Minimal important differences in the EORTC QLQ-C30 in patients with advanced cancer.

Abstract:

AIMS:Quality of life (QOL) is important in patients with advanced cancer. The European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 is a general QOL tool used in cancer patients. Often, with a large enough sample, statistical significance of changecan be reached, however the clinical significance is often unknown. This study aimed to determine the magnitude of change that is meaningful to advanced cancer patients in the EORTC QLQ-C30. METHODS:Patients completed the EORTC QLQ-C30 at baseline and 1 month post-radiation to assess changes in their QOL. Minimal important differences (MID) were calculated through anchor and distribution-based methods for improvement and deterioration. The two anchors of overall health and overall QOL were used to determine meaningful change. RESULTS:Statistically significant meaningful changes were seen in the use of both anchors. The overall health anchor produced a greater number of scales and symptoms that reached a statistically significant meaningful change. Meaningful change for improvement with these two anchors ranged from 9.1 units (cognitive functioning) to 23.5 units (pain), and for deterioration it ranged from 7.2 units (physical functioning) to 13.5 units (role functioning). Distribution-based estimates were closest to 0.5 SD. CONCLUSION:Knowledge of meaningful change on the EORTC QLQ-C30 allows physicians to assess patients' changes over time, along with evaluating the impact of treatment on a patient's QOL. This knowledge gives insight into whether the treatment is effective and, ultimately, whether it should be continued. Knowledge of MID may assist in the determination of sample size for future trials.

journal_name

Asia Pac J Clin Oncol

authors

Bedard G,Zeng L,Zhang L,Lauzon N,Holden L,Tsao M,Danjoux C,Barnes E,Sahgal A,Poon M,Chow E

doi

10.1111/ajco.12070

subject

Has Abstract

pub_date

2014-06-01 00:00:00

pages

109-17

issue

2

eissn

1743-7555

issn

1743-7563

journal_volume

10

pub_type

杂志文章
  • Radiation oncology during COVID-19: Strategies to avoid compromised care.

    abstract::The COVID-19 pandemic will present a range of challenges to radiation oncology departments. Early data suggest that cancer patients carry a higher than average, but still low absolute risk of hospitalization from COVID-19. The risk of severe events for those who are hospitalized however, is high. Resources for usual c...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/ajco.13456

    authors: Horsley PJ,Back M,Lamoury G,Porter B,Booth J,Eade TN

    更新日期:2021-02-01 00:00:00

  • Addition of oxaliplatin to neoadjuvant radiochemotherapy in MRI-defined T3, T4 or N+ rectal cancer: a randomized clinical trial.

    abstract:BACKGROUND:Clinical trials investigating the effects of addition of oxaliplatin to neoadjuvant radiochemotherapy in locally advanced rectal cancers (LARCs) have brought controversial results for pathologic complete response as an endpoint. This randomized clinical trial investigated downstaging as a short-term surrogat...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ajco.12675

    authors: Haddad P,Miraie M,Farhan F,Fazeli MS,Alikhassi A,Maddah-Safaei A,Aghili M,Kalaghchi B,Babaei M

    更新日期:2017-12-01 00:00:00

  • Comparison of magnetic resonance spectroscopy and positron emission tomography in detection of tumor recurrence in posttreatment of glioma: A diagnostic meta-analysis.

    abstract::It is important to distinguish between tumor recurrence and treatment effects in posttreatment patients with high-grade gliomas. Several imaging modalities have been reported in differentiating between tumor recurrence and treatment effects. However, there were no consistent conclusions between different studies. We p...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ajco.12202

    authors: Wang X,Hu X,Xie P,Li W,Li X,Ma L

    更新日期:2015-06-01 00:00:00

  • Longitudinal validation and comparison of the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life-Chemotherapy-Induced Peripheral Neuropathy Questionnaire (EORTC QLQ-CIPN20) and the Functional Assessment of Ca

    abstract:AIM:To validate and compare the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life-Chemotherapy-Induced Peripheral Neuropathy Questionnaire (EORTC QLQ-CIPN20) and the Functional Assessment of Cancer-Gynecologic Oncology Group-Neurotoxicity subscale (FACT/GOG-Ntx) for measu...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ajco.13000

    authors: Cheng HL,Molassiotis A

    更新日期:2019-02-01 00:00:00

  • Serum CA 19-9 as a prognostic factor in patients with metastatic gastric cancer.

