Abstract：
AIMS:The optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who achieved complete remission (CR) and complete consolidation chemotherapy is still controversial. Whether the use of arsenic trioxide (ATO) alone or along with all-trans retinoic acid (ATRA) improves overall survival (OS) or disease-free survival (DFS) is still debated. METHODS:A retrospective reivew was conducted of 20 patients diagnosed with APL according to the French - American - British system. After achieving CR and receiving consolidation chemotherapy, nine patients were given maintenance therapy for 1 year (ATRA 45 mg/m(2) /day p.o., mercaptopurine 60 mg/m(2) /day p.o. and ATO 0.15 mg/kg/day × 5 days/week for six cycles in five patients; ATRA 45 mg/m(2) /d p.o. alternating with ATO 0.15 mg/kg/day × 5 days/week in 1 patient; ATRA only in three patients). RESULTS:In all patients the rates of CR, 3-year OS and 5-year OS were 75, 71 and 57%, respectively. For patients treated with ATO maintenance, the rates were 100% for both 5-year OS and 5-year DFS. Four of six patients on ATO maintenance had grade 1 or grade 2 adverse events. Excluding the two patients who died from intracerebral hemorrhage within 4 days after diagnosis, these rates were 85, 82 and 78%, respectively. CONCLUSION:Upfront ATO maintenance therapy for one year is safe and appears to be effective, with the benefits restricted to patients with APL with t(15;17) translocation. Larger studies will be required to confirm this observation.
journal_name
Asia Pac J Clin Oncoljournal_title
Asia-Pacific journal of clinical oncologyauthors
Chiang YH,Chang YF,Hsieh RK,Lin J,Chen CG,Lim KH,Lin HC,Chang MCdoi
10.1111/j.1743-7563.2011.01496.xsubject
Has Abstractpub_date
2012-12-01 00:00:00pages
330-6issue
4eissn
1743-7555issn
1743-7563journal_volume
8pub_type
杂志文章abstract：AIM:The purpose of this study was to investigate the impact of subcarinal dissection on short-term outcome and survival following esophagectomy in patients with thoracic esophageal squamous cell carcinoma. METHODS:A total of 2252 patients underwent an esophagectomy for esophageal cancer from January 1997 to December 2...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12095
更新日期：2014-06-01 00:00:00
abstract：AIM:For several decades urinary arylsulfatase (ARS) activity has been reported to be elevated in many cancers. It has been shown that urinary ARS activity may serve as a marker of tumor progression and therapy surveillance. This study was designed to evaluate the clinical application of detection of urinary ARS activit...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2012.01545.x
更新日期：2012-12-01 00:00:00
abstract：AIMS:Esophageal cancer (EC) is one of the most prevalent and deadly cancers worldwide. Along with nutrition, smoking and alcohol consumption, human papillomavirus (HPV) infection is one of the major risk factors, which is modulated by host immune response. This study is aimed at elucidating how HPV modifies host immune...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12135
更新日期：2014-03-01 00:00:00
abstract：INTRODUCTION:Left- and right-sided colon cancers were significantly different in epidemiologic, clinical and histological parameters. However, the impact of primary tumor location in metastatic colon cancer treated with front-line targeted triplet regimens is unclear, particularly in Asian populations. METHODS:A total...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12469
更新日期：2016-09-01 00:00:00
abstract：BACKGROUND:Docetaxel is an effective therapy for metastatic castration-resistant prostate cancer (mCRPC); however, many patients experience febrile neutropenia (FN) and cease treatment early due to toxicity. It is not known whether lower dose (LD) q3-weekly docetaxel impacts toxicity or efficacy. METHODS:Multicenter r...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,多中心研究
doi：10.1111/ajco.12840
更新日期：2018-10-01 00:00:00
abstract：AIM:The aim of this study was to explore the dynamics within second medical opinion consultations in patients with cancer. METHODS:Semi-structured interviews were held with four oncologists and were subjected to a thematic analysis to define the broad issues. These formed the basis of a survey distributed to Australia...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2010.01330.x
更新日期：2011-03-01 00:00:00
abstract：AIM:The role of germline testing in prostate cancer is evolving and knowledge of an individual's genetic profile may be used to guide not only an assessment of their familial risk but also have prognostic and therapeutic implications. Although international guidelines have incorporated recommendations for germline test...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13148
更新日期：2019-08-01 00:00:00
