Prospects for nucleic acid-based therapeutics against hepatitis C virus.

abstract：:The number of patients with gastric cancer has more than doubled since 1985 in developing countries. Thus, the questions of whether it can be predicted from gastritis morphology, who is at risk and who has a lower risk of developing gastric carcinoma are raised. H pylori-infection leads to erosions, ulcerations, carci...

journal_title：World journal of gastroenterology

authors： Vieth M,Stolte M

更新日期：2006-10-14 00:00:00

abstract：AIM:To explore the transcriptional gene expression profiles of HGF/SF-met signaling pathway in colorectal carcinoma to understand mechanisms of the signaling pathway at so gene level. METHODS:Total RNA was isolated from human colorectal carcinoma cell line LoVo treated with HGF/SF (80 ng/L) for 48 h. Fluorescent probe...

journal_title：World journal of gastroenterology

authors： Li XN,Ding YQ,Liu GB

更新日期：2003-08-01 00:00:00

abstract：:Management of hepatocellular carcinoma (HCC) with portal vein thrombosis (PVT) is complex and requires an understanding of multiple therapeutic options. PVT is present in 10%-40% of HCC at the time of diagnosis, and is an adverse prognostic factor. Management options are limited, as transplantation is generally contra...

journal_title：World journal of gastroenterology

authors： Quirk M,Kim YH,Saab S,Lee EW

更新日期：2015-03-28 00:00:00

abstract：AIM:To develop a novel Helicobacter pylori (H. pylori) CagA antibody enzyme-linked immunosorbent assay (ELISA) suitable for detecting serum anti-CagA antibodies with high sensitivity. METHODS:Recombinant East Asian-type CagA protein was purified and immobilized for ELISA. Serum samples from 217 Vietnamese individuals ...

journal_title：World journal of gastroenterology

authors： Matsuo Y,Kido Y,Akada J,Shiota S,Binh TT,Trang TT,Dung HD,Tung PH,Tri TD,Thuan NP,Tam LQ,Nam BC,Khien VV,Yamaoka Y

更新日期：2017-01-07 00:00:00

abstract：AIM:To find evidences about whether NOD1/CARD4 insertion/deletion polymorphism is associated with inflammatory bowel disease by meta-analysis. METHODS:We surveyed the studies on the association of NOD1/CARD4 insertion/deletion polymorphism with inflammatory bowel disease in PubMed. Meta-analysis was performed for geno...

journal_title：World journal of gastroenterology

authors： Lu WG,Zou YF,Feng XL,Yuan FL,Gu YL,Li X,Li CW,Jin C,Li JP

更新日期：2010-09-14 00:00:00

abstract：:Recently, inflammatory bowel disease (IBD) has been the subject of considerable research, with increasing attention being paid to the loss of intestinal epithelial cell barrier function as a mechanism of pathogenesis. Ste20-related proline/alanine-rich kinase (SPAK) is involved in regulating barrier function. SPAK is ...

journal_title：World journal of gastroenterology

authors： Yan Y,Merlin D

更新日期：2008-10-28 00:00:00

abstract：:A variety of hepatic and biliary tract disorders may complicate the clinical course of celiac disease. Some of these have been hypothesized to share common genetic factors or have a common immunopathogenesis, such as primary biliary cirrhosis, primary sclerosing cholangitis and autoimmune forms of hepatitis or cholang...

journal_title：World journal of gastroenterology

authors： Freeman HJ

更新日期：2006-03-14 00:00:00

abstract：BACKGROUND:Treatments for hepatic sinusoidal obstruction syndrome (HSOS) are limited. AIM:To evaluate transjugular intrahepatic portosystemic shunting (TIPS) as a treatment for pyrrolidine alkaloid-related HSOS (PA-HSOS). METHODS:This retrospective analysis included patients with PA-HSOS admitted to the First Affilia...

journal_title：World journal of gastroenterology

authors： Zhou CZ,Wang RF,Lv WF,Fu YQ,Cheng DL,Zhu YJ,Hou CL,Ye XJ

更新日期：2020-06-28 00:00:00

abstract：AIM:To evaluate the detection and differentiation ability of contrast-enhanced intraoperative ultrasonography (CE-IOUS) in hepatocellular carcinoma (HCC) operations. METHODS:Clinical data of 50 HCC patients were retrospective analyzed. The sensitivity, specificity, false negative and false positive rates of contrast e...

journal_title：World journal of gastroenterology

authors： Wu H,Lu Q,Luo Y,He XL,Zeng Y

更新日期：2010-01-28 00:00:00

abstract：AIM:To elucidate the relationship between apoptotic protease activating factor-1 (Apaf-1) gene and gastric cancer. METHODS:Thirty-five postoperative cancer and adjacent normal tissue samples were collected in the present study. Expression of the Apaf-1 gene in these samples was analyzed by semi-quantitative RT-PCR. Lo...

