Outpatient transition of an infant with permanent neonatal diabetes due to a KCNJ11 activating mutation from subcutaneous insulin to oral glyburide.

abstract：CONTEXT:Type 1 diabetes mellitus (T1DM) is a pro-inflammatory stress state, which, with its attendant hyperglycemia, likely disrupts hypothalamo-pituitary-adrenal (HPA) control, further dysregulating glucose homeostasis. OBJECTIVE:To test the hypothesis that endogenous adrenocorticotropic hormone (ACTH)-cortisol dose-...

journal_title：Pediatric diabetes

authors： Sharma AN,Wigham J,Veldhuis JD

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:To determine reliability and validity of the acceptance and action diabetes questionnaire (AADQ) and the diabetes acceptance and action scale for children and adolescents (DAAS), measures of diabetes-specific psychological flexibility. METHODS:One hundred and eight-one youth with type 1 diabetes completed th...

journal_title：Pediatric diabetes

authors： Berlin KS,Keenan ME,Cook JL,Ankney RL,Klages KL,Semenkovich K,Rybak TM,Banks GG,Alemzadeh R,Eddington AR

更新日期：2020-12-01 00:00:00

abstract：:The adult brain accounts for a disproportionally large percentage of the body’s total energy consumption (1). However, during brain development,energy demand is even higher, reaching the adult rate by age 2 and increasing to nearly twice the adult rate by age 10, followed by gradual reduction toward adult levels in th...

journal_title：Pediatric diabetes

authors： Arbelaez AM,Semenkovich K,Hershey T

更新日期：2013-12-01 00:00:00

abstract：:Type 1 diabetes is the most common form of diabetes in most part of the world, although reliable data are still unavailable in several countries. Wide variations exist between the incidence rates of different populations, incidence is lowest in China and Venezuela (0.1 per 100,000 per year) and highest in Finland and ...

journal_title：Pediatric diabetes

authors： Soltesz G,Patterson CC,Dahlquist G,EURODIAB Study Group.

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Dysglycemia is prevalent in cystic fibrosis (CF) but screening with annual oral glucose tolerance tests (OGTT) can be burdensome. We investigated alternate glycemic markers-hemoglobin A1c (HbA1c), 1,5-anhydroglucitol (1,5AG), fructosamine (FA), and glycated albumin (GA)-as screening tests for CF-related diabe...

journal_title：Pediatric diabetes

authors： Tommerdahl KL,Brinton JT,Vigers T,Nadeau KJ,Zeitler PS,Chan CL

更新日期：2019-12-01 00:00:00

abstract：BACKGROUND:The Practice Management Committee (PMC) of the Pediatric Endocrine Society (PES) conducted a survey of its membership in February/March, 2016 to assess the current state of pediatric diabetes care delivery across multiple practice types in the United States. METHODS:The PES distributed an anonymous electron...

journal_title：Pediatric diabetes

authors： Guttmann-Bauman I,Thornton P,Adhikari S,Reifschneider K,Wood MA,Hamby T,Rubin K

更新日期：2018-08-01 00:00:00

abstract：:Regulatory T cells (Tregs) are responsible for the maintenance of peripheral tolerance. Animal studies have shown that administration of Tregs can prevent type 1 diabetes (DM1). Several clinical trials attempted to induce Tregs with various agents, and thus provide long-term tolerance of β cells in DM1. Nevertheless, ...

journal_title：Pediatric diabetes

authors： Marek-Trzonkowska N,Myśliwec M,Siebert J,Trzonkowski P

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:To determine the effects of omitting meal time insulin on arterial stiffness in children with type 1 diabetes. RESEARCH DESIGN AND METHODS:In this prospective, randomized, crossover study, radial artery tonometry and augmentation index adjusted to heart rate 75 (AI75 ) were used to measure arterial stiffness...

journal_title：Pediatric diabetes

authors： Meehan CS,Kethireddy PL,Ashcraft JK,Shuster JJ,Haller MJ

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Despite increased diabetes device use, few adolescents with type 1 diabetes (T1D) meet glycemic targets. We examine associations between utilization of insulin pumps and continuous glucose monitoring (CGM) and glycemic control. RESEARCH DESIGN AND METHODS:This prospective cohort study included 80 youths (10-...

journal_title：Pediatric diabetes

authors： Faulds ER,Hoffman RP,Grey M,Tan A,Tubbs-Cooley H,Militello LK,Happ MB

更新日期：2020-12-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:The global increase in childhood obesity has in some countries been followed by an increase in type 2 diabetes mellitus (T2DM); however, the prevalence of T2DM among Danish children and adolescents is currently unknown. The aims of this cross-sectional study were to determine the prevalence of T2DM...

journal_title：Pediatric diabetes

authors： Oester IM,Kloppenborg JT,Olsen BS,Johannesen J

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To assess the experiences of participants and parents of children in the oral insulin study of the Diabetes Prevention Trial - Type 1. METHOD:Before trial results were publicized, surveys were completed by 124 participants and 219 parents of children in the oral trial. RESULTS:Although most of those surveye...

journal_title：Pediatric diabetes

authors： Johnson SB,Baughcum AE,Rafkin-Mervis LE,Schatz DA,DPT-1 Study Group.

