Abstract:
INTRODUCTION:The goal of this study was to determine the relationships among type 2 diabetes mellitus (DM), specific cancer histological types and mortality in hospitalized women. METHODS:Patients over 19 years of age were included if the indication for hospital admission was a diagnosis of type 2 DM or a malignancy. In total, 67,660 female patients with a mean age 62.76 ± 14.48 years were enrolled. These patients were categorized into the following three groups: patients with cancer but without type 2 DM (group A); patients with cancer and type 2 DM (group B) and patients with type 2 DM but without cancer (group C). Attributable fractions (AF) were calculated as ([hazard ratio - 1]/hazard ratio) × 100 to evaluate the impact of type 2 DM on mortality for specific cancers. RESULTS:Of the study participants, 37,204 (55%) were diagnosed with type 2 DM. The patients were categorized as follows: group A, 30,456 patients; group B, 5992 patients and group C, 31,212 patients. Group B patients had high frequencies of pancreatic, liver and renal cancers and low frequencies of thyroid, breast and ovarian cancers. Of the 36,448 cancer patients, 2906 (8%) died. The mortality rate in group B (10 %) was significantly higher than that in groups A and C. Type 2 DM was associated with increased mortality and AF for thyroid, nasopharyngeal, urinary tract, ovarian, breast and cervical cancers (hazard ratio over 1.50). CONCLUSION:The incidence of type 2 DM in patients with different histological types of cancer varied widely, ranging from 8-34%. Among the cancer patients, type 2 DM had a significantly greater impact on the mortality rates of patients with cancers associated with relatively low mortality.
journal_name
Asia Pac J Clin Oncoljournal_title
Asia-Pacific journal of clinical oncologyauthors
Chen JY,Chiou WK,Chou WY,Lin JDdoi
10.1111/ajco.12084subject
Has Abstractpub_date
2016-03-01 00:00:00pages
e75-81issue
1eissn
1743-7555issn
1743-7563journal_volume
12pub_type
杂志文章abstract:AIM:Gastric cancer patients are normally treated with oral fluoropyrimidine and cisplatin or oxaliplatin; however, treating patients who also have a gastrointestinal obstruction is often difficult because of their poor oral intake. Instead, a modified (m)FOLFOX-6 regimen is administered, even to patients with gastroint...
journal_title:Asia-Pacific journal of clinical oncology
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journal_title:Asia-Pacific journal of clinical oncology
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journal_title:Asia-Pacific journal of clinical oncology
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pub_type: 临床试验,杂志文章
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更新日期:2014-09-01 00:00:00
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pub_type: 杂志文章,随机对照试验
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pub_type: 杂志文章,多中心研究,评审
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