DNA methylation and its role in the pathogenesis of diabetes.

abstract：:The extant literature finds that children with type 1 diabetes mellitus (T1D) experience mild cognitive alterations compared to healthy age-matched controls. The neural basis of these cognitive differences is unclear but may relate in part to the effects of dysglycemia on the developing brain. We investigated longitud...

journal_title：Pediatric diabetes

authors： Foland-Ross LC,Reiss AL,Mazaika PK,Mauras N,Weinzimer SA,Aye T,Tansey MJ,White NH,Diabetes Research in Children Network (DirecNet).

更新日期：2018-04-19 00:00:00

abstract：:Families of children with diabetes increasingly obtain health information from a variety of sources. Doctor-patient relationships have accordingly become more fluid and dynamic with input from other parties. These outside parties include representatives from the diabetes health care industry-industry third parties (IT...

journal_title：Pediatric diabetes

authors： Cameron FJ,Moore B,Gillam L

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Diabetes ketoacidosis (DKA) is a common presentation and complication of type 1 diabetes (T1D). While intravenous insulin is typically used to treat acute metabolic abnormalities, the transition from intravenous to subcutaneous treatment can present a challenge. We hypothesize that co-administration of glarg...

journal_title：Pediatric diabetes

authors： Harrison VS,Rustico S,Palladino AA,Ferrara C,Hawkes CP

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Despite increased diabetes device use, few adolescents with type 1 diabetes (T1D) meet glycemic targets. We examine associations between utilization of insulin pumps and continuous glucose monitoring (CGM) and glycemic control. RESEARCH DESIGN AND METHODS:This prospective cohort study included 80 youths (10-...

journal_title：Pediatric diabetes

authors： Faulds ER,Hoffman RP,Grey M,Tan A,Tubbs-Cooley H,Militello LK,Happ MB

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND:Insulin pump therapy is well established in the treatment of children and adolescents with type 1 diabetes. Most studies focus on outcome parameters like hemoglobin A1c (HbA1c), hypoglycemia, and quality of life, whereas few reports address patients who discontinue pump therapy. OBJECTIVE:This survey focuse...

journal_title：Pediatric diabetes

authors： Hofer SE,Heidtmann B,Raile K,Fröhlich-Reiterer E,Lilienthal E,Berghaeuser MA,Holl RW,DPV-Science-Initiative and the German working group for insulin pump treatment in pediatric patients.

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVE:To examine the extent to which self-regulation skills of adolescents with type 1 diabetes (T1D), including executive functioning and emotion regulation, relate to treatment adherence and glycemic control. METHOD:Participants were 109 adolescents aged 12-18 yr with TID and their primary caregiver who attended...

journal_title：Pediatric diabetes

authors： Graziano PA,Geffken GR,Williams LB,Lewin AB,Duke DC,Storch EA,Silverstein JH

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Hypoglycemia is the most common and severe complication of insulin treatment during the management of type 1 diabetes mellitus (T1DM). Despite its importance, there is a lack of data about the efficacy and superiority of the carbohydrate sources used in hypoglycemia management in children and adolescents. O...

journal_title：Pediatric diabetes

authors： Erbas IM,Abaci A,Anik A,Simsek E,Tuhan HU,Kocyigit C,Yıldız M,Dundar BN,Bober E,Catli G

更新日期：2020-07-13 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There are substantial controversies about the clinical utility of adolescent metabolic syndrome (MetS). The current study examined the stability of adolescent MetS by assessing the agreement and discriminative abilities of four different definitions of adolescent MetS and the adult MetS definit...

journal_title：Pediatric diabetes

authors： Asghari G,Eftekharzadeh A,Hosseinpanah F,Ghareh S,Mirmiran P,Azizi F

更新日期：2017-02-01 00:00:00

abstract：:The prevalence of youth-onset type 2 diabetes is increasing worldwide in parallel with the obesity epidemic. In India, the age at onset of type 2 diabetes had traditionally been a decade or two earlier compared with the western population. Hence, it is not surprising that the prevalence of youth-onset type 2 diabetes ...

journal_title：Pediatric diabetes

authors： Mohan V,Jaydip R,Deepa R

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:Higher birthweight is associated with increased type 1 diabetes mellitus (T1DM) risk, but the contribution of higher adiposity or lean mass is unclear. In this Tasmanian infant cohort, early upper respiratory infection has been associated with higher asthma risk. PATIENTS AND METHODS:Eligible infants repres...

journal_title：Pediatric diabetes

authors： Ponsonby AL,Pezic A,Cochrane J,Cameron FJ,Pascoe M,Kemp A,Dwyer T

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. SUBJECTS AND METHODS:We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6...

journal_title：Pediatric diabetes

authors： RISE Consortium.

