Abstract:
BACKGROUND/OBJECTIVE:Type 2 Diabetes (T2DM) is increasing in childhood especially among females and South-Asians. Our objective was to report outcomes from a national cohort of children and adolescents with T2DM 1 year following diagnosis. METHODS:Clinician reported, 1-year follow-up of a cohort of children (<17 years) diagnosed with T2DM reported through the British Paediatric Surveillance Unit (BPSU) (April 2015-April 2016). RESULTS:One hundred (94%) of 106 baseline cases were available for review. Of these, five were lost to follow up and one had a revised diagnosis. Mean age at follow up was 15.3 years. Median BMI standard deviation scores (SDS) was 2.81 with a decrease of 0.13 SDS over a year. HbA1c <48 mmol/mol (UK target) was achieved in 38.8%. logHbA1c was predicted by clinician reported compliance and attendance concerns (β = 0.12, P = <0.0001) and change in body mass index (BMI) SDS at 1-year (β = 0.13, P=0.007). In over 50%, clinicians reported issues with compliance and attendance. Mean clinic attendance was 75%. Metformin was the most frequently used treatment at baseline (77%) and follow-up (87%). Microalbuminuria prevalence at 1-year was 16.4% compared to 4.2% at baseline and was associated with a higher HbA1c compared to those without microalbuminuria (60 vs 49 mmol/mol, P = 0.03). CONCLUSIONS:Adherence to treatment and a reduction in BMI appear key to better outcomes a year after T2DM diagnosis. Retention and clinic attendance are concerning. The prevalence of microalbuminuria has increased 4-fold in the year following diagnosis and was associated with higher HbA1c.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Candler TP,Mahmoud O,Lynn RM,Majbar AA,Barrett TG,Shield JPHdoi
10.1111/pedi.12761subject
Has Abstractpub_date
2018-12-01 00:00:00pages
1393-1399issue
8eissn
1399-543Xissn
1399-5448journal_volume
19pub_type
杂志文章abstract:OBJECTIVE:We assessed whether differing autoantibody screening criteria for type 1 diabetes (T1D) prevention trials result in different baseline metabolic profiles of those who screen positive. METHODS:Diabetes Prevention Trial-Type 1 (DPT-1) participants were screened for islet cell autoantibodies, whereas TrialNet N...
journal_title:Pediatric diabetes
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更新日期:2018-12-01 00:00:00
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更新日期:2016-12-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5448.2008.00396.x
更新日期:2008-07-28 00:00:00
abstract:BACKGROUND:The global rise in incidence of type 1 diabetes (T1D) is too rapid to be attributed to susceptible genetic background, pinpointing a significant role for environmental factors. Unlike the theory that the need for genetic susceptibility has lessened over time, we hypothesized that the rise in T1D incidence is...
journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2018-06-01 00:00:00
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journal_title:Pediatric diabetes
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更新日期:2020-07-13 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
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更新日期:2012-11-01 00:00:00
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journal_title:Pediatric diabetes
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更新日期:2007-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12353
更新日期:2017-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12598
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:The aim of the study was to search for mutations in the NEUROD1 and IPF-1 genes in patients with clinical characteristics of maturity-onset diabetes of the young (MODY) but with no mutations in the HNF-4A (MODY1), GCK (MODY2) and TCF1 (MODY3) genes. METHODS:We studied 30 unrelated Czech probands with a clin...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00379.x
更新日期:2008-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2008-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12296
更新日期:2016-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2010.00692.x
更新日期:2011-06-01 00:00:00
abstract:OBJECTIVE:To determine the effects of omitting meal time insulin on arterial stiffness in children with type 1 diabetes. RESEARCH DESIGN AND METHODS:In this prospective, randomized, crossover study, radial artery tonometry and augmentation index adjusted to heart rate 75 (AI75 ) were used to measure arterial stiffness...
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:2017-06-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
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更新日期:2017-08-01 00:00:00
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更新日期:2011-06-01 00:00:00
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journal_title:Pediatric diabetes
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更新日期:2008-12-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2002-12-01 00:00:00
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journal_title:Pediatric diabetes
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更新日期:2014-09-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2018-05-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2007.00241.x
更新日期:2007-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-05-01 00:00:00
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journal_title:Pediatric diabetes
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更新日期:2004-01-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2009.00636.x
更新日期:2010-12-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1034/j.1399-5448.2003.00021.x
更新日期:2003-09-01 00:00:00