Abstract:
:Persistent 'IgE-mediated' insulin allergy (type 1 allergy) (1), unresponsive to changes in insulin type or the use of antihistamines, necessitates desensitization. A number of case reports (2-7) and recent reviews (8, 9) have demonstrated that desensitization can be achieved with continuous subcutaneous insulin infusion (CSII), but in type 1 diabetes mellitus, the need to slowly increase insulin dose from sub-therapeutic levels competes with the need for glycaemic control and suppression of ketogenesis. Tolerance to intravenous (IV) insulin despite persistent life-threatening allergic reactions to subcutaneous human insulin (bolus or CSII) has been recently described (10). We present the cases of two unrelated 9-yr-old boys with persistent generalized urticarial reactions to subcutaneous injections of all available insulin types, despite treatment with oral antihistamines. After failed rapid desensitization to insulin delivered by either subcutaneous injection or CSII, the concurrent use of IV insulin allowed desensitization to CSII over 5-6 d.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Neville KA,Verge CF,Wainstein BK,Woodhead HJ,Ziegler JB,Walker JLdoi
10.1111/j.1399-5448.2008.00348.xsubject
Has Abstractpub_date
2008-08-01 00:00:00pages
420-2issue
4 Pt 2eissn
1399-543Xissn
1399-5448pii
PDI348journal_volume
9pub_type
杂志文章abstract::Families of children with diabetes increasingly obtain health information from a variety of sources. Doctor-patient relationships have accordingly become more fluid and dynamic with input from other parties. These outside parties include representatives from the diabetes health care industry-industry third parties (IT...
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journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
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更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:The demands of diabetes care can place substantial burden on youth with type 1 diabetes (T1D), who must manage their treatment in conjunction with the developmentally typical tasks of adolescence. How diabetes affects the normative task of identity development deserves further exploration. METHODS:A sample ...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12932
更新日期:2020-02-01 00:00:00
abstract:AIM:To report C-peptide results in newly diagnosed patients and the relation to clinical diagnosis of diabetes. METHODS:A nation-wide cohort, the Better Diabetes Diagnosis study was used to determine serum C-peptide at diagnosis in 2734 children and adolescents. Clinical data were collected at diagnosis and follow-up....
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2011.00807.x
更新日期:2012-02-01 00:00:00
abstract:OBJECTIVE:To determine whether the association between family history of diabetes (FHD) and impaired fasting glucose (IFG) is independent of body mass index (BMI) in children and adolescents. METHODS:In all 443 (11.9%) children and adolescents with FHD, and 3280 (88.1%) without FHD were enrolled in a population-based ...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2009.00590.x
更新日期:2010-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12677
更新日期:2018-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2007.00335.x
更新日期:2008-04-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.13133
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a comorbidity of childhood obesity. OBJECTIVE:We examined whole-body substrate metabolism and metabolic characteristics in obese adolescents with vs. without NAFLD. SUBJECTS:Twelve obese (BMI ≥ 95th percentile) adolescents with and without NAFLD [intrahepatic tr...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12141
更新日期:2015-05-01 00:00:00
abstract:AIMS/HYPOTHESIS:Adolescents with type 1 diabetes (T1D) often have a less atherogenic-appearing fasting lipid profile than controls, despite increased rates of cardiovascular disease (CVD) as adults. We previously reported an atherogenic lipoprotein subfraction cholesterol distribution associated with insulin resistance...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12277
更新日期:2016-06-01 00:00:00
abstract:AIMS:Intravenous glucose tolerance testing (IVGTT) is a common test of β-cell function in which a glucose load is administered and insulin and/or C-peptide responses are monitored. Since the first IVGTT may be more stressful and stress may alter β-cell secretion or hepatic insulin extraction, we asked whether there was...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12064
更新日期:2015-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Incidence rates of type 1 diabetes have long been on the rise across the globe, however, there is emerging evidence that the rate of rise may be slowing. The objective of this study was to describe trends in the incidence and prevalence of type 1 diabetes in a sample of Canadian children and yo...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12566
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the effectiveness of directly integrating self-monitoring blood glucose (BG) information with insulin pump therapy on overall glycemic control. METHODS:In this randomized trial, 34 youth with type 1 diabetes using insulin pump therapy were trained on the use of the ...
journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5448.2007.00268.x
更新日期:2008-04-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2011.00836.x
更新日期:2012-08-01 00:00:00
abstract:PURPOSE:To examine risk factors for re-hospitalization after diagnosis of diabetes mellitus amongst urban minority children. METHODS:Families of insulin-treated African-American and Latino patients aged < 18 yr at diagnosis (n = 216) were interviewed about sociodemographics and other characteristics, on average 5.9 yr...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1034/j.1399-5448.2002.30104.x
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:There are substantial controversies about the clinical utility of adolescent metabolic syndrome (MetS). The current study examined the stability of adolescent MetS by assessing the agreement and discriminative abilities of four different definitions of adolescent MetS and the adult MetS definit...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12349
更新日期:2017-02-01 00:00:00
abstract::This study aimed to analyse the impact of the disease and treatment on health-related quality of life (HRQOL) in intensively treated young patients with diabetes. Our main hypothesis was that metabolic control, gender, age and socio-economic status predict HRQOL. All children and adolescents (n = 400, 191 girls) and p...
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pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00496.x
更新日期:2009-09-01 00:00:00
abstract::Glucokinase gene (GCK) mutations comprise approximately 10% of cases of maturity-onset diabetes of the young (MODY). Over 800 different mutations in GCK have been reported in the Human Gene Mutation Database, the vast majority of which result in MODY type 2. The missense mutation p.Leu122Val is listed in that database...
journal_title:Pediatric diabetes
pub_type:
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更新日期:2020-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1399-5448.2007.00316.x
更新日期:2008-06-01 00:00:00
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doi:10.1111/pedi.13110
更新日期:2020-12-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00472.x
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND:Type 1 diabetes is an autoimmune disease occurring in genetically susceptible individuals. The precipitating cause is unclear. Recently, the Second Lebanon War exposed a large civilian population in northern Israel to significant psychological stress in the form of repeated barrages of missile attacks. HYPO...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2011.00838.x
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:Type 2 diabetes mellitus (T2DM) is increasingly common among children and adolescents. However, achievement of good metabolic control has been difficult in this population. The aim of this study was to survey pediatric endocrine and diabetes specialists regarding the issues they consider to be barriers to suc...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1034/j.1399-5448.2003.00027.x
更新日期:2003-03-01 00:00:00
abstract::There are two peaks in the distribution of the age of onset of type 1 diabetes mellitus (T1DM)--the first in early childhood and the second at the time of puberty. Although T1DM results from the interaction of genetic and non-genetic factors, it has not been established which factors contribute to the bimodal distribu...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-543X.2005.00132.x
更新日期:2005-12-01 00:00:00
abstract::Regulatory T cells (Tregs) are responsible for the maintenance of peripheral tolerance. Animal studies have shown that administration of Tregs can prevent type 1 diabetes (DM1). Several clinical trials attempted to induce Tregs with various agents, and thus provide long-term tolerance of β cells in DM1. Nevertheless, ...
journal_title:Pediatric diabetes
pub_type: 杂志文章,评审
doi:10.1111/pedi.12029
更新日期:2013-08-01 00:00:00
abstract::Although it is known that the incidence of type 1 diabetes mellitus (DM) in childhood is progressively increasing, it is less clear whether the presentation of newly diagnosed DM is changing. The aim of this study was to establish whether any biochemical or clinical presentation parameters have altered over time. A re...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1034/j.1399-5448.2001.20403.x
更新日期:2001-12-01 00:00:00
abstract:BACKGROUND:Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. SUBJECTS AND METHODS:We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12883
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:The objective of this study was to investigate the importance of trust in researchers and other reasons that participating parents, former participants, and non-participants had for participating, or not participating, in a longitudinal cohort study on prediction and development of diabetes in children. STUD...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00498.x
更新日期:2009-09-01 00:00:00