更新日期：2019-11-01 00:00:00

abstract：:Neonatal diabetes mellitus is a rare (1/400 000 newborns) but potentially devastating condition, which may be transient or permanent; typical symptoms occur within the first 4 wk of life. The transient form is a developmental insulin production disorder that resolves postnatally. Fifty to 60% of cases can be seen as t...

journal_title：Pediatric diabetes

authors： Goksen D,Darcan S,Coker M,Aksu G,Yildiz B,Kara S,Kültürsay N

更新日期：2006-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Incidence rates of type 1 diabetes have long been on the rise across the globe, however, there is emerging evidence that the rate of rise may be slowing. The objective of this study was to describe trends in the incidence and prevalence of type 1 diabetes in a sample of Canadian children and yo...

journal_title：Pediatric diabetes

authors： Fox DA,Islam N,Sutherland J,Reimer K,Amed S

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:We assessed whether differing autoantibody screening criteria for type 1 diabetes (T1D) prevention trials result in different baseline metabolic profiles of those who screen positive. METHODS:Diabetes Prevention Trial-Type 1 (DPT-1) participants were screened for islet cell autoantibodies, whereas TrialNet N...

journal_title：Pediatric diabetes

authors： Sosenko JM,Mahon J,Rafkin L,Lachin JM,Krause-Steinrauf H,Krischer JP,Cuthbertson D,Palmer JP,Thompson C,Greenbaum CJ,Skyler JS,Diabetes Prevention Trial-Type 1 and TrialNet Study Groups.

更新日期：2011-03-01 00:00:00

abstract：AIMS:We aimed to analyze the relationship between epilepsy and glutamic acid decarboxylase autoantibodies (GADA) in patients with type 1 diabetes mellitus (T1DM) and the impact of GADA on demographic, clinical, and metabolic data in T1DM patients with epilepsy. METHODS:We searched for patients with T1DM ≤20 years and ...

journal_title：Pediatric diabetes

authors： de Sousa GJ,Tittel SR,Häusler M,Holterhus PM,Berger G,Holder M,Kamrath C,Golembowski S,Herrlinger S,Holl RW

更新日期：2020-08-01 00:00:00

abstract：BACKGROUND:Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) is one of the rare H syndrome diseases mainly characterized by hyperpigmentation, hypertrichosis, sensorineural hearing loss, cardiac complications, developmental delay, and diabetes mellitus (DM). Mutations in the coding...

journal_title：Pediatric diabetes

authors： Riachi M,Bas F,Darendeliler F,Hussain K

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:Type 2 diabetes (T2D) in youth is recognized as a pediatric disease, but few reports describe the characteristics during diagnosis. We describe the clinical presentation of 503 youth with T2D. METHODS:The Pediatric Diabetes Consortium (PDC) T2D Clinic Registry enrolled T2D participants from eight pediatric d...

journal_title：Pediatric diabetes

authors： Klingensmith GJ,Connor CG,Ruedy KJ,Beck RW,Kollman C,Haro H,Wood JR,Lee JM,Willi SM,Cengiz E,Tamborlane WV,Pediatric Diabetes Consortium.

更新日期：2016-06-01 00:00:00

abstract：:A subgroup of diabetic patients presents with features typical of type 1 diabetes, but over months to years has variable insulin requirements and develops features of type 2 diabetes. This subgroup is referred to as atypical diabetes mellitus (ADM). Over a span of 50 yr, reports on disease epidemiology, clinical chara...

journal_title：Pediatric diabetes

authors： Egede LE,Willi SM

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to determine the influence of regular physical activity on ghrelin and IGF-1/IGFBP-3 levels during a diabetes camp. METHODS:Twenty-eight children and adolescents (14 boys; mean age 12.1 yr) with type 1 diabetes mellitus (T1DM, mean duration of diabetes 4.8 yr) attending a 2-wk diabe...

journal_title：Pediatric diabetes

authors： Huber J,Fröhlich-Reiterer EE,Sudi K,Suppan E,Weinhandl G,Jasser-Nitsche H,Aigner R,Borkenstein MH

更新日期：2010-09-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is the archetypal example of a T cell-mediated autoimmune disease characterized by selective destruction of pancreatic β cells. The pathogenic equation for T1DM presents a complex interrelation of genetic and environmental factors, most of which have yet to be identified. On the basis o...

journal_title：Pediatric diabetes

authors： Michels A,Zhang L,Khadra A,Kushner JA,Redondo MJ,Pietropaolo M

更新日期：2015-11-01 00:00:00

abstract：:Neonatal diabetes mellitus is rare, may either be transient or permanent, and may be caused by mutations in any of the several different genes. Until recently, most forms of permanent neonatal diabetes required lifelong subcutaneous insulin for management; however, permanent neonatal diabetes due to activating mutatio...

journal_title：Pediatric diabetes

authors： Bremer AA,Ranadive S,Lustig RH

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The global rise in incidence of type 1 diabetes (T1D) is too rapid to be attributed to susceptible genetic background, pinpointing a significant role for environmental factors. Unlike the theory that the need for genetic susceptibility has lessened over time, we hypothesized that the rise in T1D incidence is...

journal_title：Pediatric diabetes

authors： Zung A,Na'amnih W,Bluednikov Y,Mery N,Blumenfeld O,Israel IDDM Registry Study Group (IRRSG).

