National and subnational mortality of urological cancers in Iran, 1990-2015.


PURPOSE:To study trends of urological cancers mortalities in Iran between 1990 and 2015 as a part of a larger project named national and subnational burden of diseases, injuries, and risk factors. METHODS:The primary dataset of this project comprises data of national death registration system. Cause-specific mortality fraction for each age, sex, province, and year group was calculated using a two-stage mixed effects and spatiotemporal models, and then these fractions were applied to all-cause mortality rates, obtained from a parallel study to estimate mortality rates attributable to each cause. RESULTS:In 2015, urological cancers constituted 8% of cancer-related deaths in Iran, and number of deaths due to prostate, bladder, testicular, and kidney and other urinary organs cancers were estimated as 2,128 (1,565-2,891), 297 (230-385), 301 (144-639), and 195 (143-267), respectively. Our estimates show that age-standardized death rates (ASDRs) of these cancers reached 6.8 (5-9.23), 0.47 (0.37-0.61), 0.96 (0.46-2.04), and 0.24 (0.18-0.33) deaths per 100,000 individuals in 2015, a reduction in the three latter cancers, from 4.09 (2.92-5.76), 13.04 (10.04-16.95), 1.23 (0.46-3.34), and 1.76 (1.28-2.42) deaths per 100,000 individuals in 1990, respectively. CONCLUSIONS:In conclusion, despite disparities among different provinces, overall mortality rate of urological cancers decreased significantly since 1990s in Iran.


Asia Pac J Clin Oncol


Pishgar F,Amini E,Gohari K,Aminorroaya A,Sheidaei A,Rostamabadi Y,Ebrahimi H,Yoosefi M,Naderimagham S,Rezaei N,Modirian M,Namazi Shabestari A,Kompani F,Farzadfar F




Has Abstract


2019-04-01 00:00:00












  • Hormone receptor positive, HER2 negative metastatic breast cancer: Impact of CDK4/6 inhibitors on the current treatment paradigm.

    abstract::Resistance to endocrine therapy is a significant therapeutic challenge in the treatment of women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer. Cyclin-dependent kinase (CDK)4/6 inhibitors in combination with endocrine therapy have been shown to i...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Boyle F,Beith J,Burslem K,de Boer R,Hui R,Lim E,McCarthy N,Redfern A,Woodward N

    更新日期:2018-10-01 00:00:00

  • Oxaliplatin/5-fluorouracil-based adjuvant chemotherapy as a standard of care for colon cancer in clinical practice: Outcomes of the ACCElox registry.

    abstract:AIM:The ACCElox registry was set up to assess therapeutic management of early-stage colon cancer with oxaliplatin/5-fluorouracil (5-FU)-based regimen and the duration of adjuvant chemotherapy in current clinical practice. METHODS:This prospective observational study was conducted between 2006 and 2008 in 19 countries ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,多中心研究


    authors: Park YS,Ji J,Zalcberg JR,El-Serafi M,Buzaid A,Ghosn M

    更新日期:2015-12-01 00:00:00

  • Postoperative radiotherapy improves overall survival in patients with primary squamous cell carcinoma of the breast.

    abstract:BACKGROUND:Primary squamous cell carcinoma of the breast (PSCCB) is a rare clinical classification of breast tumors. Little is known about its clinicopathological features, prognosis and potential therapeutic strategies. The purpose of this study is to evaluate the effect of postoperative radiotherapy (PORT) on patient...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Wang X,Zhang L,Luo J,Jin K,Yang Z,Meng J,Zhang X,Zhang Z,Shao Z,Guo X,Chen X,Yu X

    更新日期:2020-10-20 00:00:00

  • Radiation oncology during COVID-19: Strategies to avoid compromised care.

    abstract::The COVID-19 pandemic will present a range of challenges to radiation oncology departments. Early data suggest that cancer patients carry a higher than average, but still low absolute risk of hospitalization from COVID-19. The risk of severe events for those who are hospitalized however, is high. Resources for usual c...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审


    authors: Horsley PJ,Back M,Lamoury G,Porter B,Booth J,Eade TN

    更新日期:2021-02-01 00:00:00

  • Treatment and outcomes of melanoma in Asia: Results from the National Cancer Centre Singapore.

    abstract:BACKGROUND:Acral melanoma (AM) and mucosal melanoma (MM) make up more than half of melanomas in Asia but comprise only 5% of cases in Caucasians, where cutaneous melanoma (CM) predominates. AM and MM are thought to be genetically and biologically distinct from CM. We report the characteristics and outcomes of melanoma ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Teh YL,Goh WL,Tan SH,Yong G,Sairi ANH,Soo KC,Ong J,Chia C,Tan G,Soeharno H,Tan MH,Chan M,Sathiyamoorthy S,Sittampalam K,Teh J,Chin F,Sethi V,Teo M,Quek R,Farid M

