Genetic interaction among three genomic regions creates distinct contributions to early- and late-onset type 1 diabetes mellitus.

abstract：AIMS:To design, develop, and evaluate the feasibility of delivering a multi-component community based intervention to parents and primary health care professionals to raise awareness of the symptoms of Type 1 diabetes (T1D) in childhood in 3 adjoining borough counties of South Wales. MATERIALS AND METHODS:Parent and p...

journal_title：Pediatric diabetes

authors： Townson J,Gregory JW,Cowley L,Gallagher D,Channon S,Robling M,Williams D,Hughes C,Murphy S,Lowes L

更新日期：2017-12-01 00:00:00

abstract：:The SLC29A3 gene, encoding hENT3, a member of the equilibrative nucleoside transporter family, has recently been found mutated in Faisalabad histiocytosis, pigmented hypertrichotic dermatosis with insulin-dependent diabetes, familial sinus histiocytosis with massive lymphadenopathy (SHML), and H syndromes. We here rep...

journal_title：Pediatric diabetes

authors： Elbarbary NS,Tjora E,Molnes J,Lie BA,Habib MA,Salem MA,Njølstad PR

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:The global rise in incidence of type 1 diabetes (T1D) is too rapid to be attributed to susceptible genetic background, pinpointing a significant role for environmental factors. Unlike the theory that the need for genetic susceptibility has lessened over time, we hypothesized that the rise in T1D incidence is...

journal_title：Pediatric diabetes

authors： Zung A,Na'amnih W,Bluednikov Y,Mery N,Blumenfeld O,Israel IDDM Registry Study Group (IRRSG).

更新日期：2018-06-01 00:00:00

abstract：OBJECTIVE:To describe insulin pump use by youth since introduction of universal funding in Ontario, Canada and to explore the relationship between pump use and pediatric diabetes center characteristics and the relationship between discontinuation and center and patient characteristics. RESEARCH DESIGN AND METHODS:Obse...

journal_title：Pediatric diabetes

authors： Shulman R,Stukel TA,Miller FA,Newman A,Daneman D,Guttmann A

更新日期：2017-02-01 00:00:00

abstract：OBJECTIVE:To investigate if maternal diet during pregnancy is associated with occurrence of islet autoimmunity (IA) in the offspring. METHODS:Of 21 700 infants invited to the All Babies in South-east Sweden (ABIS) study, 16 004 screening questionnaires, including a 22-item food frequency questionnaire (FFQ) regarding ...

journal_title：Pediatric diabetes

authors： Brekke HK,Ludvigsson J

更新日期：2010-06-01 00:00:00

abstract：AIMS/HYPOTHESIS:Adolescents with type 1 diabetes (T1D) often have a less atherogenic-appearing fasting lipid profile than controls, despite increased rates of cardiovascular disease (CVD) as adults. We previously reported an atherogenic lipoprotein subfraction cholesterol distribution associated with insulin resistance...

journal_title：Pediatric diabetes

authors： Cree-Green M,Maahs DM,Ferland A,Hokanson JE,Wang H,Pyle L,Kinney GL,King M,Eckel RH,Nadeau KJ

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:To determine the HLA-DRB1, DQB1, DPB1, A, C, and B genotypes among Japanese children with autoimmune type 1 diabetes. METHODS:Four hundred and thirty patients who were GADAb and/or IA-2Ab-positive (Type 1A) were recruited from 37 medical centers as part of a nationwide multicenter collaborative study. DNA sa...

journal_title：Pediatric diabetes

authors： Sugihara S,Ogata T,Kawamura T,Urakami T,Takemoto K,Kikuchi N,Takubo N,Tsubouchi K,Horikawa R,Kobayashi K,Kasahara Y,Kikuchi T,Koike A,Mochizuki T,Minamitani K,Takaya R,Mochizuki H,Nishii A,Yokota I,Kizaki Z,Mori T

更新日期：2012-02-01 00:00:00

abstract：BACKGROUND:The Practice Management Committee (PMC) of the Pediatric Endocrine Society (PES) conducted a survey of its membership in February/March, 2016 to assess the current state of pediatric diabetes care delivery across multiple practice types in the United States. METHODS:The PES distributed an anonymous electron...

journal_title：Pediatric diabetes

authors： Guttmann-Bauman I,Thornton P,Adhikari S,Reifschneider K,Wood MA,Hamby T,Rubin K

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Studies indicate high rates of treatment failure and early onset diabetes-related complications in youth-onset type 2 diabetes (T2D). We aim to describe the quality of care provided to children and youth with T2D. METHODS:This prospective cohort study used administrative datasets to describe individuals age...

journal_title：Pediatric diabetes

authors： Amed S,Nuernberger K,Reimer K,Krueger H,Aydede SK,Ayers D,Collet JP

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:To investigate the changes of peripheral nerve conduction in children with insulin-dependent diabetes mellitus (IDDM) prospectively from diagnosis and to know how those results were related to clinical risk factors. METHODS:A total of 37 patients (14 males and 23 females) aged 3-19 yr (mean 12.0 ± 3.7) with ...

