Abstract:
OBJECTIVE:To investigate the effect of initial insulin dosage on blood glucose (BG) dynamics, β-cell protection, and oxidative stress in type 1 diabetes mellitus. METHODS:Sixty newly diagnosed type 1 diabetes mellitus patients were randomly assigned to continuous subcutaneous insulin infusions of 0.6 ± 0.2 IU/kg/d (group 1), 1.0 ± 0.2 IU/kg/d (group 2), or 1.4 ± 0.2 IU/kg/d (group 3) for 3 wk. BG was monitored continuously for the first 10 d and the last 2 d of wk 2 and 3. A total of 24-hour urinary 8-iso-PGF2α was assayed on days 8, 9, and 10. The occurrence and duration of the honeymoon period were recorded. Fasting C-peptide and glycosylated hemoglobin (HbA1c) were assayed after 1, 6, and 12 months of insulin treatment. RESULTS:BG decreased to the target range by the end of wk 3 (group 1), wk 2 (group 2), or wk 1 (group 3). The actual insulin dosage over the 3 wk, frequency of hypoglycemia on wk 1 and 2, and median BG at the end of wk 1 differed significantly, but not 8-iso-PGF2α and the honeymoon period in the three groups. No severe hypoglycemia event was observed in any patient, but there was significant difference in the first occurrence of hypoglycemia. CONCLUSIONS:Differences in initial insulin dosage produced different BG dynamics in wk 1, equivalent BG dynamics on wk 2 and 3, but had no influence on short- and long-term BG control and honeymoon phase. The wide range of initial insulin dosage could be chosen if guided by BG monitoring.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Wang Y,Gong C,Cao B,Meng X,Wei L,Wu D,Liang X,Li W,Liu M,Gu Y,Su Cdoi
10.1111/pedi.12374subject
Has Abstractpub_date
2017-05-01 00:00:00pages
196-203issue
3eissn
1399-543Xissn
1399-5448journal_volume
18pub_type
杂志文章,随机对照试验abstract:BACKGROUND:Hypoglycemia is the most common and severe complication of insulin treatment during the management of type 1 diabetes mellitus (T1DM). Despite its importance, there is a lack of data about the efficacy and superiority of the carbohydrate sources used in hypoglycemia management in children and adolescents. O...
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journal_title:Pediatric diabetes
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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journal_title:Pediatric diabetes
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更新日期:2016-08-01 00:00:00
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pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Pediatric diabetes
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pub_type: 杂志文章,多中心研究
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journal_title:Pediatric diabetes
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journal_title:Pediatric diabetes
pub_type: 杂志文章
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更新日期:2003-09-01 00:00:00
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journal_title:Pediatric diabetes
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journal_title:Pediatric diabetes
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pub_type: 杂志文章
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更新日期:2007-10-01 00:00:00
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journal_title:Pediatric diabetes
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pub_type: 杂志文章,随机对照试验
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journal_title:Pediatric diabetes
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更新日期:2014-12-01 00:00:00
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journal_title:Pediatric diabetes
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