当前位置： SCI文献检索 > PEDIATRIC DIABETES期刊下所有文献 > First test effect in intravenous glucose tolerance testing.

First test effect in intravenous glucose tolerance testing.

Abstract：

AIMS:Intravenous glucose tolerance testing (IVGTT) is a common test of β-cell function in which a glucose load is administered and insulin and/or C-peptide responses are monitored. Since the first IVGTT may be more stressful and stress may alter β-cell secretion or hepatic insulin extraction, we asked whether there was a first test effect. METHODS:Insulin and C-peptide responses were compared from two sequential IVGTTs performed within 6 months during staging for the Diabetes Prevention Trial-Type 1 (DPT-1) in 368 people at high risk for type 1 diabetes. Insulin data (1+3 min) were used because the first phase insulin response (and peak insulin concentration) occurs within this time frame. Areas under the curve (AUC) calculations represent early insulin or C-peptide responses from 0 through 10 min post-glucose challenge. RESULTS:More than half of all subjects were found to have first test values lower than the second. This was true for all measures of both insulin and C-peptide but the frequency was significantly different only for insulin measures corrected for basal and for insulin AUC (p < 0.05). However, for subjects (n = 99) whose 1+3 min insulin response was <10th percentile on the first test, there was a significant increase on the second test (p < 0.05). The C-peptide: insulin ratio did not change significantly between tests, indicating that differences are due to changes in β-cell secretion rather than hepatic insulin uptake. CONCLUSIONS:A statistically significant first test effect occurs during the IVGTT attributable to variations in insulin secretion rather than hepatic uptake.

journal_name

Pediatr Diabetes

journal_title

Pediatric diabetes

authors

Ismail HM,White KS,Krischer JP,Chase HP,Cuthbertson D,Palmer JP,DPT-1 Study Group.

doi

10.1111/pedi.12064

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

129-37

issue

2

eissn

1399-543X

issn

1399-5448

journal_volume

16

pub_type

杂志文章

相关文献

PEDIATRIC DIABETES文献大全
  • Children followed in the TEDDY study are diagnosed with type 1 diabetes at an early stage of disease.

    abstract：OBJECTIVE:The Environmental Determinants of Diabetes in the Young (TEDDY) study is designed to identify environmental exposures triggering islet autoimmunity and type 1 diabetes (T1D) in genetically high-risk children. We describe the first 100 participants diagnosed with T1D, hypothesizing that (i) they are diagnosed ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,多中心研究

    doi：10.1111/pedi.12066

    authors： Elding Larsson H,Vehik K,Gesualdo P,Akolkar B,Hagopian W,Krischer J,Lernmark Å,Rewers M,Simell O,She JX,Ziegler A,Haller MJ,TEDDY Study Group.

    更新日期：2014-03-01 00:00:00

  • Validation of a self-report version of the diabetes self-management profile.

    abstract：:Inadequate treatment adherence impedes achievement of glycemic control targets in type 1 diabetes (T1D). Valid and reliable measurement of treatment adherence is a prerequisite to rigorous evaluation of pertinent interventions. The diabetes self-management profile (DSMP), a structured interview measure of T1D adherenc...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2011.00823.x

    authors： Wysocki T,Buckloh LM,Antal H,Lochrie A,Taylor A

    更新日期：2012-08-01 00:00:00

  • An Egyptian family with H syndrome due to a novel mutation in SLC29A3 illustrating overlapping features with pigmented hypertrichotic dermatosis with insulin-dependent diabetes and Faisalabad histiocytosis.

    abstract：:The SLC29A3 gene, encoding hENT3, a member of the equilibrative nucleoside transporter family, has recently been found mutated in Faisalabad histiocytosis, pigmented hypertrichotic dermatosis with insulin-dependent diabetes, familial sinus histiocytosis with massive lymphadenopathy (SHML), and H syndromes. We here rep...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2012.00925.x

    authors： Elbarbary NS,Tjora E,Molnes J,Lie BA,Habib MA,Salem MA,Njølstad PR

    更新日期：2013-09-01 00:00:00

  • Insulin pump use in young children in the T1D Exchange clinic registry is associated with lower hemoglobin A1c levels than injection therapy.

