Abstract：
:Squamous cell carcinoma (SCC) of the lung is the second most common subtype of lung cancer. With limited treatment options, the 5-year survival rate of SCC is only 15%. Although genomic alterations in SCC have been characterized, identifying the alterations that drive SCC is critical for improving treatment strategies. Mouse models of SCC are currently limited. Using lentiviral delivery of Sox2 specifically to the mouse lung, we tested the ability of Sox2 to promote tumorigenesis in multiple tumor suppressor backgrounds. Expression of Sox2, frequently amplified in human SCC, specifically cooperates with loss of Lkb1 to promote squamous lung tumors. Mouse tumors exhibit characteristic histopathology and biomarker expression similar to human SCC. They also mimic human SCCs by activation of therapeutically relevant pathways including STAT and mTOR. This model may be utilized to test the contribution of additional driver alterations in SCC, as well as for preclinical drug discovery.
journal_name
Cell Repjournal_title
Cell reportsauthors
Mukhopadhyay A,Berrett KC,Kc U,Clair PM,Pop SM,Carr SR,Witt BL,Oliver TGdoi
10.1016/j.celrep.2014.05.036subject
Has Abstractpub_date
2014-07-10 00:00:00pages
40-9issue
1issn
2211-1247pii
S2211-1247(14)00430-6journal_volume
8pub_type
杂志文章相关文献
Cell Reports文献大全abstract：:High-throughput single-cell RNA sequencing (scRNA-seq) has become a frequently used tool to assess immune cell heterogeneity. Recently, the combined measurement of RNA and protein expression was developed, commonly known as cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq). Acquisition of prote...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.03.063
更新日期：2020-04-07 00:00:00
abstract：:The innate immune system plays key roles in tissue regeneration. For example, microglia promote neurogenesis in Müller glia in birds and fish after injury. Although mammalian retina does not normally regenerate, neurogenesis can be induced in mouse Müller glia by Ascl1, a proneural transcription factor. We show that i...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108507
更新日期：2020-12-15 00:00:00
abstract：:Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells. Here, we demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumor progression. NRCP was highly upregulated in ovarian tumors, a...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.11.047
更新日期：2015-12-22 00:00:00
abstract：:The Argonaute subfamily of proteins (AGO) loads microRNAs (miRNAs) to form the effector complex that mediates target gene silencing. Empty AGO, but not miRNA-loaded AGO, is selectively degraded across species. We have reported that the degradation of empty AGO is part of a quality control pathway that eliminates dysfu...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.07.003
更新日期：2019-07-30 00:00:00
abstract：:Tripartite motif-containing protein 5α (TRIM5α) is a cellular antiviral restriction factor that prevents early events in retrovirus replication. The activity of TRIM5α is thought to be limited to retroviruses as a result of highly specific interactions with capsid lattices. In contrast to this current understanding, w...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.05.040
更新日期：2019-06-11 00:00:00
abstract：:Modeling late-onset disorders such as Parkinson's disease (PD) using iPSC technology remains a challenge, as current differentiation protocols yield cells with the properties of fetal-stage cells. Here, we tested whether it is possible to accelerate aging in vitro to trigger late-onset disease phenotypes in an iPSC mo...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.09.062
更新日期：2016-10-18 00:00:00
abstract：:Transcriptome analyses have revealed that convergent gene transcription can produce many 3'-overlapping mRNAs in diverse organisms. Few studies have examined the fate of 3'-complementary mRNAs in double-stranded RNA-dependent nuclear phenomena, and nothing is known about the cytoplasmic destiny of 3'-overlapping messe...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.08.016
更新日期：2015-09-22 00:00:00
abstract：:In the presynaptic terminal, the magnitude and location of Ca2+ entry through voltage-gated Ca2+ channels (VGCCs) regulate the efficacy of neurotransmitter release. However, how presynaptic active zone proteins control mammalian VGCC levels and organization is unclear. To address this, we deleted the CAST/ELKS protein...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.06.024
更新日期：2018-07-10 00:00:00
abstract：:Neurons face unique transport challenges. They need to deliver cargo over long axonal distances and to many presynaptic nerve terminals. Rab GTPases are master regulators of vesicular traffic, but essential presynaptic Rabs have not been identified. Here, we find that Rab6, a Golgi-derived GTPase for constitutive secr...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.107712
更新日期：2020-06-09 00:00:00
abstract：:Neutrophils are short-lived blood cells that play a critical role in host defense against infections. To better comprehend neutrophil functions and their regulation, we provide a complete epigenetic overview, assessing important functional features of their differentiation stages from bone marrow-residing progenitors ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.08.018
更新日期：2018-09-04 00:00:00
abstract：:Within the field of computational neuroscience there are great expectations of finding new ways to rebalance the complex dynamic system of the human brain through controlled pharmacological or electromagnetic perturbation. Yet many obstacles remain between the ability to accurately predict how and where best to pertur...