abstract：:First-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are used as first-line therapy in patients with non-small cell lung cancer (NSCLC) harboring a sensitizing mutation in the EGFR gene. Unfortunately, resistance to these therapies often occurs within 10 months of commencing treat...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/ajco.12699
更新日期：2017-08-01 00:00:00
abstract：AIM:A proportion of locally advanced rectal cancer patients who receive neoadjuvant chemoradiotherapy (NACRT) are still unresectable. This study was undertaken to assess the outcomes of giving additional chemotherapy to rectal cancer patients with unresectable disease after NACRT. METHODS:Patients with poor response t...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12660
更新日期：2017-08-01 00:00:00
abstract：AIM:Metadherin (MTDH) is a potential oncogene in tumor development and is highly expressed in various types of human cancers. However, there has been no report on the role of MTDH in bladder cancer. Our aim was to investigate the expression pattern of MTDH in bladder tissue at different clinic pathological stages and e...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2012.01541.x
更新日期：2012-09-01 00:00:00
abstract：AIMS:Wilms tumor (WT) is rare in Asia. Treatment of bilateral WT is challenging, and the treatment outcome of bilateral WT is rarely reported in low incidence areas. METHODS:We enrolled patients with bilateral WT registered in Chang Gung Memorial Hospital, Taoyuan, Taiwan, between January 1986 and June 2015. They were...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12501
更新日期：2016-09-01 00:00:00
abstract：:The COVID-19 pandemic will present a range of challenges to radiation oncology departments. Early data suggest that cancer patients carry a higher than average, but still low absolute risk of hospitalization from COVID-19. The risk of severe events for those who are hospitalized however, is high. Resources for usual c...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/ajco.13456
更新日期：2021-02-01 00:00:00
abstract：PURPOSE:Mitomycin C (MMC) plus standard 5-fluorouracil (FU) infusion in weeks 1 and 5 often contributes to radiotherapy interruptions and possibly less-than-ideal outcomes in anal cancer. This study was to evaluate alternative strategies for chemotherapy delivery that might be less toxic or more efficacious, and outcom...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13106
更新日期：2019-02-01 00:00:00
abstract：AIMS:In this study, we intended to analyze the clinical significance of CD4+ FoxP3+ Tregs in gastric cancer patients and investigate the relationship between the proportion of CD4+ FoxP3+ Tregs in the peripheral blood and the expression of FoxM1 and Ki-67 in gastric cancer tissues. METHODS:Flow cytometry was used to m...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13302
更新日期：2020-01-19 00:00:00
abstract：AIMS:There is currently no routine collection of cancer stages in population-based data in Australia. This study evaluates the accuracy of International classification of diseases (ICD) codes for secondary neoplasms recorded in hospital morbidity data to assign spread of disease at diagnosis for colorectal cancer. MET...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2012.01537.x
更新日期：2012-09-01 00:00:00
abstract：AIM:The ACCElox registry was set up to assess therapeutic management of early-stage colon cancer with oxaliplatin/5-fluorouracil (5-FU)-based regimen and the duration of adjuvant chemotherapy in current clinical practice. METHODS:This prospective observational study was conducted between 2006 and 2008 in 19 countries ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,多中心研究
doi：10.1111/ajco.12409
更新日期：2015-12-01 00:00:00
abstract：AIM:Autoimmune hemolytic anemia (AIHA) is frequently associated with B-cell lymphoproliferative disorders, and patients rarely develop overt clinical manifestations of AIHA. AIHA is rare in patients with multiple myeloma (MM). We conducted a prospective study to detect the presence of AIHA in MM patients and its impact...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12230
更新日期：2016-06-01 00:00:00
abstract：BACKGROUND:The comprehensive genetic alterations underlying the pathogenesis of Sézary syndrome (SS) remains largely unknown. Previous studies showed that alterations of tumor necrosis factor-α-induced protein 3 gene (TNFAIP3; A20) are frequent in SS. In this study, we characterized the mutation and polymorphisms of A2...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12672
更新日期：2018-04-01 00:00:00
abstract：AIM:To describe the development of the content and pilot testing of a radiation therapist-led educational intervention for breast cancer patients about to commence radiotherapy. Pilot testing consisted of testing the intervention for appropriateness, feasibility and acceptance. METHODS:A tailored intervention consisti...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1743-7563.2012.01520.x
