Abstract:
:The aim of this study was to examine secular trends in the incidence of type 1 diabetes in children aged 0-14 yr in Hungary over the period 1989-2009. Newly diagnosed children with type 1 diabetes aged 0-14 yr in Hungary were prospectively registered from 1989 to 2009. Primary ascertainment of cases was by prospective registration using hospital notifications. Case ascertainment was over 96% complete using the capture-recapture method. Standardized incidence rates were calculated and secular trends estimated using Poisson regression analysis. In Hungary during 1989-2009 a total number of 3432 children were identified, giving a standardized incidence rate of 12.5 [95% confidence interval (CI) 12.1-12.9] per 100,000 person yr. The overall incidence rate has doubled from 7.7 (95% CI 6.4-9.15) per 100,000 per yr in 1989 to 18.2 (95% CI 15.7-20.9) per 100,000 per yr in 2009. A significant linear trend in incidence (p < 0.001) has been observed over time, with a mean annual increase of 4.4%. The increase in incidence was present in both genders and in all age groups, with the largest relative increase in the youngest age group (6.2%; p < 0.001). The incidence of type 1 diabetes in Hungarian children continues to increase, with the highest rate in the very young. Although it seems that transient periods of stabilization followed by increases in incidence are apparent, the long-term trend continues to be steadily upward. Incidence of childhood type 1 diabetes is a dynamic process, probably reflecting the changes of the environmental exposures and continued registration is necessary to recognize these trends.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Gyurus EK,Patterson C,Soltesz G,Hungarian Childhood Diabetes Epidemiology Group.doi
10.1111/j.1399-5448.2011.00826.xsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
21-5issue
1eissn
1399-543Xissn
1399-5448journal_volume
13pub_type
杂志文章abstract::Because amylin is co-secreted with insulin from beta cells, patients with type 1 diabetes (T1DM) are deficient in both insulin and amylin. Amylin delays gastric emptying and suppresses glucagon in the postprandial period. Hence, we hypothesized that children with complication-naive T1DM have accelerated gastric emptyi...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00430.x
更新日期:2008-12-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:The global increase in childhood obesity has in some countries been followed by an increase in type 2 diabetes mellitus (T2DM); however, the prevalence of T2DM among Danish children and adolescents is currently unknown. The aims of this cross-sectional study were to determine the prevalence of T2DM...
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pub_type: 杂志文章
doi:10.1111/pedi.12291
更新日期:2016-08-01 00:00:00
abstract::Monogenic forms of diabetes in children are frequently misclassified as either type 1 diabetes or young-onset type 2 diabetes. There is a paucity of literature regarding pediatric monogenic diabetes in the Indian population. A retrospective analysis of case records of 37 children with monogenic diabetes who were diagn...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.13040
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Mild hypoglycemia is commonly observed in children treated for type 1 diabetes mellitus (T1DM). Hypoglycemia disturbs cognition and learning. OBJECTIVE:To describe how and to what extent hypoglycemia in young children with T1DM is detected in everyday life. To learn how parents and caregivers treat hypoglyc...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12057
更新日期:2014-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5448.2012.00880.x
更新日期:2012-11-01 00:00:00
abstract:PURPOSE:To examine risk factors for re-hospitalization after diagnosis of diabetes mellitus amongst urban minority children. METHODS:Families of insulin-treated African-American and Latino patients aged < 18 yr at diagnosis (n = 216) were interviewed about sociodemographics and other characteristics, on average 5.9 yr...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1034/j.1399-5448.2002.30104.x
更新日期:2002-03-01 00:00:00
abstract:BACKGROUND:Faster-acting insulin aspart (faster aspart) is insulin aspart (IAsp) in a new formulation with additional excipients (L-arginine and niacinamide). In adults, faster aspart provides faster onset and greater early exposure and action vs IAsp. AIM:This randomized, double-blind, 2-period crossover trial invest...
journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/pedi.12506
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine the degree of left ventricular (LV) dysfunction and its determinants in adolescents with type 2 diabetes (T2D). We hypothesized that adolescents with T2D would display impaired LV diastolic function and that these cardiovascular complications would be exacerbated in youth exposed...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12954
更新日期:2020-03-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12353
更新日期:2017-02-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1034/j.1399-5448.2003.00021.x
更新日期:2003-09-01 00:00:00
abstract::Persistent 'IgE-mediated' insulin allergy (type 1 allergy) (1), unresponsive to changes in insulin type or the use of antihistamines, necessitates desensitization. A number of case reports (2-7) and recent reviews (8, 9) have demonstrated that desensitization can be achieved with continuous subcutaneous insulin infusi...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00348.x
更新日期:2008-08-01 00:00:00
abstract:OBJECTIVE:We aimed to assess the prevalence of autoantibodies against the 4A subunit of the gastric proton pump (ATP4A) in pediatric type 1 diabetes (T1D) patients and explore the relationship between ATP4A positivity and blood cell count, iron turnover, and vitamin B12 concentration. SUBJECTS:The study included 94 (5...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12528
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Pigmentary hypertrichosis and non-autoimmune insulin-dependent diabetes mellitus (PHID) is one of the rare H syndrome diseases mainly characterized by hyperpigmentation, hypertrichosis, sensorineural hearing loss, cardiac complications, developmental delay, and diabetes mellitus (DM). Mutations in the coding...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12839
更新日期:2019-06-01 00:00:00
abstract:BACKGROUND:Pediatric diabetes clinics around the world rapidly adapted care in response to COVID-19. We explored provider perceptions of care delivery adaptations and challenges for providers and patients across nine international pediatric diabetes clinics. METHODS:Providers in a quality improvement collaborative com...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.13180
更新日期:2021-01-19 00:00:00
abstract:BACKGROUND:Few diabetes-specific quality of life (QOL) tools are available for young children. OBJECTIVES:To design and evaluate, a new age-specific QOL questionnaire and its associations with treatment regimens and metabolic control. METHODS:Clinical, demographic data and centrally analyzed HbA1c were collected on 1...
