Hepatitis B virus reactivation in hepatocellular carcinoma patients undergoing transcatheter arterial chemoembolization therapy.

Abstract:

AIM:The effect of transcatheter arterial chemoembolization (TACE) therapy on hepatitis B virus (HBV) reactivation in hepatocellular carcinoma (HCC) patients with prior resolved hepatitis B is not fully understood. METHODS:From January 2006 to December 2010, 43 hepatitis B surface antigen (HBsAg)-negative/anti-hepatitis B core antigen (HBc) positive patients with newly diagnosed unresectable HCC were enrolled in the study. All underwent TACE therapy. RESULTS:Four patients (9.3%) developed HBV reactivation with mild/moderate hepatitis. The median number of TACE cycles received was 3.5 (range 3-4 cycles). The median time interval between the occurrence of HBV reactivation and the completion of TACE therapy was 3 months (range 1-5 months) and their median HBV DNA level was 1.58 × 10(4) IU/mL (range, 1.65 × 10(3) -6.42 × 10(4)  IU/mL). After the introduction of lamivudine at the occurrence of HBV reactivation, all had resolution of hepatitis. An exploratory analysis indicated that significant predictors of HBV reactivation included increased serum total bilirubin coexisting with cirrhosis and the total number of cycles of TACE received. CONCLUSION:The administration of TACE therapy may increase the risk of HBV reactivation in HBsAg-negative/anti-HBc-positive patients diagnosed with unresectable HCC. Further studies are warranted to explore the optimal management of HBV reactivation in patients with prior resolved hepatitis B.

journal_name

Asia Pac J Clin Oncol

authors

Peng JW,Lin GN,Xiao JJ,Jiang XM

doi

10.1111/j.1743-7563.2012.01534.x

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

356-61

issue

4

eissn

1743-7555

issn

1743-7563

journal_volume

8

pub_type

杂志文章
  • Right versus left sided metastatic colorectal cancer: Teasing out clinicopathologic drivers of disparity in survival.

    abstract:BACKGROUND:Metastatic colorectal cancer (mCRC) patients with a right-sided primary (RC) have an inferior survival to mCRC arising from a left-sided primary (LC). Previous analyses have suggested multiple factors contribute. METHODS:The Treatment of Recurrent and Advanced Colorectal Cancer (TRACC) Registry prospectivel...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13135

    authors: Mendis S,Beck S,Lee B,Lee M,Wong R,Kosmider S,Shapiro J,Yip D,Steel S,Nott L,Jennens R,Lipton L,Burge M,Field K,Ananda S,Wong HL,Gibbs P

    更新日期:2019-06-01 00:00:00

  • Toxicity profile differences of adjuvant docetaxel/cyclophosphamide (TC) between Asian and Caucasian breast cancer patients.

    abstract:AIM:For early-stage breast cancer, four cycles of docetaxel and cyclophosphamide (TC) was proven superior to doxorubicin plus cyclophosphamide in the US Oncology 9375 trial. Given primary prophylactic antibiotics, 5% febrile neutropenia was recorded in a population comprising 75.5% Caucasians. Smaller trials and retros...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12682

    authors: Chow LWC,Biganzoli L,Leo AD,Kuroi K,Han HS,Patel J,Huang CS,Lu YS,Zhu L,Chow CYC,Loo WTY,Glück S,Toi M

    更新日期:2017-12-01 00:00:00

  • Importance of health literacy in oncology.

    abstract::Health literacy refers to one's ability to obtain, process and understand health information and services to enable sound health decision-making. This is an area of increasing importance due to the complexity of the health system, especially in the cancer setting. A certain level of health literacy is required for pat...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1743-7563.2012.01522.x

    authors: Koay K,Schofield P,Jefford M

    更新日期:2012-03-01 00:00:00

  • Comparison of triamcinolone acetonide mucoadhesive film with licorice mucoadhesive film on radiotherapy-induced oral mucositis: A randomized double-blinded clinical trial.

