Abstract:
:The association between the rs498872 single nucleotide polymorphism (SNP) and glioma risk has been studied, but these studies have yielded conflicting results. In order to explore this association, we performed a meta-analysis. A comprehensive literature search was performed using PubMed and EMBASE database, with the last search up to August 23, 2013. Six articles including 10 case-control studies in English with 18 002 controls and 8434 cases were eligible for the meta-analysis. Subgroup analyses were conducted by source of controls and ethnicity. The combined results showed that rs498872 polymorphism was significantly associated with glioma risks (TT vs CC: OR = 1.337, 95% CI = 1.222-1.462; TC vs CC: OR = 1.173, 95% CI = 1.081-1.272; dominant model: OR = 1.199, 95% CI = 1.101-1.306; recessive model: OR = 1.237, 95% CI = 1.135-1.347; additive model: OR = 1.156, 95% CI = 1.085-1.232). Moreover, there was increased cancer risk in all genetic models after stratification of the SNP data by the source of controls and ethnicity, and no evidence of publication bias was produced. Our meta-analysis suggested that rs498872 polymorphism was associated with increased risk of glioma. However, additional studies exploring the combined effects of rs498872 polymorphisms in Asian population should be investigated.
journal_name
Asia Pac J Clin Oncoljournal_title
Asia-Pacific journal of clinical oncologyauthors
Gao X,Mi Y,Yan A,Sha B,Guo N,Hu Z,Zhang N,Jiang F,Gou Xdoi
10.1111/ajco.12211subject
Has Abstractpub_date
2015-12-01 00:00:00pages
e13-21issue
4eissn
1743-7555issn
1743-7563journal_volume
11pub_type
杂志文章,meta分析,评审abstract:AIM:Integration of clinical genetics into oncology is variable. Sarcomas have a strong genetic component, with up to 1/30 patients carrying germline TP53 mutations. This study aimed to define genetic risk awareness among sarcoma physicians. Outcomes were attitudes toward genetic testing, level of cancer risk and awaren...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12457
更新日期:2016-06-01 00:00:00
abstract:AIM:Elevated neutrophil-to-lymphocyte ratio (NLR) has been demonstrated to be a poor prognostic factor in multiple types of malignancies, whereas the effect of NLR on the prognosis of epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer (NSCLC) patients treated with first-line EGFR tyrosi...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12273
更新日期:2017-10-01 00:00:00
abstract:AIM:A proportion of locally advanced rectal cancer patients who receive neoadjuvant chemoradiotherapy (NACRT) are still unresectable. This study was undertaken to assess the outcomes of giving additional chemotherapy to rectal cancer patients with unresectable disease after NACRT. METHODS:Patients with poor response t...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12660
更新日期:2017-08-01 00:00:00
abstract:AIMS:Currently, the only standard systemic treatment for advanced hepatocellular carcinoma is sorafenib monotherapy. The study was conducted to assess the efficacy and safety of the novel combination of sorafenib and gemcitabine in the treatment of advanced hepatocellular carcinoma. METHODS:Between March 2008 and Octo...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1111/ajco.12191
更新日期:2014-09-01 00:00:00
abstract::The rationale for certain patterns of metastatic spread seen in melanoma is not well understood. Currently, there is no clear experimental evidence to support the potential for metastases to form metastases in this disease. We report a case of a 31-year-old woman, with metastatic melanoma, who developed axillary lymph...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12169
更新日期:2014-12-01 00:00:00
abstract:AIM:In colorectal cancer (CRC), adjuvant therapy is offered on the basis of stage and attempts to identify factors to better target treatment have not been successful. Recent work suggested that mismatch repair deficient CRCs may not benefit from 5FU adjuvant chemotherapy but studies remain conflicting. We aimed to det...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12411
更新日期:2015-12-01 00:00:00
abstract:AIM:To explore the incidence of subclinical cardiotoxicity in women treated with adjuvant trastuzumab in the early breast cancer setting using cardiac magnetic resonance imaging (cMRI). METHODS:The cardiac function and myocardial tissue characteristics of 25 women who had completed adjuvant trastuzumab therapy greater...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2011.01462.x
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Clinical trials investigating the effects of addition of oxaliplatin to neoadjuvant radiochemotherapy in locally advanced rectal cancers (LARCs) have brought controversial results for pathologic complete response as an endpoint. This randomized clinical trial investigated downstaging as a short-term surrogat...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ajco.12675
更新日期:2017-12-01 00:00:00
abstract:AIM:For several decades urinary arylsulfatase (ARS) activity has been reported to be elevated in many cancers. It has been shown that urinary ARS activity may serve as a marker of tumor progression and therapy surveillance. This study was designed to evaluate the clinical application of detection of urinary ARS activit...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2012.01545.x
更新日期:2012-12-01 00:00:00
abstract:AIM:Carboplatin dosing depends on accurate glomerular filtration rate (GFR) estimation. There is a lack of clinical agreement about carboplatin dosing when the GFR measurement is very high (>110 mL/min). METHODS:A retrospective audit of pre-chemotherapy 99m technetium (Tc) diethylenetriamene pentaacetate (DTPA) radion...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2011.01409.x
更新日期:2011-09-01 00:00:00
abstract:AIM:Retroperitoneal sarcomas (RPSs) are large, rare tumors. The role of core biopsy for retroperitoneal masses identified by preoperative imaging is unclear and we report the safety and accuracy of core biopsies at a specialized sarcoma unit in Sydney, Australia. METHODS:A retrospective analysis of a prospectively col...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12125
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:MRI and PET/CT scans are the main supportive methods for nasopharyngeal cancer (NPC) for staging and planning. The aim of this study is to compare MRI and PET/CT scanning in terms of survival in patients with NPC who had MRI or PET/CT-simulated radiotherapy planning. METHODS:Pathological diagnosed nonkerati...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13400
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Small cell lung cancer is a rapidly progressive disease with high fatality. No sensitive and specific biomarker to assist in managing this disease exists currently. AIM:Role of pretreatment serum lactate dehydrogenase as a biomarker in small cell lung cancer. METHODS:A hospital-based cancer registry was us...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12674
