Abstract:
AIM:This systematic review and meta-analysis was performed to assess the efficacy and side effects between single-agent and doublet chemotherapy in first-line treatment of advanced non-small cell lung cancer with performance status 2 (PS2). METHODS:We searched for randomized controlled trials in online electronic databases and extracted data from eligible studies for meta-analysis. Pooled hazard ratio (HR) for overall survival (OS), pooled risk difference (RD) for 1-year survival, pooled risk ratio (RR) for objective response rate (ORR) and adverse effects were calculated using a fixed-effect model. RESULTS:Six trials with 386 participants in the single-agent group and 389 participants in the doublet group were included in this review. Compared with single-agent chemotherapy, doublet significantly improved OS (HR 0.72; 95% CI 0.61-0.84; P < 0.0001) and significantly increased 1-year survival rate (RD -0.09; 95% CI -0.14 to -0.03; P = 0.004) and ORR (RR 0.4; 95% CI 0.30-0.69; P = 0.0002). Doublet chemotherapy also significantly increased the risk of grade 3/4 neutropenia (RR = 4.97; 95% CI 2.93-8.43; P < 0.00001), thrombocytopenia (RR = 10.29; 95% CI 3.80-27.85; P < 0.00001) and anemia (RR = 2.50; 95% CI 1.27-4.90; P = 0.008). CONCLUSIONS:Our study implies that carboplatin-containing doublet chemotherapy improved OS, 1-year survival rate and ORR, but increased the risk of grade 3/4 hematotoxicity. Carboplatin-containing doublet may well be superior to non-carboplatin-containing treatment.
journal_name
Asia Pac J Clin Oncoljournal_title
Asia-Pacific journal of clinical oncologyauthors
Luo L,Hu Q,Jiang JX,Yang X,Dinglin XX,Lin X,Yao HRdoi
10.1111/ajco.12359subject
Has Abstractpub_date
2015-09-01 00:00:00pages
253-61issue
3eissn
1743-7555issn
1743-7563journal_volume
11pub_type
杂志文章,meta分析,评审abstract:AIMS:Cyclophosphamide was widely used as a single agent prior to the advent of platinum-based regimens for epithelial ovarian cancer, and, in combination with platinum, prior to the adoption of platinum and paclitaxel as standard first-line therapy. As cyclophosphamide currently has no defined role in ovarian cancer we...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12074
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:Anti-HER2 therapy-related cardiotoxicity is well described in the context of clinical trials, particularly in the setting of early stage disease, but there is more limited data in advanced breast cancer and in the real world setting. MATERIAL AND METHODS:A prospectively-maintained registry database with 312...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13381
更新日期:2020-12-01 00:00:00
abstract::Disparities in cancer outcomes for people from culturally and linguistically diverse (CALD) groups are well known. Improving CALD patients' active participation in treatment processes holds potential to improve outcomes, but little is known of effective strategies to facilitate this. This systematic review investigate...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1111/j.1743-7563.2012.01531.x
更新日期:2013-06-01 00:00:00
abstract:AIMS:To evaluate the response and progression-free survival (PFS) of Malaysian patients with advanced lung adenocarcinoma and unknown epidermal growth factor receptor (EGFR) mutation status treated with gefitinib. METHODS:A retrospective analysis of consecutive patients with EGFR mutation unknown stage III or IV lung ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2011.01509.x
更新日期:2012-09-01 00:00:00
abstract:BACKGROUND:Docetaxel is an effective therapy for metastatic castration-resistant prostate cancer (mCRPC); however, many patients experience febrile neutropenia (FN) and cease treatment early due to toxicity. It is not known whether lower dose (LD) q3-weekly docetaxel impacts toxicity or efficacy. METHODS:Multicenter r...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1111/ajco.12840
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Neutrophil count reduction after chemotherapy has been related with longer survival of patients with metastatic pancreatic adenocarcinoma, but there is not a standardized measurement for this phenomenon. METHODS:Some parameters related to the change in neutrophil count between the first and the second cycle...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13325
更新日期:2020-08-01 00:00:00
abstract:AIM:A proportion of locally advanced rectal cancer patients who receive neoadjuvant chemoradiotherapy (NACRT) are still unresectable. This study was undertaken to assess the outcomes of giving additional chemotherapy to rectal cancer patients with unresectable disease after NACRT. METHODS:Patients with poor response t...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12660