journal_title：World journal of gastroenterology

authors： Wang HL,Bai H,Li Y,Sun J,Wang XQ

更新日期：2007-10-14 00:00:00

abstract：:Primary hepatic neuroendocrine tumor (PHNET) is an extremely rare liver tumor. Patients often have no clinical symptoms or have only non-specific symptoms, such as abdominal pain and abdominal mass. The clinical manifestations, disease development, treatment methods, and treatment outcomes of PHNET vary greatly among ...

journal_title：World journal of gastroenterology

authors： Meng XF,Pan YW,Wang ZB,Duan WD

更新日期：2018-06-28 00:00:00

abstract：:This paper reviews the progress made in understanding the mechanical behaviour of the biliary system. Gallstones and diseases of the biliary tract affect more than 10% of the adult population. The complications of gallstones, i.e. acute pancreatitis and obstructive jandice, can be lethal, and patients with acalculous ...

journal_title：World journal of gastroenterology

authors： Luo X,Li W,Bird N,Chin SB,Hill NA,Johnson AG

更新日期：2007-03-07 00:00:00

abstract：:Irritable bowel syndrome (IBS) is a highly prevalent functional disorder that reduces patients' quality of life. It is a chronic disorder characterized by abdominal pain or discomfort associated with disordered defecation in the absence of identifiable structural or biochemical abnormalities. IBS imposes a significant...

journal_title：World journal of gastroenterology

authors： Lazaraki G,Chatzimavroudis G,Katsinelos P

更新日期：2014-07-21 00:00:00

abstract：AIM:To investigate the relationship between 579 G>T polymorphisms in the DNMT3B gene, which is involved in de novo methylation and associated with the risk of esophagus cancer (EC) in Chinese. METHODS:DNMT3B 579 G>T genotypes were determined by PCR-RFLP in 194 EC patients and 210 healthy controls matched for age and s...

journal_title：World journal of gastroenterology

authors： Fan H,Liu DS,Zhang SH,Hu JB,Zhang F,Zhao ZJ

更新日期：2008-04-14 00:00:00

abstract：AIM:To assess the incidence of infantile colic and its association with variable predictors in infants born in a community maternity hospital, Tehran, Iran. METHODS:In this prospective cohort study, mothers who gave birth to live newborns between February 21 and March 20, 2003 at the hospital were invited to join to t...

journal_title：World journal of gastroenterology

authors： Talachian E,Bidari A,Rezaie MH

更新日期：2008-08-07 00:00:00

abstract：:The main treatment of patients with non-alcoholic fatty liver disease (NAFLD) is life style modification including weight reduction and dietary regimen. Majority of patients are safely treated with this management and pharmacologic interventions are not recommended. However, a subgroup of NAFLD patients with non-alcoh...

journal_title：World journal of gastroenterology

authors： Eshraghian A

更新日期：2017-11-14 00:00:00

abstract：AIM:To study the inhibitory effects of a Shuangling Fuzheng anticancer preparation (SFAP) on the human gastric cancer cell line SGC-7901 in vitro as well as its immune-modulated effects in a cyclophosphamide-treated murine model. METHODS:MTT experiments and immunocytochemistry ABC experiments were performed for detect...

journal_title：World journal of gastroenterology

authors： Chen HS,Chen J,Cui DL,Zheng YY,Xu AH,Chen G,Jia LC

更新日期：2007-12-28 00:00:00

abstract：AIM:To detect significant clusters of co-expressed genes associated with tumorigenesis that might help to predict stomach adenocarcinoma (SA) prognosis. METHODS:The Cancer Genome Atlas database was used to obtain RNA sequences as well as complete clinical data of SA and adjacent normal tissues from patients. Weighted ...

journal_title：World journal of gastroenterology

authors： Zhang J,Wu Y,Jin HY,Guo S,Dong Z,Zheng ZC,Wang Y,Zhao Y

更新日期：2018-11-21 00:00:00

abstract：:Hepatitis C virus (HCV) infection is estimated to affect 130-150 million people globally which corresponds to 2%-3% of the total world population. It remains the leading indication for liver transplant worldwide and has been demonstrated to negatively impact both patient and graft survival following non-hepatic organ ...

journal_title：World journal of gastroenterology

authors： Belga S,Doucette KE

更新日期：2016-01-28 00:00:00

abstract：AIM:To study the role of gastric mucosal ascorbic acid (AA) in the progression of acute gastric mucosal lesions induced by compound 48/80 (C48/80), a mast cell degranulator, in rats. METHODS:C48/80 (0.75 mg/kg) was intraperitoneally injected to fasted Wistar rats. Oral administration of AA (10, 50 or 100 mg/kg) was pe...

journal_title：World journal of gastroenterology

authors： Kamiya Y,Ohta Y,Imai Y,Arisawa T,Nakano H

更新日期：2005-03-07 00:00:00

abstract：AIM:To explore the relation between heparanase (HPA) and nm23-H1 in hepatocellular carcinoma (HCC), and whether they could be used as valuable markers in predicting post-operative metastasis and recurrence of HCC. METHODS:Reverse transcription-polymerase chain reaction and immunohistochemistry (S-P method) were used t...

