Abstract：
AIM:The role of germline testing in prostate cancer is evolving and knowledge of an individual's genetic profile may be used to guide not only an assessment of their familial risk but also have prognostic and therapeutic implications. Although international guidelines have incorporated recommendations for germline testing in prostate cancer, there is little Australian data to guide referrals. The aim of this study is to review the frequency of relevant pathogenic mutations in an Australian center, their associated clinical factors and clinical impact. METHODS:We conducted a single-center retrospective review of men with prostate cancer that undertook prospective germline testing using a targeted next generation sequencing panel. RESULTS:Results for 100 men were analyzed. Median age at diagnosis was 62 years (range 43-84); 92% had metastatic disease at referral. A pathogenic mutation was confirmed in 9%, a likely pathogenic variant in 2% and a variant of uncertain significance in 15%. Age ≤60 years was associated with an increased risk for a pathogenic germline variant (P = 0.0096). Two of the nine (22%) with pathogenic variants went on to receive targeted treatment. CONCLUSIONS:In this single center study, the incidence of germline mutations in genes associated with DNA-repair was consistent with rates seen previously published international series of men with metastatic disease. A pathogenic variant was only seen in one patient >60 years of age and no man referred solely on the basis of age or high-risk localized disease had a relevant finding.
journal_name
Asia Pac J Clin Oncoljournal_title
Asia-Pacific journal of clinical oncologyauthors
Crumbaker M,Wong J,Joshua AM,Spigelman ADdoi
10.1111/ajco.13148subject
Has Abstractpub_date
2019-08-01 00:00:00pages
257-261issue
4eissn
1743-7555issn
1743-7563journal_volume
15pub_type
杂志文章abstract：AIM:Vascular endothelial growth facto receptor-tyrosine kinase inhibitors (VEGFR-TKIs) are widely used for metastatic renal cell carcinoma (mRCC). The aim of this study was to investigate the association between the response to VEGFR-TKIs and hyperlipidemia and hypothyroidism. METHODS:Clinical data on 155 patients wit...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12473
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:Definitive chemoradiotherapy (CRT) is the standard treatment for locally advanced head and neck cancer (HNC). However, for very elderly patients, the comparison of benefit/risk between definitive radiotherapy (RT) with and without systemic chemotherapy was equivocal. PATIENTS AND METHODS:The study was a sin...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12764
更新日期：2018-06-01 00:00:00
abstract：AIM:This systematic review and meta-analysis was performed to assess the efficacy and side effects between single-agent and doublet chemotherapy in first-line treatment of advanced non-small cell lung cancer with performance status 2 (PS2). METHODS:We searched for randomized controlled trials in online electronic data...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/ajco.12359
更新日期：2015-09-01 00:00:00
abstract：:Cancer, its therapy, and related adverse effects have been associated with reduced work performance, including absenteeism (i.e. absence from scheduled work due to health problems) and presenteeism (i.e. impaired on-the-job performance due to health problems) among cancer survivors. This review aimed to compare the wo...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/ajco.12515
更新日期：2016-12-01 00:00:00
abstract：INTRODUCTION:The goal of this study was to determine the relationships among type 2 diabetes mellitus (DM), specific cancer histological types and mortality in hospitalized women. METHODS:Patients over 19 years of age were included if the indication for hospital admission was a diagnosis of type 2 DM or a malignancy. ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12084
更新日期：2016-03-01 00:00:00
abstract：BACKGROUND:Clinical trials investigating the effects of addition of oxaliplatin to neoadjuvant radiochemotherapy in locally advanced rectal cancers (LARCs) have brought controversial results for pathologic complete response as an endpoint. This randomized clinical trial investigated downstaging as a short-term surrogat...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,随机对照试验
doi：10.1111/ajco.12675
更新日期：2017-12-01 00:00:00
abstract：AIM:The purpose of this study was to investigate the impact of subcarinal dissection on short-term outcome and survival following esophagectomy in patients with thoracic esophageal squamous cell carcinoma. METHODS:A total of 2252 patients underwent an esophagectomy for esophageal cancer from January 1997 to December 2...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12095
更新日期：2014-06-01 00:00:00
abstract：BACKGROUND:Anti-HER2 therapy-related cardiotoxicity is well described in the context of clinical trials, particularly in the setting of early stage disease, but there is more limited data in advanced breast cancer and in the real world setting. MATERIAL AND METHODS:A prospectively-maintained registry database with 312...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13381
更新日期：2020-12-01 00:00:00
abstract：AIMS:Currently, the only standard systemic treatment for advanced hepatocellular carcinoma is sorafenib monotherapy. The study was conducted to assess the efficacy and safety of the novel combination of sorafenib and gemcitabine in the treatment of advanced hepatocellular carcinoma. METHODS:Between March 2008 and Octo...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,多中心研究
doi：10.1111/ajco.12191
更新日期：2014-09-01 00:00:00
abstract：:The association between the rs498872 single nucleotide polymorphism (SNP) and glioma risk has been studied, but these studies have yielded conflicting results. In order to explore this association, we performed a meta-analysis. A comprehensive literature search was performed using PubMed and EMBASE database, with the ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/ajco.12211
更新日期：2015-12-01 00:00:00
abstract：BACKGROUND:Providing appropriate educational resources to patients with head and neck cancer (HNC) is important but challenging. The aim of this study was to determine Australian clinicians' perceptions of currently used HNC information resources. METHODS:A purpose-designed questionnaire was disseminated electronicall...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12858
更新日期：2018-10-01 00:00:00
abstract：AIM:For several decades urinary arylsulfatase (ARS) activity has been reported to be elevated in many cancers. It has been shown that urinary ARS activity may serve as a marker of tumor progression and therapy surveillance. This study was designed to evaluate the clinical application of detection of urinary ARS activit...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2012.01545.x