更新日期:2017-08-01 00:00:00
abstract:AIM:Elevated neutrophil-to-lymphocyte ratio (NLR) has been demonstrated to be a poor prognostic factor in multiple types of malignancies, whereas the effect of NLR on the prognosis of epidermal growth factor receptor (EGFR)-mutated advanced non-small-cell lung cancer (NSCLC) patients treated with first-line EGFR tyrosi...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12273
更新日期:2017-10-01 00:00:00
abstract:BACKGROUND:An elevated preoperative aspartate aminotransferase-to-lymphocyte ratio index (ALRI) may predict poor survival in various cancers. However, the prognostic value of aminotransferase-to-lymphocyte ratio index (ALRI) in patients with hepatocellular carcinoma (HCC) remains to be determined. MATERIALS AND METHOD...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13458
更新日期:2020-10-30 00:00:00
abstract:INTRODUCTION:Ki-67 proliferation index (Ki-67 index) is used to quantify cell proliferation during histopathological assessment of various tumors including glioblastoma (GB). AIM:We aimed to assess correlation between Ki-67 index and overall survival in patients with GB and determine a cut-point for Ki-67 index that p...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12826
更新日期:2019-02-01 00:00:00
abstract:AIM:In colorectal cancer (CRC), adjuvant therapy is offered on the basis of stage and attempts to identify factors to better target treatment have not been successful. Recent work suggested that mismatch repair deficient CRCs may not benefit from 5FU adjuvant chemotherapy but studies remain conflicting. We aimed to det...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12411
更新日期:2015-12-01 00:00:00
abstract:AIM:The purpose of this study was to investigate the impact of subcarinal dissection on short-term outcome and survival following esophagectomy in patients with thoracic esophageal squamous cell carcinoma. METHODS:A total of 2252 patients underwent an esophagectomy for esophageal cancer from January 1997 to December 2...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12095
更新日期:2014-06-01 00:00:00
abstract:AIM:Colorectal cancer (CRC) is one of the most common malignancies worldwide and adjuvant chemotherapy is proven to improve survival in patients with Dukes' C CRC. The purpose of this study was to analyze factors influencing referral to medical oncology in patients with Dukes' C colonic cancer in our institutions. MET...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2010.01312.x
更新日期:2010-09-01 00:00:00
abstract:AIMS:Wilms tumor (WT) is rare in Asia. Treatment of bilateral WT is challenging, and the treatment outcome of bilateral WT is rarely reported in low incidence areas. METHODS:We enrolled patients with bilateral WT registered in Chang Gung Memorial Hospital, Taoyuan, Taiwan, between January 1986 and June 2015. They were...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12501
更新日期:2016-09-01 00:00:00
abstract:AIM:To examine the treatment practices for cancer pain relief and adverse event management, and the factors related to patient outcomes in the participating countries/regions. METHODS:The study was a cross-sectional survey conducted between September and December 2013 in 10 countries/regions across Asia. Adult patient...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1111/ajco.12696
更新日期:2018-06-01 00:00:00
abstract:AIM:For several decades urinary arylsulfatase (ARS) activity has been reported to be elevated in many cancers. It has been shown that urinary ARS activity may serve as a marker of tumor progression and therapy surveillance. This study was designed to evaluate the clinical application of detection of urinary ARS activit...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2012.01545.x
更新日期:2012-12-01 00:00:00
abstract:AIM:To describe the overall survival, progression-free survival, response rate and toxicity of pegylated liposomal doxorubicin (PLD) in recurrent ovarian cancer. METHODS:A retrospective study of 45 patients with recurrent or progressive ovarian cancer was conducted at the Westmead Cancer Care Centre. Patients received...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2009.01263.x
更新日期:2010-03-01 00:00:00
abstract:AIM:Advanced esophagogastric carcinoma has a poor prognosis. Palliative chemotherapy provides a survival advantage and improved quality of life. Epirubicin, cisplatin and continuous infusional 5-fluorouracil (5-FU) (ECF) is a well-established chemotherapy regimen but a continuous chemotherapy infusion is not always fea...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2010.01340.x