更新日期：2009-05-01 00:00:00

abstract：AIM:To explore racial differences in adiponectin, and leptin and their relationship with islet autoimmunity in children with new-onset type 1 diabetes (T1D). METHODS:Medical records were reviewed from a cohort of new-onset clinically diagnosed T1D subjects matched by race, age, gender, and year of diagnosis. Sera were...

journal_title：Pediatric diabetes

authors： Hecht Baldauff N,Tfayli H,Dong W,Arena VC,Gurtunca N,Pietropaolo M,Becker DJ,Libman IM

更新日期：2016-06-01 00:00:00

abstract：:Activating mutations in the K(ATP)-channel cause neonatal diabetes mellitus (NDM), and patients have been safely transitioned from insulin to sulfonylureas. We report a male infant with permanent NDM (PNDM), born to a PNDM mother. Blood glucose began to rise on day of life (DOL) 2, and sulfonylurea (glyburide) therapy...

journal_title：Pediatric diabetes

authors： Wambach JA,Marshall BA,Koster JC,White NH,Nichols CG

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Studies indicate high rates of treatment failure and early onset diabetes-related complications in youth-onset type 2 diabetes (T2D). We aim to describe the quality of care provided to children and youth with T2D. METHODS:This prospective cohort study used administrative datasets to describe individuals age...

journal_title：Pediatric diabetes

authors： Amed S,Nuernberger K,Reimer K,Krueger H,Aydede SK,Ayers D,Collet JP

更新日期：2014-11-01 00:00:00

abstract：:Type 1 diabetes is often accompanied with acute hypoinsulinemia that may theoretically inhibit the conversion of essential fatty acids to their longer-chain metabolites. Previously, we found significant reduction in plasma arachidonic (C20:4n-6) and docosahexaenoic (C22:6n-3) acid values in a group of diabetic childre...

journal_title：Pediatric diabetes

authors： Szabó E,Marosvölgyi T,Kozári A,Erhardt E,Soltész G,Decsi T

更新日期：2009-05-01 00:00:00

abstract：OBJECTIVE:Health inequities persist in youth and young adults (YYA) with type 1diabetes in achieving optimal glycemic control. The purpose of this study was to assess the contribution of multiple indicators of social need to these inequities. RESEARCH DESIGN AND METHODS:Two hundred and twenty two YYA withtype 1 diabet...

journal_title：Pediatric diabetes

authors： Sutherland MW,Ma X,Reboussin BA,Mendoza JA,Bell BA,Kahkoska AR,Sauder KA,Lawrence JM,Pihoker C,Liese AD

更新日期：2020-12-01 00:00:00

abstract：:Persistent 'IgE-mediated' insulin allergy (type 1 allergy) (1), unresponsive to changes in insulin type or the use of antihistamines, necessitates desensitization. A number of case reports (2-7) and recent reviews (8, 9) have demonstrated that desensitization can be achieved with continuous subcutaneous insulin infusi...

journal_title：Pediatric diabetes

authors： Neville KA,Verge CF,Wainstein BK,Woodhead HJ,Ziegler JB,Walker JL

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Regulatory T cells (Tregs) play an important role in maintaining tolerance to self-antigens. Defects in the frequency and function of polyclonal Tregs have been reported in type 1 diabetes (T1D). However, characteristics of proinsulin (PI)-specific Tregs in human T1D have not yet been explored...

journal_title：Pediatric diabetes

authors： Paul M,Dayal D,Bhansali A,Sachdeva N

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Few diabetes-specific quality of life (QOL) tools are available for young children. OBJECTIVES:To design and evaluate, a new age-specific QOL questionnaire and its associations with treatment regimens and metabolic control. METHODS:Clinical, demographic data and centrally analyzed HbA1c were collected on 1...

journal_title：Pediatric diabetes

authors： Hoey H,Lange K,Skinner TC,Mortensen H,Swift P,Aanstoot HJ,Castaňo L,Cameron F,de Beaufort C,Hvidoere International Study Group.

