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Synchronous regulation of the determinants of endometrial receptivity to interleukin 1 at key stages of early embryo implantation in vivo.

Abstract：

OBJECTIVE:To investigate the expression kinetics of interleukin-1 receptors (IL-1R), receptor antagonist (IL-1RN), and monocyte chemotactic protein 1 (MCP-1) throughout early gestation in mice. DESIGN:Assessment of IL-1R, IL-1RN, and MCP-1 throughout early pregnancy. SETTING:Reproduction laboratory. ANIMAL(S):B6C3F1 female mice bred with fertile males of the same strain. INTERVENTION(S):Collection of endometrial tissue at necropsy from nonimplanted and implanted sites. MAIN OUTCOME MEASURE(S):IL-1R, IL-1RN, and MCP-1 mRNA expression by quantitative reverse-transcription polymerase chain reaction and protein expression by enzyme-linked immunosorbent assay and immunohistochemistry. RESULT(S):The expression of the signaling IL-1R1 significantly increased in the first 2 days of gestation, which corresponded to the inflammatory-like period triggered by the seminal fluid, before increasing again at the implantation window and lasting throughout embryo implantation. The expression of inhibitory IL-1R2 and IL-1RN concomitantly increased during gestational days 1-2 but remained low, particularly within the embryo implantation sites and throughout the implantation period. The expression of MCP-1 significantly increased only at the embryo implantation sites and showed a significant positive correlation with IL-1R1 expression. CONCLUSION(S):Our data identified for the first time synchronous changes in endometrial IL-1R throughout early gestation in vivo and point to a deep modulation of endometrial receptivity to IL-1 by embryo-driven signals. This may play a key role in the creation of a receptive phenotype in the maternal endometrium and represent a key mechanism underlying embryo implantation.

journal_name

Fertil Steril

journal_title

Fertility and sterility

authors

Bourdiec A,Martel V,Akoum A

doi

10.1016/j.fertnstert.2014.01.011

subject

Has Abstract

pub_date

2014-04-01 00:00:00

pages

1183-93

issue

4

eissn

0015-0282

issn

1556-5653

pii

S0015-0282(14)00041-7

journal_volume

101

pub_type

杂志文章

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