更新日期:2010-12-01 00:00:00
abstract:BACKGROUND:Small cell lung cancer is a rapidly progressive disease with high fatality. No sensitive and specific biomarker to assist in managing this disease exists currently. AIM:Role of pretreatment serum lactate dehydrogenase as a biomarker in small cell lung cancer. METHODS:A hospital-based cancer registry was us...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12674
更新日期:2018-04-01 00:00:00
abstract::For advanced and metastatic urothelial carcinomas (UCs), platinum (preferably cisplatin)-based chemotherapy has been the standard treatment for many years. However, many patients are ineligible for cisplatin-based chemotherapy because of poor performance status and/or other age-related conditions. At the other end of ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1111/ajco.13312
更新日期:2020-09-01 00:00:00
abstract:AIM:This study examined pathological quality-of-surgery indicators in laparoscopic and open rectal cancer resection specimens. METHODS:Retrospective analysis of consecutive, prospectively recorded laparoscopic (LR) or open (OR) resections for rectal cancer. Indicators included integrity of the perirectal fascial envel...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12781
更新日期:2018-04-01 00:00:00
abstract:AIM:To evaluate the distribution of the Oncotype DX Recurrence Score (a validated prognostic/predictive tool in early-stage estrogen-receptor positive [ER+] breast cancer) and its impact on adjuvant treatment decisions in the United Arab Emirates. METHODS:A retrospective analysis of a single-center cohort. RESULTS:Th...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12259
更新日期:2014-12-01 00:00:00
abstract:AIMS:Currently, the only standard systemic treatment for advanced hepatocellular carcinoma is sorafenib monotherapy. The study was conducted to assess the efficacy and safety of the novel combination of sorafenib and gemcitabine in the treatment of advanced hepatocellular carcinoma. METHODS:Between March 2008 and Octo...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1111/ajco.12191
更新日期:2014-09-01 00:00:00
abstract:AIM:Important factors typically associated with prognosis in brain metastases include Karnofsky performance status (KPS), extracranial or cerebellar localization and combination chemotherapy. However, few studies investigated the prognostic role of leptomeningeal metastases (LM) following whole brain radiotherapy (WBRT...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12597
更新日期:2017-10-01 00:00:00
abstract:AIM:To assess the prognostic significance of enhancement rate (ER) measured by contrast-enhanced ultrasonography (CEUS) in patients with hepatocellular carcinoma (HCC) undergoing radiofrequency ablation (RFA). MATERIALS AND METHODS:A total of 253 patients with single primary HCC undergoing preoperative CEUS and RFA we...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13157
更新日期:2019-08-01 00:00:00
abstract::Resistance to endocrine therapy is a significant therapeutic challenge in the treatment of women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer. Cyclin-dependent kinase (CDK)4/6 inhibitors in combination with endocrine therapy have been shown to i...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13064
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute. METHODS:The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectivel...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13135
更新日期:2019-06-01 00:00:00
abstract::We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomograph...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2011.01515.x
更新日期:2012-06-01 00:00:00
abstract:AIMS:To determine the feasibility of stereotactic body radiotherapy (SBRT) in patients with pelvic sidewall recurrence of uterine cervical cancer after radical hysterectomy or definitive radiotherapy. METHODS:We retrospectively reviewed 23 patients with locally recurrent uterine cervical cancer limited to the pelvic s...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12185
更新日期:2016-06-01 00:00:00
abstract:AIM:Vascular endothelial growth facto receptor-tyrosine kinase inhibitors (VEGFR-TKIs) are widely used for metastatic renal cell carcinoma (mRCC). The aim of this study was to investigate the association between the response to VEGFR-TKIs and hyperlipidemia and hypothyroidism. METHODS:Clinical data on 155 patients wit...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12473
更新日期:2016-06-01 00:00:00