Hormone receptor positive, HER2 negative metastatic breast cancer: Impact of CDK4/6 inhibitors on the current treatment paradigm.

Abstract:

:Resistance to endocrine therapy is a significant therapeutic challenge in the treatment of women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer. Cyclin-dependent kinase (CDK)4/6 inhibitors in combination with endocrine therapy have been shown to improve progression free survival, overall response rate and clinical benefit rate in women with HR+ HER2- metastatic breast cancer compared with endocrine therapy alone. This review examines the clinical evidence to support the use of CDK4/6 inhibitors in first and second line settings. Practical guidance is provided for the use of CDK4/6 inhibitors, including tolerability data, monitoring requirements and management of key toxicities for each of the available agents.

journal_name

Asia Pac J Clin Oncol

authors

Boyle F,Beith J,Burslem K,de Boer R,Hui R,Lim E,McCarthy N,Redfern A,Woodward N

doi

10.1111/ajco.13064

subject

Has Abstract

pub_date

2018-10-01 00:00:00

pages

3-11

eissn

1743-7555

issn

1743-7563

journal_volume

14 Suppl 4

pub_type

杂志文章
  • Survival of lung cancer patients in a resource-limited country.

    abstract:AIM:Data on lung cancer survival are lacking in developing countries. Our objectives were to describe the survival of our lung cancer patients and to determine independent prognostic factors affecting survival. METHOD:All patients diagnosed with lung cancer from August 2007 to August 2010 were recruited from a single ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12179

    authors: How SH,Ng TH,Kuan YC,Jamalludin AR,Fauzi AR

    更新日期:2015-09-01 00:00:00

  • Oral cyclophosphamide in recurrent ovarian cancer.

    abstract:AIMS:Cyclophosphamide was widely used as a single agent prior to the advent of platinum-based regimens for epithelial ovarian cancer, and, in combination with platinum, prior to the adoption of platinum and paclitaxel as standard first-line therapy. As cyclophosphamide currently has no defined role in ovarian cancer we...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12074

    authors: Handolias D,Quinn M,Foo S,Mileshkin L,Grant P,Dutu G,Rischin D

    更新日期:2016-03-01 00:00:00

  • Result of extracorporeal irradiation and re-implantation for malignant bone tumors: a review of 30 patients.

    abstract:AIMS:Extracorporeal irradiation and re-implantation (ECI) has been used as limb salvage surgery for musculoskeletal oncology patients. Biological reconstruction, no risk of disease transmission and immunological reaction, ready availability and preservation of bone stock are the major advantage of this surgical techniq...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12036

    authors: Arpornchayanon O,Leerapun T,Pruksakorn D,Panichkul P

    更新日期:2013-09-01 00:00:00

  • Posterior reversible encephalopathy syndrome following chemotherapy with oxaliplatin and a fluoropyrimidine: a case report and literature review.

    abstract::Posterior reversible encephalopathy syndrome (PRES) is a neuro-radiological syndrome characterized by seizures, altered level of consciousness and visual disturbance. PRES is associated with hyperintense lesions on magnetic resonance imaging (MRI) most commonly seen in the posterior regions. In most cases symptoms and...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1743-7563.2012.01544.x

    authors: Femia G,Hardy TA,Spies JM,Horvath LG

    更新日期:2012-06-01 00:00:00

  • Outcomes of Malaysian patients with advanced lung adenocarcinoma and unknown epidermal growth factor receptor mutation status treated with gefitinib.

    abstract:AIMS:To evaluate the response and progression-free survival (PFS) of Malaysian patients with advanced lung adenocarcinoma and unknown epidermal growth factor receptor (EGFR) mutation status treated with gefitinib. METHODS:A retrospective analysis of consecutive patients with EGFR mutation unknown stage III or IV lung ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2011.01509.x

    authors: Liam CK,Ruthranesan M,Lee CH,Pang YK,Chua KT,Lim BK

    更新日期:2012-09-01 00:00:00

  • An exploration of the dynamics and influences upon second medical opinion consultations in cancer care.

    abstract:AIM:The aim of this study was to explore the dynamics within second medical opinion consultations in patients with cancer. METHODS:Semi-structured interviews were held with four oncologists and were subjected to a thematic analysis to define the broad issues. These formed the basis of a survey distributed to Australia...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2010.01330.x

    authors: Philip J,Gold M,Schwarz M,Komesaroff P

    更新日期:2011-03-01 00:00:00

  • Effectiveness of image-guided radiotherapy for rectal cancer patients treated with neoadjuvant concurrent chemoradiotherapy: A population-based propensity score-matched analysis.

