Abstract:
BACKGROUND:The global rise in incidence of type 1 diabetes (T1D) is too rapid to be attributed to susceptible genetic background, pinpointing a significant role for environmental factors. Unlike the theory that the need for genetic susceptibility has lessened over time, we hypothesized that the rise in T1D incidence is faster in a genetically susceptible population. SUBJECTS AND METHODS:The study population comprised of 5080 patients aged 0 to 17 years who were reported to the National Israel Diabetes Registry between 1997 and 2014. The patients were divided into familial cases (first-degree relative has T1D), and sporadic cases. Demographic and clinical data were retrieved from the registry. The change in annual percent (from the entire cohort) was computed separately for the sporadic and familial cohorts. RESULTS:The familial (n = 546; 10.7%) and sporadic (n = 4534; 89.3%) cases were comparable for gender, ethnicity, and age at diagnosis. Consanguinity was more common in the familial vs sporadic group (10% vs 6.1%; P = .001). The average annual percent change increased by 1.9% in the familial cases and decreased by 0.2% in the sporadic cases (P = .04). CONCLUSIONS:The rapid rise in the proportion of familial cases of T1D suggests that environmental factors impose higher diabetogenic pressure in patients with a susceptible genetic background.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Zung A,Na'amnih W,Bluednikov Y,Mery N,Blumenfeld O,Israel IDDM Registry Study Group (IRRSG).doi
10.1111/pedi.12617subject
Has Abstractpub_date
2018-06-01 00:00:00pages
693-698issue
4eissn
1399-543Xissn
1399-5448journal_volume
19pub_type
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pub_type: 杂志文章
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2007.00246.x
更新日期:2007-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12677
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2012.00894.x
更新日期:2013-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,多中心研究
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12954
更新日期:2020-03-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,评审
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更新日期:2016-07-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00379.x
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND:Dominant inactivating mutations in HNF1A and HNF4A have been described to cause hyperinsulinism (HI) before evolving to diabetes. However, information available in the literature regarding the clinical phenotype is limited. OBJECTIVE:To report the prevalence of HNF1A and HNF4A mutations in a large cohort of...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12655
更新日期:2018-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.13077
更新日期:2020-07-13 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00348.x
更新日期:2008-08-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12598
更新日期:2018-05-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2006.00201.x
更新日期:2006-10-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2011.00807.x
更新日期:2012-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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journal_title:Pediatric diabetes
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2016-06-01 00:00:00
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journal_title:Pediatric diabetes
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2018-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2009.00628.x
更新日期:2010-11-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12932
更新日期:2020-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type:
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更新日期:2020-09-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12991
更新日期:2020-05-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12350
更新日期:2017-02-01 00:00:00