Abstract:
BACKGROUND:Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. METHODS:We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multivariate-adjusted hazard ratios (aHRs) of lung cancer mortality by presence, time intervals with lung cancer diagnosis and combinations of pre-existing chronic obstructive pulmonary disease (COPD), pneumonia, asthma and tuberculosis were calculated using the Cox-proportional hazards model. RESULTS:The total number of person-years of follow-up was 397 780 and 60.2% of patients died (mean survival 23.2 months after lung cancer diagnosis). Lung cancer patients with previous respiratory disease had increased aHR for mortality (COPD, hazard ratio [HR] = 1.32, CI 1.29-1.35; pneumonia, HR = 1.14, CI 1.08-1.19; and asthma, HR = 1.11, CI 1.06-1.16). Risks were positively associated with longer duration of pre-existing disease diagnosis; cases with >5 years since diagnosis compared to <2 years: COPD, HR = 2.91, CI 2.82-3.00; pneumonia, HR = 1.67, CI 1.51-1.85; asthma, HR = 1.56, CI 1.45-1.68; and tuberculosis, HR = 2.03, CI 1.90-2.17. Furthermore, elevated HRs of death were found among patients with multiple pre-existing co-morbidities. CONCLUSION:Hazards of death from lung cancer are significantly increased in cases with pre-existing lung disease, and worse with longer durations, and with multiple combinations before cancer diagnosis. Patients and physicians should be aware of these meaningful risk/prognostic factors for lung cancer when identifying high-risk patient groups.
journal_name
Asia Pac J Clin Oncoljournal_title
Asia-Pacific journal of clinical oncologyauthors
Hong S,Park EC,Kim TH,Kwon JA,Yoo KB,Han KT,Yoo JW,Kim SJdoi
10.1111/ajco.12697subject
Has Abstractpub_date
2018-04-01 00:00:00pages
e71-e80issue
2eissn
1743-7555issn
1743-7563journal_volume
14pub_type
杂志文章abstract:AIMS:The optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who achieved complete remission (CR) and complete consolidation chemotherapy is still controversial. Whether the use of arsenic trioxide (ATO) alone or along with all-trans retinoic acid (ATRA) improves overall survival (OS) or di...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2011.01496.x
更新日期:2012-12-01 00:00:00
abstract:AIM:Gastric cancer patients are normally treated with oral fluoropyrimidine and cisplatin or oxaliplatin; however, treating patients who also have a gastrointestinal obstruction is often difficult because of their poor oral intake. Instead, a modified (m)FOLFOX-6 regimen is administered, even to patients with gastroint...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13110
更新日期:2019-10-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12179
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND:Anti-HER2 therapy-related cardiotoxicity is well described in the context of clinical trials, particularly in the setting of early stage disease, but there is more limited data in advanced breast cancer and in the real world setting. MATERIAL AND METHODS:A prospectively-maintained registry database with 312...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13381
更新日期:2020-12-01 00:00:00
abstract:AIM:A viable and sustainable medical oncology profession is integral for meeting the increasing demand for quality cancer care. The aim of this study was to explore the workforce-related experiences, perceptions and career expectations of early-career medical oncologists in Australia. METHODS:A mixed-methods design, i...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12844
更新日期:2018-10-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12411
更新日期:2015-12-01 00:00:00
abstract::For advanced and metastatic urothelial carcinomas (UCs), platinum (preferably cisplatin)-based chemotherapy has been the standard treatment for many years. However, many patients are ineligible for cisplatin-based chemotherapy because of poor performance status and/or other age-related conditions. At the other end of ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2020-09-01 00:00:00
abstract:AIM:To describe the development of the content and pilot testing of a radiation therapist-led educational intervention for breast cancer patients about to commence radiotherapy. Pilot testing consisted of testing the intervention for appropriateness, feasibility and acceptance. METHODS:A tailored intervention consisti...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1743-7563.2012.01520.x
更新日期:2012-09-01 00:00:00
abstract:AIMS:Esophageal cancer (EC) is one of the most prevalent and deadly cancers worldwide. Along with nutrition, smoking and alcohol consumption, human papillomavirus (HPV) infection is one of the major risk factors, which is modulated by host immune response. This study is aimed at elucidating how HPV modifies host immune...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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更新日期:2014-03-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13418
更新日期:2020-10-30 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,meta分析,评审
doi:10.1111/ajco.12211
更新日期:2015-12-01 00:00:00
abstract:AIM:As survival rates for aggressive and conservative breast and lymph node surgery are similar, surgical treatment decisions for patients with early-stage breast cancer should take patient preference into account. Decision aids have been demonstrated to increase patient knowledge and satisfaction with decision making,...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1743-7563.2010.01375.x
更新日期:2011-06-01 00:00:00
abstract:AIM:To describe the overall survival, progression-free survival, response rate and toxicity of pegylated liposomal doxorubicin (PLD) in recurrent ovarian cancer. METHODS:A retrospective study of 45 patients with recurrent or progressive ovarian cancer was conducted at the Westmead Cancer Care Centre. Patients received...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2009.01263.x
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:Mitomycin C (MMC) plus standard 5-fluorouracil (FU) infusion in weeks 1 and 5 often contributes to radiotherapy interruptions and possibly less-than-ideal outcomes in anal cancer. This study was to evaluate alternative strategies for chemotherapy delivery that might be less toxic or more efficacious, and outcom...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13106