journal_title：Pediatric diabetes

authors： Lee SS,Han HS,Kim H

更新日期：2010-12-01 00:00:00

abstract：OBJECTIVE:The main objective of this work was to follow-up the development of diabetic neuropathy (DN) and its severity in patients with type 1 diabetes over 10 yr. Our intention was also to observe risk factor changes and verify which of them influence the development of neuropathy. The other objective was longitudina...

journal_title：Pediatric diabetes

authors： Hajas G,Kissova V,Tirpakova A

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVE:To compare outcomes of diabetic ketoacidosis (DKA) 6 yrs before and 6 yrs after changing rehydration fluids from ½ normal saline to Lactated Ringer's and decreasing the total intended fluid volume administered in the first 24 hrs from 3500 mL/m(2) /d to ≤ 2500 mL/m(2) /d at Texas Children's Hospital (TCH) in ...

journal_title：Pediatric diabetes

authors： Hsia DS,Tarai SG,Alimi A,Coss-Bu JA,Haymond MW

更新日期：2015-08-01 00:00:00

abstract：BACKGROUND:Alterations in glucose metabolism that lead to the development of metabolic and cardiovascular disease may begin already in childhood. OBJECTIVE:This study aims to generate pediatric age and sex-specific reference values for fasting concentrations of glucose, hemoglobin A1c (HbA1c), insulin, C-peptide, and ...

journal_title：Pediatric diabetes

authors： Frithioff-Bøjsøe C,Lund MAV,Kloppenborg JT,Nielsen TTH,Fonvig CE,Lausten-Thomsen U,Hedley PL,Hansen T,Pedersen OB,Christiansen M,Baker JL,Hansen T,Holm JC

更新日期：2019-08-01 00:00:00

abstract：BACKGROUND:Diabetes ketoacidosis (DKA) is a common presentation and complication of type 1 diabetes (T1D). While intravenous insulin is typically used to treat acute metabolic abnormalities, the transition from intravenous to subcutaneous treatment can present a challenge. We hypothesize that co-administration of glarg...

journal_title：Pediatric diabetes

authors： Harrison VS,Rustico S,Palladino AA,Ferrara C,Hawkes CP

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:This study aimed to determine the degree of left ventricular (LV) dysfunction and its determinants in adolescents with type 2 diabetes (T2D). We hypothesized that adolescents with T2D would display impaired LV diastolic function and that these cardiovascular complications would be exacerbated in youth exposed...

journal_title：Pediatric diabetes

authors： Guillemette L,Dart A,Wicklow B,Dolinsky VW,Cheung D,Jassal DS,Sellers EAC,Gelinas J,Eves ND,Balshaw R,Agarwal P,Duhamel TA,Gordon JW,McGavock JM

更新日期：2020-03-01 00:00:00

abstract：AIM:The aim of this study was to compare genetic (HLA-DQ) and immune markers in a large population of type 1 diabetic (T1D) children and adolescents residing in the same environment, but of different ethnic origin: European Caucasians (EC), Moghrabin Caucasians (MC), Black Africans (BA) and of Mixed Origin (MO). METHO...

journal_title：Pediatric diabetes

authors： Stoupa A,Dorchy H

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Children who inject insulin need clear guidelines as to the length of needle best for them. We studied the distance from surface to muscle in children in order to make needle choices which are evidence-based. METHODS:One hundred one children with type 1 diabetes were divided into three groups according to a...

journal_title：Pediatric diabetes

authors： Lo Presti D,Ingegnosi C,Strauss K

更新日期：2012-11-01 00:00:00

abstract：:Neonatal diabetes mellitus is rare, may either be transient or permanent, and may be caused by mutations in any of the several different genes. Until recently, most forms of permanent neonatal diabetes required lifelong subcutaneous insulin for management; however, permanent neonatal diabetes due to activating mutatio...

journal_title：Pediatric diabetes

authors： Bremer AA,Ranadive S,Lustig RH

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVES:We assessed pubertal development, height, weight, and waist-to-hip ratio (WHR), an index of central adiposity during puberty, in girls with type-1 diabetes mellitus (T1DM), compared to a contemporary control group. METHODS:Pubertal development, weight, height and WHR were studied in 100 pubertal girls with ...

journal_title：Pediatric diabetes

authors： Codner E,Barrera A,Mook-Kanamori D,Bazaes RA,Unanue N,Gaete X,Avila A,Ugarte F,Torrealba I,Pérez V,Panteón E,Cassorla F

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVE:To investigate carbohydrate (CARB) and supplementary fat/protein (CFP) counting using normal and dual-wave bolus in pump therapy of children and young people with type 1 diabetes (T1D). STUDY DESIGN AND METHODS:A randomized clinical trial was conducted in 42 patients (age 6-21 yr) with T1D for at least 1 yr ...