    abstract:AIM:The effects of image-guided radiotherapy (IGRT, an advanced RT technology) have been debated in the literature. We compared the outcomes of locally advanced rectal cancer (LARC) patients treated with neoadjuvant concurrent chemoradiotherapy (NCCRT; with vs without IGRT) in a large population-based propensity score ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13196

    authors: Li CC,Liang JA,Chen WT,Chien CR

    更新日期:2019-10-01 00:00:00

  • Real-world impact of anti-HER2 therapy-related cardiotoxicity in patients with advanced HER2-positive breast cancer.

    abstract:BACKGROUND:Anti-HER2 therapy-related cardiotoxicity is well described in the context of clinical trials, particularly in the setting of early stage disease, but there is more limited data in advanced breast cancer and in the real world setting. MATERIAL AND METHODS:A prospectively-maintained registry database with 312...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13381

    authors: Conduit C,de Boer RH,Lok S,Gibbs P,Malik L,Loh Z,Yeo B,Greenberg S,Devitt B,Lombard J,Nottage M,Collins I,Torres J,Nolan M,Nott L

    更新日期:2020-12-01 00:00:00

  • Prognostic value of enhancement rate by enhanced ultrasound in hepatitis B virus-positive hepatocellular carcinoma undergoing radiofrequency ablation.

    abstract:AIM:To assess the prognostic significance of enhancement rate (ER) measured by contrast-enhanced ultrasonography (CEUS) in patients with hepatocellular carcinoma (HCC) undergoing radiofrequency ablation (RFA). MATERIALS AND METHODS:A total of 253 patients with single primary HCC undergoing preoperative CEUS and RFA we...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13157

    authors: Zhou G,Cai ZQ,Luo J,Hu ZX,Luo H,Wu H,Chen Q

    更新日期:2019-08-01 00:00:00

  • International survey of awareness of genetic risk in the clinical sarcoma community.

    abstract:AIM:Integration of clinical genetics into oncology is variable. Sarcomas have a strong genetic component, with up to 1/30 patients carrying germline TP53 mutations. This study aimed to define genetic risk awareness among sarcoma physicians. Outcomes were attitudes toward genetic testing, level of cancer risk and awaren...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12457

    authors: McBride KA,Schlub TE,Ballinger ML,Thomas DM,Tattersall MH

    更新日期:2016-06-01 00:00:00

  • Efficacy and safety of sorafenib in combination with gemcitabine in patients with advanced hepatocellular carcinoma: a multicenter, open-label, single-arm phase II study.

    abstract:AIMS:Currently, the only standard systemic treatment for advanced hepatocellular carcinoma is sorafenib monotherapy. The study was conducted to assess the efficacy and safety of the novel combination of sorafenib and gemcitabine in the treatment of advanced hepatocellular carcinoma. METHODS:Between March 2008 and Octo...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ajco.12191

    authors: Srimuninnimit V,Sriuranpong V,Suwanvecho S

    更新日期:2014-09-01 00:00:00

  • Pre-treatment serum lactate dehydrogenase as a biomarker in small cell lung cancer.

    abstract:BACKGROUND:Small cell lung cancer is a rapidly progressive disease with high fatality. No sensitive and specific biomarker to assist in managing this disease exists currently. AIM:Role of pretreatment serum lactate dehydrogenase as a biomarker in small cell lung cancer. METHODS:A hospital-based cancer registry was us...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12674

    authors: Hsieh AH,Tahkar H,Koczwara B,Kichenadasse G,Beckmann K,Karapetis C,Sukumaran S

    更新日期:2018-04-01 00:00:00

  • Is definitive concurrent chemoradiotherapy effective for locally advanced head and neck cancer in the elderly aged ≥ 75 years: A single-institute, retrospective, cohort study.

    abstract:BACKGROUND:Definitive chemoradiotherapy (CRT) is the standard treatment for locally advanced head and neck cancer (HNC). However, for very elderly patients, the comparison of benefit/risk between definitive radiotherapy (RT) with and without systemic chemotherapy was equivocal. PATIENTS AND METHODS:The study was a sin...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12764

    authors: Lai KM,Lin JT,Lu HJ,Liang CC,Chen MK

    更新日期:2018-06-01 00:00:00

  • Effect of pre existing respiratory conditions on survival of lung cancer patients: A nationwide population-based cohort study.