    abstract:AIM:Mucositis is a major complication of irradiation in head and neck tumors, the addition of chemotherapy to irradiation may enhance this dose-limiting problem. Licorice is a strong demulcent that had been effectively used in treatment of peptic ulcer. The main purpose of this study was to compare the therapeutic safe...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/ajco.12295

    authors: Ghalayani P,Emami H,Pakravan F,Nasr Isfahani M

    更新日期:2017-04-01 00:00:00

  • Outcomes of universal germline testing for men with prostate cancer in an Australian tertiary center.

    abstract:AIM:The role of germline testing in prostate cancer is evolving and knowledge of an individual's genetic profile may be used to guide not only an assessment of their familial risk but also have prognostic and therapeutic implications. Although international guidelines have incorporated recommendations for germline test...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13148

    authors: Crumbaker M,Wong J,Joshua AM,Spigelman AD

    更新日期:2019-08-01 00:00:00

  • Cancer multidisciplinary team meetings in practice: Results from a multi-institutional quantitative survey and implications for policy change.

    abstract:AIM:Multidisciplinary care is advocated as best practice in cancer care. Relatively little is documented about multidisciplinary team (MDT) meeting functioning, decision making and the use of evidence to support decision making in Australia. This descriptive study aimed to examine team functioning, the role of team mee...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12765

    authors: Rankin NM,Lai M,Miller D,Beale P,Spigelman A,Prest G,Turley K,Simes J

    更新日期:2018-02-01 00:00:00

  • Association of plasma visfatin with risk of colorectal cancer: An observational study of Chinese patients.

    abstract:AIM:To investigate the association between plasma visfatin levels and risk of early and advanced colorectal cancer (CRC). METHODS:In total, 358 CRC patients and 286 controls were enrolled. According to the T factor of the TNM system. cancer patients were divided into two subgroups: early and advanced cancer. Levels of...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12090

    authors: Chen M,Wang Y,Li Y,Zhao L,Ye S,Wang S,Yu C,Xie H

    更新日期:2016-03-01 00:00:00

  • Serious hepatic complications of selective internal radiation therapy with yttrium-90 microsphere radioembolization for unresectable liver tumors.

    abstract:AIM:Selective internal radiation therapy with yttrium-90 microsphere radioembolization has been used to treat unresectable liver tumors and its acute toxicity has been well described. Subacute and long-term hepatic complications related to radioembolization however may be underreported in the literature. This retrospec...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12229

    authors: Kuo JC,Tazbirkova A,Allen R,Kosmider S,Gibbs P,Yip D

    更新日期:2014-09-01 00:00:00

  • Comparing single-agent with doublet chemotherapy in first-line treatment of advanced non-small cell lung cancer with performance status 2: a meta-analysis.

    abstract:AIM:This systematic review and meta-analysis was performed to assess the efficacy and side effects between single-agent and doublet chemotherapy in first-line treatment of advanced non-small cell lung cancer with performance status 2 (PS2). METHODS:We searched for randomized controlled trials in online electronic data...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ajco.12359

    authors: Luo L,Hu Q,Jiang JX,Yang X,Dinglin XX,Lin X,Yao HR

    更新日期:2015-09-01 00:00:00

  • Examining clinicians' perceptions of head and neck cancer (HNC) information.

    abstract:BACKGROUND:Providing appropriate educational resources to patients with head and neck cancer (HNC) is important but challenging. The aim of this study was to determine Australian clinicians' perceptions of currently used HNC information resources. METHODS:A purpose-designed questionnaire was disseminated electronicall...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12858

    authors: Jabbour J,Wykes J,Milross C,Sundaresan P,Ebrahimi A,Shepherd HL,Dhillon HM,Clark JR

    更新日期:2018-10-01 00:00:00

  • International survey of awareness of genetic risk in the clinical sarcoma community.