journal_title：Pediatric diabetes

authors： Kordonouri O,Hartmann R,Remus K,Bläsig S,Sadeghian E,Danne T

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The autoimmune destruction of beta cells, resulting in clinical type 1 diabetes, may start early in life and last for several months or years. During this period of time, we have an opportunity to try to prevent or delay further beta-cell destruction and clinical onset of type 1 diabetes. OBJECTIVES:Ongoing...

journal_title：Pediatric diabetes

authors： Elding Larsson H

更新日期：2016-07-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Restrictive eligibility criteria have hampered enrollment into trials for new drugs for youth with type 2 diabetes (T2D). We utilized Pediatric Diabetes Consortium (PDC) T2D Registry enrollment data to estimate the percentage of patients who would be excluded from current T2D trials based on out-of...

journal_title：Pediatric diabetes

authors： Tamborlane WV,Chang P,Kollman C,Klingensmith GJ,Ruedy K,Gal RL,Van Name M,Bacha F,Willi S,Beck RW,Pediatric Diabetes Consortium.

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Effects of pump treatment vs. four times daily injections were explored in children with diabetes with regard to quality of life and impact of disease as well as adverse effects and parameters of metabolic control. METHODS:An open, parallel, randomized controlled prospective comparative study lasting 14 mont...

journal_title：Pediatric diabetes

authors： Nuboer R,Borsboom GJ,Zoethout JA,Koot HM,Bruining J

更新日期：2008-07-28 00:00:00

abstract：:This review highlights the evidence of linking small for gestational age (SGA) with metabolic/cardiovascular disturbances (dysmetabolic syndrome) in later life. The metabolic and cardiovascular complications associated with in utero undernutrition have been identified during the past 10 yr. Reduced fetal growth is ind...

journal_title：Pediatric diabetes

authors： Levy-Marchal C,Jaquet D

更新日期：2004-09-01 00:00:00

abstract：:The association of type 1 diabetes mellitus (T1DM) and acute chorea is rare. We report an 8-yr-old boy with T1DM who developed acute hemichorea-hemiballism of the right arm in whom magnetic resonance imaging (MRI) of the brain revealed hyperintense signal in putamen and considerable atrophy and focal area of gliosis i...

journal_title：Pediatric diabetes

authors： Alves C,Sampaio S,Barbosa V,Machado M

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:We assessed whether differing autoantibody screening criteria for type 1 diabetes (T1D) prevention trials result in different baseline metabolic profiles of those who screen positive. METHODS:Diabetes Prevention Trial-Type 1 (DPT-1) participants were screened for islet cell autoantibodies, whereas TrialNet N...

journal_title：Pediatric diabetes

authors： Sosenko JM,Mahon J,Rafkin L,Lachin JM,Krause-Steinrauf H,Krischer JP,Cuthbertson D,Palmer JP,Thompson C,Greenbaum CJ,Skyler JS,Diabetes Prevention Trial-Type 1 and TrialNet Study Groups.

更新日期：2011-03-01 00:00:00

abstract：:Type 1 diabetes is often accompanied with acute hypoinsulinemia that may theoretically inhibit the conversion of essential fatty acids to their longer-chain metabolites. Previously, we found significant reduction in plasma arachidonic (C20:4n-6) and docosahexaenoic (C22:6n-3) acid values in a group of diabetic childre...

journal_title：Pediatric diabetes

authors： Szabó E,Marosvölgyi T,Kozári A,Erhardt E,Soltész G,Decsi T

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) is one of the rare H syndrome diseases mainly characterized by hyperpigmentation, hypertrichosis, sensorineural hearing loss, cardiac complications, developmental delay, and diabetes mellitus (DM). Mutations in the coding...

journal_title：Pediatric diabetes

authors： Riachi M,Bas F,Darendeliler F,Hussain K

更新日期：2019-06-01 00:00:00

abstract：BACKGROUND:Hypoglycemia is the most common and severe complication of insulin treatment during the management of type 1 diabetes mellitus (T1DM). Despite its importance, there is a lack of data about the efficacy and superiority of the carbohydrate sources used in hypoglycemia management in children and adolescents. O...

journal_title：Pediatric diabetes

authors： Erbas IM,Abaci A,Anik A,Simsek E,Tuhan HU,Kocyigit C,Yıldız M,Dundar BN,Bober E,Catli G

更新日期：2020-07-13 00:00:00

abstract：AIM:To explore racial differences in adiponectin, and leptin and their relationship with islet autoimmunity in children with new-onset type 1 diabetes (T1D). METHODS:Medical records were reviewed from a cohort of new-onset clinically diagnosed T1D subjects matched by race, age, gender, and year of diagnosis. Sera were...

journal_title：Pediatric diabetes

authors： Hecht Baldauff N,Tfayli H,Dong W,Arena VC,Gurtunca N,Pietropaolo M,Becker DJ,Libman IM

更新日期：2016-06-01 00:00:00