journal_title：Cell reports
pub_type： 杂志文章,评审
doi：10.1016/j.celrep.2020.108128
更新日期：2020-09-08 00:00:00
abstract：:Amyloidosis is a major problem in over one hundred diseases, including Alzheimer's disease (AD). Using the iDISCO visualization method involving targeted molecular labeling, tissue clearing, and light-sheet microscopy, we studied plaque formation in the intact AD mouse brain at up to 27 months of age. We visualized am...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.06.060
更新日期：2016-07-26 00:00:00
abstract：:In Drosophila, it is thought that peptidoglycan recognition proteins (PGRPs) SA and LC structurally discriminate between bacterial peptidoglycans with lysine (Lys) or diaminopimelic (DAP) acid, respectively, thus inducing differential antimicrobial transcription response. Here, we find that accessibility to PG at the ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.04.103
更新日期：2019-05-21 00:00:00
abstract：:Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and Cdt1. We find that the three origins in the single chromosome of the...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2013.01.002
更新日期：2013-02-21 00:00:00
abstract：:Thymic epithelial cells (TECs) are critically required for T cell development, but the cellular mechanisms that maintain adult TECs are poorly understood. Here, we show that a previously unidentified subpopulation, EpCam(+)UEA1(-)Ly-51(+)PLET1(+)MHC class II(hi), which comprises <0.5% of adult TECs, contains bipotent ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.02.080
更新日期：2016-03-29 00:00:00
abstract：:Interleukin-38 (IL-38) is a cytokine of the IL-1 family with a role in chronic inflammation. However, its main cellular targets and receptors remain obscure. IL-38 is highly expressed in the skin and downregulated in psoriasis patients. We report an investigation in cellular targets of IL-38 during the progression of ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.03.082
更新日期：2019-04-16 00:00:00
abstract：:Electrons feed into the mitochondrial electron transport chain (mETC) from NAD- or FAD-dependent enzymes. A shift from glucose to fatty acids increases electron flux through FAD, which can saturate the oxidation capacity of the dedicated coenzyme Q (CoQ) pool and result in the generation of reactive oxygen species. To...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.03.009
更新日期：2016-04-05 00:00:00
abstract：:Previous efforts to identify cross-neutralizing antibodies to the receptor-binding site (RBS) of ebolavirus glycoproteins have been unsuccessful, largely because the RBS is occluded on the viral surface. We report a monoclonal antibody (FVM04) that targets a uniquely exposed epitope within the RBS; cross-neutralizes E...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2016.04.026
更新日期：2016-05-17 00:00:00
abstract：:Amyotrophic lateral sclerosis (ALS) is a devastating disease that progresses from detachment of motor nerve terminals to complete muscle paralysis and lethal respiratory failure within 5 years of diagnosis. Genetic studies have linked mutations in several genes to ALS, and mice bearing mutations in SOD1 recapitulate h...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2012.08.004
更新日期：2012-09-27 00:00:00
abstract：:PARP1 is the main sensor of single- and double-strand breaks in DNA and, in building chains of poly(ADP-ribose), promotes the recruitment of many downstream signaling and effector proteins involved in the DNA damage response (DDR). We show a robust physical interaction between PARP1 and the replication fork protein TI...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.09.017
更新日期：2015-10-20 00:00:00
abstract：:HIV-1 is transmitted between T cells through the release of cell-free particles and through cell-cell contact. Cell-to-cell transmission is more efficient than cell-free virus transmission, mediates resistance to immune responses, and facilitates the spread of virus among T cells. However, whether HIV cell-to-cell tra...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.07.079
