Pilot study evaluating the role of cardiac magnetic resonance imaging in monitoring adjuvant trastuzumab therapy for breast cancer.

Abstract:

AIM:To explore the incidence of subclinical cardiotoxicity in women treated with adjuvant trastuzumab in the early breast cancer setting using cardiac magnetic resonance imaging (cMRI). METHODS:The cardiac function and myocardial tissue characteristics of 25 women who had completed adjuvant trastuzumab therapy greater than 6 months previously was evaluated using MRI and comparing this with symptoms and routine echocardiography. RESULTS:Evidence of myocardial tissue damage was seen in two women in the absence of functional change or previous cardiac symptoms. CONCLUSION:Tissue characterization using cMRI may provide a useful tool in defining trastuzumab induced cardiotoxicity.

journal_name

Asia Pac J Clin Oncol

authors

Lawley C,Wainwright C,Segelov E,Lynch J,Beith J,McCrohon J

doi

10.1111/j.1743-7563.2011.01462.x

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

95-100

issue

1

eissn

1743-7555

issn

1743-7563

journal_volume

8

pub_type

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