    abstract:AIM:To evaluate tumor markers as prognostic factors in patients with metastatic or recurrent gastric cancer receiving first-line chemotherapy. METHODS:Between January 2000 and December 2008, 1178 patients with metastatic or recurrent gastric cancer were assayed for expression of three serum tumor markers, CA 19-9, CA ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12019

    authors: Jo JC,Ryu MH,Koo DH,Ryoo BY,Kim HJ,Kim TW,Choi KD,Lee GH,Jung HY,Yook JH,Oh ST,Kim BS,Kim JH,Kang YK

    更新日期:2013-12-01 00:00:00

  • The challenge of putting principles into practice: Resource tensions and real-world constraints in multidisciplinary oncology team meetings.

    abstract::Multidisciplinary oncology team meetings are crucial hubs for integrated, patient-centered diagnosis and treatment planning. Team meetings are designed to enact the best practice principles of multidisciplinary care. Yet surveys of clinicians and allied health providers who are members of multidisciplinary teams (MDTs...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/ajco.13166

    authors: Lamprell K,Arnolda G,Delaney GP,Liauw W,Braithwaite J

    更新日期:2019-08-01 00:00:00

  • Development and pilot testing of a radiation therapist-led educational intervention for breast cancer patients prior to commencing radiotherapy.

    abstract:AIM:To describe the development of the content and pilot testing of a radiation therapist-led educational intervention for breast cancer patients about to commence radiotherapy. Pilot testing consisted of testing the intervention for appropriateness, feasibility and acceptance. METHODS:A tailored intervention consisti...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1743-7563.2012.01520.x

    authors: Halkett GK,Schofield P,O'Connor M,York D,Jefford M,Jiwa M,Spry N,Taylor M,Aranda S

    更新日期:2012-09-01 00:00:00

  • Prevalence of autoimmune hemolytic anemia in multiple myeloma: A prospective study.

    abstract:AIM:Autoimmune hemolytic anemia (AIHA) is frequently associated with B-cell lymphoproliferative disorders, and patients rarely develop overt clinical manifestations of AIHA. AIHA is rare in patients with multiple myeloma (MM). We conducted a prospective study to detect the presence of AIHA in MM patients and its impact...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12230

    authors: Kashyap R,Singh A,Kumar P

    更新日期:2016-06-01 00:00:00

  • Toxicity profile differences of adjuvant docetaxel/cyclophosphamide (TC) between Asian and Caucasian breast cancer patients.

    abstract:AIM:For early-stage breast cancer, four cycles of docetaxel and cyclophosphamide (TC) was proven superior to doxorubicin plus cyclophosphamide in the US Oncology 9375 trial. Given primary prophylactic antibiotics, 5% febrile neutropenia was recorded in a population comprising 75.5% Caucasians. Smaller trials and retros...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12682

    authors: Chow LWC,Biganzoli L,Leo AD,Kuroi K,Han HS,Patel J,Huang CS,Lu YS,Zhu L,Chow CYC,Loo WTY,Glück S,Toi M

    更新日期:2017-12-01 00:00:00

  • National and subnational mortality of urological cancers in Iran, 1990-2015.

    abstract:PURPOSE:To study trends of urological cancers mortalities in Iran between 1990 and 2015 as a part of a larger project named national and subnational burden of diseases, injuries, and risk factors. METHODS:The primary dataset of this project comprises data of national death registration system. Cause-specific mortality...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 历史文章,杂志文章

    doi:10.1111/ajco.13074

    authors: Pishgar F,Amini E,Gohari K,Aminorroaya A,Sheidaei A,Rostamabadi Y,Ebrahimi H,Yoosefi M,Naderimagham S,Rezaei N,Modirian M,Namazi Shabestari A,Kompani F,Farzadfar F

