 yr. Reduced fetal growth is ind...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,评审

    doi：10.1111/j.1399-543X.2004.00057.x

    authors： Levy-Marchal C,Jaquet D

    更新日期：2004-09-01 00:00:00

  • Exploring self-management characteristics in youths with type 1 diabetes mellitus: does membership in a glycemic control category matter?

    abstract：BACKGROUND:Hemoglobin A1c (HbA1c) levels have been shown to worsen in adolescence and be related to long-term diabetes complications. Although categories of diabetes control (e.g., ideal, satisfactory, and poor) are routinely used in clinical practice, research has not fully explored whether these categories meaningful...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2010.00638.x

    authors： Kichler JC,Kaugars AS,Ellis J,Alemzadeh R

    更新日期：2010-12-01 00:00:00

  • Presentation of youth with type 2 diabetes in the Pediatric Diabetes Consortium.

    abstract：OBJECTIVE:Type 2 diabetes (T2D) in youth is recognized as a pediatric disease, but few reports describe the characteristics during diagnosis. We describe the clinical presentation of 503 youth with T2D. METHODS:The Pediatric Diabetes Consortium (PDC) T2D Clinic Registry enrolled T2D participants from eight pediatric d...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,多中心研究

    doi：10.1111/pedi.12281

    authors： Klingensmith GJ,Connor CG,Ruedy KJ,Beck RW,Kollman C,Haro H,Wood JR,Lee JM,Willi SM,Cengiz E,Tamborlane WV,Pediatric Diabetes Consortium.

    更新日期：2016-06-01 00:00:00

  • Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease.

    abstract：OBJECTIVE:The Environmental Determinants of Diabetes in the Young (TEDDY) study is designed to identify environmental exposures triggering islet autoimmunity and type 1 diabetes (T1D) in genetically high-risk children. We describe the first 100 participants diagnosed with T1D, hypothesizing that (i) they are diagnosed ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,多中心研究

    doi：10.1111/pedi.12066

    authors： Elding Larsson H,Vehik K,Gesualdo P,Akolkar B,Hagopian W,Krischer J,Lernmark Å,Rewers M,Simell O,She JX,Ziegler A,Haller MJ,TEDDY Study Group.

    更新日期：2014-03-01 00:00:00

  • Measurement site of visceral adipose tissue and prediction of metabolic syndrome in youth.

    abstract：OBJECTIVE:It is unknown whether measurement site of visceral adipose tissue (VAT) influences the relationship between VAT and associated health risk in youth and if so, whether ethnic differences exist in this relationship. We examined the influence of the measurement site of VAT on the relationships between VAT and me...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2010.00705.x

    authors： Lee S,Kuk JL,Kim Y,Arslanian SA

    更新日期：2011-05-01 00:00:00

  • Increased arterial stiffness in children and adolescents with type 1 diabetes: no association between arterial stiffness and serum levels of adiponectin.

    abstract：OBJECTIVE:Type 1 diabetes is associated with an increased risk of atherosclerosis. Adiponectin serum levels correlate inversely with cardiovascular disease in adults. The aim of this study was to examine associations between arterial stiffness indices and serum adiponectin concentrations in children and adolescents wit...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2009.00525.x

    authors： Galler A,Heitmann A,Siekmeyer W,Gelbrich G,Kapellen T,Kratzsch J,Kiess W

    更新日期：2010-02-01 00:00:00

  • Self-management among pre-teen and adolescent diabetes device users.

    abstract：OBJECTIVE:Despite increased diabetes device use, few adolescents with type 1 diabetes (T1D) meet glycemic targets. We examine associations between utilization of insulin pumps and continuous glucose monitoring (CGM) and glycemic control. RESEARCH DESIGN AND METHODS:This prospective cohort study included 80 youths (10-...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.13131

    authors： Faulds ER,Hoffman RP,Grey M,Tan A,Tubbs-Cooley H,Militello LK,Happ MB

    更新日期：2020-12-01 00:00:00

  • ATP4A autoimmunity in pediatric patients with type 1 diabetes and its relationship to blood count, iron metabolism, and vitamin B12.

    abstract：OBJECTIVE:We aimed to assess the prevalence of autoantibodies against the 4A subunit of the gastric proton pump (ATP4A) in pediatric type 1 diabetes (T1D) patients and explore the relationship between ATP4A positivity and blood cell count, iron turnover, and vitamin B12 concentration. SUBJECTS:The study included 94 (5...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12528

    authors： Chobot A,Rusak E,Wenzlau J,Davidson H,Adamczyk P,Krzywicka A,Mazur B,Polańska J,Rewers M

    更新日期：2018-02-01 00:00:00