Abstract:
AIM:To report C-peptide results in newly diagnosed patients and the relation to clinical diagnosis of diabetes. METHODS:A nation-wide cohort, the Better Diabetes Diagnosis study was used to determine serum C-peptide at diagnosis in 2734 children and adolescents. Clinical data were collected at diagnosis and follow-up. C-peptide was determined in a validated and controlled time-resolved fluoroimmunoassay. RESULTS:The clinical classification of diabetes, before any information on human leukocyte antigen, islet autoantibodies, or C-peptide was received, was type 1 diabetes (T1D) in 93%, type 2 diabetes (T2D) in 1.9%, maturity onset diabetes of the young (MODY) in 0.8%, secondary diabetes (0.6%), while 3.3% could not be classified. In a random, non-fasting serum sample at diagnosis, 56% of the patients had a C-peptide value >0.2 nmol/L. Children classified as T2D had the highest mean C-peptide (1.83 + 1.23 nmol/L) followed by MODY (1.04 ± 0.71 nmol/L) and T1D (0.28 ± 0.25 nmol/L). Only 1/1037 children who had C-peptide <0.2 nmol/L at diagnosis was classified with a type of diabetes other than T1D. Predictive value of C-peptide >1.0 nmol/L for the classification of either T2D or MODY was 0.46 [confidence interval 0.37-0.58]. CONCLUSIONS:More than half of children with newly diagnosed diabetes have clinically important residual beta-cell function. As the clinical diagnosis is not always straightforward, a random C-peptide taken at diagnosis may help to classify diabetes. There is an obvious use for C-peptide determinations to evaluate beta-cell function in children with diabetes.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Ludvigsson J,Carlsson A,Forsander G,Ivarsson S,Kockum I,Lernmark A,Lindblad B,Marcus C,Samuelsson Udoi
10.1111/j.1399-5448.2011.00807.xsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
45-50issue
1eissn
1399-543Xissn
1399-5448journal_volume
13pub_type
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更新日期:2012-09-01 00:00:00
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更新日期:2016-03-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究,随机对照试验
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pub_type: 杂志文章,评审
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更新日期:2013-08-01 00:00:00
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更新日期:2020-06-01 00:00:00
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