    更新日期:2019-04-01 00:00:00

  • An exploration of the dynamics and influences upon second medical opinion consultations in cancer care.

    abstract:AIM:The aim of this study was to explore the dynamics within second medical opinion consultations in patients with cancer. METHODS:Semi-structured interviews were held with four oncologists and were subjected to a thematic analysis to define the broad issues. These formed the basis of a survey distributed to Australia...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2010.01330.x

    authors: Philip J,Gold M,Schwarz M,Komesaroff P

    更新日期:2011-03-01 00:00:00

  • The efficacy of axitinib as a first-line treatment for metastatic renal cell carcinoma.

    abstract:AIM:To evaluate predictive factors which associated with oncological outcomes to first-line axitinib for metastatic renal cell carcinoma (mRCC). METHODS:A retrospective chart review was conducted patients who had been treated with axitinib as first-line therapy for the treatment of mRCC from September 2013 to February...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13323

    authors: Kameda T,Takayama T,Sugihara T,Takeshima S,Yamazaki M,Komatsubara M,Kamei J,Fujisaki A,Ando S,Kurokawa S,Fujimura T

    更新日期:2020-08-01 00:00:00

  • Effect of pre existing respiratory conditions on survival of lung cancer patients: A nationwide population-based cohort study.

    abstract:BACKGROUND:Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. METHODS:We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multi...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12697

    authors: Hong S,Park EC,Kim TH,Kwon JA,Yoo KB,Han KT,Yoo JW,Kim SJ

    更新日期:2018-04-01 00:00:00

  • Cancer in Pregnancy.

    abstract::Cancer in pregnancy may be increasing in incidence with advancing maternal age and higher rates of obesity. The diagnosis of cancer in pregnancy provokes complex management issues balancing short- and long-term risks for both mother and baby. Every case needs to be individualized, with a multidisciplinary team of midw...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/ajco.13235

    authors: Eastwood-Wilshere N,Turner J,Oliveira N,Morton A

    更新日期:2019-12-01 00:00:00

  • Immunotherapy for urothelial carcinoma: Metastatic disease and beyond.

    abstract::For advanced and metastatic urothelial carcinomas (UCs), platinum (preferably cisplatin)-based chemotherapy has been the standard treatment for many years. However, many patients are ineligible for cisplatin-based chemotherapy because of poor performance status and/or other age-related conditions. At the other end of ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/ajco.13312

    authors: Poon DM

    更新日期:2020-09-01 00:00:00

  • Outcomes of Malaysian patients with advanced lung adenocarcinoma and unknown epidermal growth factor receptor mutation status treated with gefitinib.

    abstract:AIMS:To evaluate the response and progression-free survival (PFS) of Malaysian patients with advanced lung adenocarcinoma and unknown epidermal growth factor receptor (EGFR) mutation status treated with gefitinib. METHODS:A retrospective analysis of consecutive patients with EGFR mutation unknown stage III or IV lung ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2011.01509.x

    authors: Liam CK,Ruthranesan M,Lee CH,Pang YK,Chua KT,Lim BK

    更新日期:2012-09-01 00:00:00

  • Cut-point for Ki-67 proliferation index as a prognostic marker for glioblastoma.

    abstract:INTRODUCTION:Ki-67 proliferation index (Ki-67 index) is used to quantify cell proliferation during histopathological assessment of various tumors including glioblastoma (GB). AIM:We aimed to assess correlation between Ki-67 index and overall survival in patients with GB and determine a cut-point for Ki-67 index that p...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12826

    authors: Wong E,Nahar N,Hau E,Varikatt W,Gebski V,Ng T,Jayamohan J,Sundaresan P

    更新日期:2019-02-01 00:00:00

  • Recurrent ovarian cancer: treatment with pegylated liposomal doxorubicin; a Westmead Cancer Care Centre experience.