journal_title：World journal of gastroenterology

authors： Liu YB,Gao SL,Chen XP,Peng SY,Fang HQ,Wu YL,Peng CH,Tang Z,Xu B,Wang JW,Deng GL,Li HJ,Feng XD,Qian HR

更新日期：2005-03-07 00:00:00

abstract：AIM:To investigate the effects of early enteral nutrition (EEN) on the immune function and clinical outcome of patients with severe acute pancreatitis (SAP). METHODS:Patients were randomly allocated to receive EEN or delayed enteral nutrition (DEN). Enteral nutrition was started within 48 h after admission in EEN grou...

journal_title：World journal of gastroenterology

authors： Sun JK,Mu XW,Li WQ,Tong ZH,Li J,Zheng SY

更新日期：2013-02-14 00:00:00

abstract：AIM:To evaluate the impact of sociodemographic/clinical factors on early virological response (EVR) to peginterferon/ribavirin for chronic hepatitis C (CHC) in clinical practice. METHODS:We conducted a multicenter, cross-sectional, observational study in Hepatology Units of 91 Spanish hospitals. CHC patients treated w...

journal_title：World journal of gastroenterology

authors： García-Samaniego J,Romero M,Granados R,Alemán R,Jorge Juan M,Suárez D,Pérez R,Castellano G,González-Portela C

更新日期：2013-03-28 00:00:00

abstract：:Single-incision laparoscopic surgery (SILS) and natural orifice transluminal endoscopic surgery (NOTES) have rapidly gained pace worldwide, potentially replacing conventional laparoscopic surgery (CLS) as the preferred colorectal surgery technique. Currently available data mainly consist of retrospective series analyz...

journal_title：World journal of gastroenterology

authors： Daher R,Chouillard E,Panis Y

更新日期：2014-12-28 00:00:00

abstract：BACKGROUND:End-stage liver disease caused by non-alcoholic steatohepatitis (NASH) is the second leading indication for liver transplantation. To date, only moderately effective pharmacotherapies exist to treat NASH. Understanding the pathogenesis of NASH is therefore crucial for the development of new therapies. The in...

journal_title：World journal of gastroenterology

authors： Bluemel S,Wang Y,Lee S,Schnabl B

更新日期：2020-09-07 00:00:00

abstract：AIM:To investigate genetic factors that might help define which Crohn's disease (CD) patients are likely to benefit from anti-tumor necrosis factor (TNF) therapy. METHODS:This was a prospective cohort study. Patients were recruited from a university digestive disease practice database. We included CD patients who rece...

journal_title：World journal of gastroenterology

authors： Netz U,Carter JV,Eichenberger MR,Dryden GW,Pan J,Rai SN,Galandiuk S

更新日期：2017-07-21 00:00:00

abstract：:Foreign body ingestion is a common complaint in gastrointestinal clinics. It is usually not difficult to diagnose because most of the patients report a definitive history of accidental foreign body ingestion. However, in rare cases, patients do not have a clear history. Thus, the actual condition of the patient is dif...

journal_title：World journal of gastroenterology

authors： Lu YP,Yao M,Zhou XY,Huang B,Qi WB,Chen ZH,Xu LS

更新日期：2014-10-21 00:00:00

abstract：AIM:To investigate the expression of leukemia related protein 16 (LRP16), and the possible relationship between LRP16 expression and clinicopathological indices in 336 gastric carcinoma patients. METHODS:Immunohistochemistry was used to detect LRP16 expression in 336 cases of paraffin-embedded gastric carcinoma tissue...

journal_title：World journal of gastroenterology

authors： Li YZ,Zhao P,Han WD

更新日期：2009-10-14 00:00:00

abstract：AIM:To study the distribution and expression of non-muscle myosin light chain kinase (nmMLCK) in rabbit livers. METHODS:Human nmMLCK N-terminal cDNA was amplified by polymerase chain reaction (PCR) and was inserted into pBKcmv to construct expression vectors. The recombinant plasmid was transformed into XL1-blue. Expr...

journal_title：World journal of gastroenterology

authors： Zhu HQ,Wang Y,Hu RL,Ren B,Zhou Q,Jiang ZK,Gui SY

更新日期：2003-12-01 00:00:00

abstract：AIM:To investigate the effect of hepatitis B virus (HBV) specific immunoglobin (HBIG) and lamivudine on HBV intrauterine transmission in HBsAg positive pregnant women. METHODS:Each subject in the HBIG group (56 cases) was given 200 IU HBIG intramuscularly (im.) every 4 weeks from 28-week (wk) of gestation, while each ...

journal_title：World journal of gastroenterology

authors： Li XM,Yang YB,Hou HY,Shi ZJ,Shen HM,Teng BQ,Li AM,Shi MF,Zou L

更新日期：2003-07-01 00:00:00