更新日期：2018-08-21 00:00:00
abstract：:Long-term information storage in the brain requires continual modification of the neuronal transcriptome. Synaptic inputs located hundreds of micrometers from the nucleus can regulate gene transcription, requiring high-fidelity, long-range signaling from synapses in dendrites to the nucleus in the cell soma. Here, we ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.03.005
更新日期：2019-03-26 00:00:00
abstract：:Early infantile epileptic encephalopathies (EOEE) are a debilitating spectrum of disorders associated with cognitive impairments. We present a clinical report of a KCNT2 mutation in an EOEE patient. The de novo heterozygous variant Phe240Leu SLICK was identified by exome sequencing and confirmed by Sanger sequencing. ...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2017.09.088
更新日期：2017-10-24 00:00:00
abstract：:We provide a catalog for the effects of the human kinome on cell survival in response to DNA-damaging agents, covering all major DNA repair pathways. By treating 313 kinase-deficient cell lines with ten diverse DNA-damaging agents, including seven commonly used chemotherapeutics, we identified examples of vulnerabilit...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.12.087
更新日期：2019-01-15 00:00:00
abstract：:The use of oligonucleotides to activate the splicing of selected exons is limited by a poor understanding of the mechanisms affected. A targeted bifunctional oligonucleotide enhancer of splicing (TOES) anneals to SMN2 exon 7 and carries an exonic splicing enhancer (ESE) sequence. We show that it stimulates splicing sp...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.08.051
更新日期：2014-10-09 00:00:00
abstract：:Altered physiological states require neuronal adaptation. In late pregnancy and lactation, a sub-population of the mouse hypothalamic tuberoinfundibular dopaminergic (TIDA) neurons alters their behavior to synthesize and release met-enkephalin rather than dopamine. These neurons normally release dopamine to inhibit pr...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2019.01.067
更新日期：2019-02-12 00:00:00
abstract：:Transient receptor potential (TRP) channels are regulated by diverse stimuli comprising thermal, chemical, and mechanical modalities. They are also commonly regulated by phosphatidylinositol-4,5-bisphosphate (PIP2), with underlying mechanisms largely unknown. We here revealed an intramolecular interaction of the TRPP3...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2018.01.042
更新日期：2018-02-06 00:00:00
abstract：:S1PR1 signaling has been shown to restrain the number and function of regulatory T (Treg) cells in the periphery under physiological conditions and in colitis models, but its role in regulating tumor-associated T cells is unknown. Here, we show that S1PR1 signaling in T cells drives Treg accumulation in tumors, limits...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2014.02.016
更新日期：2014-03-27 00:00:00
abstract：:Graft-versus-host disease (GVHD) limits the success of allogeneic hematopoietic cell transplantation (allo-HCT). Lysosomal acid lipase (LAL) mediates the intrinsic lipolysis of cells to generate free fatty acids (FFAs), which play an essential role in the development, proliferation, and function of T cells. Here, we f...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2020.108316
更新日期：2020-10-27 00:00:00
abstract：:SUMOylation has been implicated in cellular stress adaptation, but its role in regulating liver kinase B1 (LKB1), a major upstream kinase of the energy sensor AMP-activated protein kinase (AMPK), is unknown. Here, we show that energy stress triggers an increase in SUMO1 modification of LKB1, despite a global reduction...
journal_title：Cell reports
pub_type： 杂志文章
doi：10.1016/j.celrep.2015.07.002
更新日期：2015-08-04 00:00:00
