Hormone receptor positive, HER2 negative metastatic breast cancer: Impact of CDK4/6 inhibitors on the current treatment paradigm.

abstract：AIMS:Cyclophosphamide was widely used as a single agent prior to the advent of platinum-based regimens for epithelial ovarian cancer, and, in combination with platinum, prior to the adoption of platinum and paclitaxel as standard first-line therapy. As cyclophosphamide currently has no defined role in ovarian cancer we...

journal_title：Asia-Pacific journal of clinical oncology

authors： Handolias D,Quinn M,Foo S,Mileshkin L,Grant P,Dutu G,Rischin D

更新日期：2016-03-01 00:00:00

abstract：AIM:For early-stage breast cancer, four cycles of docetaxel and cyclophosphamide (TC) was proven superior to doxorubicin plus cyclophosphamide in the US Oncology 9375 trial. Given primary prophylactic antibiotics, 5% febrile neutropenia was recorded in a population comprising 75.5% Caucasians. Smaller trials and retros...

journal_title：Asia-Pacific journal of clinical oncology

authors： Chow LWC,Biganzoli L,Leo AD,Kuroi K,Han HS,Patel J,Huang CS,Lu YS,Zhu L,Chow CYC,Loo WTY,Glück S,Toi M

更新日期：2017-12-01 00:00:00

abstract：AIM:Important factors typically associated with prognosis in brain metastases include Karnofsky performance status (KPS), extracranial or cerebellar localization and combination chemotherapy. However, few studies investigated the prognostic role of leptomeningeal metastases (LM) following whole brain radiotherapy (WBRT...

journal_title：Asia-Pacific journal of clinical oncology

authors： Sakaguchi M,Maebayashi T,Aizawa T,Ishibashi N,Saito T

更新日期：2017-10-01 00:00:00

abstract：INTRODUCTION:Ki-67 proliferation index (Ki-67 index) is used to quantify cell proliferation during histopathological assessment of various tumors including glioblastoma (GB). AIM:We aimed to assess correlation between Ki-67 index and overall survival in patients with GB and determine a cut-point for Ki-67 index that p...

journal_title：Asia-Pacific journal of clinical oncology

authors： Wong E,Nahar N,Hau E,Varikatt W,Gebski V,Ng T,Jayamohan J,Sundaresan P

更新日期：2019-02-01 00:00:00

abstract：:The COVID-19 pandemic will present a range of challenges to radiation oncology departments. Early data suggest that cancer patients carry a higher than average, but still low absolute risk of hospitalization from COVID-19. The risk of severe events for those who are hospitalized however, is high. Resources for usual c...

journal_title：Asia-Pacific journal of clinical oncology

authors： Horsley PJ,Back M,Lamoury G,Porter B,Booth J,Eade TN

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND:Azacitidine safety and efficacy were established in studies of mainly Caucasian patients. Differences in drug metabolism enzymes between Caucasian and East Asian populations prevent extrapolation of drug effects between these groups. This phase 2 study evaluated azacitidine safety, efficacy and pharmacokinet...

journal_title：Asia-Pacific journal of clinical oncology

authors： Du X,Lai YY,Xiao Z,Liu T,Hu Y,Sun A,Li X,Shen ZX,Jin J,Yu L,Laille E,Dong Q,Songer S,Beach CL

更新日期：2018-06-01 00:00:00

abstract：AIMS:Extracorporeal irradiation and re-implantation (ECI) has been used as limb salvage surgery for musculoskeletal oncology patients. Biological reconstruction, no risk of disease transmission and immunological reaction, ready availability and preservation of bone stock are the major advantage of this surgical techniq...

journal_title：Asia-Pacific journal of clinical oncology

authors： Arpornchayanon O,Leerapun T,Pruksakorn D,Panichkul P

更新日期：2013-09-01 00:00:00

abstract：BACKGROUND:Primary squamous cell carcinoma of the breast (PSCCB) is a rare clinical classification of breast tumors. Little is known about its clinicopathological features, prognosis and potential therapeutic strategies. The purpose of this study is to evaluate the effect of postoperative radiotherapy (PORT) on patient...

journal_title：Asia-Pacific journal of clinical oncology

authors： Wang X,Zhang L,Luo J,Jin K,Yang Z,Meng J,Zhang X,Zhang Z,Shao Z,Guo X,Chen X,Yu X

更新日期：2020-10-20 00:00:00

abstract：AIM:Retroperitoneal sarcomas (RPSs) are large, rare tumors. The role of core biopsy for retroperitoneal masses identified by preoperative imaging is unclear and we report the safety and accuracy of core biopsies at a specialized sarcoma unit in Sydney, Australia. METHODS:A retrospective analysis of a prospectively col...

journal_title：Asia-Pacific journal of clinical oncology

authors： Hwang SY,Warrier S,Thompson S,Davidson T,Yang JL,Crowe P

更新日期：2016-03-01 00:00:00

abstract：INTRODUCTION:Left- and right-sided colon cancers were significantly different in epidemiologic, clinical and histological parameters. However, the impact of primary tumor location in metastatic colon cancer treated with front-line targeted triplet regimens is unclear, particularly in Asian populations. METHODS:A total...