    abstract：:Insulin delivery via injection and continuous subcutaneous insulin infusion (CSII) via insulin pump were compared in a cross-sectional study (n = 669) and retrospective longitudinal study (n = 1904) of young children (<6 yr) with type 1 diabetes (T1D) participating in the T1D Exchange clinic registry. Use of CSII corr...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12121

    authors： Blackman SM,Raghinaru D,Adi S,Simmons JH,Ebner-Lyon L,Chase HP,Tamborlane WV,Schatz DA,Block JM,Litton JC,Raman V,Foster NC,Kollman CR,DuBose SN,Miller KM,Beck RW,DiMeglio LA

    更新日期：2014-12-01 00:00:00

  • Sweet dreams?--nocturnal hypoglycemia in children with type 1 diabetes.

    abstract：:Hypoglycemia is an inevitable consequence of the treatment of type 1 diabetes in childhood. Nocturnal hypoglycemia is often considered as merely the submerged part of this serious complication yet there are reasons to believe that hypoglycemia occurring during sleep may be different in physiological terms. Glucose hom...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1034/j.1399-5448.2002.30203.x

    authors： Matyka KA

    更新日期：2002-06-01 00:00:00

  • Presentation of youth with type 2 diabetes in the Pediatric Diabetes Consortium.

    abstract：OBJECTIVE:Type 2 diabetes (T2D) in youth is recognized as a pediatric disease, but few reports describe the characteristics during diagnosis. We describe the clinical presentation of 503 youth with T2D. METHODS:The Pediatric Diabetes Consortium (PDC) T2D Clinic Registry enrolled T2D participants from eight pediatric d...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,多中心研究

    doi：10.1111/pedi.12281

    authors： Klingensmith GJ,Connor CG,Ruedy KJ,Beck RW,Kollman C,Haro H,Wood JR,Lee JM,Willi SM,Cengiz E,Tamborlane WV,Pediatric Diabetes Consortium.

    更新日期：2016-06-01 00:00:00

  • Instability of different adolescent metabolic syndrome definitions tracked into early adulthood metabolic syndrome: Tehran Lipid and Glucose Study (TLGS).

    abstract：BACKGROUND AND OBJECTIVE:There are substantial controversies about the clinical utility of adolescent metabolic syndrome (MetS). The current study examined the stability of adolescent MetS by assessing the agreement and discriminative abilities of four different definitions of adolescent MetS and the adult MetS definit...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12349

    authors： Asghari G,Eftekharzadeh A,Hosseinpanah F,Ghareh S,Mirmiran P,Azizi F

    更新日期：2017-02-01 00:00:00

  • Harmonize care to optimize outcome in children and adolescents with diabetes mellitus: treatment recommendations in Europe.

    abstract：OBJECTIVE:Identify and evaluate current treatment recommendations in Europe for the care of children with diabetes in view of the European Union (EU) recommendations for Reference Centers. METHODS:A questionnaire was sent in 2008 to representatives of all EU countries and Norway, all known to be actively involved in p...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2012.00908.x

    authors： de Beaufort C,Vazeou A,Sumnik Z,Cinek O,Hanas R,Danne T,Aschemeier B,Forsander G,SWEET group.

    更新日期：2012-09-01 00:00:00

  • Accuracy assessment of bolus and basal rate delivery of different insulin pump systems used in insulin pump therapy of children and adolescents.

    abstract：BACKGROUND:Continuous subcutaneous insulin infusion (CSII) is commonly used in patients with diabetes. Accurate and reliable delivery by insulin pumps is essential for a safe and effective therapy, particularly when using small doses. In this study, accuracy of bolus and basal rate delivery of various available insulin...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12993

    authors： Ziegler R,Waldenmaier D,Kamecke U,Mende J,Haug C,Freckmann G

    更新日期：2020-06-01 00:00:00

  • Gastric emptying and postprandial glucose excursions in adolescents with type 1 diabetes.

    abstract：:Because amylin is co-secreted with insulin from beta cells, patients with type 1 diabetes (T1DM) are deficient in both insulin and amylin. Amylin delays gastric emptying and suppresses glucagon in the postprandial period. Hence, we hypothesized that children with complication-naive T1DM have accelerated gastric emptyi...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2008.00430.x

    authors： Heptulla RA,Rodriguez LM,Mason KJ,Haymond MW

    更新日期：2008-12-01 00:00:00

  • Intramyocellular lipid, adiposity, and muscle oxygen supply in prepubertal type 1 diabetes.