    abstract:BACKGROUND:Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. METHODS:We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multi...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12697

    authors: Hong S,Park EC,Kim TH,Kwon JA,Yoo KB,Han KT,Yoo JW,Kim SJ

    更新日期:2018-04-01 00:00:00

  • KRAS mutation testing of metastatic colorectal cancer in Australia: where are we at?

    abstract:AIM:To carry out a nationwide study of KRAS testing in metastatic colorectal cancer as reported by nine major molecular pathology service providers in Australia, including mutation frequencies and turnaround times that might impact on patient care. METHODS:Participating laboratories contributed information on KRAS mut...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12201

    authors: Scott RJ,Fox SB,Desai J,Grieu F,Amanuel B,Garrett K,Harraway J,Cheetham G,Pattle N,Haddad A,Byron K,Rudzki B,Waring P,Iacopetta B

    更新日期:2014-09-01 00:00:00

  • Examining clinicians' perceptions of head and neck cancer (HNC) information.

    abstract:BACKGROUND:Providing appropriate educational resources to patients with head and neck cancer (HNC) is important but challenging. The aim of this study was to determine Australian clinicians' perceptions of currently used HNC information resources. METHODS:A purpose-designed questionnaire was disseminated electronicall...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12858

    authors: Jabbour J,Wykes J,Milross C,Sundaresan P,Ebrahimi A,Shepherd HL,Dhillon HM,Clark JR

    更新日期:2018-10-01 00:00:00

  • Cancer in Pregnancy.

    abstract::Cancer in pregnancy may be increasing in incidence with advancing maternal age and higher rates of obesity. The diagnosis of cancer in pregnancy provokes complex management issues balancing short- and long-term risks for both mother and baby. Every case needs to be individualized, with a multidisciplinary team of midw...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/ajco.13235

    authors: Eastwood-Wilshere N,Turner J,Oliveira N,Morton A

    更新日期:2019-12-01 00:00:00

  • Upfront maintenance therapy with arsenic trioxide in acute promyelocytic leukemia provides no benefit for non-t(15;17) subtype.

    abstract:AIMS:The optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who achieved complete remission (CR) and complete consolidation chemotherapy is still controversial. Whether the use of arsenic trioxide (ATO) alone or along with all-trans retinoic acid (ATRA) improves overall survival (OS) or di...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2011.01496.x

    authors: Chiang YH,Chang YF,Hsieh RK,Lin J,Chen CG,Lim KH,Lin HC,Chang MC

    更新日期:2012-12-01 00:00:00

  • The challenge of putting principles into practice: Resource tensions and real-world constraints in multidisciplinary oncology team meetings.

    abstract::Multidisciplinary oncology team meetings are crucial hubs for integrated, patient-centered diagnosis and treatment planning. Team meetings are designed to enact the best practice principles of multidisciplinary care. Yet surveys of clinicians and allied health providers who are members of multidisciplinary teams (MDTs...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/ajco.13166

    authors: Lamprell K,Arnolda G,Delaney GP,Liauw W,Braithwaite J

    更新日期:2019-08-01 00:00:00

  • Factors influencing medical oncology referral in Dukes' C colonic cancer.

    abstract:AIM:Colorectal cancer (CRC) is one of the most common malignancies worldwide and adjuvant chemotherapy is proven to improve survival in patients with Dukes' C CRC. The purpose of this study was to analyze factors influencing referral to medical oncology in patients with Dukes' C colonic cancer in our institutions. MET...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2010.01312.x

    authors: Lu CT,Stephens JH,Rieger NA

    更新日期:2010-09-01 00:00:00

  • Australian recommendations for EGFR T790M testing in advanced non-small cell lung cancer.

    abstract::First-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are used as first-line therapy in patients with non-small cell lung cancer (NSCLC) harboring a sensitizing mutation in the EGFR gene. Unfortunately, resistance to these therapies often occurs within 10 months of commencing treat...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/ajco.12699

    authors: John T,Bowden JJ,Clarke S,Fox SB,Garrett K,Horwood K,Karapetis CS

    更新日期:2017-08-01 00:00:00

  • Immunotherapy for urothelial carcinoma: Metastatic disease and beyond.

    abstract::For advanced and metastatic urothelial carcinomas (UCs), platinum (preferably cisplatin)-based chemotherapy has been the standard treatment for many years. However, many patients are ineligible for cisplatin-based chemotherapy because of poor performance status and/or other age-related conditions. At the other end of ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/ajco.13312

    authors: Poon DM

    更新日期:2020-09-01 00:00:00

  • Primary tumor location is an important predictive factor for wild-type KRAS metastatic colon cancer treated with cetuximab as front-line bio-therapy.