更新日期:2018-04-01 00:00:00
abstract:AIMS:Quality of life (QOL) is important in patients with advanced cancer. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 is a general QOL tool used in cancer patients. Often, with a large enough sample, statistical significance of changecan be reached, however the clinical significance i...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12070
更新日期:2014-06-01 00:00:00
abstract:PURPOSE:Mitomycin C (MMC) plus standard 5-fluorouracil (FU) infusion in weeks 1 and 5 often contributes to radiotherapy interruptions and possibly less-than-ideal outcomes in anal cancer. This study was to evaluate alternative strategies for chemotherapy delivery that might be less toxic or more efficacious, and outcom...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13106
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:An elevated preoperative aspartate aminotransferase-to-lymphocyte ratio index (ALRI) may predict poor survival in various cancers. However, the prognostic value of aminotransferase-to-lymphocyte ratio index (ALRI) in patients with hepatocellular carcinoma (HCC) remains to be determined. MATERIALS AND METHOD...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13458
更新日期:2020-10-30 00:00:00
abstract:BACKGROUND:Anti-HER2 therapy-related cardiotoxicity is well described in the context of clinical trials, particularly in the setting of early stage disease, but there is more limited data in advanced breast cancer and in the real world setting. MATERIAL AND METHODS:A prospectively-maintained registry database with 312...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13381
更新日期:2020-12-01 00:00:00
abstract::For advanced and metastatic urothelial carcinomas (UCs), platinum (preferably cisplatin)-based chemotherapy has been the standard treatment for many years. However, many patients are ineligible for cisplatin-based chemotherapy because of poor performance status and/or other age-related conditions. At the other end of ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1111/ajco.13312
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute. METHODS:The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectivel...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13135
更新日期:2019-06-01 00:00:00
abstract:AIM:The effects of image-guided radiotherapy (IGRT, an advanced RT technology) have been debated in the literature. We compared the outcomes of locally advanced rectal cancer (LARC) patients treated with neoadjuvant concurrent chemoradiotherapy (NCCRT; with vs without IGRT) in a large population-based propensity score ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13196
更新日期:2019-10-01 00:00:00
abstract::Health literacy refers to one's ability to obtain, process and understand health information and services to enable sound health decision-making. This is an area of increasing importance due to the complexity of the health system, especially in the cancer setting. A certain level of health literacy is required for pat...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1111/j.1743-7563.2012.01522.x
更新日期:2012-03-01 00:00:00
abstract::Non-small cell lung cancers (NSCLC) harboring the uncommon epidermal growth factor receptor (EGFR) exon 20 insertion mutations are generally thought to be unresponsive to EGFR-tyrosine kinase inhibitor (TKI) therapy. Presented here is a case of stage IV NSCLC harboring an uncommon EGFR exon 20 insertion mutation that ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12853
更新日期:2018-03-01 00:00:00
abstract:PURPOSE:To study trends of urological cancers mortalities in Iran between 1990 and 2015 as a part of a larger project named national and subnational burden of diseases, injuries, and risk factors. METHODS:The primary dataset of this project comprises data of national death registration system. Cause-specific mortality...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 历史文章,杂志文章
doi:10.1111/ajco.13074
更新日期:2019-04-01 00:00:00
abstract:AIM:For early-stage breast cancer, four cycles of docetaxel and cyclophosphamide (TC) was proven superior to doxorubicin plus cyclophosphamide in the US Oncology 9375 trial. Given primary prophylactic antibiotics, 5% febrile neutropenia was recorded in a population comprising 75.5% Caucasians. Smaller trials and retros...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12682
更新日期:2017-12-01 00:00:00
abstract::Disparities in cancer outcomes for people from culturally and linguistically diverse (CALD) groups are well known. Improving CALD patients' active participation in treatment processes holds potential to improve outcomes, but little is known of effective strategies to facilitate this. This systematic review investigate...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1111/j.1743-7563.2012.01531.x
更新日期:2013-06-01 00:00:00
abstract::We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomograph...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2011.01515.x
更新日期:2012-06-01 00:00:00
abstract:AIM:While first-line palliative chemotherapy (CT1) improves survival and quality of life in advanced biliary cancer (ABC), there is no randomized evidence to support second-line chemotherapy (CT2) in ABC. We aim to explore to role of CT2 in ABC. METHODS:We performed a retrospective review of all patients who received ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究,评审
doi:10.1111/ajco.12638
更新日期:2017-10-01 00:00:00
abstract::Resistance to endocrine therapy is a significant therapeutic challenge in the treatment of women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer. Cyclin-dependent kinase (CDK)4/6 inhibitors in combination with endocrine therapy have been shown to i...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13064
更新日期:2018-10-01 00:00:00
abstract:AIM:As survival rates for aggressive and conservative breast and lymph node surgery are similar, surgical treatment decisions for patients with early-stage breast cancer should take patient preference into account. Decision aids have been demonstrated to increase patient knowledge and satisfaction with decision making,...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1743-7563.2010.01375.x
更新日期:2011-06-01 00:00:00
abstract::Cancer in pregnancy may be increasing in incidence with advancing maternal age and higher rates of obesity. The diagnosis of cancer in pregnancy provokes complex management issues balancing short- and long-term risks for both mother and baby. Every case needs to be individualized, with a multidisciplinary team of midw...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1111/ajco.13235
更新日期:2019-12-01 00:00:00