Abstract：
AIMS:Cyclophosphamide was widely used as a single agent prior to the advent of platinum-based regimens for epithelial ovarian cancer, and, in combination with platinum, prior to the adoption of platinum and paclitaxel as standard first-line therapy. As cyclophosphamide currently has no defined role in ovarian cancer we aimed to assess its activity in women with recurrent disease. METHODS:A retrospective review was conducted of patients from three centers in Melbourne, Australia who had received oral cyclophosphamide treatment for recurrent ovarian cancer. The primary end-point was response rate to oral cyclophosphamide (150 mg p.o. day 1-14) based on Gynecologic Cancer InterGroup (GCIG) CA125 and/or Response Evaluation Criteria in Solid Tumors (RECIST) criteria. Secondary end-points included overall and progression-free survival and toxicity. RESULTS:In all, 26 patients were identified and 23 patients were evaluable for response. The median number of prior chemotherapy regimens was three (range 1-6). The response rate to oral cyclophosphamide was 44% with 10 of the 23 patients achieving a partial response (PR) based on GCIG (CA125) criteria. The median number of cycles received was three (range 1-16). Cyclophosphamide showed activity both in patients with platinum-sensitive (seven of 13 PR) and resistant or refractory disease (three of 10 PR). There was no grade 3 or 4 toxicity but two patients ceased cyclophosphamide due to less severe non-hematological toxicity. CONCLUSION:Single agent oral cyclophosphamide is active and well tolerated in recurrent ovarian cancer. Further investigation of oral cyclophosphamide in patients with platinum-sensitive and platinum-resistant disease is warranted.
journal_name
Asia Pac J Clin Oncoljournal_title
Asia-Pacific journal of clinical oncologyauthors
Handolias D,Quinn M,Foo S,Mileshkin L,Grant P,Dutu G,Rischin Ddoi
10.1111/ajco.12074subject
Has Abstractpub_date
2016-03-01 00:00:00pages
e154-60issue
1eissn
1743-7555issn
1743-7563journal_volume
12pub_type
杂志文章abstract：BACKGROUND:Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute. METHODS:The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectivel...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13135
更新日期：2019-06-01 00:00:00
abstract：:The association between the rs498872 single nucleotide polymorphism (SNP) and glioma risk has been studied, but these studies have yielded conflicting results. In order to explore this association, we performed a meta-analysis. A comprehensive literature search was performed using PubMed and EMBASE database, with the ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/ajco.12211
更新日期：2015-12-01 00:00:00
abstract：PURPOSE:To study trends of urological cancers mortalities in Iran between 1990 and 2015 as a part of a larger project named national and subnational burden of diseases, injuries, and risk factors. METHODS:The primary dataset of this project comprises data of national death registration system. Cause-specific mortality...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 历史文章,杂志文章
doi：10.1111/ajco.13074
更新日期：2019-04-01 00:00:00
abstract：AIM:The effect of transcatheter arterial chemoembolization (TACE) therapy on hepatitis B virus (HBV) reactivation in hepatocellular carcinoma (HCC) patients with prior resolved hepatitis B is not fully understood. METHODS:From January 2006 to December 2010, 43 hepatitis B surface antigen (HBsAg)-negative/anti-hepatiti...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2012.01534.x
更新日期：2012-12-01 00:00:00
abstract：AIM:To investigate the role of endothelial cell damage in radiation-induced lung injury. METHODS:A total of 60 male Sprague-Dawley rats were irradiated to the right hemithorax with a single dose of 0, 7.0 or 14.4 Gy. Serial studies were performed before and at 1, 7, 30 and 90 days after radiation, respectively. Pathol...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2011.01461.x
更新日期：2011-12-01 00:00:00
abstract：:First-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are used as first-line therapy in patients with non-small cell lung cancer (NSCLC) harboring a sensitizing mutation in the EGFR gene. Unfortunately, resistance to these therapies often occurs within 10 months of commencing treat...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/ajco.12699
更新日期：2017-08-01 00:00:00
abstract：:Cancer in pregnancy may be increasing in incidence with advancing maternal age and higher rates of obesity. The diagnosis of cancer in pregnancy provokes complex management issues balancing short- and long-term risks for both mother and baby. Every case needs to be individualized, with a multidisciplinary team of midw...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/ajco.13235