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To determine the HLA-DRB1, DQB1, DPB1, A, C, and B genotypes among Japanese children with autoimmune type 1 diabetes. METHODS:Four hundred and thirty patients who were GADAb and/or IA-2Ab-positive (Type 1A) were recruited from 37 medical centers as part of a nationwide multicenter collaborative study. DNA sa...

journal_title：Pediatric diabetes

authors： Sugihara S,Ogata T,Kawamura T,Urakami T,Takemoto K,Kikuchi N,Takubo N,Tsubouchi K,Horikawa R,Kobayashi K,Kasahara Y,Kikuchi T,Koike A,Mochizuki T,Minamitani K,Takaya R,Mochizuki H,Nishii A,Yokota I,Kizaki Z,Mori T

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Characterization of partial remission using the insulin dose-adjusted HbA1c (IDAA1c) ≤ 9 definition in a multiethnic Brazilian population of children and adolescents with type 1 diabetes (T1D), in addition with the determination of both Class II HLA genotype and autoantibodies. METHODS:We analyzed the preval...

journal_title：Pediatric diabetes

authors： Camilo DS,Pradella F,Paulino MF,Baracat ECE,Marini SH,Guerra G Jr,Pavin EJ,Parisi C,Longhini ALF,Marques SB,Guariento EG,Lieber SR,Macedo CF,Gama E Silva L,Farias AS,Santos LMB,Volpini WMG

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:Several intervention studies have convincingly demonstrated the importance of good glycemic control to avoid long-term diabetic complications, but the importance of other risk factors remains controversial. We previously reported a markedly reduced incidence of severe retinopathy and nephropathy during the p...

journal_title：Pediatric diabetes

authors： Nordwall M,Arnqvist HJ,Bojestig M,Ludvigsson J

更新日期：2009-05-01 00:00:00

abstract：:The adult brain accounts for a disproportionally large percentage of the body’s total energy consumption (1). However, during brain development,energy demand is even higher, reaching the adult rate by age 2 and increasing to nearly twice the adult rate by age 10, followed by gradual reduction toward adult levels in th...

journal_title：Pediatric diabetes

authors： Arbelaez AM,Semenkovich K,Hershey T

更新日期：2013-12-01 00:00:00

abstract：INTRODUCTION:Trials in adults have demonstrated that interventions targeting lifestyle are effective in preventing or delaying type 2 diabetes (T2D). To address this need in youth, we developed ENCOURAGE Healthy Families (ENCOURAGE), based on the US Diabetes Prevention Program (DPP). STUDY DESIGN:Here, we present resu...

journal_title：Pediatric diabetes

authors： Hannon TS,Saha CK,Carroll AE,Palmer KN,O'Kelly Phillips E,Marrero DG

更新日期：2018-05-20 00:00:00

abstract：BACKGROUND:The autoimmune destruction of beta cells, resulting in clinical type 1 diabetes, may start early in life and last for several months or years. During this period of time, we have an opportunity to try to prevent or delay further beta-cell destruction and clinical onset of type 1 diabetes. OBJECTIVES:Ongoing...

journal_title：Pediatric diabetes

authors： Elding Larsson H

更新日期：2016-07-01 00:00:00

abstract：:In connection with the article entitled "A randomized trial comparing the rate of hypoglycemia – assessed using continuous glucose monitoring – in 125 preschool children with type 1 diabetes treated with insulin glargine or NPH insulin (the PRESCHOOL study)" which appeared in [1], we wish to bring the following correc...

journal_title：Pediatric diabetes

authors：

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To compare outcomes of diabetic ketoacidosis (DKA) 6 yrs before and 6 yrs after changing rehydration fluids from ½ normal saline to Lactated Ringer's and decreasing the total intended fluid volume administered in the first 24 hrs from 3500 mL/m(2) /d to ≤ 2500 mL/m(2) /d at Texas Children's Hospital (TCH) in ...

journal_title：Pediatric diabetes

authors： Hsia DS,Tarai SG,Alimi A,Coss-Bu JA,Haymond MW

更新日期：2015-08-01 00:00:00