Abstract：
AIM:To investigate the association between plasma visfatin levels and risk of early and advanced colorectal cancer (CRC). METHODS:In total, 358 CRC patients and 286 controls were enrolled. According to the T factor of the TNM system. cancer patients were divided into two subgroups: early and advanced cancer. Levels of visfatin, anthropometric and metabolic parameters, which were classified as low, medium, and high, based on the tertile distributions in the control group, were determined. RESULTS:The visfatin levels in patients with advanced and early cancer were higher than in controls (least significant difference test, P = 0.004 and 0.013, respectively). The patients in the highest tertile of visfatin concentration presented significantly higher odds for early and advanced CRC, adjusted for potential confounding factors (odds ratio 3.37; 95% CI, 1.93-8.37; P = 0.011; odds ratio 2.38; 95% CI: 1.82-8.35; P = 0.015, respectively). The visfatin level correlated significantly with waist:hip ratio (P < 0.05 for all) among case and control participants. Plasma visfatin levels in early and advanced CRC yielded a receiver operating characteristic curve area of 72 and 86%, respectively. The optimal sensitivity and specificity were 73% and 57% in discriminating between early CRC and normal controls while they were 76% and 68% in discriminating between advanced CRC and normal controls. CONCLUSION:An increased level of visfatin was a strong risk factor for both early and advanced CRC in Chinese patients. Plasma visfatin levels might be a potential biomarker for CRC detection.
journal_name
Asia Pac J Clin Oncoljournal_title
Asia-Pacific journal of clinical oncologyauthors
Chen M,Wang Y,Li Y,Zhao L,Ye S,Wang S,Yu C,Xie Hdoi
10.1111/ajco.12090subject
Has Abstractpub_date
2016-03-01 00:00:00pages
e65-74issue
1eissn
1743-7555issn
1743-7563journal_volume
12pub_type
杂志文章abstract：BACKGROUND:Docetaxel is an effective therapy for metastatic castration-resistant prostate cancer (mCRPC); however, many patients experience febrile neutropenia (FN) and cease treatment early due to toxicity. It is not known whether lower dose (LD) q3-weekly docetaxel impacts toxicity or efficacy. METHODS:Multicenter r...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,多中心研究
doi：10.1111/ajco.12840
更新日期：2018-10-01 00:00:00
abstract：AIM:This systematic review and meta-analysis was performed to assess the efficacy and side effects between single-agent and doublet chemotherapy in first-line treatment of advanced non-small cell lung cancer with performance status 2 (PS2). METHODS:We searched for randomized controlled trials in online electronic data...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,meta分析,评审
doi：10.1111/ajco.12359
更新日期：2015-09-01 00:00:00
abstract：AIM:To describe the overall survival, progression-free survival, response rate and toxicity of pegylated liposomal doxorubicin (PLD) in recurrent ovarian cancer. METHODS:A retrospective study of 45 patients with recurrent or progressive ovarian cancer was conducted at the Westmead Cancer Care Centre. Patients received...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2009.01263.x
更新日期：2010-03-01 00:00:00
abstract：BACKGROUND:Small cell lung cancer is a rapidly progressive disease with high fatality. No sensitive and specific biomarker to assist in managing this disease exists currently. AIM:Role of pretreatment serum lactate dehydrogenase as a biomarker in small cell lung cancer. METHODS:A hospital-based cancer registry was us...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12674
更新日期：2018-04-01 00:00:00
abstract：AIM:The aim of this study was to explore the dynamics within second medical opinion consultations in patients with cancer. METHODS:Semi-structured interviews were held with four oncologists and were subjected to a thematic analysis to define the broad issues. These formed the basis of a survey distributed to Australia...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2010.01330.x
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Common diseases with potential to increase the risk of death from lung cancer have so far not been studied in large populations. METHODS:We did a population-based retrospective cohort study using nationwide health insurance claims data from 2005 to 2012 in Korea including 205 403 lung cancer patients. Multi...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12697
更新日期：2018-04-01 00:00:00
abstract：AIM:Survival rates for patients with cancer who live in rural and regional areas are worse than in metropolitan areas. This may be due to geographical isolation, delayed diagnosis, inadequate transport, lower socioeconomic status and workforce shortages. We conducted a qualitative study of rural patients, carers and he...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12014