    更新日期:2018-04-01 00:00:00

  • A clinical trial with protracted infusion 5-fluorouracil and mitomycin C for localized squamous cell carcinoma of the anus.

    abstract:PURPOSE:Mitomycin C (MMC) plus standard 5-fluorouracil (FU) infusion in weeks 1 and 5 often contributes to radiotherapy interruptions and possibly less-than-ideal outcomes in anal cancer. This study was to evaluate alternative strategies for chemotherapy delivery that might be less toxic or more efficacious, and outcom...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Ngan D,Chu J,Chander S,Michael M,Heriot AG,Ngan SY,Rischin D,Leong T

    更新日期:2019-02-01 00:00:00

  • Metadherin is a novel prognostic marker for bladder cancer progression and overall patient survival.

    abstract:AIM:Metadherin (MTDH) is a potential oncogene in tumor development and is highly expressed in various types of human cancers. However, there has been no report on the role of MTDH in bladder cancer. Our aim was to investigate the expression pattern of MTDH in bladder tissue at different clinic pathological stages and e...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Zhou J,Li J,Wang Z,Yin C,Zhang W

    更新日期:2012-09-01 00:00:00

  • Patient outcomes of whole brain radiotherapy for brain metastases versus leptomeningeal metastases: A retrospective study.

    abstract:AIM:Important factors typically associated with prognosis in brain metastases include Karnofsky performance status (KPS), extracranial or cerebellar localization and combination chemotherapy. However, few studies investigated the prognostic role of leptomeningeal metastases (LM) following whole brain radiotherapy (WBRT...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Sakaguchi M,Maebayashi T,Aizawa T,Ishibashi N,Saito T

    更新日期:2017-10-01 00:00:00

  • Endothelial cell damage induces a blood-alveolus barrier breakdown in the development of radiation-induced lung injury.

    abstract:AIM:To investigate the role of endothelial cell damage in radiation-induced lung injury. METHODS:A total of 60 male Sprague-Dawley rats were irradiated to the right hemithorax with a single dose of 0, 7.0 or 14.4 Gy. Serial studies were performed before and at 1, 7, 30 and 90 days after radiation, respectively. Pathol...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Qiu J,Li J,He TC

    更新日期:2011-12-01 00:00:00

  • Attitudes of patients with metastatic cancer towards research biopsies.

    abstract:AIM:To evaluate the attitudes of patients with different cancers towards research biopsies outside a clinical trial. METHODS:Patients with metastatic cancer completed a questionnaire that assessed patients' willingness to consider research biopsies. Research biopsies were divided into two groups: biopsies performed as...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Robinson DH,Churilov L,Lin NU,Lim E,Seah D

    更新日期:2018-06-01 00:00:00

  • Importance of health literacy in oncology.

    abstract::Health literacy refers to one's ability to obtain, process and understand health information and services to enable sound health decision-making. This is an area of increasing importance due to the complexity of the health system, especially in the cancer setting. A certain level of health literacy is required for pat...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审


    authors: Koay K,Schofield P,Jefford M

    更新日期:2012-03-01 00:00:00

  • Pre-treatment serum lactate dehydrogenase as a biomarker in small cell lung cancer.

    abstract:BACKGROUND:Small cell lung cancer is a rapidly progressive disease with high fatality. No sensitive and specific biomarker to assist in managing this disease exists currently. AIM:Role of pretreatment serum lactate dehydrogenase as a biomarker in small cell lung cancer. METHODS:A hospital-based cancer registry was us...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Hsieh AH,Tahkar H,Koczwara B,Kichenadasse G,Beckmann K,Karapetis C,Sukumaran S

    更新日期:2018-04-01 00:00:00

  • Human papillomavirus promotes esophageal squamous cell carcinoma by regulating DNA methylation and expression of HLA-DQB1.

    abstract:AIMS:Esophageal cancer (EC) is one of the most prevalent and deadly cancers worldwide. Along with nutrition, smoking and alcohol consumption, human papillomavirus (HPV) infection is one of the major risk factors, which is modulated by host immune response. This study is aimed at elucidating how HPV modifies host immune...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Feng B,Awuti I,Deng Y,Li D,Niyazi M,Aniwar J,Sheyhidin I,Lu G,Li G,Zhang L