    abstract:AIM:Integration of clinical genetics into oncology is variable. Sarcomas have a strong genetic component, with up to 1/30 patients carrying germline TP53 mutations. This study aimed to define genetic risk awareness among sarcoma physicians. Outcomes were attitudes toward genetic testing, level of cancer risk and awaren...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12457

    authors: McBride KA,Schlub TE,Ballinger ML,Thomas DM,Tattersall MH

    更新日期:2016-06-01 00:00:00

  • Acute inflammatory demyelinating polyradiculoneuropathy in a patient receiving oxaliplatin-based chemotherapy.

    abstract::We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomograph...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2011.01515.x

    authors: Yoon JY,Nam TS,Kim MK,Hwang JE,Shim HJ,Cho SH,Chung IJ,Bae WK

    更新日期:2012-06-01 00:00:00

  • Are visiting oncologists enough? A qualitative study of the needs of Australian rural and regional cancer patients, carers and health professionals.

    abstract:AIM:Survival rates for patients with cancer who live in rural and regional areas are worse than in metropolitan areas. This may be due to geographical isolation, delayed diagnosis, inadequate transport, lower socioeconomic status and workforce shortages. We conducted a qualitative study of rural patients, carers and he...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12014

    authors: Grimison P,Phillips F,Butow P,White K,Yip D,Sardelic F,Underhill C,Tse R,Simes R,Turley K,Raymond C,Goldstein D

    更新日期:2013-09-01 00:00:00

  • Development and pilot testing of a radiation therapist-led educational intervention for breast cancer patients prior to commencing radiotherapy.

    abstract:AIM:To describe the development of the content and pilot testing of a radiation therapist-led educational intervention for breast cancer patients about to commence radiotherapy. Pilot testing consisted of testing the intervention for appropriateness, feasibility and acceptance. METHODS:A tailored intervention consisti...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1743-7563.2012.01520.x

    authors: Halkett GK,Schofield P,O'Connor M,York D,Jefford M,Jiwa M,Spry N,Taylor M,Aranda S

    更新日期:2012-09-01 00:00:00

  • Decision aids for breast and nodal surgery in patients with early breast cancer: development and a pilot study.

    abstract:AIM:As survival rates for aggressive and conservative breast and lymph node surgery are similar, surgical treatment decisions for patients with early-stage breast cancer should take patient preference into account. Decision aids have been demonstrated to increase patient knowledge and satisfaction with decision making,...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1743-7563.2010.01375.x

    authors: Harwood R,Douglas C,Clark D

    更新日期:2011-06-01 00:00:00

  • Additional chemotherapy and salvage surgery for poor response to chemoradiotherapy in rectal cancers.

    abstract:AIM:A proportion of locally advanced rectal cancer patients who receive neoadjuvant chemoradiotherapy (NACRT) are still unresectable. This study was undertaken to assess the outcomes of giving additional chemotherapy to rectal cancer patients with unresectable disease after NACRT. METHODS:Patients with poor response t...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12660

    authors: Engineer R,Ostwal V,Arya S,Gupta P,Chopra S,Patil P,Jatal S,Saklani A

    更新日期:2017-08-01 00:00:00

  • Phase II APEC trial: The impact of primary tumor side on outcomes of first-line cetuximab plus FOLFOX or FOLFIRI in patients with RAS wild-type metastatic colorectal cancer.

    abstract:AIM:The open-label, nonrandomized, phase II APEC study enrolled 167 patients with RAS wild-type (wt) metastatic colorectal cancer (mCRC) to investigate the safety and efficacy of first-line, every-2-weeks cetuximab plus investigator's choice of FOLFIRI or FOLFOX in this patient population. METHODS:A subgroup analysis ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13154

    authors: Price T,Shen L,Ma B,Esser R,Chen W,Gibbs P,Lim R,Cheng AL

    更新日期:2019-08-01 00:00:00

  • Are cancer survivors well-performing workers? A systematic review.