    abstract：BACKGROUND:In the non-diabetic population, intramyocellular lipid (IMCL) accumulation is associated with obesity and poor muscle oxygen supply. IMCL levels are increased in type 1 diabetes, but their significance is less clear. METHODS:We studied a group of 16 prepubertal boys (age 6.4-9.9 yr) with type 1 diabetes and...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1034/j.1399-5448.2003.00021.x

    authors： Ling AH,Donaghue KC,Howard NJ,Arrowsmith FE,Ward JA,Baur LA,Thompson CH

    更新日期：2003-09-01 00:00:00

  • Faster-acting insulin aspart provides faster onset and greater early exposure vs insulin aspart in children and adolescents with type 1 diabetes mellitus.

    abstract：BACKGROUND:Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with additional excipients (L-arginine and niacinamide). In adults, faster aspart provides faster onset and greater early exposure and action vs IAsp. AIM:This randomized, double-blind, 2-period crossover trial invest...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/pedi.12506

    authors： Fath M,Danne T,Biester T,Erichsen L,Kordonouri O,Haahr H

    更新日期：2017-12-01 00:00:00

  • Prediction and prevention of type 1 diabetes: update on success of prediction and struggles at prevention.

    abstract：:Type 1 diabetes mellitus (T1DM) is the archetypal example of a T cell-mediated autoimmune disease characterized by selective destruction of pancreatic β cells. The pathogenic equation for T1DM presents a complex interrelation of genetic and environmental factors, most of which have yet to be identified. On the basis o...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,评审

    doi：10.1111/pedi.12299

    authors： Michels A,Zhang L,Khadra A,Kushner JA,Redondo MJ,Pietropaolo M

    更新日期：2015-11-01 00:00:00

  • Measurement properties of Patient Reported Outcomes Measurement Information System domains for children with type 1 diabetes.

    abstract：OBJECTIVE:Patient Reported Outcomes Measurement Information System (PROMIS) includes numerous domains to assess functioning among the pediatric population. These domains, however, have not been evaluated for use in children with type 1 diabetes (T1D). The objective of this study was to determine the measurement propert...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.13134

    authors： Singh A,Dasgupta M,Retherford D,Fiallo-Scharer R,Simpson PM,Panepinto JA

    更新日期：2020-10-07 00:00:00

  • Worldwide childhood type 1 diabetes incidence--what can we learn from epidemiology?

    abstract：:Type 1 diabetes is the most common form of diabetes in most part of the world, although reliable data are still unavailable in several countries. Wide variations exist between the incidence rates of different populations, incidence is lowest in China and Venezuela (0.1 per 100,000 per year) and highest in Finland and ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2007.00280.x

    authors： Soltesz G,Patterson CC,Dahlquist G,EURODIAB Study Group.

    更新日期：2007-10-01 00:00:00

  • Glargine co-administration with intravenous insulin in pediatric diabetic ketoacidosis is safe and facilitates transition to a subcutaneous regimen.

    abstract：BACKGROUND:Diabetes ketoacidosis (DKA) is a common presentation and complication of type 1 diabetes (T1D). While intravenous insulin is typically used to treat acute metabolic abnormalities, the transition from intravenous to subcutaneous treatment can present a challenge. We hypothesize that co-administration of glarg...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12462

    authors： Harrison VS,Rustico S,Palladino AA,Ferrara C,Hawkes CP

    更新日期：2017-12-01 00:00:00

  • Autosomal inheritance of diabetes in two families characterized by obesity and a novel H241Q mutation in NEUROD1.

    abstract：BACKGROUND:The aim of the study was to search for mutations in the NEUROD1 and IPF-1 genes in patients with clinical characteristics of maturity-onset diabetes of the young (MODY) but with no mutations in the HNF-4A (MODY1), GCK (MODY2) and TCF1 (MODY3) genes. METHODS:We studied 30 unrelated Czech probands with a clin...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2008.00379.x

    authors： Gonsorcíková L,Průhová S,Cinek O,Ek J,Pelikánová T,Jørgensen T,Eiberg H,Pedersen O,Hansen T,Lebl J

    更新日期：2008-08-01 00:00:00

  • A novel 3' untranslated region mutation in the SLC29A3 gene associated with pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus syndrome.

