Abstract:
BACKGROUND:We set out to explore associations between the stool bacteriome profiles and early-onset islet autoimmunity, taking into account the interactions with the virus component of the microbiome. METHODS:Serial stool samples were longitudinally collected from 18 infants and toddlers with early-onset islet autoimmunity (median age 17.4 months) followed by type 1 diabetes, and 18 tightly matched controls from the Finnish Diabetes Prediction and Prevention (DIPP) cohort. Three stool samples were analyzed, taken 3, 6, and 9 months before the first detection of serum autoantibodies in the case child. The risk of islet autoimmunity was evaluated in relation to the composition of the bacteriome 16S rDNA profiles assessed by mass sequencing, and to the composition of DNA and RNA viromes. RESULTS:Four operational taxonomic units were significantly less abundant in children who later on developed islet autoimmunity as compared to controls-most markedly the species of Bacteroides vulgatus and Bifidobacterium bifidum. The alpha or beta diversity, or the taxonomic levels of bacterial phyla, classes or genera, showed no differences between cases and controls. A correlation analysis suggested a possible relation between CrAssphage signals and quantities of Bacteroides dorei. No apparent associations were seen between development of islet autoimmunity and sequences of yet unknown origin. CONCLUSIONS:The results confirm previous findings that an imbalance within the prevalent Bacteroides genus is associated with islet autoimmunity. The detected quantitative relation of the novel "orphan" bacteriophage CrAssphage with a prevalent species of the Bacteroides genus may exemplify possible modifiers of the bacteriome.
journal_name
Pediatr Diabetesjournal_title
Pediatric diabetesauthors
Cinek O,Kramna L,Lin J,Oikarinen S,Kolarova K,Ilonen J,Simell O,Veijola R,Autio R,Hyöty Hdoi
10.1111/pedi.12468subject
Has Abstractpub_date
2017-11-01 00:00:00pages
588-598issue
7eissn
1399-543Xissn
1399-5448journal_volume
18pub_type
杂志文章,多中心研究abstract::Because amylin is co-secreted with insulin from beta cells, patients with type 1 diabetes (T1DM) are deficient in both insulin and amylin. Amylin delays gastric emptying and suppresses glucagon in the postprandial period. Hence, we hypothesized that children with complication-naive T1DM have accelerated gastric emptyi...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00430.x
更新日期:2008-12-01 00:00:00
abstract:OBJECTIVE:To investigate the effect of initial insulin dosage on blood glucose (BG) dynamics, β-cell protection, and oxidative stress in type 1 diabetes mellitus. METHODS:Sixty newly diagnosed type 1 diabetes mellitus patients were randomly assigned to continuous subcutaneous insulin infusions of 0.6 ± 0.2 IU/kg/d (gr...
journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/pedi.12374
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Diabetes ketoacidosis (DKA) is a common presentation and complication of type 1 diabetes (T1D). While intravenous insulin is typically used to treat acute metabolic abnormalities, the transition from intravenous to subcutaneous treatment can present a challenge. We hypothesize that co-administration of glarg...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12462
更新日期:2017-12-01 00:00:00
abstract:OBJECTIVE:This study aimed to determine the degree of left ventricular (LV) dysfunction and its determinants in adolescents with type 2 diabetes (T2D). We hypothesized that adolescents with T2D would display impaired LV diastolic function and that these cardiovascular complications would be exacerbated in youth exposed...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12954
更新日期:2020-03-01 00:00:00
abstract:OBJECTIVE:To explore the outcomes of monthly video consultations for children with diabetes. METHODS:The Virtual Outpatient Diabetes Clinic for Children and Youth (VIDIKI) was a 6-month multicenter controlled clinical trial followed by an extension phase. The 240 participants (1-16 years), all using a CGM, were quasi-...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.13133
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:High serum uric acid (SUA) levels are present in patients with metabolic syndrome (MetS), when the latter is associated with endothelial dysfunction, inflammation, and hypertension. This increase in SUA levels may have a key role in cardiovascular diseases. OBJECTIVE:We aim to quantify the differences in in...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12199
更新日期:2015-09-01 00:00:00
abstract:OBJECTIVE:Bilirubin is a potent antioxidant, and serum total bilirubin (STB) concentrations correlate negatively with cardiovascular risk. In adult diabetic patients and in healthy adults, a negative correlation between STB and glycated hemoglobin (HbA1c) has been reported. We investigated whether there is such an asso...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12102
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) is a comorbidity of childhood obesity. OBJECTIVE:We examined whole-body substrate metabolism and metabolic characteristics in obese adolescents with vs. without NAFLD. SUBJECTS:Twelve obese (BMI ≥ 95th percentile) adolescents with and without NAFLD [intrahepatic tr...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12141
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to evaluate the effectiveness of directly integrating self-monitoring blood glucose (BG) information with insulin pump therapy on overall glycemic control. METHODS:In this randomized trial, 34 youth with type 1 diabetes using insulin pump therapy were trained on the use of the ...
journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5448.2007.00268.x
更新日期:2008-04-01 00:00:00
abstract::Beta cell replacement is a valid alternative to exogenous insulin injections to treat type 1 diabetic patients. The rate of success obtained after whole-pancreas transplantation, performed alone or in combination with kidney, and, as shown recently, by islet transplantation, justifies optimism and sets the stage for a...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1034/j.1399-5448.2002.30408.x
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:The prevalence of macrovascular complications is probably underestimated in children with type 1 diabetes (T1D). Arterial stiffness (AS) is a subclinical marker of cardiovascular (CV) risk. The most validated, non-invasive method for AS measurement is pulse wave velocity (PWV). Only a few PWV studies have be...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12385
更新日期:2017-06-01 00:00:00
abstract:BACKGROUND:Obesity and pubertal insulin resistance worsen cardiovascular (CV) risk factors in youth. It is unclear how the relationships of obesity and insulin resistance with CV risk compare to adults. SUBJECTS AND METHODS:We evaluated 66 pubertal youth (mean ± SD: age 14.2 ± 2.0 years, body mass index [BMI] 36.6 ± 6...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12883
更新日期:2019-11-01 00:00:00
abstract::Families of children with diabetes increasingly obtain health information from a variety of sources. Doctor-patient relationships have accordingly become more fluid and dynamic with input from other parties. These outside parties include representatives from the diabetes health care industry-industry third parties (IT...
journal_title:Pediatric diabetes
pub_type: 杂志文章,评审
doi:10.1111/pedi.12786
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:Few diabetes-specific quality of life (QOL) tools are available for young children. OBJECTIVES:To design and evaluate, a new age-specific QOL questionnaire and its associations with treatment regimens and metabolic control. METHODS:Clinical, demographic data and centrally analyzed HbA1c were collected on 1...
journal_title:Pediatric diabetes
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1111/pedi.12602
更新日期:2018-05-01 00:00:00
abstract:AIMS:We aimed to analyze the relationship between epilepsy and glutamic acid decarboxylase autoantibodies (GADA) in patients with type 1 diabetes mellitus (T1DM) and the impact of GADA on demographic, clinical, and metabolic data in T1DM patients with epilepsy. METHODS:We searched for patients with T1DM ≤20 years and ...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.13034
更新日期:2020-08-01 00:00:00
abstract:OBJECTIVE:To evaluate an ambulatory, portable prototype, overnight automated closed-loop (CL) system and to explore optimal time of CL initiation. METHODS:We performed a randomized crossover study and compared automated overnight glucose control started at the time of an evening-meal or at bedtime. Eight young people ...
journal_title:Pediatric diabetes
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1399-5448.2012.00903.x
更新日期:2012-09-01 00:00:00
abstract::Persistent 'IgE-mediated' insulin allergy (type 1 allergy) (1), unresponsive to changes in insulin type or the use of antihistamines, necessitates desensitization. A number of case reports (2-7) and recent reviews (8, 9) have demonstrated that desensitization can be achieved with continuous subcutaneous insulin infusi...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00348.x
更新日期:2008-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVE:Restrictive eligibility criteria have hampered enrollment into trials for new drugs for youth with type 2 diabetes (T2D). We utilized Pediatric Diabetes Consortium (PDC) T2D Registry enrollment data to estimate the percentage of patients who would be excluded from current T2D trials based on out-of...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12763
更新日期:2018-12-01 00:00:00
abstract::A subgroup of diabetic patients presents with features typical of type 1 diabetes, but over months to years has variable insulin requirements and develops features of type 2 diabetes. This subgroup is referred to as atypical diabetes mellitus (ADM). Over a span of 50 yr, reports on disease epidemiology, clinical chara...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1046/j.1399543x.2000.010409.x
更新日期:2000-12-01 00:00:00
abstract::Diabetic neuropathy (DN) represents a major complication of type 1 diabetes mellitus (T1DM) but there is considerable uncertainty as to its incidence, prevalence, diagnosis and prognosis in pediatric population. Generally, DN is classified as polyneuropathy, focal neuropathy and autonomic neuropathy. The latter seems ...