更新日期：2012-09-01 00:00:00
abstract：AIM:Complementary medicine (CAM) use in the cancer population is higher than the general population: some studies estimate up to 70%. Our Medicines Information Centre, in a tertiary cancer institution, receives many enquiries regarding use and safety of CAM with conventional cancer therapies (chemotherapy, radiotherapy...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13026
更新日期：2018-10-01 00:00:00
abstract：AIMS:To determine the feasibility of stereotactic body radiotherapy (SBRT) in patients with pelvic sidewall recurrence of uterine cervical cancer after radical hysterectomy or definitive radiotherapy. METHODS:We retrospectively reviewed 23 patients with locally recurrent uterine cervical cancer limited to the pelvic s...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12185
更新日期：2016-06-01 00:00:00
abstract：AIMS:The Australian Institute of Health and Welfare (AIHW) is a major national agency established by the Australian government to provide information and statistics on Australia's health and welfare. The AIHW and the Australasian Association of Cancer Registries collaborate every year to provide updated information on ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12127
更新日期：2013-09-01 00:00:00
abstract：:Ipilimumab is a human anti-CTLA-4 monoclonal antibody recently approved for the treatment of advanced melanoma. Stimulation of T-cell activity unmasks antitumor activity, but can cause immune-related adverse events. Autoimmune hypophysitis is of particular importance because its presentation can be subtle but life thr...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12348
更新日期：2015-06-01 00:00:00
abstract：AIM:Vascular endothelial growth facto receptor-tyrosine kinase inhibitors (VEGFR-TKIs) are widely used for metastatic renal cell carcinoma (mRCC). The aim of this study was to investigate the association between the response to VEGFR-TKIs and hyperlipidemia and hypothyroidism. METHODS:Clinical data on 155 patients wit...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12473
更新日期：2016-06-01 00:00:00
abstract：AIM:Survival rates for patients with cancer who live in rural and regional areas are worse than in metropolitan areas. This may be due to geographical isolation, delayed diagnosis, inadequate transport, lower socioeconomic status and workforce shortages. We conducted a qualitative study of rural patients, carers and he...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12014
更新日期：2013-09-01 00:00:00
abstract：AIM:Mucositis is a major complication of irradiation in head and neck tumors, the addition of chemotherapy to irradiation may enhance this dose-limiting problem. Licorice is a strong demulcent that had been effectively used in treatment of peptic ulcer. The main purpose of this study was to compare the therapeutic safe...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,随机对照试验
doi：10.1111/ajco.12295
更新日期：2017-04-01 00:00:00
abstract：AIM:Multidisciplinary care is advocated as best practice in cancer care. Relatively little is documented about multidisciplinary team (MDT) meeting functioning, decision making and the use of evidence to support decision making in Australia. This descriptive study aimed to examine team functioning, the role of team mee...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12765
更新日期：2018-02-01 00:00:00
abstract：AIM:While first-line palliative chemotherapy (CT1) improves survival and quality of life in advanced biliary cancer (ABC), there is no randomized evidence to support second-line chemotherapy (CT2) in ABC. We aim to explore to role of CT2 in ABC. METHODS:We performed a retrospective review of all patients who received ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,多中心研究,评审
doi：10.1111/ajco.12638
更新日期：2017-10-01 00:00:00
abstract：BACKGROUND:Acral melanoma (AM) and mucosal melanoma (MM) make up more than half of melanomas in Asia but comprise only 5% of cases in Caucasians, where cutaneous melanoma (CM) predominates. AM and MM are thought to be genetically and biologically distinct from CM. We report the characteristics and outcomes of melanoma ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12802
更新日期：2018-04-01 00:00:00
abstract：:Multidisciplinary oncology team meetings are crucial hubs for integrated, patient-centered diagnosis and treatment planning. Team meetings are designed to enact the best practice principles of multidisciplinary care. Yet surveys of clinicians and allied health providers who are members of multidisciplinary teams (MDTs...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/ajco.13166
更新日期：2019-08-01 00:00:00