更新日期：2019-12-01 00:00:00
abstract：AIM:We investigated prognostic significance of methylation status of MASPIN gene and its protein expression in normal subjects, cholelithiasis and gallbladder cancer (GBC) patients. METHODS:MASPIN protein expression and its promoter methylation in gallbladder tissue of cholelithiasis (n = 36), GBC (n = 46) and control...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13129
更新日期：2019-10-01 00:00:00
abstract：AIM:To evaluate the distribution of the Oncotype DX Recurrence Score (a validated prognostic/predictive tool in early-stage estrogen-receptor positive [ER+] breast cancer) and its impact on adjuvant treatment decisions in the United Arab Emirates. METHODS:A retrospective analysis of a single-center cohort. RESULTS:Th...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12259
更新日期：2014-12-01 00:00:00
abstract：:For advanced and metastatic urothelial carcinomas (UCs), platinum (preferably cisplatin)-based chemotherapy has been the standard treatment for many years. However, many patients are ineligible for cisplatin-based chemotherapy because of poor performance status and/or other age-related conditions. At the other end of ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/ajco.13312
更新日期：2020-09-01 00:00:00
abstract：INTRODUCTION:Ki-67 proliferation index (Ki-67 index) is used to quantify cell proliferation during histopathological assessment of various tumors including glioblastoma (GB). AIM:We aimed to assess correlation between Ki-67 index and overall survival in patients with GB and determine a cut-point for Ki-67 index that p...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12826
更新日期：2019-02-01 00:00:00
abstract：AIM:For several decades urinary arylsulfatase (ARS) activity has been reported to be elevated in many cancers. It has been shown that urinary ARS activity may serve as a marker of tumor progression and therapy surveillance. This study was designed to evaluate the clinical application of detection of urinary ARS activit...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2012.01545.x
更新日期：2012-12-01 00:00:00
abstract：AIMS:The Australian Institute of Health and Welfare (AIHW) is a major national agency established by the Australian government to provide information and statistics on Australia's health and welfare. The AIHW and the Australasian Association of Cancer Registries collaborate every year to provide updated information on ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12127
更新日期：2013-09-01 00:00:00
abstract：:Resistance to endocrine therapy is a significant therapeutic challenge in the treatment of women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer. Cyclin-dependent kinase (CDK)4/6 inhibitors in combination with endocrine therapy have been shown to i...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13064
更新日期：2018-10-01 00:00:00
abstract：AIM:Integration of clinical genetics into oncology is variable. Sarcomas have a strong genetic component, with up to 1/30 patients carrying germline TP53 mutations. This study aimed to define genetic risk awareness among sarcoma physicians. Outcomes were attitudes toward genetic testing, level of cancer risk and awaren...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12457
更新日期：2016-06-01 00:00:00
abstract：:Posterior reversible encephalopathy syndrome (PRES) is a neuro-radiological syndrome characterized by seizures, altered level of consciousness and visual disturbance. PRES is associated with hyperintense lesions on magnetic resonance imaging (MRI) most commonly seen in the posterior regions. In most cases symptoms and...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/j.1743-7563.2012.01544.x
更新日期：2012-06-01 00:00:00
abstract：INTRODUCTION:Left- and right-sided colon cancers were significantly different in epidemiologic, clinical and histological parameters. However, the impact of primary tumor location in metastatic colon cancer treated with front-line targeted triplet regimens is unclear, particularly in Asian populations. METHODS:A total...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12469
更新日期：2016-09-01 00:00:00
abstract：AIM:To explore the incidence of subclinical cardiotoxicity in women treated with adjuvant trastuzumab in the early breast cancer setting using cardiac magnetic resonance imaging (cMRI). METHODS:The cardiac function and myocardial tissue characteristics of 25 women who had completed adjuvant trastuzumab therapy greater...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2011.01462.x
更新日期：2012-03-01 00:00:00