更新日期：2013-09-01 00:00:00
abstract：AIM:Selective internal radiation therapy with yttrium-90 microsphere radioembolization has been used to treat unresectable liver tumors and its acute toxicity has been well described. Subacute and long-term hepatic complications related to radioembolization however may be underreported in the literature. This retrospec...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12229
更新日期：2014-09-01 00:00:00
abstract：:Ipilimumab is a human anti-CTLA-4 monoclonal antibody recently approved for the treatment of advanced melanoma. Stimulation of T-cell activity unmasks antitumor activity, but can cause immune-related adverse events. Autoimmune hypophysitis is of particular importance because its presentation can be subtle but life thr...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12348
更新日期：2015-06-01 00:00:00
abstract：BACKGROUND:The comprehensive genetic alterations underlying the pathogenesis of Sézary syndrome (SS) remains largely unknown. Previous studies showed that alterations of tumor necrosis factor-α-induced protein 3 gene (TNFAIP3; A20) are frequent in SS. In this study, we characterized the mutation and polymorphisms of A2...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12672
更新日期：2018-04-01 00:00:00
abstract：AIMS:In this study, we intended to analyze the clinical significance of CD4+ FoxP3+ Tregs in gastric cancer patients and investigate the relationship between the proportion of CD4+ FoxP3+ Tregs in the peripheral blood and the expression of FoxM1 and Ki-67 in gastric cancer tissues. METHODS:Flow cytometry was used to m...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13302
更新日期：2020-01-19 00:00:00
abstract：AIM:To validate and compare the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life-Chemotherapy-Induced Peripheral Neuropathy Questionnaire (EORTC QLQ-CIPN20) and the Functional Assessment of Cancer-Gynecologic Oncology Group-Neurotoxicity subscale (FACT/GOG-Ntx) for measu...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,多中心研究
doi：10.1111/ajco.13000
更新日期：2019-02-01 00:00:00
abstract：INTRODUCTION:Ki-67 proliferation index (Ki-67 index) is used to quantify cell proliferation during histopathological assessment of various tumors including glioblastoma (GB). AIM:We aimed to assess correlation between Ki-67 index and overall survival in patients with GB and determine a cut-point for Ki-67 index that p...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12826
更新日期：2019-02-01 00:00:00
abstract：:For advanced and metastatic urothelial carcinomas (UCs), platinum (preferably cisplatin)-based chemotherapy has been the standard treatment for many years. However, many patients are ineligible for cisplatin-based chemotherapy because of poor performance status and/or other age-related conditions. At the other end of ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/ajco.13312
更新日期：2020-09-01 00:00:00
abstract：AIM:To explore the incidence of subclinical cardiotoxicity in women treated with adjuvant trastuzumab in the early breast cancer setting using cardiac magnetic resonance imaging (cMRI). METHODS:The cardiac function and myocardial tissue characteristics of 25 women who had completed adjuvant trastuzumab therapy greater...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2011.01462.x
更新日期：2012-03-01 00:00:00
abstract：AIM:A newly developed cervical cancer screening method - folate receptor-mediated epithelium staining utilizes methylene blue internalized by folate receptor-mediated endocytosis to stain cervical intra-epithelial neoplasia. We test the clinical feasibility of this method in this study. METHODS:A total of 14 344 women...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12573
更新日期：2017-02-01 00:00:00
abstract：BACKGROUND:MRI and PET/CT scans are the main supportive methods for nasopharyngeal cancer (NPC) for staging and planning. The aim of this study is to compare MRI and PET/CT scanning in terms of survival in patients with NPC who had MRI or PET/CT-simulated radiotherapy planning. METHODS:Pathological diagnosed nonkerati...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13400
更新日期：2021-02-01 00:00:00
abstract：AIM:Autoimmune hemolytic anemia (AIHA) is frequently associated with B-cell lymphoproliferative disorders, and patients rarely develop overt clinical manifestations of AIHA. AIHA is rare in patients with multiple myeloma (MM). We conducted a prospective study to detect the presence of AIHA in MM patients and its impact...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12230
更新日期：2016-06-01 00:00:00
abstract：:First-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are used as first-line therapy in patients with non-small cell lung cancer (NSCLC) harboring a sensitizing mutation in the EGFR gene. Unfortunately, resistance to these therapies often occurs within 10 months of commencing treat...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/ajco.12699
