Abstract:
AIM:Important factors typically associated with prognosis in brain metastases include Karnofsky performance status (KPS), extracranial or cerebellar localization and combination chemotherapy. However, few studies investigated the prognostic role of leptomeningeal metastases (LM) following whole brain radiotherapy (WBRT). On the basis of our experience suggesting better survival of asymptomatic patients with LM than those with brain metastases, we herein evaluated LM as a prognostic factor after WBRT. METHODS:Medical records of 206 patients (median age, 65 years) who received WBRT in 2007-2015 were retrospectively reviewed. The two most common cancers were of lung, breast origin in 78.5%, 10%, patients, respectively. Patients received parallel-opposed WBRT, with a dose of 20-40 Gy. Additional doses of 9-12 Gy were used in patients who were operated on or had single metastases. Overall survival (OS) was determined, and clinical parameters including age, KPS, symptoms, radiation dose, dose per fraction, type of metastasis, extracranial metastases, primary status and surgery plus WBRT were assessed as prognostic factors. RESULTS:The median survival was 6 months (range, 1-100), and 1- and 2-year survival rates were 28% and 17%, respectively. In univariate analysis, improved survival was associated with KPS of ≥70, absence of symptoms, radiation dose of ≥37.5 Gy, favorable primary lesion, LM, and surgery plus WBRT. Multivariate analysis revealed that these factors with the exception of radiation dose was significant prognostic factors for OS. CONCLUSION:We found that LM were independent prognostic factors for good clinical outcomes.
journal_name
Asia Pac J Clin Oncoljournal_title
Asia-Pacific journal of clinical oncologyauthors
Sakaguchi M,Maebayashi T,Aizawa T,Ishibashi N,Saito Tdoi
10.1111/ajco.12597subject
Has Abstractpub_date
2017-10-01 00:00:00pages
e449-e457issue
5eissn
1743-7555issn
1743-7563journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Access to palliative care services is essential for attaining universal health coverage for patients with a terminal cancer. Despite this, many patients with advanced cancer in low-income countries, such as Myanmar, suffer at the end of life (EOL) due to little or no access to palliative care. However, actua...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1111/ajco.13373
更新日期:2020-12-01 00:00:00
abstract:INTRODUCTION:Ki-67 proliferation index (Ki-67 index) is used to quantify cell proliferation during histopathological assessment of various tumors including glioblastoma (GB). AIM:We aimed to assess correlation between Ki-67 index and overall survival in patients with GB and determine a cut-point for Ki-67 index that p...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1111/j.1743-7563.2010.01279.x
更新日期:2010-06-01 00:00:00
abstract:AIM:To carry out a nationwide study of KRAS testing in metastatic colorectal cancer as reported by nine major molecular pathology service providers in Australia, including mutation frequencies and turnaround times that might impact on patient care. METHODS:Participating laboratories contributed information on KRAS mut...
journal_title:Asia-Pacific journal of clinical oncology
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doi:10.1111/ajco.12201
更新日期:2014-09-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
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abstract::First-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are used as first-line therapy in patients with non-small cell lung cancer (NSCLC) harboring a sensitizing mutation in the EGFR gene. Unfortunately, resistance to these therapies often occurs within 10 months of commencing treat...
journal_title:Asia-Pacific journal of clinical oncology
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更新日期:2017-08-01 00:00:00
abstract:AIMS:The Australian Institute of Health and Welfare (AIHW) is a major national agency established by the Australian government to provide information and statistics on Australia's health and welfare. The AIHW and the Australasian Association of Cancer Registries collaborate every year to provide updated information on ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12127
更新日期:2013-09-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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更新日期:2020-01-19 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12765
更新日期:2018-02-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2020-09-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12230
更新日期:2016-06-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2012.01534.x
更新日期:2012-12-01 00:00:00
abstract:AIM:The ACCElox registry was set up to assess therapeutic management of early-stage colon cancer with oxaliplatin/5-fluorouracil (5-FU)-based regimen and the duration of adjuvant chemotherapy in current clinical practice. METHODS:This prospective observational study was conducted between 2006 and 2008 in 19 countries ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1111/ajco.12409
更新日期:2015-12-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ajco.12295
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Clinical trials investigating the effects of addition of oxaliplatin to neoadjuvant radiochemotherapy in locally advanced rectal cancers (LARCs) have brought controversial results for pathologic complete response as an endpoint. This randomized clinical trial investigated downstaging as a short-term surrogat...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ajco.12675
更新日期:2017-12-01 00:00:00
abstract:AIMS:There is currently no routine collection of cancer stages in population-based data in Australia. This study evaluates the accuracy of International classification of diseases (ICD) codes for secondary neoplasms recorded in hospital morbidity data to assign spread of disease at diagnosis for colorectal cancer. MET...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2012.01537.x
更新日期:2012-09-01 00:00:00
abstract:AIM:A viable and sustainable medical oncology profession is integral for meeting the increasing demand for quality cancer care. The aim of this study was to explore the workforce-related experiences, perceptions and career expectations of early-career medical oncologists in Australia. METHODS:A mixed-methods design, i...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12844
更新日期:2018-10-01 00:00:00
abstract:AIM:To evaluate the distribution of the Oncotype DX Recurrence Score (a validated prognostic/predictive tool in early-stage estrogen-receptor positive [ER+] breast cancer) and its impact on adjuvant treatment decisions in the United Arab Emirates. METHODS:A retrospective analysis of a single-center cohort. RESULTS:Th...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12259
更新日期:2014-12-01 00:00:00
abstract:AIMS:The optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who achieved complete remission (CR) and complete consolidation chemotherapy is still controversial. Whether the use of arsenic trioxide (ATO) alone or along with all-trans retinoic acid (ATRA) improves overall survival (OS) or di...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2011.01496.x
更新日期:2012-12-01 00:00:00
abstract::Ipilimumab is a human anti-CTLA-4 monoclonal antibody recently approved for the treatment of advanced melanoma. Stimulation of T-cell activity unmasks antitumor activity, but can cause immune-related adverse events. Autoimmune hypophysitis is of particular importance because its presentation can be subtle but life thr...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12348
更新日期:2015-06-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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更新日期:2019-08-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13323
更新日期:2020-08-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12764
更新日期:2018-06-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12014
更新日期:2013-09-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2010.01330.x
更新日期:2011-03-01 00:00:00
abstract:AIM:The objective of this economic evaluation, which was based on patients from two randomized controlled clinical trials (NO16966 and NO16967), was to compare direct medical costs to the Australian health-care system of capecitabine plus oxaliplatin (XELOX) and bolus and/or infusional 5-fluorouracil (5-FU) plus folini...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,随机对照试验
doi:10.1111/ajco.12044
更新日期:2013-09-01 00:00:00
abstract::We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomograph...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2011.01515.x
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. METHODS:We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multi...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12697
更新日期:2018-04-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12019
更新日期:2013-12-01 00:00:00