    abstract::Cancer, its therapy, and related adverse effects have been associated with reduced work performance, including absenteeism (i.e. absence from scheduled work due to health problems) and presenteeism (i.e. impaired on-the-job performance due to health problems) among cancer survivors. This review aimed to compare the wo...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,评审

    doi:10.1111/ajco.12515

    authors: Soejima T,Kamibeppu K

    更新日期:2016-12-01 00:00:00

  • Cut-point for Ki-67 proliferation index as a prognostic marker for glioblastoma.

    abstract:INTRODUCTION:Ki-67 proliferation index (Ki-67 index) is used to quantify cell proliferation during histopathological assessment of various tumors including glioblastoma (GB). AIM:We aimed to assess correlation between Ki-67 index and overall survival in patients with GB and determine a cut-point for Ki-67 index that p...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12826

    authors: Wong E,Nahar N,Hau E,Varikatt W,Gebski V,Ng T,Jayamohan J,Sundaresan P

    更新日期:2019-02-01 00:00:00

  • Afatinib for an EGFR exon 20 insertion mutation: A case report of progressive stage IV metastatic lung adenocarcinoma with 54 months' survival.

    abstract::Non-small cell lung cancers (NSCLC) harboring the uncommon epidermal growth factor receptor (EGFR) exon 20 insertion mutations are generally thought to be unresponsive to EGFR-tyrosine kinase inhibitor (TKI) therapy. Presented here is a case of stage IV NSCLC harboring an uncommon EGFR exon 20 insertion mutation that ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12853

    authors: Chan RT

    更新日期:2018-03-01 00:00:00

  • Clinical application of a rapid cervical cancer screening method: Folate receptor-mediated staining of cervical neoplastic epithelia.

    abstract:AIM:A newly developed cervical cancer screening method - folate receptor-mediated epithelium staining utilizes methylene blue internalized by folate receptor-mediated endocytosis to stain cervical intra-epithelial neoplasia. We test the clinical feasibility of this method in this study. METHODS:A total of 14 344 women...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12573

    authors: Li D,Chen L,Wang H,Yang H,Dai Y,Yu C,Dong Y

    更新日期:2017-02-01 00:00:00

  • Neutrophil count kinetics during the first cycle of chemotherapy predicts the outcome of patients with locally advanced or metastatic pancreatic cancer.

    abstract:BACKGROUND:Neutrophil count reduction after chemotherapy has been related with longer survival of patients with metastatic pancreatic adenocarcinoma, but there is not a standardized measurement for this phenomenon. METHODS:Some parameters related to the change in neutrophil count between the first and the second cycle...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13325

    authors: Colloca GA,Venturino A,Guarneri D

    更新日期:2020-08-01 00:00:00

  • Different genetic alteration of A20 in a Sézary syndrome case with Vα2-Jα22 T cell clone.

    abstract:BACKGROUND:The comprehensive genetic alterations underlying the pathogenesis of Sézary syndrome (SS) remains largely unknown. Previous studies showed that alterations of tumor necrosis factor-α-induced protein 3 gene (TNFAIP3; A20) are frequent in SS. In this study, we characterized the mutation and polymorphisms of A2...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12672

    authors: Zhou L,Zheng H,Huang X,Zhu L,Wu S,Zeng C,Yang L,Chen S,Luo G,Du X,Li Y

    更新日期:2018-04-01 00:00:00

  • Syndrome of inappropriate anti-diuretic hormone secretion secondary to carboplatin after docetaxel-carboplatin-trastuzumab combination for early stage HER-2 positive breast cancer.

    abstract::Carboplatin is a platinum analogue, widely used in the treatment of numerous cancer types including lung, genitourinary and ovarian cancers. It is also used in the adjuvant treatment of human epidermal growth factor receptor 2 positive breast cancer, where a non-anthracycline regimen is preferred. It is considered gen...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2012.01526.x

    authors: Turner N,Stewart J,Barnett F,White S

    更新日期:2012-09-01 00:00:00

  • The PHLDB1 rs498872 (11q23.3) polymorphism and glioma risk: A meta-analysis.