更新日期：2017-08-01 00:00:00
abstract：:The COVID-19 pandemic will present a range of challenges to radiation oncology departments. Early data suggest that cancer patients carry a higher than average, but still low absolute risk of hospitalization from COVID-19. The risk of severe events for those who are hospitalized however, is high. Resources for usual c...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/ajco.13456
更新日期：2021-02-01 00:00:00
abstract：BACKGROUND:Access to palliative care services is essential for attaining universal health coverage for patients with a terminal cancer. Despite this, many patients with advanced cancer in low-income countries, such as Myanmar, suffer at the end of life (EOL) due to little or no access to palliative care. However, actua...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,多中心研究
doi：10.1111/ajco.13373
更新日期：2020-12-01 00:00:00
abstract：AIM:For several decades urinary arylsulfatase (ARS) activity has been reported to be elevated in many cancers. It has been shown that urinary ARS activity may serve as a marker of tumor progression and therapy surveillance. This study was designed to evaluate the clinical application of detection of urinary ARS activit...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2012.01545.x
更新日期：2012-12-01 00:00:00
abstract：AIMS:The Australian Institute of Health and Welfare (AIHW) is a major national agency established by the Australian government to provide information and statistics on Australia's health and welfare. The AIHW and the Australasian Association of Cancer Registries collaborate every year to provide updated information on ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12127
更新日期：2013-09-01 00:00:00
abstract：:Non-small cell lung cancers (NSCLC) harboring the uncommon epidermal growth factor receptor (EGFR) exon 20 insertion mutations are generally thought to be unresponsive to EGFR-tyrosine kinase inhibitor (TKI) therapy. Presented here is a case of stage IV NSCLC harboring an uncommon EGFR exon 20 insertion mutation that ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12853
更新日期：2018-03-01 00:00:00
abstract：AIM:Self-expandable metallic stents (SEMS) have been used for palliation in patients with malignant gastroduodenal obstructions. We evaluated clinical outcomes after SEMS placement and identified prognostic factors of SEMS patency, including chemotherapy. METHODS:A review of records of 85 patients with unresectable ga...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/j.1743-7563.2012.01590.x
更新日期：2013-06-01 00:00:00
abstract：AIM:We aimed to analyze surgical outcomes of open or laparoscopic adrenalectomy for solitary adrenal metastasis and assess the factors influencing survival. METHODS:We retrospectively reviewed our institutional clinicopathological database for cases of adrenalectomy for solitary adrenal metastasis from solid tumors be...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13078
更新日期：2020-04-01 00:00:00
abstract：AIM:The effects of image-guided radiotherapy (IGRT, an advanced RT technology) have been debated in the literature. We compared the outcomes of locally advanced rectal cancer (LARC) patients treated with neoadjuvant concurrent chemoradiotherapy (NCCRT; with vs without IGRT) in a large population-based propensity score ...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13196
更新日期：2019-10-01 00:00:00
abstract：:Health literacy refers to one's ability to obtain, process and understand health information and services to enable sound health decision-making. This is an area of increasing importance due to the complexity of the health system, especially in the cancer setting. A certain level of health literacy is required for pat...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章,评审
doi：10.1111/j.1743-7563.2012.01522.x
更新日期：2012-03-01 00:00:00
abstract：AIM:To evaluate the attitudes of patients with different cancers towards research biopsies outside a clinical trial. METHODS:Patients with metastatic cancer completed a questionnaire that assessed patients' willingness to consider research biopsies. Research biopsies were divided into two groups: biopsies performed as...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.12783
更新日期：2018-06-01 00:00:00
abstract：PURPOSE:Mitomycin C (MMC) plus standard 5-fluorouracil (FU) infusion in weeks 1 and 5 often contributes to radiotherapy interruptions and possibly less-than-ideal outcomes in anal cancer. This study was to evaluate alternative strategies for chemotherapy delivery that might be less toxic or more efficacious, and outcom...
journal_title：Asia-Pacific journal of clinical oncology
pub_type： 杂志文章
doi：10.1111/ajco.13106
更新日期：2019-02-01 00:00:00