abstract：AIM:The open-label, nonrandomized, phase II APEC study enrolled 167 patients with RAS wild-type (wt) metastatic colorectal cancer (mCRC) to investigate the safety and efficacy of first-line, every-2-weeks cetuximab plus investigator's choice of FOLFIRI or FOLFOX in this patient population. METHODS:A subgroup analysis ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13154
更新日期：2019-08-01 00:00:00
abstract：AIM:To examine the treatment practices for cancer pain relief and adverse event management, and the factors related to patient outcomes in the participating countries/regions. METHODS:The study was a cross-sectional survey conducted between September and December 2013 in 10 countries/regions across Asia. Adult patient...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,多中心研究
doi：10.1111/ajco.12696
更新日期：2018-06-01 00:00:00
abstract：:Ipilimumab is a human anti-CTLA-4 monoclonal antibody recently approved for the treatment of advanced melanoma. Stimulation of T-cell activity unmasks antitumor activity, but can cause immune-related adverse events. Autoimmune hypophysitis is of particular importance because its presentation can be subtle but life thr...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12348
更新日期：2015-06-01 00:00:00
abstract：AIM:Complementary medicine (CAM) use in the cancer population is higher than the general population: some studies estimate up to 70%. Our Medicines Information Centre, in a tertiary cancer institution, receives many enquiries regarding use and safety of CAM with conventional cancer therapies (chemotherapy, radiotherapy...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13026
更新日期：2018-10-01 00:00:00
abstract：AIM:To describe the overall survival, progression-free survival, response rate and toxicity of pegylated liposomal doxorubicin (PLD) in recurrent ovarian cancer. METHODS:A retrospective study of 45 patients with recurrent or progressive ovarian cancer was conducted at the Westmead Cancer Care Centre. Patients received...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2009.01263.x
更新日期：2010-03-01 00:00:00
abstract：AIM:Long noncoding RNAs play a key role in the development and progression of various human cancers. Recently, LINC00852 has been reported to be associated with spinal metastasis lung adenocarcinoma. However, the role and potential mechanisms of LINC00852 in prostate cancer cells remain largely unknown. METHODS:LINC00...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13418
更新日期：2020-10-30 00:00:00
abstract：BACKGROUND:MRI and PET/CT scans are the main supportive methods for nasopharyngeal cancer (NPC) for staging and planning. The aim of this study is to compare MRI and PET/CT scanning in terms of survival in patients with NPC who had MRI or PET/CT-simulated radiotherapy planning. METHODS:Pathological diagnosed nonkerati...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13400
更新日期：2021-02-01 00:00:00
abstract：AIM:Mucositis is a major complication of irradiation in head and neck tumors, the addition of chemotherapy to irradiation may enhance this dose-limiting problem. Licorice is a strong demulcent that had been effectively used in treatment of peptic ulcer. The main purpose of this study was to compare the therapeutic safe...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,随机对照试验
doi：10.1111/ajco.12295
更新日期：2017-04-01 00:00:00
abstract：:Health literacy refers to one's ability to obtain, process and understand health information and services to enable sound health decision-making. This is an area of increasing importance due to the complexity of the health system, especially in the cancer setting. A certain level of health literacy is required for pat...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/j.1743-7563.2012.01522.x
更新日期：2012-03-01 00:00:00
abstract：:Disparities in cancer outcomes for people from culturally and linguistically diverse (CALD) groups are well known. Improving CALD patients' active participation in treatment processes holds potential to improve outcomes, but little is known of effective strategies to facilitate this. This systematic review investigate...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/j.1743-7563.2012.01531.x
更新日期：2013-06-01 00:00:00
abstract：:We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomograph...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2011.01515.x
更新日期：2012-06-01 00:00:00
abstract：BACKGROUND:Providing appropriate educational resources to patients with head and neck cancer (HNC) is important but challenging. The aim of this study was to determine Australian clinicians' perceptions of currently used HNC information resources. METHODS:A purpose-designed questionnaire was disseminated electronicall...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12858
更新日期：2018-10-01 00:00:00