journal_title：Asia-Pacific journal of clinical oncology

authors： Lu HJ,Lin JK,Chen WS,Jiang JK,Yang SH,Lan YT,Lin CC,Chang SC,Teng HW

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Access to palliative care services is essential for attaining universal health coverage for patients with a terminal cancer. Despite this, many patients with advanced cancer in low-income countries, such as Myanmar, suffer at the end of life (EOL) due to little or no access to palliative care. However, actua...

journal_title：Asia-Pacific journal of clinical oncology

authors： Mon SW,Ozdemir S,Zu WWM,Win H,Maw MM,Win KC,Thant KZ,Teo I,Krishnan A,Goh CR,Finkelstein EA,Malhotra C

更新日期：2020-12-01 00:00:00

abstract：AIM:To examine the treatment practices for cancer pain relief and adverse event management, and the factors related to patient outcomes in the participating countries/regions. METHODS:The study was a cross-sectional survey conducted between September and December 2013 in 10 countries/regions across Asia. Adult patient...

journal_title：Asia-Pacific journal of clinical oncology

authors： Ho KY,Ahn JS,Calimag MM,Chao TC,Kim YC,Moon H,Tho LM,Xia ZJ,You D

更新日期：2018-06-01 00:00:00

abstract：AIM:Colorectal cancer (CRC) is one of the most common malignancies worldwide and adjuvant chemotherapy is proven to improve survival in patients with Dukes' C CRC. The purpose of this study was to analyze factors influencing referral to medical oncology in patients with Dukes' C colonic cancer in our institutions. MET...

journal_title：Asia-Pacific journal of clinical oncology

authors： Lu CT,Stephens JH,Rieger NA

更新日期：2010-09-01 00:00:00

abstract：AIMS:To determine the feasibility of stereotactic body radiotherapy (SBRT) in patients with pelvic sidewall recurrence of uterine cervical cancer after radical hysterectomy or definitive radiotherapy. METHODS:We retrospectively reviewed 23 patients with locally recurrent uterine cervical cancer limited to the pelvic s...

journal_title：Asia-Pacific journal of clinical oncology

authors： Seo Y,Kim MS,Yoo HJ,Jang WI,Rhu SY,Choi SC,Kim MH,Kim BJ,Lee DH,Cho CK

更新日期：2016-06-01 00:00:00

abstract：AIM:This study examined pathological quality-of-surgery indicators in laparoscopic and open rectal cancer resection specimens. METHODS:Retrospective analysis of consecutive, prospectively recorded laparoscopic (LR) or open (OR) resections for rectal cancer. Indicators included integrity of the perirectal fascial envel...

journal_title：Asia-Pacific journal of clinical oncology

authors： Cheung HYC,Dent OF,Richardson GL,Chan C,Keshava A,Young CJ

更新日期：2018-04-01 00:00:00

abstract：:Carboplatin is a platinum analogue, widely used in the treatment of numerous cancer types including lung, genitourinary and ovarian cancers. It is also used in the adjuvant treatment of human epidermal growth factor receptor 2 positive breast cancer, where a non-anthracycline regimen is preferred. It is considered gen...

journal_title：Asia-Pacific journal of clinical oncology

authors： Turner N,Stewart J,Barnett F,White S

更新日期：2012-09-01 00:00:00

abstract：BACKGROUND:Anti-HER2 therapy-related cardiotoxicity is well described in the context of clinical trials, particularly in the setting of early stage disease, but there is more limited data in advanced breast cancer and in the real world setting. MATERIAL AND METHODS:A prospectively-maintained registry database with 312...

journal_title：Asia-Pacific journal of clinical oncology

authors： Conduit C,de Boer RH,Lok S,Gibbs P,Malik L,Loh Z,Yeo B,Greenberg S,Devitt B,Lombard J,Nottage M,Collins I,Torres J,Nolan M,Nott L

更新日期：2020-12-01 00:00:00

abstract：AIM:A newly developed cervical cancer screening method - folate receptor-mediated epithelium staining utilizes methylene blue internalized by folate receptor-mediated endocytosis to stain cervical intra-epithelial neoplasia. We test the clinical feasibility of this method in this study. METHODS:A total of 14 344 women...

journal_title：Asia-Pacific journal of clinical oncology

authors： Li D,Chen L,Wang H,Yang H,Dai Y,Yu C,Dong Y

更新日期：2017-02-01 00:00:00

abstract：:Disparities in cancer outcomes for people from culturally and linguistically diverse (CALD) groups are well known. Improving CALD patients' active participation in treatment processes holds potential to improve outcomes, but little is known of effective strategies to facilitate this. This systematic review investigate...