    abstract:AIM:To describe the overall survival, progression-free survival, response rate and toxicity of pegylated liposomal doxorubicin (PLD) in recurrent ovarian cancer. METHODS:A retrospective study of 45 patients with recurrent or progressive ovarian cancer was conducted at the Westmead Cancer Care Centre. Patients received...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2009.01263.x

    authors: Dear RF,Gao B,Harnett P

    更新日期:2010-03-01 00:00:00

  • The prognostic value of aspartate aminotransferase-to-lymphocyte ratio index in early-stage hepatocellular carcinoma after hepatectomy: A propensity-score matched analysis.

    abstract:BACKGROUND:An elevated preoperative aspartate aminotransferase-to-lymphocyte ratio index (ALRI) may predict poor survival in various cancers. However, the prognostic value of aminotransferase-to-lymphocyte ratio index (ALRI) in patients with hepatocellular carcinoma (HCC) remains to be determined. MATERIALS AND METHOD...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13458

    authors: Chen Y,He C,Wen T,Yan L,Yang J

    更新日期:2020-10-30 00:00:00

  • Upfront maintenance therapy with arsenic trioxide in acute promyelocytic leukemia provides no benefit for non-t(15;17) subtype.

    abstract:AIMS:The optimal maintenance therapy for patients with acute promyelocytic leukemia (APL) who achieved complete remission (CR) and complete consolidation chemotherapy is still controversial. Whether the use of arsenic trioxide (ATO) alone or along with all-trans retinoic acid (ATRA) improves overall survival (OS) or di...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2011.01496.x

    authors: Chiang YH,Chang YF,Hsieh RK,Lin J,Chen CG,Lim KH,Lin HC,Chang MC

    更新日期:2012-12-01 00:00:00

  • Phase II APEC trial: The impact of primary tumor side on outcomes of first-line cetuximab plus FOLFOX or FOLFIRI in patients with RAS wild-type metastatic colorectal cancer.

    abstract:AIM:The open-label, nonrandomized, phase II APEC study enrolled 167 patients with RAS wild-type (wt) metastatic colorectal cancer (mCRC) to investigate the safety and efficacy of first-line, every-2-weeks cetuximab plus investigator's choice of FOLFIRI or FOLFOX in this patient population. METHODS:A subgroup analysis ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13154

    authors: Price T,Shen L,Ma B,Esser R,Chen W,Gibbs P,Lim R,Cheng AL

    更新日期:2019-08-01 00:00:00

  • MR-guided simulation is superior than FDG/PET-guided simulation for local control in nasopharyngeal cancer patients treated with intensity-modulated radiotherapy.

    abstract:BACKGROUND:MRI and PET/CT scans are the main supportive methods for nasopharyngeal cancer (NPC) for staging and planning. The aim of this study is to compare MRI and PET/CT scanning in terms of survival in patients with NPC who had MRI or PET/CT-simulated radiotherapy planning. METHODS:Pathological diagnosed nonkerati...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13400

    authors: Gundog M,Basaran H,Dogan S,Abdulrezzak U

    更新日期:2021-02-01 00:00:00

  • Is definitive concurrent chemoradiotherapy effective for locally advanced head and neck cancer in the elderly aged ≥ 75 years: A single-institute, retrospective, cohort study.

    abstract:BACKGROUND:Definitive chemoradiotherapy (CRT) is the standard treatment for locally advanced head and neck cancer (HNC). However, for very elderly patients, the comparison of benefit/risk between definitive radiotherapy (RT) with and without systemic chemotherapy was equivocal. PATIENTS AND METHODS:The study was a sin...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12764

    authors: Lai KM,Lin JT,Lu HJ,Liang CC,Chen MK

    更新日期:2018-06-01 00:00:00

  • Patient outcomes of whole brain radiotherapy for brain metastases versus leptomeningeal metastases: A retrospective study.