    更新日期:2014-03-01 00:00:00

  • Immunotherapy for urothelial carcinoma: Metastatic disease and beyond.

    abstract::For advanced and metastatic urothelial carcinomas (UCs), platinum (preferably cisplatin)-based chemotherapy has been the standard treatment for many years. However, many patients are ineligible for cisplatin-based chemotherapy because of poor performance status and/or other age-related conditions. At the other end of ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审


    authors: Poon DM

    更新日期:2020-09-01 00:00:00

  • Association of plasma visfatin with risk of colorectal cancer: An observational study of Chinese patients.

    abstract:AIM:To investigate the association between plasma visfatin levels and risk of early and advanced colorectal cancer (CRC). METHODS:In total, 358 CRC patients and 286 controls were enrolled. According to the T factor of the TNM system. cancer patients were divided into two subgroups: early and advanced cancer. Levels of...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Chen M,Wang Y,Li Y,Zhao L,Ye S,Wang S,Yu C,Xie H

    更新日期:2016-03-01 00:00:00

  • Endoscopic self-expandable metallic stent placement in malignant pyloric or duodenal obstruction: does chemotherapy affect stent patency?

    abstract:AIM:Self-expandable metallic stents (SEMS) have been used for palliation in patients with malignant gastroduodenal obstructions. We evaluated clinical outcomes after SEMS placement and identified prognostic factors of SEMS patency, including chemotherapy. METHODS:A review of records of 85 patients with unresectable ga...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Cha BH,Lee SH,Kim JE,Yoo JY,Park YS,Kim JW,Jeong SH,Kim N,Lee DH,Hwang JH

    更新日期:2013-06-01 00:00:00

  • Differentiating malignant colorectal tumor patients from benign colorectal tumor patients by assaying morning urinary arylsulfatase activity.

    abstract:AIM:For several decades urinary arylsulfatase (ARS) activity has been reported to be elevated in many cancers. It has been shown that urinary ARS activity may serve as a marker of tumor progression and therapy surveillance. This study was designed to evaluate the clinical application of detection of urinary ARS activit...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Niu R,Jing H,Chen Z,Xu J,Dai J,Yan Z

    更新日期:2012-12-01 00:00:00

  • Toxicity profile differences of adjuvant docetaxel/cyclophosphamide (TC) between Asian and Caucasian breast cancer patients.

    abstract:AIM:For early-stage breast cancer, four cycles of docetaxel and cyclophosphamide (TC) was proven superior to doxorubicin plus cyclophosphamide in the US Oncology 9375 trial. Given primary prophylactic antibiotics, 5% febrile neutropenia was recorded in a population comprising 75.5% Caucasians. Smaller trials and retros...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Chow LWC,Biganzoli L,Leo AD,Kuroi K,Han HS,Patel J,Huang CS,Lu YS,Zhu L,Chow CYC,Loo WTY,Glück S,Toi M

    更新日期:2017-12-01 00:00:00

  • Development and pilot testing of a radiation therapist-led educational intervention for breast cancer patients prior to commencing radiotherapy.

    abstract:AIM:To describe the development of the content and pilot testing of a radiation therapist-led educational intervention for breast cancer patients about to commence radiotherapy. Pilot testing consisted of testing the intervention for appropriateness, feasibility and acceptance. METHODS:A tailored intervention consisti...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 临床试验,杂志文章


    authors: Halkett GK,Schofield P,O'Connor M,York D,Jefford M,Jiwa M,Spry N,Taylor M,Aranda S

    更新日期:2012-09-01 00:00:00

  • Survival of lung cancer patients in a resource-limited country.

    abstract:AIM:Data on lung cancer survival are lacking in developing countries. Our objectives were to describe the survival of our lung cancer patients and to determine independent prognostic factors affecting survival. METHOD:All patients diagnosed with lung cancer from August 2007 to August 2010 were recruited from a single ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: How SH,Ng TH,Kuan YC,Jamalludin AR,Fauzi AR

    更新日期:2015-09-01 00:00:00

  • Afatinib for an EGFR exon 20 insertion mutation: A case report of progressive stage IV metastatic lung adenocarcinoma with 54 months' survival.

    abstract::Non-small cell lung cancers (NSCLC) harboring the uncommon epidermal growth factor receptor (EGFR) exon 20 insertion mutations are generally thought to be unresponsive to EGFR-tyrosine kinase inhibitor (TKI) therapy. Presented here is a case of stage IV NSCLC harboring an uncommon EGFR exon 20 insertion mutation that ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Chan RT