    abstract:INTRODUCTION:Left- and right-sided colon cancers were significantly different in epidemiologic, clinical and histological parameters. However, the impact of primary tumor location in metastatic colon cancer treated with front-line targeted triplet regimens is unclear, particularly in Asian populations. METHODS:A total...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12469

    authors: Lu HJ,Lin JK,Chen WS,Jiang JK,Yang SH,Lan YT,Lin CC,Chang SC,Teng HW

    更新日期:2016-09-01 00:00:00

  • The significance of subcarinal dissection in esophageal cancer surgery.

    abstract:AIM:The purpose of this study was to investigate the impact of subcarinal dissection on short-term outcome and survival following esophagectomy in patients with thoracic esophageal squamous cell carcinoma. METHODS:A total of 2252 patients underwent an esophagectomy for esophageal cancer from January 1997 to December 2...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12095

    authors: Hu W,Liang Y,Zhang S,Hu Y,Liu J

    更新日期:2014-06-01 00:00:00

  • Cancer multidisciplinary team meetings in practice: Results from a multi-institutional quantitative survey and implications for policy change.

    abstract:AIM:Multidisciplinary care is advocated as best practice in cancer care. Relatively little is documented about multidisciplinary team (MDT) meeting functioning, decision making and the use of evidence to support decision making in Australia. This descriptive study aimed to examine team functioning, the role of team mee...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12765

    authors: Rankin NM,Lai M,Miller D,Beale P,Spigelman A,Prest G,Turley K,Simes J

    更新日期:2018-02-01 00:00:00

  • Endoscopic self-expandable metallic stent placement in malignant pyloric or duodenal obstruction: does chemotherapy affect stent patency?

    abstract:AIM:Self-expandable metallic stents (SEMS) have been used for palliation in patients with malignant gastroduodenal obstructions. We evaluated clinical outcomes after SEMS placement and identified prognostic factors of SEMS patency, including chemotherapy. METHODS:A review of records of 85 patients with unresectable ga...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2012.01590.x

    authors: Cha BH,Lee SH,Kim JE,Yoo JY,Park YS,Kim JW,Jeong SH,Kim N,Lee DH,Hwang JH

    更新日期:2013-06-01 00:00:00

  • Inadequate treatment practices for pain relief and adverse event management in cancer patients across 10 countries/regions in Asia: a call for greater efforts to improve standards for patient care.

    abstract:AIM:To examine the treatment practices for cancer pain relief and adverse event management, and the factors related to patient outcomes in the participating countries/regions. METHODS:The study was a cross-sectional survey conducted between September and December 2013 in 10 countries/regions across Asia. Adult patient...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ajco.12696

    authors: Ho KY,Ahn JS,Calimag MM,Chao TC,Kim YC,Moon H,Tho LM,Xia ZJ,You D

    更新日期:2018-06-01 00:00:00

  • Acute inflammatory demyelinating polyradiculoneuropathy in a patient receiving oxaliplatin-based chemotherapy.

    abstract::We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomograph...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2011.01515.x

    authors: Yoon JY,Nam TS,Kim MK,Hwang JE,Shim HJ,Cho SH,Chung IJ,Bae WK

    更新日期:2012-06-01 00:00:00

  • Antiangiogenic therapy in the management of breast cancer.

    abstract::An improved understanding of the important role of angiogenesis in tumor biology has led to development of different antiangiogenic therapies. Numerous clinical studies for several antiangiogenic agents have recently been conducted in breast cancer patients and have shown clinically significant improvement in outcomes...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1743-7563.2012.01569.x

    authors: Wu Y,Sun WL,Feng JF

    更新日期:2013-06-01 00:00:00

  • Patient outcomes of whole brain radiotherapy for brain metastases versus leptomeningeal metastases: A retrospective study.

    abstract:AIM:Important factors typically associated with prognosis in brain metastases include Karnofsky performance status (KPS), extracranial or cerebellar localization and combination chemotherapy. However, few studies investigated the prognostic role of leptomeningeal metastases (LM) following whole brain radiotherapy (WBRT...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12597

    authors: Sakaguchi M,Maebayashi T,Aizawa T,Ishibashi N,Saito T

    更新日期:2017-10-01 00:00:00