更新日期:2019-02-01 00:00:00
abstract:AIM:The open-label, nonrandomized, phase II APEC study enrolled 167 patients with RAS wild-type (wt) metastatic colorectal cancer (mCRC) to investigate the safety and efficacy of first-line, every-2-weeks cetuximab plus investigator's choice of FOLFIRI or FOLFOX in this patient population. METHODS:A subgroup analysis ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13154
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Azacitidine safety and efficacy were established in studies of mainly Caucasian patients. Differences in drug metabolism enzymes between Caucasian and East Asian populations prevent extrapolation of drug effects between these groups. This phase 2 study evaluated azacitidine safety, efficacy and pharmacokinet...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1111/ajco.12835
更新日期:2018-06-01 00:00:00
abstract:AIM:This multicenter, observational study aimed to investigate the survival benefit of eribulin as well as that of taxane-based regimens in Japanese patients with metastatic breast cancer (MBC) in a real-world setting. METHODS:This study enrolled women with MBC who received eribulin or taxane-based regimens with or wi...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1111/ajco.12863
更新日期:2018-10-01 00:00:00
abstract:INTRODUCTION:The goal of this study was to determine the relationships among type 2 diabetes mellitus (DM), specific cancer histological types and mortality in hospitalized women. METHODS:Patients over 19 years of age were included if the indication for hospital admission was a diagnosis of type 2 DM or a malignancy. ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12084
更新日期:2016-03-01 00:00:00
abstract:AIM:To evaluate tumor markers as prognostic factors in patients with metastatic or recurrent gastric cancer receiving first-line chemotherapy. METHODS:Between January 2000 and December 2008, 1178 patients with metastatic or recurrent gastric cancer were assayed for expression of three serum tumor markers, CA 19-9, CA ...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12019
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2012.01590.x
更新日期:2013-06-01 00:00:00
abstract:AIM:Multidisciplinary care is advocated as best practice in cancer care. Relatively little is documented about multidisciplinary team (MDT) meeting functioning, decision making and the use of evidence to support decision making in Australia. This descriptive study aimed to examine team functioning, the role of team mee...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12765
更新日期:2018-02-01 00:00:00
abstract:AIM:Metadherin (MTDH) is a potential oncogene in tumor development and is highly expressed in various types of human cancers. However, there has been no report on the role of MTDH in bladder cancer. Our aim was to investigate the expression pattern of MTDH in bladder tissue at different clinic pathological stages and e...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2012.01541.x
更新日期:2012-09-01 00:00:00
abstract:AIM:To evaluate predictive factors which associated with oncological outcomes to first-line axitinib for metastatic renal cell carcinoma (mRCC). METHODS:A retrospective chart review was conducted patients who had been treated with axitinib as first-line therapy for the treatment of mRCC from September 2013 to February...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13323
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:An elevated preoperative aspartate aminotransferase-to-lymphocyte ratio index (ALRI) may predict poor survival in various cancers. However, the prognostic value of aminotransferase-to-lymphocyte ratio index (ALRI) in patients with hepatocellular carcinoma (HCC) remains to be determined. MATERIALS AND METHOD...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13458
更新日期:2020-10-30 00:00:00
abstract::Cancer, its therapy, and related adverse effects have been associated with reduced work performance, including absenteeism (i.e. absence from scheduled work due to health problems) and presenteeism (i.e. impaired on-the-job performance due to health problems) among cancer survivors. This review aimed to compare the wo...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1111/ajco.12515
更新日期:2016-12-01 00:00:00
abstract:AIM:Carboplatin dosing depends on accurate glomerular filtration rate (GFR) estimation. There is a lack of clinical agreement about carboplatin dosing when the GFR measurement is very high (>110 mL/min). METHODS:A retrospective audit of pre-chemotherapy 99m technetium (Tc) diethylenetriamene pentaacetate (DTPA) radion...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2011.01409.x
更新日期:2011-09-01 00:00:00
abstract::Disparities in cancer outcomes for people from culturally and linguistically diverse (CALD) groups are well known. Improving CALD patients' active participation in treatment processes holds potential to improve outcomes, but little is known of effective strategies to facilitate this. This systematic review investigate...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1111/j.1743-7563.2012.01531.x
更新日期:2013-06-01 00:00:00
abstract:AIM:Vascular endothelial growth facto receptor-tyrosine kinase inhibitors (VEGFR-TKIs) are widely used for metastatic renal cell carcinoma (mRCC). The aim of this study was to investigate the association between the response to VEGFR-TKIs and hyperlipidemia and hypothyroidism. METHODS:Clinical data on 155 patients wit...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12473
更新日期:2016-06-01 00:00:00
abstract:INTRODUCTION:Ki-67 proliferation index (Ki-67 index) is used to quantify cell proliferation during histopathological assessment of various tumors including glioblastoma (GB). AIM:We aimed to assess correlation between Ki-67 index and overall survival in patients with GB and determine a cut-point for Ki-67 index that p...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12826
更新日期:2019-02-01 00:00:00
abstract:AIM:Cabazitaxel is a next generation taxane that has been shown to improve overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC) whose disease progressed during or after docetaxel-based therapy. A worldwide early access program (EAP) study was established to provide access to cabazit...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12679
更新日期:2017-12-01 00:00:00