    abstract：BACKGROUND:Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) is one of the rare H syndrome diseases mainly characterized by hyperpigmentation, hypertrichosis, sensorineural hearing loss, cardiac complications, developmental delay, and diabetes mellitus (DM). Mutations in the coding...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12839

    authors： Riachi M,Bas F,Darendeliler F,Hussain K

    更新日期：2019-06-01 00:00:00

  • Increased arterial stiffness in children and adolescents with type 1 diabetes: no association between arterial stiffness and serum levels of adiponectin.

    abstract：OBJECTIVE:Type 1 diabetes is associated with an increased risk of atherosclerosis. Adiponectin serum levels correlate inversely with cardiovascular disease in adults. The aim of this study was to examine associations between arterial stiffness indices and serum adiponectin concentrations in children and adolescents wit...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2009.00525.x

    authors： Galler A,Heitmann A,Siekmeyer W,Gelbrich G,Kapellen T,Kratzsch J,Kiess W

    更新日期：2010-02-01 00:00:00

  • Proinsulin, GLP-1, and glucagon are associated with partial remission in children and adolescents with newly diagnosed type 1 diabetes.

    abstract：OBJECTIVE:Proinsulin is a marker of beta-cell distress and dysfunction in type 2 diabetes and transplanted islets. Proinsulin levels are elevated in patients newly diagnosed with type 1 diabetes. Our aim was to assess the relationship between proinsulin, insulin dose-adjusted haemoglobin A1c (IDAA1C), glucagon-like pep...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1399-5448.2011.00812.x

    authors： Kaas A,Andersen ML,Fredheim S,Hougaard P,Buschard K,Petersen JS,de Beaufort C,Robertson KJ,Hansen L,Mortensen HB,Nielsen LB,Hvidoere Study Group on childhood diabetes.

    更新日期：2012-02-01 00:00:00

  • Achieving ADA/ISPAD clinical guideline goals is associated with higher insulin sensitivity and cardiopulmonary fitness in adolescents with type 1 diabetes: Results from RESistance to InSulin in Type 1 ANd Type 2 diabetes (RESISTANT) and Effects of MEtform

    abstract：OBJECTIVE:Most youth with type 1 diabetes do not meet the American Diabetes Association (ADA) and International Society for Pediatric and Adolescent Diabetes (ISPAD) targets for hemoglobin A1c (HbA1c), blood pressure (BP), lipids, and body mass index (BMI). We hypothesized that ISPAD/ADA goal achievement would be assoc...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12598

    authors： Bjornstad P,Cree-Green M,Baumgartner A,Coe G,Reyes YG,Schäfer M,Pyle L,Regensteiner JG,Reusch JE,Nadeau KJ

    更新日期：2018-05-01 00:00:00

  • The pancreatic ductal epithelium serves as a potential pool of progenitor cells.

    abstract：:With the increasing success of islet transplantation, beta-cell replacement therapy has had renewed interest. To make such a therapy available to more than a few of the thousands of patients with diabetes, new sources of insulin-producing cells must become readily available. The most promising sources are stem cells, ...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,评审

    doi：10.1111/j.1399-543X.2004.00075.x

    authors： Bonner-Weir S,Toschi E,Inada A,Reitz P,Fonseca SY,Aye T,Sharma A

    更新日期：2004-01-01 00:00:00

  • Glycemic control and self-rated health among ethnically diverse adolescents with type 1 diabetes.

    abstract：OBJECTIVE:Patient-reported outcomes have received increased attention as treatment outcomes and indicators of wellbeing. A1c has been criticized as lacking patient-centered relevance because individuals are often unaware of their A1c, and studies also often fail to show a benefit of intensive control on quality of life...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12928

    authors： Kane NS,Hoogendoorn CJ,Commissariat PV,Schulder TE,Gonzalez JS

    更新日期：2020-02-01 00:00:00

  • Monogenic diabetes: A single center experience from South India.

    abstract：:Monogenic forms of diabetes in children are frequently misclassified as either type 1 diabetes or young-onset type 2 diabetes. There is a paucity of literature regarding pediatric monogenic diabetes in the Indian population. A retrospective analysis of case records of 37 children with monogenic diabetes who were diagn...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.13040

    authors： Lakshmanan NK,Pavithran PV,Bhavani N,Abraham N,Kumar H,Nair V,Menon U,Menon AS,Narayanan P,Lakshmi G

