Abstract:
AIM:The effects of image-guided radiotherapy (IGRT, an advanced RT technology) have been debated in the literature. We compared the outcomes of locally advanced rectal cancer (LARC) patients treated with neoadjuvant concurrent chemoradiotherapy (NCCRT; with vs without IGRT) in a large population-based propensity score (PS)-matched analysis. METHODS:We identified LARC patients diagnosed between 2007 and 2015 via the Taiwan cancer registry (TCR) and constructed a PS-matched cohort to balance observable potential confounders. Outcomes (R0 resection, overall survival, incidence of local regional recurrence [ILRR], rectal cancer mortality [IRCM], other cancer mortality [IOCM] and cardiovascular mortality [ICVM]) were obtained from TCR and the national death registry. We compared the hazard ratio (HR) of death and other endpoints between IGRT and non-IGRT groups. We performed supplementary analysis (SA) to evaluate the robustness of these results in a subgroup, taking an additional potential confounder into account. RESULTS:Our study population comprised of 586 patients that were balanced with regard to observed covariables. There was no significant difference in HR for death (0.99; 95% confidence interval 0.70-1.39; P = 0.94) between IGRT and non-IGRT groups. There were also no significant differences in R0 resection, ILRR, IRCM, IOCM or ICVM. The results of our SA were consistent with these findings. CONCLUSION:For LARC patients treated with NCCRT, the treatment outcome was not significantly different among patients treated with and without IGRT. Further study is needed to clarify these results with consideration to additional potential confounding factors and toxicity profiles at endpoints.
journal_name
Asia Pac J Clin Oncoljournal_title
Asia-Pacific journal of clinical oncologyauthors
Li CC,Liang JA,Chen WT,Chien CRdoi
10.1111/ajco.13196subject
Has Abstractpub_date
2019-10-01 00:00:00pages
e197-e203issue
5eissn
1743-7555issn
1743-7563journal_volume
15pub_type
杂志文章abstract:AIM:Cabazitaxel is a next generation taxane that has been shown to improve overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC) whose disease progressed during or after docetaxel-based therapy. A worldwide early access program (EAP) study was established to provide access to cabazit...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12679
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:Docetaxel is an effective therapy for metastatic castration-resistant prostate cancer (mCRPC); however, many patients experience febrile neutropenia (FN) and cease treatment early due to toxicity. It is not known whether lower dose (LD) q3-weekly docetaxel impacts toxicity or efficacy. METHODS:Multicenter r...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
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journal_title:Asia-Pacific journal of clinical oncology
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journal_title:Asia-Pacific journal of clinical oncology
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journal_title:Asia-Pacific journal of clinical oncology
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journal_title:Asia-Pacific journal of clinical oncology
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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journal_title:Asia-Pacific journal of clinical oncology
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journal_title:Asia-Pacific journal of clinical oncology
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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更新日期:2018-04-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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abstract::An improved understanding of the important role of angiogenesis in tumor biology has led to development of different antiangiogenic therapies. Numerous clinical studies for several antiangiogenic agents have recently been conducted in breast cancer patients and have shown clinically significant improvement in outcomes...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
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abstract:AIM:Autoimmune hemolytic anemia (AIHA) is frequently associated with B-cell lymphoproliferative disorders, and patients rarely develop overt clinical manifestations of AIHA. AIHA is rare in patients with multiple myeloma (MM). We conducted a prospective study to detect the presence of AIHA in MM patients and its impact...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12230
更新日期:2016-06-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2021-02-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12179
更新日期:2015-09-01 00:00:00
abstract:AIM:To validate and compare the Chinese version of the European Organization for Research and Treatment of Cancer Quality of Life-Chemotherapy-Induced Peripheral Neuropathy Questionnaire (EORTC QLQ-CIPN20) and the Functional Assessment of Cancer-Gynecologic Oncology Group-Neurotoxicity subscale (FACT/GOG-Ntx) for measu...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,多中心研究
doi:10.1111/ajco.13000
更新日期:2019-02-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12674
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12826
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2019-08-01 00:00:00
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journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12084
更新日期:2016-03-01 00:00:00
abstract::Carboplatin is a platinum analogue, widely used in the treatment of numerous cancer types including lung, genitourinary and ovarian cancers. It is also used in the adjuvant treatment of human epidermal growth factor receptor 2 positive breast cancer, where a non-anthracycline regimen is preferred. It is considered gen...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/j.1743-7563.2012.01526.x
更新日期:2012-09-01 00:00:00
abstract:AIM:Multidisciplinary care is advocated as best practice in cancer care. Relatively little is documented about multidisciplinary team (MDT) meeting functioning, decision making and the use of evidence to support decision making in Australia. This descriptive study aimed to examine team functioning, the role of team mee...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12765
更新日期:2018-02-01 00:00:00
abstract:AIM:A proportion of locally advanced rectal cancer patients who receive neoadjuvant chemoradiotherapy (NACRT) are still unresectable. This study was undertaken to assess the outcomes of giving additional chemotherapy to rectal cancer patients with unresectable disease after NACRT. METHODS:Patients with poor response t...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12660
更新日期:2017-08-01 00:00:00
abstract::Resistance to endocrine therapy is a significant therapeutic challenge in the treatment of women with hormone receptor positive (HR+), human epidermal growth factor receptor 2 negative (HER2-) advanced breast cancer. Cyclin-dependent kinase (CDK)4/6 inhibitors in combination with endocrine therapy have been shown to i...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
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abstract::First-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) are used as first-line therapy in patients with non-small cell lung cancer (NSCLC) harboring a sensitizing mutation in the EGFR gene. Unfortunately, resistance to these therapies often occurs within 10 months of commencing treat...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章,评审
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更新日期:2017-08-01 00:00:00
abstract:INTRODUCTION:Left- and right-sided colon cancers were significantly different in epidemiologic, clinical and histological parameters. However, the impact of primary tumor location in metastatic colon cancer treated with front-line targeted triplet regimens is unclear, particularly in Asian populations. METHODS:A total...
journal_title:Asia-Pacific journal of clinical oncology
pub_type: 杂志文章
doi:10.1111/ajco.12469
更新日期:2016-09-01 00:00:00