Abstract:
OBJECTIVE:Type 2 diabetes (T2D) in youth is recognized as a pediatric disease, but few reports describe the characteristics during diagnosis. We describe the clinical presentation of 503 youth with T2D. METHODS:The Pediatric Diabetes Consortium (PDC) T2D Clinic Registry enrolled T2D participants from eight pediatric diabetes centers in the USA. Clinical and laboratory characteristics at the time of diagnosis were analyzed. RESULTS:In total 67% presented with symptoms of diabetes and confirming laboratory data, but 33% were identified by testing at risk children, 11% presented with diabetic ketoacidosis (DKA), and 2% with hyperglycemic hyperosmolar state (HHS). The mean age was 13.1 ± 2.3 yr (range, 4.6-19.8 yr) with 38 (8%) less than 10 yr of age at diagnosis. The majority was female (65%), Hispanic (54%) and had a family history of T2D (92%). The median body mass index (BMI) z-score was 2.3 (interquartile range 2.0-2.6). Fewer than half (46%) lived with both parents, only 30% had parents with education beyond high school, and 43% lived in a household with an income of <$25 000 per year. In the initial month after diagnosis, almost all (92%) were treated with insulin (30%), metformin (31%), or a combination of insulin and metformin (32%); 7% were treated with lifestyle modification alone. CONCLUSIONS:The demographics of T2D in youth indicate significant social vulnerability which may affect outcomes. Metformin and insulin were the initial treatment in most youth. Importantly, T2D may occur at younger ages than previously thought and should be considered in all high-risk children presenting with diabetes.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Klingensmith GJ,Connor CG,Ruedy KJ,Beck RW,Kollman C,Haro H,Wood JR,Lee JM,Willi SM,Cengiz E,Tamborlane WV,Pediatric Diabetes Consortium.doi
10.1111/pedi.12281subject
Has Abstractpub_date
2016-06-01 00:00:00pages
266-73issue
4eissn
1399-543Xissn
1399-5448journal_volume
17pub_type
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journal_title:Pediatric diabetes
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2019-05-01 00:00:00
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doi:10.1034/j.1399-5448.2003.00021.x
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pub_type: 杂志文章
doi:10.1111/pedi.12109
更新日期:2014-09-01 00:00:00
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更新日期:2017-02-01 00:00:00
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更新日期:2016-12-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1399-5448.2009.00604.x
更新日期:2010-09-01 00:00:00
abstract:AIMS:Children with type 1 diabetes (T1D) risk and islet autoantibodies are recruited to a secondary prevention study. The aims were to determine metabolic control in relation to human leukocyte antigen (HLA) genetic risk and islet autoantibodies in prepubertal children. METHODS:In 47 healthy children with GADA and at ...
journal_title:Pediatric diabetes
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更新日期:2013-08-01 00:00:00
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更新日期:2020-05-01 00:00:00
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pub_type: 杂志文章
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更新日期:2015-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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更新日期:2017-12-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12462
更新日期:2017-12-01 00:00:00
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pub_type: 临床试验,杂志文章,多中心研究
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更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/pedi.13034
更新日期:2020-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2011.00807.x
更新日期:2012-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2007.00282.x
更新日期:2007-10-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5448.2008.00463.x
更新日期:2009-05-01 00:00:00