Abstract:
:Type 1 diabetes is often accompanied with acute hypoinsulinemia that may theoretically inhibit the conversion of essential fatty acids to their longer-chain metabolites. Previously, we found significant reduction in plasma arachidonic (C20:4n-6) and docosahexaenoic (C22:6n-3) acid values in a group of diabetic children during diabetic ketoacidosis. Here we report data on the changes of fatty acids in plasma phospholipids in a diabetic teenager during and after nine subsequent episodes of diabetic ketoacidosis (DKA). Plasma phospholipid linoleic acid (C18:2n-6) values significantly decreased [23.05 (1.05) versus 19.22 (3.22), % w/w, median (IQR), p < 0.01], while values of dihomo-gamma-linolenic acid (C20:3n-6) and docosatetraenoic acid (C22:4n-6) significantly increased [1.72 (0.44) versus 1.80 (0.63) and 0.40 (0.01) versus 0.45 (0.07), respectively, p < 0.05]. Values of alpha-linolenic acid (C18:3n-3) did not change, while values of docosahexaenoic acid were significantly higher after than during the ketoacidosis [1.57 (0.67) versus 1.87 (0.32), p < 0.05). These data obtained in the same patient during repeated episodes of diabetic ketoacidosis support the concept that hypoinsulinemia plays an important role in disturbances of essential fatty acid metabolism in diabetes.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Szabó E,Marosvölgyi T,Kozári A,Erhardt E,Soltész G,Decsi Tdoi
10.1111/j.1399-5448.2008.00487.xsubject
Has Abstractpub_date
2009-05-01 00:00:00pages
209-12issue
3eissn
1399-543Xissn
1399-5448pii
PDI487journal_volume
10pub_type
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journal_title:Pediatric diabetes
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pub_type: 杂志文章
doi:10.1111/pedi.12763
更新日期:2018-12-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,随机对照试验
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pub_type: 临床试验,杂志文章,多中心研究
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pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00430.x
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更新日期:2020-09-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1034/j.1399-5448.2002.30408.x
更新日期:2002-12-01 00:00:00
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更新日期:2017-02-01 00:00:00
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更新日期:2018-05-01 00:00:00
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