    更新日期:2018-03-01 00:00:00

  • Risk of febrile neutropenia and early treatment cessation in men receiving standard and dose-reduced 3-weekly docetaxel for metastatic castration-resistant prostate cancer.

    abstract:BACKGROUND:Docetaxel is an effective therapy for metastatic castration-resistant prostate cancer (mCRPC); however, many patients experience febrile neutropenia (FN) and cease treatment early due to toxicity. It is not known whether lower dose (LD) q3-weekly docetaxel impacts toxicity or efficacy. METHODS:Multicenter r...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,多中心研究


    authors: Hamid AA,Willson K,Vincent AD,Tamjid B,Lee M,Bergin A,Gan C,Campbell A,Stewart J,Pezaro C,Tran B,Weickhardt AJ

    更新日期:2018-10-01 00:00:00

  • Pilot study evaluating the role of cardiac magnetic resonance imaging in monitoring adjuvant trastuzumab therapy for breast cancer.

    abstract:AIM:To explore the incidence of subclinical cardiotoxicity in women treated with adjuvant trastuzumab in the early breast cancer setting using cardiac magnetic resonance imaging (cMRI). METHODS:The cardiac function and myocardial tissue characteristics of 25 women who had completed adjuvant trastuzumab therapy greater...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Lawley C,Wainwright C,Segelov E,Lynch J,Beith J,McCrohon J

    更新日期:2012-03-01 00:00:00

  • Insights into the cell of origin in breast cancer and breast cancer stem cells.

    abstract::The precise cell types that give rise to tumors and mechanisms that underpin tumor heterogeneity are poorly understood. There is increasing evidence to suggest that diverse solid tumors are hierarchically organized and may be sustained by a distinct subpopulation of cancer stem cells (CSCs). The CSC hypothesis provide...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审


    authors: Lindeman GJ,Visvader JE

    更新日期:2010-06-01 00:00:00

  • Impact of Oncotype DX testing on adjuvant treatment decisions in patients with early breast cancer: a single-center study in the United Arab Emirates.

    abstract:AIM:To evaluate the distribution of the Oncotype DX Recurrence Score (a validated prognostic/predictive tool in early-stage estrogen-receptor positive [ER+] breast cancer) and its impact on adjuvant treatment decisions in the United Arab Emirates. METHODS:A retrospective analysis of a single-center cohort. RESULTS:Th...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Jaafar H,Bashir MA,Taher A,Qawasmeh K,Jaloudi M

    更新日期:2014-12-01 00:00:00

  • The challenge of putting principles into practice: Resource tensions and real-world constraints in multidisciplinary oncology team meetings.

    abstract::Multidisciplinary oncology team meetings are crucial hubs for integrated, patient-centered diagnosis and treatment planning. Team meetings are designed to enact the best practice principles of multidisciplinary care. Yet surveys of clinicians and allied health providers who are members of multidisciplinary teams (MDTs...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审


    authors: Lamprell K,Arnolda G,Delaney GP,Liauw W,Braithwaite J

    更新日期:2019-08-01 00:00:00

  • Are visiting oncologists enough? A qualitative study of the needs of Australian rural and regional cancer patients, carers and health professionals.

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    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Grimison P,Phillips F,Butow P,White K,Yip D,Sardelic F,Underhill C,Tse R,Simes R,Turley K,Raymond C,Goldstein D

    更新日期:2013-09-01 00:00:00

  • Factors influencing medical oncology referral in Dukes' C colonic cancer.

    abstract:AIM:Colorectal cancer (CRC) is one of the most common malignancies worldwide and adjuvant chemotherapy is proven to improve survival in patients with Dukes' C CRC. The purpose of this study was to analyze factors influencing referral to medical oncology in patients with Dukes' C colonic cancer in our institutions. MET...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Lu CT,Stephens JH,Rieger NA

    更新日期:2010-09-01 00:00:00

  • Decision aids for breast and nodal surgery in patients with early breast cancer: development and a pilot study.

    abstract:AIM:As survival rates for aggressive and conservative breast and lymph node surgery are similar, surgical treatment decisions for patients with early-stage breast cancer should take patient preference into account. Decision aids have been demonstrated to increase patient knowledge and satisfaction with decision making,...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 临床试验,杂志文章


    authors: Harwood R,Douglas C,Clark D

    更新日期:2011-06-01 00:00:00

  • Examining clinicians' perceptions of head and neck cancer (HNC) information.

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    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章


    authors: Jabbour J,Wykes J,Milross C,Sundaresan P,Ebrahimi A,Shepherd HL,Dhillon HM,Clark JR

    更新日期:2018-10-01 00:00:00