Abstract:
BACKGROUND:Some noninvasive brain-computer interface (BCI) systems are currently available for locked-in syndrome (LIS) but none have incorporated a statistical language model during text generation. OBJECTIVE:To begin to address the communication needs of individuals with LIS using a noninvasive BCI that involves rapid serial visual presentation (RSVP) of symbols and a unique classifier with electroencephalography (EEG) and language model fusion. METHODS:The RSVP Keyboard was developed with several unique features. Individual letters are presented at 2.5 per second. Computer classification of letters as targets or nontargets based on EEG is performed using machine learning that incorporates a language model for letter prediction via Bayesian fusion enabling targets to be presented only 1 to 4 times. Nine participants with LIS and 9 healthy controls were enrolled. After screening, subjects first calibrated the system, and then completed a series of balanced word generation mastery tasks that were designed with 5 incremental levels of difficulty, which increased by selecting phrases for which the utility of the language model decreased naturally. RESULTS:Six participants with LIS and 9 controls completed the experiment. All LIS participants successfully mastered spelling at level 1 and one subject achieved level 5. Six of 9 control participants achieved level 5. CONCLUSIONS:Individuals who have incomplete LIS may benefit from an EEG-based BCI system, which relies on EEG classification and a statistical language model. Steps to further improve the system are discussed.
journal_name
Neurorehabil Neural Repairjournal_title
Neurorehabilitation and neural repairauthors
Oken BS,Orhan U,Roark B,Erdogmus D,Fowler A,Mooney A,Peters B,Miller M,Fried-Oken MBdoi
10.1177/1545968313516867subject
Has Abstractpub_date
2014-05-01 00:00:00pages
387-94issue
4eissn
1545-9683issn
1552-6844pii
1545968313516867journal_volume
28pub_type
杂志文章abstract:BACKGROUND:Stroke survivors can exhibit abnormally elevated oxygen consumption during walking. Therapeutic interventions can improve gait deficits and oxygen consumption. A practical measure of oxygen cost is not available. This study tested the usefulness of an indirect index of oxygen cost, the Physiological Cost Ind...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968307300400
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Confidence about balance may be an important factor affecting self-efficacy for daily activities after stroke. OBJECTIVE:The authors investigated whether confidence changes and the parameters that may predict changes in self-perceived balance within the first year of community reintegration. METHODS:In thi...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968312437941
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Highly challenging exercises have been suggested to induce neuroplasticity in individuals with Parkinson's disease (PD); however, its effect on clinical outcomes remains largely unknown. OBJECTIVE:To evaluate the short-term effects of the HiBalance program, a highly challenging balance-training regimen that...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968314567150
更新日期:2015-10-01 00:00:00
abstract:BACKGROUND:Conventional methods of rehabilitation in patients with chronic, severe motor impairments after stroke usually do not lessen paresis. OBJECTIVE:A novel therapeutic approach (assisted movement with enhanced sensation [AMES]) was employed in a medical device phase I clinical trial to reduce paresis and spasti...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968308317437
更新日期:2009-01-01 00:00:00
abstract:BACKGROUND:The use of exercise in amyotrophic lateral sclerosis (ALS) is controversial. Although moderate exercise appears to be beneficial for limb muscles in ALS, the effects of exercise on bulbar muscles such as the tongue have not been studied. OBJECTIVE:To determine the effects of tongue force training on bulbar ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968316666956
更新日期:2017-02-01 00:00:00
abstract::Current assessments do not provide reliable factors predictive of outcome from stroke for stroke survivors of intermediate age and severity of deficit. We sought to investigate whether early rate of functional improvement can facilitate prediction of functional outcome, length of stay, and disposition beyond that affo...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/154596830001400309
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:To investigate the effectiveness of upper limb rehabilitation, sound measures of upper limb function, capacity, and performance are paramount. OBJECTIVES:This systematic review investigates reliability and responsiveness of upper limb measurement tools used in pediatric neurorehabilitation. METHODS:A 2-tie...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,评审
doi:10.1177/1545968315583723
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Several pilot studies have evoked interest in robot-assisted therapy (RAT) in children with cerebral palsy (CP). OBJECTIVE:To assess the effectiveness of RAT in children with CP through a single-blind randomized controlled trial. PATIENTS AND METHODS:Sixteen children with CP were randomized into 2 groups. ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968314541172
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Fatigue is a debilitating symptom in multiple sclerosis (MS). Previous studies showed no association between fatigue as perceived by the patient and physiological measures of fatigability. OBJECTIVE:The authors investigated associations between perceived fatigue and measures of fatigability after correction...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968311416991
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The question of the best therapeutic window in which noninvasive brain stimulation (NIBS) could potentiate the plastic changes for motor recovery after a stroke is still unresolved. Most of the previous NIBS studies included patients in the chronic phase of recovery and very few in the subacute...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968314565465
更新日期:2015-09-01 00:00:00
abstract::Background The reliable stratification of homogeneous subgroups and the prediction of future clinical outcomes within heterogeneous neurological disorders is a particularly challenging task. Nonetheless, it is essential for the implementation of targeted care and effective therapeutic interventions. Objective This stu...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究
doi:10.1177/1545968313520413
更新日期:2014-07-01 00:00:00
abstract:BACKGROUND:Surface electrical stimulation of the abdominal muscles, with electrodes placed in the posterolateral position, combined with a voluntary cough can assist clearance of airway secretions in individuals with high-level spinal cord injury (SCI). OBJECTIVE:To determine whether an increase in stimulus intensity ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968314552527
更新日期:2015-05-01 00:00:00
abstract:BACKGROUND:Functional electrical stimulation (FES) allows active exercises in stroke patients with upper extremity paralysis. OBJECTIVE:To investigate the effect of motor training with FES on motor recovery in acute and subacute stroke patients with severe to complete arm and/or hand paralysis. METHODS:For this pilot...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968308324548
更新日期:2009-02-01 00:00:00
abstract::Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for the pre-clinical modeling of stroke recovery and for the alignment of pre-clinical studies to clinical trials in stroke recovery. ...
