Early recognition of ipilimumab-related autoimmune hypophysitis in patients with metastatic melanoma: Case studies and recommendations for management.

Abstract:

:Ipilimumab is a human anti-CTLA-4 monoclonal antibody recently approved for the treatment of advanced melanoma. Stimulation of T-cell activity unmasks antitumor activity, but can cause immune-related adverse events. Autoimmune hypophysitis is of particular importance because its presentation can be subtle but life threatening. We present two cases where early recognition of ipilimumab-related autoimmune hypophysitis led to timely intervention and low subsequent morbidity, without compromise of antitumor effects. We provide recommendations for detection and management of this potentially life-threatening complication of ipilimumab.

journal_name

Asia Pac J Clin Oncol

authors

Tiu C,Pezaro C,Davis ID,Grossmann M,Parente P

doi

10.1111/ajco.12348

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

190-4

issue

2

eissn

1743-7555

issn

1743-7563

journal_volume

11

pub_type

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