更新日期：2012-12-01 00:00:00
abstract：AIM:To evaluate tumor markers as prognostic factors in patients with metastatic or recurrent gastric cancer receiving first-line chemotherapy. METHODS:Between January 2000 and December 2008, 1178 patients with metastatic or recurrent gastric cancer were assayed for expression of three serum tumor markers, CA 19-9, CA ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12019
更新日期：2013-12-01 00:00:00
abstract：BACKGROUND:Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. METHODS:We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multi...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12697
更新日期：2018-04-01 00:00:00
abstract：:We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomograph...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2011.01515.x
更新日期：2012-06-01 00:00:00
abstract：AIMS:Quality of life (QOL) is important in patients with advanced cancer. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 is a general QOL tool used in cancer patients. Often, with a large enough sample, statistical significance of changecan be reached, however the clinical significance i...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12070
更新日期：2014-06-01 00:00:00
abstract：AIM:For early-stage breast cancer, four cycles of docetaxel and cyclophosphamide (TC) was proven superior to doxorubicin plus cyclophosphamide in the US Oncology 9375 trial. Given primary prophylactic antibiotics, 5% febrile neutropenia was recorded in a population comprising 75.5% Caucasians. Smaller trials and retros...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12682
更新日期：2017-12-01 00:00:00
abstract：AIM:To evaluate the attitudes of patients with different cancers towards research biopsies outside a clinical trial. METHODS:Patients with metastatic cancer completed a questionnaire that assessed patients' willingness to consider research biopsies. Research biopsies were divided into two groups: biopsies performed as...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12783
更新日期：2018-06-01 00:00:00
abstract：AIMS:The optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who achieved complete remission (CR) and complete consolidation chemotherapy is still controversial. Whether the use of arsenic trioxide (ATO) alone or along with all-trans retinoic acid (ATRA) improves overall survival (OS) or di...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2011.01496.x
更新日期：2012-12-01 00:00:00
abstract：AIMS:To determine the feasibility of stereotactic body radiotherapy (SBRT) in patients with pelvic sidewall recurrence of uterine cervical cancer after radical hysterectomy or definitive radiotherapy. METHODS:We retrospectively reviewed 23 patients with locally recurrent uterine cervical cancer limited to the pelvic s...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12185
更新日期：2016-06-01 00:00:00
abstract：AIMS:Wilms tumor (WT) is rare in Asia. Treatment of bilateral WT is challenging, and the treatment outcome of bilateral WT is rarely reported in low incidence areas. METHODS:We enrolled patients with bilateral WT registered in Chang Gung Memorial Hospital, Taoyuan, Taiwan, between January 1986 and June 2015. They were...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12501
更新日期：2016-09-01 00:00:00
abstract：AIM:We investigated prognostic significance of methylation status of MASPIN gene and its protein expression in normal subjects, cholelithiasis and gallbladder cancer (GBC) patients. METHODS:MASPIN protein expression and its promoter methylation in gallbladder tissue of cholelithiasis (n = 36), GBC (n = 46) and control...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13129
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:MRI and PET/CT scans are the main supportive methods for nasopharyngeal cancer (NPC) for staging and planning. The aim of this study is to compare MRI and PET/CT scanning in terms of survival in patients with NPC who had MRI or PET/CT-simulated radiotherapy planning. METHODS:Pathological diagnosed nonkerati...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13400
更新日期：2021-02-01 00:00:00
abstract：AIM:To evaluate the distribution of the Oncotype DX Recurrence Score (a validated prognostic/predictive tool in early-stage estrogen-receptor positive [ER+] breast cancer) and its impact on adjuvant treatment decisions in the United Arab Emirates. METHODS:A retrospective analysis of a single-center cohort. RESULTS:Th...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12259
更新日期：2014-12-01 00:00:00
abstract：AIM:Colorectal cancer (CRC) is one of the most common malignancies worldwide and adjuvant chemotherapy is proven to improve survival in patients with Dukes' C CRC. The purpose of this study was to analyze factors influencing referral to medical oncology in patients with Dukes' C colonic cancer in our institutions. MET...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2010.01312.x
更新日期：2010-09-01 00:00:00
abstract：BACKGROUND:Docetaxel is an effective therapy for metastatic castration-resistant prostate cancer (mCRPC); however, many patients experience febrile neutropenia (FN) and cease treatment early due to toxicity. It is not known whether lower dose (LD) q3-weekly docetaxel impacts toxicity or efficacy. METHODS:Multicenter r...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,多中心研究
doi：10.1111/ajco.12840
更新日期：2018-10-01 00:00:00
abstract：BACKGROUND:Small cell lung cancer is a rapidly progressive disease with high fatality. No sensitive and specific biomarker to assist in managing this disease exists currently. AIM:Role of pretreatment serum lactate dehydrogenase as a biomarker in small cell lung cancer. METHODS:A hospital-based cancer registry was us...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12674
更新日期：2018-04-01 00:00:00
abstract：:Non-small cell lung cancers (NSCLC) harboring the uncommon epidermal growth factor receptor (EGFR) exon 20 insertion mutations are generally thought to be unresponsive to EGFR-tyrosine kinase inhibitor (TKI) therapy. Presented here is a case of stage IV NSCLC harboring an uncommon EGFR exon 20 insertion mutation that ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12853
更新日期：2018-03-01 00:00:00
abstract：INTRODUCTION:Left- and right-sided colon cancers were significantly different in epidemiologic, clinical and histological parameters. However, the impact of primary tumor location in metastatic colon cancer treated with front-line targeted triplet regimens is unclear, particularly in Asian populations. METHODS:A total...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12469
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute. METHODS:The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectivel...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13135
更新日期：2019-06-01 00:00:00