    abstract:AIM:Important factors typically associated with prognosis in brain metastases include Karnofsky performance status (KPS), extracranial or cerebellar localization and combination chemotherapy. However, few studies investigated the prognostic role of leptomeningeal metastases (LM) following whole brain radiotherapy (WBRT...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12597

    authors: Sakaguchi M,Maebayashi T,Aizawa T,Ishibashi N,Saito T

    更新日期:2017-10-01 00:00:00

  • Comparison of triamcinolone acetonide mucoadhesive film with licorice mucoadhesive film on radiotherapy-induced oral mucositis: A randomized double-blinded clinical trial.

    abstract:AIM:Mucositis is a major complication of irradiation in head and neck tumors, the addition of chemotherapy to irradiation may enhance this dose-limiting problem. Licorice is a strong demulcent that had been effectively used in treatment of peptic ulcer. The main purpose of this study was to compare the therapeutic safe...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ajco.12295

    authors: Ghalayani P,Emami H,Pakravan F,Nasr Isfahani M

    更新日期:2017-04-01 00:00:00

  • Effectiveness of image-guided radiotherapy for rectal cancer patients treated with neoadjuvant concurrent chemoradiotherapy: A population-based propensity score-matched analysis.

    abstract:AIM:The effects of image-guided radiotherapy (IGRT, an advanced RT technology) have been debated in the literature. We compared the outcomes of locally advanced rectal cancer (LARC) patients treated with neoadjuvant concurrent chemoradiotherapy (NCCRT; with vs without IGRT) in a large population-based propensity score ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13196

    authors: Li CC,Liang JA,Chen WT,Chien CR

    更新日期:2019-10-01 00:00:00

  • Systemic treatment in advanced biliary cancers: A multicenter Australian analysis and review.

    abstract:AIM:While first-line palliative chemotherapy (CT1) improves survival and quality of life in advanced biliary cancer (ABC), there is no randomized evidence to support second-line chemotherapy (CT2) in ABC. We aim to explore to role of CT2 in ABC. METHODS:We performed a retrospective review of all patients who received ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1111/ajco.12638

    authors: Brungs D,Aghmesheh M,Sjoquist K,Goldstein D

    更新日期:2017-10-01 00:00:00

  • Efficacy, safety and pharmacokinetics of subcutaneous azacitidine in Chinese patients with higher risk myelodysplastic syndromes: Results from a multicenter, single-arm, open-label phase 2 study.

    abstract:BACKGROUND:Azacitidine safety and efficacy were established in studies of mainly Caucasian patients. Differences in drug metabolism enzymes between Caucasian and East Asian populations prevent extrapolation of drug effects between these groups. This phase 2 study evaluated azacitidine safety, efficacy and pharmacokinet...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/ajco.12835

    authors: Du X,Lai YY,Xiao Z,Liu T,Hu Y,Sun A,Li X,Shen ZX,Jin J,Yu L,Laille E,Dong Q,Songer S,Beach CL

    更新日期:2018-06-01 00:00:00

  • Safety and accuracy of core biopsy in retroperitoneal sarcomas.

    abstract:AIM:Retroperitoneal sarcomas (RPSs) are large, rare tumors. The role of core biopsy for retroperitoneal masses identified by preoperative imaging is unclear and we report the safety and accuracy of core biopsies at a specialized sarcoma unit in Sydney, Australia. METHODS:A retrospective analysis of a prospectively col...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12125

    authors: Hwang SY,Warrier S,Thompson S,Davidson T,Yang JL,Crowe P

    更新日期:2016-03-01 00:00:00

  • Acute inflammatory demyelinating polyradiculoneuropathy in a patient receiving oxaliplatin-based chemotherapy.

    abstract::We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomograph...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2011.01515.x

    authors: Yoon JY,Nam TS,Kim MK,Hwang JE,Shim HJ,Cho SH,Chung IJ,Bae WK

    更新日期:2012-06-01 00:00:00