journal_title:Pediatric diabetes
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/pedi.12602
更新日期:2018-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The presence of β-cell antibodies is associated with a high risk of type 1 diabetes. With increasing rates of obesity, the distinction between obese T1DM and T2DM has become difficult. Moreover, increasing body mass index (BMI) in at-risk children has been proposed not only as a possible contri...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2010.00697.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:Health inequities persist in youth and young adults (YYA) with type 1diabetes in achieving optimal glycemic control. The purpose of this study was to assess the contribution of multiple indicators of social need to these inequities. RESEARCH DESIGN AND METHODS:Two hundred and twenty two YYA withtype 1 diabet...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.13112
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:Effects of pump treatment vs. four times daily injections were explored in children with diabetes with regard to quality of life and impact of disease as well as adverse effects and parameters of metabolic control. METHODS:An open, parallel, randomized controlled prospective comparative study lasting 14 mont...
journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5448.2008.00396.x
更新日期:2008-07-28 00:00:00
abstract:OBJECTIVE:To evaluate diabetes knowledge and skills (DKS) in adolescents (>10 year) with type 1 diabetes (T1D) and their parents, and its effect on glycemic control. METHODS:A ready-to-use program and a standardized questionnaire comprising 50 true-false questions based on this program, were elaborated by a National C...
journal_title:Pediatric diabetes
pub_type: 杂志文章,多中心研究
doi:10.1111/pedi.12458
更新日期:2017-11-01 00:00:00
abstract::In connection with the article entitled "A randomized trial comparing the rate of hypoglycemia – assessed using continuous glucose monitoring – in 125 preschool children with type 1 diabetes treated with insulin glargine or NPH insulin (the PRESCHOOL study)" which appeared in [1], we wish to bring the following correc...
journal_title:Pediatric diabetes
pub_type: 已发布勘误
doi:10.1111/pedi.12207
更新日期:2015-09-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12683
更新日期:2018-04-19 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2009.00557.x
更新日期:2010-06-01 00:00:00
abstract:OBJECTIVE:Proinsulin is a marker of beta-cell distress and dysfunction in type 2 diabetes and transplanted islets. Proinsulin levels are elevated in patients newly diagnosed with type 1 diabetes. Our aim was to assess the relationship between proinsulin, insulin dose-adjusted haemoglobin A1c (IDAA1C), glucagon-like pep...
journal_title:Pediatric diabetes
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1399-5448.2011.00812.x
更新日期:2012-02-01 00:00:00
abstract:BACKGROUND:While type 1 diabetes and type 2 diabetes (T2D) are considered etiologically distinct, mixed features of autoimmunity and insulin resistance are increasingly common. We explored a familial contribution to this admixture by evaluating diabetes family history (FH) and its relationship to diabetes type, ethnici...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2007.00241.x
更新日期:2007-12-01 00:00:00
abstract:OBJECTIVE:To determine the effects of omitting meal time insulin on arterial stiffness in children with type 1 diabetes. RESEARCH DESIGN AND METHODS:In this prospective, randomized, crossover study, radial artery tonometry and augmentation index adjusted to heart rate 75 (AI75 ) were used to measure arterial stiffness...
journal_title:Pediatric diabetes
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/pedi.12389
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVE:Dysglycemia is prevalent in cystic fibrosis (CF) but screening with annual oral glucose tolerance tests (OGTT) can be burdensome. We investigated alternate glycemic markers-hemoglobin A1c (HbA1c), 1,5-anhydroglucitol (1,5AG), fructosamine (FA), and glycated albumin (GA)-as screening tests for CF-related diabe...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12914
更新日期:2019-12-01 00:00:00
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journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.13110
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Children who inject insulin need clear guidelines as to the length of needle best for them. We studied the distance from surface to muscle in children in order to make needle choices which are evidence-based. METHODS:One hundred one children with type 1 diabetes were divided into three groups according to a...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2012.00865.x
更新日期:2012-11-01 00:00:00
abstract:BACKGROUND:The global rise in incidence of type 1 diabetes (T1D) is too rapid to be attributed to susceptible genetic background, pinpointing a significant role for environmental factors. Unlike the theory that the need for genetic susceptibility has lessened over time, we hypothesized that the rise in T1D incidence is...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12617
更新日期:2018-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Care for children and youth with diabetes varies markedly around the world. We developed a standardized, reproducible measure that can be used to document and compare critical factors influencing treatment outcomes. METHODS:A questionnaire consisting of 36 multiple-choice questions covering m...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12296
更新日期:2016-08-01 00:00:00