journal_title：Asia-Pacific journal of clinical oncology

authors： Harun A,Harrison JD,Young JM

更新日期：2013-06-01 00:00:00

abstract：:Multidisciplinary oncology team meetings are crucial hubs for integrated, patient-centered diagnosis and treatment planning. Team meetings are designed to enact the best practice principles of multidisciplinary care. Yet surveys of clinicians and allied health providers who are members of multidisciplinary teams (MDTs...

journal_title：Asia-Pacific journal of clinical oncology

authors： Lamprell K,Arnolda G,Delaney GP,Liauw W,Braithwaite J

更新日期：2019-08-01 00:00:00

abstract：:The rationale for certain patterns of metastatic spread seen in melanoma is not well understood. Currently, there is no clear experimental evidence to support the potential for metastases to form metastases in this disease. We report a case of a 31-year-old woman, with metastatic melanoma, who developed axillary lymph...

journal_title：Asia-Pacific journal of clinical oncology

authors： Bowyer S,Feeney K,Millward M

更新日期：2014-12-01 00:00:00

abstract：AIMS:The Australian Institute of Health and Welfare (AIHW) is a major national agency established by the Australian government to provide information and statistics on Australia's health and welfare. The AIHW and the Australasian Association of Cancer Registries collaborate every year to provide updated information on ...

journal_title：Asia-Pacific journal of clinical oncology

authors： Australian Institute of Health and Welfare.

更新日期：2013-09-01 00:00:00

abstract：:The precise cell types that give rise to tumors and mechanisms that underpin tumor heterogeneity are poorly understood. There is increasing evidence to suggest that diverse solid tumors are hierarchically organized and may be sustained by a distinct subpopulation of cancer stem cells (CSCs). The CSC hypothesis provide...

journal_title：Asia-Pacific journal of clinical oncology

authors： Lindeman GJ,Visvader JE

更新日期：2010-06-01 00:00:00

abstract：AIM:To evaluate the attitudes of patients with different cancers towards research biopsies outside a clinical trial. METHODS:Patients with metastatic cancer completed a questionnaire that assessed patients' willingness to consider research biopsies. Research biopsies were divided into two groups: biopsies performed as...

journal_title：Asia-Pacific journal of clinical oncology

authors： Robinson DH,Churilov L,Lin NU,Lim E,Seah D

更新日期：2018-06-01 00:00:00

abstract：:Posterior reversible encephalopathy syndrome (PRES) is a neuro-radiological syndrome characterized by seizures, altered level of consciousness and visual disturbance. PRES is associated with hyperintense lesions on magnetic resonance imaging (MRI) most commonly seen in the posterior regions. In most cases symptoms and...

journal_title：Asia-Pacific journal of clinical oncology

authors： Femia G,Hardy TA,Spies JM,Horvath LG

更新日期：2012-06-01 00:00:00

abstract：:We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomograph...

journal_title：Asia-Pacific journal of clinical oncology

authors： Yoon JY,Nam TS,Kim MK,Hwang JE,Shim HJ,Cho SH,Chung IJ,Bae WK

更新日期：2012-06-01 00:00:00

abstract：AIM:The objective of this economic evaluation, which was based on patients from two randomized controlled clinical trials (NO16966 and NO16967), was to compare direct medical costs to the Australian health-care system of capecitabine plus oxaliplatin (XELOX) and bolus and/or infusional 5-fluorouracil (5-FU) plus folini...

journal_title：Asia-Pacific journal of clinical oncology

authors： Tran G,Hack SP,Kerr A,Stokes L,Gibbs P,Price T,Todd C

更新日期：2013-09-01 00:00:00

abstract：AIM:Behavioral interventions such as exercise may induce epigenetic changes. Only few studies investigated the effects of exercise on epigenetic alterations in colorectal cancer survivors. The aim of this study was to explore the changes of genome-wide DNA methylation after 6-week exercise training in colorectal cancer...

journal_title：Asia-Pacific journal of clinical oncology

authors： Hwang SH,Kang DW,Lee MK,Byeon JY,Park H,Park DH,Kim KC,Lee ST,Chu SH,Kim NK,Jeon JY

更新日期：2020-10-13 00:00:00

abstract：BACKGROUND:Providing appropriate educational resources to patients with head and neck cancer (HNC) is important but challenging. The aim of this study was to determine Australian clinicians' perceptions of currently used HNC information resources. METHODS:A purpose-designed questionnaire was disseminated electronicall...

journal_title：Asia-Pacific journal of clinical oncology

authors： Jabbour J,Wykes J,Milross C,Sundaresan P,Ebrahimi A,Shepherd HL,Dhillon HM,Clark JR

更新日期：2018-10-01 00:00:00

abstract：AIM:To investigate the association between plasma visfatin levels and risk of early and advanced colorectal cancer (CRC). METHODS:In total, 358 CRC patients and 286 controls were enrolled. According to the T factor of the TNM system. cancer patients were divided into two subgroups: early and advanced cancer. Levels of...

journal_title：Asia-Pacific journal of clinical oncology

authors： Chen M,Wang Y,Li Y,Zhao L,Ye S,Wang S,Yu C,Xie H

更新日期：2016-03-01 00:00:00