Abstract:
BACKGROUND:Although functional imaging and neurophysiological approaches reveal alterations in motor and premotor areas after stroke, insights into neurobiological events underlying these alterations are limited in human studies. OBJECTIVE:We tested whether cerebral metabolites related to neuronal and glial compartments are altered in the hand representation in bilateral motor and premotor areas and correlated with distal and proximal arm motor impairment in hemiparetic persons. METHODS:In 20 participants at >6 months postonset of a subcortical ischemic stroke and 16 age- and sex-matched healthy controls, the concentrations of N-acetylaspartate and myo-inositol were quantified by proton magnetic resonance spectroscopy. Regions of interest identified by functional magnetic resonance imaging included primary (M1), dorsal premotor (PMd), and supplementary (SMA) motor areas. Relationships between metabolite concentrations and distal (hand) and proximal (shoulder/elbow) motor impairment using Fugl-Meyer Upper Extremity (FMUE) subscores were explored. RESULTS:N-Acetylaspartate was lower in M1 (P = .04) and SMA (P = .004) and myo-inositol was higher in M1 (P = .003) and PMd (P = .03) in the injured (ipsilesional) hemisphere after stroke compared with the left hemisphere in controls. N-Acetylaspartate in ipsilesional M1 was positively correlated with hand FMUE subscores (P = .04). Significant positive correlations were also found between N-acetylaspartate in ipsilesional M1, PMd, and SMA and in contralesional M1 and shoulder/elbow FMUE subscores (P = .02, .01, .02, and .02, respectively). CONCLUSIONS:Our preliminary results demonstrated that proton magnetic resonance spectroscopy is a sensitive method to quantify relevant neuronal changes in spared motor cortex after stroke and consequently increase our knowledge of the factors leading from these changes to arm motor impairment.
journal_name
Neurorehabil Neural Repairjournal_title
Neurorehabilitation and neural repairauthors
Craciunas SC,Brooks WM,Nudo RJ,Popescu EA,Choi IY,Lee P,Yeh HW,Savage CR,Cirstea CMdoi
10.1177/1545968312469835subject
Has Abstractpub_date
2013-06-01 00:00:00pages
411-20issue
5eissn
1545-9683issn
1552-6844pii
1545968312469835journal_volume
27pub_type
杂志文章abstract:OBJECTIVE:This study investigated the course and relationship between investigator-determined and patient-reported level of independence within the first year after spinal cord injury (SCI). The authors examined variables that contributed to these scores. METHODS:In this observational cohort study, 73 patients with tr...
journal_title:Neurorehabilitation and neural repair
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doi:10.1177/1545968311407518
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journal_title:Neurorehabilitation and neural repair
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更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Research has shown that movement impairments following stroke are typically associated with the limb contralateral to the side of the stroke. Prior studies identified ipsilateral motor declines across a variety of tasks. OBJECTIVE:Two experiments were conducted to better understand the ipsilateral contribut...
journal_title:Neurorehabilitation and neural repair
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journal_title:Neurorehabilitation and neural repair
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journal_title:Neurorehabilitation and neural repair
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更新日期:2020-02-01 00:00:00
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更新日期:2008-09-01 00:00:00
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journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
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