Abstract:
:Carboplatin is a platinum analogue, widely used in the treatment of numerous cancer types including lung, genitourinary and ovarian cancers. It is also used in the adjuvant treatment of human epidermal growth factor receptor 2 positive breast cancer, where a non-anthracycline regimen is preferred. It is considered generally to be less toxic though potentially less efficacious than cisplatin, another platinum compound. Cisplatin is well recognized as causing hyponatremia, through the mechanism of renal salt wasting. Conversely, carboplatin has only rarely been associated with hyponatremia. We report here a case of severe hyponatremia occurring 6 days after adjuvant treatment with a carboplatin-containing chemotherapy regimen for early stage breast cancer. The mechanism of hyponatremia was consistent with the syndrome of inappropriate anti-diuretic hormone secretion based on biochemical and clinical findings, and response to fluid restriction. With no previously reported cases of docetaxel-associated or trastuzumab-associated hyponatremia, the causative agent was considered to be carboplatin. Additionally there was no recurrence of hyponatremia on recommencement of docetaxel and trastuzumab therapy. Hyponatremia secondary to carboplatin has been rarely reported in the literature, with only three previously reported cases. Although it is rare, oncologists should be aware of the potential for carboplatin to cause hyponatremia and the need to monitor electrolytes throughout therapy.
journal_name
Asia Pac J Clin Oncoljournal_title
Asia-Pacific journal of clinical oncologyauthors
Turner N,Stewart J,Barnett F,White Sdoi
10.1111/j.1743-7563.2012.01526.xsubject
Has Abstractpub_date
2012-09-01 00:00:00pages
e9-e11issue
3eissn
1743-7555issn
1743-7563journal_volume
8pub_type
杂志文章abstract:BACKGROUND:MRI and PET/CT scans are the main supportive methods for nasopharyngeal cancer (NPC) for staging and planning. The aim of this study is to compare MRI and PET/CT scanning in terms of survival in patients with NPC who had MRI or PET/CT-simulated radiotherapy planning. METHODS:Pathological diagnosed nonkerati...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.13400
更新日期:2021-02-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
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doi:10.1111/ajco.12230
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
doi:10.1111/j.1743-7563.2012.01544.x
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journal_title:Asia-Pacific journal of clinical oncology
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,随机对照试验
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更新日期:2017-04-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章
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abstract::It is important to distinguish between tumor recurrence and treatment effects in posttreatment patients with high-grade gliomas. Several imaging modalities have been reported in differentiating between tumor recurrence and treatment effects. However, there were no consistent conclusions between different studies. We p...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,meta分析,评审
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pub_type: 杂志文章,多中心研究
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更新日期:2018-06-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2019-12-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1111/ajco.13373
更新日期:2020-12-01 00:00:00
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更新日期:2019-08-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2011.01461.x
更新日期:2011-12-01 00:00:00
abstract:AIMS:There is currently no routine collection of cancer stages in population-based data in Australia. This study evaluates the accuracy of International classification of diseases (ICD) codes for secondary neoplasms recorded in hospital morbidity data to assign spread of disease at diagnosis for colorectal cancer. MET...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2012.01537.x
更新日期:2012-09-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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更新日期:2018-10-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2014-06-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
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doi:10.1111/j.1743-7563.2009.01263.x
更新日期:2010-03-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2010.01340.x
更新日期:2010-12-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,meta分析,评审
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更新日期:2015-12-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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更新日期:2017-12-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2012.01541.x
更新日期:2012-09-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12457
更新日期:2016-06-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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更新日期:2020-08-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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更新日期:2019-10-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12273
更新日期:2017-10-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2010.01312.x
更新日期:2010-09-01 00:00:00