    abstract::The association between the rs498872 single nucleotide polymorphism (SNP) and glioma risk has been studied, but these studies have yielded conflicting results. In order to explore this association, we performed a meta-analysis. A comprehensive literature search was performed using PubMed and EMBASE database, with the ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1111/ajco.12211

    authors: Gao X,Mi Y,Yan A,Sha B,Guo N,Hu Z,Zhang N,Jiang F,Gou X

    更新日期:2015-12-01 00:00:00

  • Differentiating malignant colorectal tumor patients from benign colorectal tumor patients by assaying morning urinary arylsulfatase activity.

    abstract:AIM:For several decades urinary arylsulfatase (ARS) activity has been reported to be elevated in many cancers. It has been shown that urinary ARS activity may serve as a marker of tumor progression and therapy surveillance. This study was designed to evaluate the clinical application of detection of urinary ARS activit...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/j.1743-7563.2012.01545.x

    authors: Niu R,Jing H,Chen Z,Xu J,Dai J,Yan Z

    更新日期:2012-12-01 00:00:00

  • Real-world impact of anti-HER2 therapy-related cardiotoxicity in patients with advanced HER2-positive breast cancer.

    abstract:BACKGROUND:Anti-HER2 therapy-related cardiotoxicity is well described in the context of clinical trials, particularly in the setting of early stage disease, but there is more limited data in advanced breast cancer and in the real world setting. MATERIAL AND METHODS:A prospectively-maintained registry database with 312...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.13381

    authors: Conduit C,de Boer RH,Lok S,Gibbs P,Malik L,Loh Z,Yeo B,Greenberg S,Devitt B,Lombard J,Nottage M,Collins I,Torres J,Nolan M,Nott L

    更新日期:2020-12-01 00:00:00

  • Oral cyclophosphamide in recurrent ovarian cancer.

    abstract:AIMS:Cyclophosphamide was widely used as a single agent prior to the advent of platinum-based regimens for epithelial ovarian cancer, and, in combination with platinum, prior to the adoption of platinum and paclitaxel as standard first-line therapy. As cyclophosphamide currently has no defined role in ovarian cancer we...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12074

    authors: Handolias D,Quinn M,Foo S,Mileshkin L,Grant P,Dutu G,Rischin D

    更新日期:2016-03-01 00:00:00

  • Safety and accuracy of core biopsy in retroperitoneal sarcomas.

    abstract:AIM:Retroperitoneal sarcomas (RPSs) are large, rare tumors. The role of core biopsy for retroperitoneal masses identified by preoperative imaging is unclear and we report the safety and accuracy of core biopsies at a specialized sarcoma unit in Sydney, Australia. METHODS:A retrospective analysis of a prospectively col...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12125

    authors: Hwang SY,Warrier S,Thompson S,Davidson T,Yang JL,Crowe P

    更新日期:2016-03-01 00:00:00

  • Efficacy, safety, and pharmacokinetics of subcutaneous azacitidine in Taiwanese patients with higher-risk myelodysplastic syndromes.

    abstract:AIM:Clinical and pharmacokinetic effects of azacitidine in higher-risk myelodysplastic syndromes were established in mainly Caucasian populations. Because of inter-ethnic genotype variability of drug-metabolizing enzymes, it is important to evaluate azacitidine in populations expected to use the drug. METHODS:In this ...

    journal_title:Asia-Pacific journal of clinical oncology

    pub_type: 杂志文章

    doi:10.1111/ajco.12659

    authors: Chou WC,Yeh SP,Hsiao LT,Lin SF,Chen YC,Chen TY,Laille E,Galettis A,Dong Q,Songer S,Beach CL

    更新日期:2017-10-01 00:00:00