更新日期：2018-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The presence of β-cell antibodies is associated with a high risk of type 1 diabetes. With increasing rates of obesity, the distinction between obese T1DM and T2DM has become difficult. Moreover, increasing body mass index (BMI) in at-risk children has been proposed not only as a possible contri...

journal_title：Pediatric diabetes

authors： Libman IM,Barinas-Mitchell E,Marcovina S,Bacha F,Hannon T,Tfayli H,Lee SJ,Bansal S,Robertson R,Arslanian S

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:To evaluate an ambulatory, portable prototype, overnight automated closed-loop (CL) system and to explore optimal time of CL initiation. METHODS:We performed a randomized crossover study and compared automated overnight glucose control started at the time of an evening-meal or at bedtime. Eight young people ...

journal_title：Pediatric diabetes

authors： Elleri D,Allen JM,Biagioni M,Kumareswaran K,Leelarathna L,Caldwell K,Nodale M,Wilinska ME,Acerini CL,Dunger DB,Hovorka R

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Adults with type 2 diabetes mellitus (T2DM) have broad impairments in beta-cell function, including severe attenuation of the first-phase insulin response to glucose, and reduced beta-cell mass. In adolescents with T2DM, there is some evidence that beta-cell dysfunction may be less severe. Our objective was ...

journal_title：Pediatric diabetes

authors： Elder DA,Woo JG,D'Alessio DA

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:Real-time continuous glucose monitoring systems (RT-CGMS) are a recently introduced technology for type 1 diabetes and experience in children is limited. OBJECTIVE:To assess patient and caregiver's perception of benefits and disadvantages of RT-CGMS in children or young adults with type 1 diabetes mellitus ...

journal_title：Pediatric diabetes

authors： Cemeroglu AP,Stone R,Kleis L,Racine MS,Postellon DC,Wood MA

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVES:Care for children and youth with diabetes varies markedly around the world. We developed a standardized, reproducible measure that can be used to document and compare critical factors influencing treatment outcomes. METHODS:A questionnaire consisting of 36 multiple-choice questions covering m...

journal_title：Pediatric diabetes

authors： Ogle GD,Middlehurst AC,Silink M

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Mothers of youth with type 1 diabetes experience increased levels of stress and depression related to the burden of diabetes management, but the concept of diabetes distress, or distress linked specifically to diabetes and its management, has not been applied to mothers. The current study examined diabetes di...

journal_title：Pediatric diabetes

authors： Rumburg TM,Lord JH,Savin KL,Jaser SS

更新日期：2017-02-01 00:00:00

abstract：:The prevalence of youth-onset type 2 diabetes is increasing worldwide in parallel with the obesity epidemic. In India, the age at onset of type 2 diabetes had traditionally been a decade or two earlier compared with the western population. Hence, it is not surprising that the prevalence of youth-onset type 2 diabetes ...

journal_title：Pediatric diabetes

authors： Mohan V,Jaydip R,Deepa R

更新日期：2007-12-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the effectiveness of directly integrating self-monitoring blood glucose (BG) information with insulin pump therapy on overall glycemic control. METHODS:In this randomized trial, 34 youth with type 1 diabetes using insulin pump therapy were trained on the use of the ...

journal_title：Pediatric diabetes

authors： Cobry E,Chase HP,Burdick P,McFann K,Yetzer H,Scrimgeour L

更新日期：2008-04-01 00:00:00

abstract：:Because amylin is co-secreted with insulin from beta cells, patients with type 1 diabetes (T1DM) are deficient in both insulin and amylin. Amylin delays gastric emptying and suppresses glucagon in the postprandial period. Hence, we hypothesized that children with complication-naive T1DM have accelerated gastric emptyi...

journal_title：Pediatric diabetes

authors： Heptulla RA,Rodriguez LM,Mason KJ,Haymond MW

更新日期：2008-12-01 00:00:00

abstract：BACKGROUND:Continuous subcutaneous insulin infusion (CSII) is commonly used in patients with diabetes. Accurate and reliable delivery by insulin pumps is essential for a safe and effective therapy, particularly when using small doses. In this study, accuracy of bolus and basal rate delivery of various available insulin...

journal_title：Pediatric diabetes

authors： Ziegler R,Waldenmaier D,Kamecke U,Mende J,Haug C,Freckmann G

更新日期：2020-06-01 00:00:00

abstract：BACKGROUND:The global rise in incidence of type 1 diabetes (T1D) is too rapid to be attributed to susceptible genetic background, pinpointing a significant role for environmental factors. Unlike the theory that the need for genetic susceptibility has lessened over time, we hypothesized that the rise in T1D incidence is...

journal_title：Pediatric diabetes

authors： Zung A,Na'amnih W,Bluednikov Y,Mery N,Blumenfeld O,Israel IDDM Registry Study Group (IRRSG).

更新日期：2018-06-01 00:00:00