    更新日期：2021-02-01 00:00:00

  • Effects of insulin pump vs. injection treatment on quality of life and impact of disease in children with type 1 diabetes mellitus in a randomized, prospective comparison.

    abstract：OBJECTIVE:Effects of pump treatment vs. four times daily injections were explored in children with diabetes with regard to quality of life and impact of disease as well as adverse effects and parameters of metabolic control. METHODS:An open, parallel, randomized controlled prospective comparative study lasting 14 mont...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1399-5448.2008.00396.x

    authors： Nuboer R,Borsboom GJ,Zoethout JA,Koot HM,Bruining J

    更新日期：2008-07-28 00:00:00

  • Improvement in glycemic control through changes in insulin regimens: findings from a Japanese cohort of children and adolescents with type 1 diabetes.

    abstract：OBJECTIVE:Although insulin analogs have dramatically changed diabetes treatment, scarce evidence is available on those effects. We aimed to explore whether glycemic control had improved, the use of insulin analogs had been increased, and hypoglycemic events had decreased over time in Japanese pediatric patients with ty...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.12409

    authors： Mochizuki M,Kikuchi T,Urakami T,Kikuchi N,Kawamura T,Yokomichi H,Hoshino T,Matsuura N,Sasaki N,Sugihara S,Amemiya S,Japanese Study Group of Insulin Therapy for Childhood Adolescent Diabetes (JSGIT).

    更新日期：2017-09-01 00:00:00

  • Measuring psychological flexibility in youth with type 1 diabetes.

    abstract：OBJECTIVE:To determine reliability and validity of the acceptance and action diabetes questionnaire (AADQ) and the diabetes acceptance and action scale for children and adolescents (DAAS), measures of diabetes-specific psychological flexibility. METHODS:One hundred and eight-one youth with type 1 diabetes completed th...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/pedi.13110

    authors： Berlin KS,Keenan ME,Cook JL,Ankney RL,Klages KL,Semenkovich K,Rybak TM,Banks GG,Alemzadeh R,Eddington AR

    更新日期：2020-12-01 00:00:00

  • HLA-class II and class I genotypes among Japanese children with Type 1A diabetes and their families.

    abstract：OBJECTIVE:To determine the HLA-DRB1, DQB1, DPB1, A, C, and B genotypes among Japanese children with autoimmune type 1 diabetes. METHODS:Four hundred and thirty patients who were GADAb and/or IA-2Ab-positive (Type 1A) were recruited from 37 medical centers as part of a nationwide multicenter collaborative study. DNA sa...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章,多中心研究

    doi：10.1111/j.1399-5448.2011.00833.x

    authors： Sugihara S,Ogata T,Kawamura T,Urakami T,Takemoto K,Kikuchi N,Takubo N,Tsubouchi K,Horikawa R,Kobayashi K,Kasahara Y,Kikuchi T,Koike A,Mochizuki T,Minamitani K,Takaya R,Mochizuki H,Nishii A,Yokota I,Kizaki Z,Mori T

    更新日期：2012-02-01 00:00:00

  • Twenty-one years of prospective incidence of childhood type 1 diabetes in Hungary--the rising trend continues (or peaks and highlands?).

    abstract：:The aim of this study was to examine secular trends in the incidence of type 1 diabetes in children aged 0-14 yr in Hungary over the period 1989-2009. Newly diagnosed children with type 1 diabetes aged 0-14 yr in Hungary were prospectively registered from 1989 to 2009. Primary ascertainment of cases was by prospective...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-5448.2011.00826.x

    authors： Gyurus EK,Patterson C,Soltesz G,Hungarian Childhood Diabetes Epidemiology Group.

    更新日期：2012-02-01 00:00:00

  • Human embryonic stem cell research and the Juvenile Diabetes Research Foundation International - a work in progress.

    abstract：:The Juvenile Diabetes Research Foundation International (JDRF) was founded in 1970 by parents of children with juvenile diabetes to find a cure for diabetes and its complications through the support of research. The foundation was an early supporter of stem cell research, recognizing the promise of stem cells to quick...

    journal_title：Pediatric diabetes

    pub_type： 杂志文章

    doi：10.1111/j.1399-543X.2004.00085.x

    authors： Nierras CR,Stallard J,Goldstein RA,Insel R

    更新日期：2004-01-01 00:00:00