journal_title:Pediatric diabetes
pub_type: 杂志文章,评审
doi:10.1111/j.1399-543X.2004.00041.x
更新日期:2004-03-01 00:00:00
abstract:BACKGROUND:The autoimmune destruction of beta cells, resulting in clinical type 1 diabetes, may start early in life and last for several months or years. During this period of time, we have an opportunity to try to prevent or delay further beta-cell destruction and clinical onset of type 1 diabetes. OBJECTIVES:Ongoing...
journal_title:Pediatric diabetes
pub_type: 杂志文章,评审
doi:10.1111/pedi.12325
更新日期:2016-07-01 00:00:00
abstract:OBJECTIVE:Identify and evaluate current treatment recommendations in Europe for the care of children with diabetes in view of the European Union (EU) recommendations for Reference Centers. METHODS:A questionnaire was sent in 2008 to representatives of all EU countries and Norway, all known to be actively involved in p...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2012.00908.x
更新日期:2012-09-01 00:00:00
abstract:AIMS:To design, develop, and evaluate the feasibility of delivering a multi-component community based intervention to parents and primary health care professionals to raise awareness of the symptoms of Type 1 diabetes (T1D) in childhood in 3 adjoining borough counties of South Wales. MATERIALS AND METHODS:Parent and p...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12516
更新日期:2017-12-01 00:00:00
abstract:INTRODUCTION:The accuracy of blood pressure (BP) measurement is a prerequisite for the reliable diagnosis and management of hypertension. OBJECTIVES:This survey evaluated the use of office and out-of-office BP measurements and the antihypertensive pharmacological treatment in expert pediatric diabetes centers. METHOD...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.13114
更新日期:2020-12-01 00:00:00
abstract::Regulatory T cells (Tregs) are responsible for the maintenance of peripheral tolerance. Animal studies have shown that administration of Tregs can prevent type 1 diabetes (DM1). Several clinical trials attempted to induce Tregs with various agents, and thus provide long-term tolerance of β cells in DM1. Nevertheless, ...
journal_title:Pediatric diabetes
pub_type: 杂志文章,评审
doi:10.1111/pedi.12029
更新日期:2013-08-01 00:00:00
abstract:BACKGROUND:Real-time continuous glucose monitoring systems (RT-CGMS) are a recently introduced technology for type 1 diabetes and experience in children is limited. OBJECTIVE:To assess patient and caregiver's perception of benefits and disadvantages of RT-CGMS in children or young adults with type 1 diabetes mellitus ...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2009.00549.x
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Several intervention studies have convincingly demonstrated the importance of good glycemic control to avoid long-term diabetic complications, but the importance of other risk factors remains controversial. We previously reported a markedly reduced incidence of severe retinopathy and nephropathy during the p...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2008.00472.x
更新日期:2009-05-01 00:00:00
abstract::Neonatal diabetes mellitus is a rare (1/400 000 newborns) but potentially devastating condition, which may be transient or permanent; typical symptoms occur within the first 4 wk of life. The transient form is a developmental insulin production disorder that resolves postnatally. Fifty to 60% of cases can be seen as t...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2006.00201.x
更新日期:2006-10-01 00:00:00
abstract:OBJECTIVE:The Environmental Determinants of Diabetes in the Young (TEDDY) study seeks to identify environmental triggers of autoimmunity and type 1 diabetes mellitus (T1DM) in children at increased human-leukocyte-antigen conferred genetic risk for this disease. The objective of this study was to identify predictors of...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/j.1399-5448.2010.00686.x
更新日期:2011-05-01 00:00:00
abstract:OBJECTIVE:Mechanisms underlying the role of non-human leukocyte antigen (HLA) genetic risk variants in type 1 diabetes (T1D) are poorly understood. We aimed to test the association between methylation and non-HLA genetic risk. METHODS:We conducted a methylation quantitative trait loci (mQTL) analysis in a nested case-...
journal_title:Pediatric diabetes
pub_type: 杂志文章
doi:10.1111/pedi.12995
更新日期:2020-06-01 00:00:00