journal_title:Neurorehabilitation and neural repair
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1177/1545968317724285
更新日期:2017-08-01 00:00:00
abstract::Background. Stroke is one of the most common causes of physical disability worldwide. The majority of survivors experience impairment of movement, often with lasting deficits affecting hand dexterity. To date, conventional rehabilitation primarily focuses on training compensatory maneuvers emphasizing goal completion ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968320939563
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:. Mental practice through motor imagery improves subsequent motor performance and thus mental training is considered to be a potential tool in neuromotor rehabilitation. OBJECTIVE:. The authors investigated whether a circadian fluctuation of the motor imagery process occurs, which could be relevant in sched...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968308321775
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The course of central and peripheral motor recovery after cervical spinal cord injury (SCI) may be investigated by electrophysiological measures. The goal of this study was to compare the 2 over the first year after injury in relation to motor gains. METHODS:Compound motor action potentials (C...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究
doi:10.1177/1545968316688796
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Cortical networks underlying motor imagery are functionally close to motor performance networks and can be activated by patients with severe motor disabilities. OBJECTIVE:The aim of the study was to examine the longitudinal effect of progressive motoneuron degeneration on cortical representation of motor im...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968307300698
更新日期:2007-11-01 00:00:00
abstract::Background. High-intensity repetitive training is challenging to provide poststroke. Robotic approaches can facilitate such training by unweighting the limb and/or by improving trajectory control, but the extent to which these types of assistance are necessary is not known. Objective. The purpose of this study was to ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968319887685
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Autologous bone marrow mesenchymal cells that include stem cells (MSCs) are a clinically attractive cellular therapy option to try to treat severe spinal cord injury (SCI). OBJECTIVE:To study the possible value of MSCs injected intrathecally to enhance rehabilitation. METHODS:This case control, convenience...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968310369801
更新日期:2010-10-01 00:00:00
abstract::Background. Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. We have previously demonstrated that partial motoneuron loss can result in dendritic atrophy and functional deficits in nearby surviving motoneurons, and that treatment with androgens can be neuroprot...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968319860485
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Damage to the callosal motor fibers (CMFs) may affect motor recovery in patients with stroke. However, whether the severity of CMF impairment varies with lesion locations remains unclear. OBJECTIVE:To investigate (1) whether CMF impairment occurs after stroke and whether the impairment varies with lesion lo...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968318779730
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVE:To examine whether cerebral activity during passive movements decreases with time after stroke, and if reduced activity in the representation for the upper extremity can be reversed with training. METHODS:Brain activity was measured by functional magnetic resonance imaging (fMRI) during passive wrist flexion...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章
doi:10.1177/1545968306296965
更新日期:2007-07-01 00:00:00
abstract:BACKGROUND:A recent review showed that no existing instrument measured the entire spectrum of health-related quality of life (HRQOL) in stroke patients. However, the HRQOL in stroke patients (HRQOLISP) questionnaire is valid and exceptionally comprehensive. Founded on a holistic model of human life, it comprises both p...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究
doi:10.1177/1545968310369113
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Selection of patients who are most and least likely to benefit from constraint-induced therapy (CIT) for the upper extremity is uncertain. OBJECTIVE:This study investigated demographic and clinical characteristics that may predict outcomes for a distributed form of CIT. METHODS:A group of 57 patients were ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968308321773
更新日期:2009-05-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This study investigated the relative effects of distributed constraint-induced therapy (CIT) and bilateral arm training (BAT) on motor performance, daily function, functional use of the affected arm, and quality of life in patients with hemiparetic stroke. METHODS:A total of 60 patients were r...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968308328719
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Hemiparetic gait following stroke requires substantial energy consumption, which would promote deconditioning and disability. Optimal modalities for decreasing this energy cost remain challenging. Excessive energy consumption, however, seems to be mainly due to extra positive muscle work to substantially lif...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968309349927
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Although functional imaging and neurophysiological approaches reveal alterations in motor and premotor areas after stroke, insights into neurobiological events underlying these alterations are limited in human studies. OBJECTIVE:We tested whether cerebral metabolites related to neuronal and glial compartmen...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968312469835
更新日期:2013-06-01 00:00:00
abstract::Despite negative association in cognition and memory, mice harboring Val66Met BDNF SNP (BDNFM/M) exhibit enhanced motor recovery accompanied by elevated excitatory synaptic markers VGLUT1 and VGLUT2 in striatum contralateral to unilateral ischemic stroke. The cortico-striatal pathway is a critical gateway for plastici...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968319872997
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Studies have demonstrated the efficacy of functional electrical stimulation in the management of foot drop after stroke. OBJECTIVE:To compare changes in walking performance with the WalkAide (WA) foot-drop stimulator and a conventional ankle-foot orthosis (AFO). METHODS:Individuals with stroke within the p...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1177/1545968313481278
更新日期:2013-09-01 00:00:00