Acute inflammatory demyelinating polyradiculoneuropathy in a patient receiving oxaliplatin-based chemotherapy.

Abstract:

:We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomography. He was treated with 5-fluorouracil, leucovorin and oxaliplatin (100 mg/m(2)). After eight cycles of treatment and a cumulative oxaliplatin dose of 780 mg/m(2), he developed an unsteady gait, dysphagia, weakness of both the upper and lower limbs and impairment of all sensory modalities. Nerve conduction studies confirmed the diagnosis of AIDP. Immunoglobulin G i.v. was administered for 5 days but the neurological deficits of both his upper and lower limbs did not improve. This case highlights unusual peripheral nervous system manifestations in a patient who received chemotherapy with oxaliplatin.

journal_name

Asia Pac J Clin Oncol

authors

Yoon JY,Nam TS,Kim MK,Hwang JE,Shim HJ,Cho SH,Chung IJ,Bae WK

doi

10.1111/j.1743-7563.2011.01515.x

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

201-4

issue

2

eissn

1743-7555

issn

1743-7563

journal_volume

8

pub_type

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