Abstract:
BACKGROUND:There is a need to identify reliable biomarkers of spinal cord injury recovery for clinical practice and clinical trials. OBJECTIVE:Our objective was to correlate serum albumin levels with spinal cord injury neurological outcomes. METHODS:We performed a secondary analysis of patients with traumatic spinal cord injury (n = 591) participating in the Sygen clinical trial. Serum albumin concentrations were obtained as part of routine blood chemistry analysis, at trial entry (24-72 hours), 1, 2, and 4 weeks after injury. The primary outcomes were "marked recovery" and lower extremity motor scores, derived from the International Standards for the Neurological Classification of Spinal Cord Injury. Data were analyzed with multivariable logistic and linear regression to adjust for potential confounders. RESULTS:Serum albumin was significantly associated with spinal cord injury neurological outcomes. Higher serum albumin concentrations at 1, 2, and 4 weeks were associated with higher 52-week lower extremity motor score. Similarly, the odds of achieving "marked neurological recovery" was greater for individuals with higher serum albumin concentrations. The association between serum albumin concentrations and neurological outcomes was independent of initial injury severity, treatment with GM-1, and polytrauma. CONCLUSIONS:In spinal cord injury, serum albumin is an independent marker of long-term neurological outcomes. Serum albumin could serve as a feasible biomarker for prognosis at the time of injury and stratification in clinical trials.
journal_name
Neurorehabil Neural Repairjournal_title
Neurorehabilitation and neural repairauthors
Tong B,Jutzeler CR,Cragg JJ,Grassner L,Schwab JM,Casha S,Geisler F,Kramer JLKdoi
10.1177/1545968317746781subject
Has Abstractpub_date
2018-01-01 00:00:00pages
7-17issue
1eissn
1545-9683issn
1552-6844journal_volume
32pub_type
杂志文章abstract::Previous literature has suggested that reflex sympathetic dystrophy, also known as complex regional pain syndrome (CRPS) type 1, is a relatively common finding after a stroke. However, much of this data was obtained before patients routinely received early intensive inpatient rehabilitation. The purpose of this study ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/154596830001400107
更新日期:2000-01-01 00:00:00
abstract::Current assessments do not provide reliable factors predictive of outcome from stroke for stroke survivors of intermediate age and severity of deficit. We sought to investigate whether early rate of functional improvement can facilitate prediction of functional outcome, length of stay, and disposition beyond that affo...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/154596830001400309
更新日期:2000-01-01 00:00:00
abstract::Background. Although dopaminergic medication improves dual task walking in people with Parkinson disease (PD), the underlying neural mechanisms are not yet fully understood. As prefrontal cognitive resources are involved in dual task walking, evaluation of the prefrontal cortex (PFC) is required. Objective. To investi...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968320924430
更新日期:2020-07-01 00:00:00
abstract:OBJECTIVE:Recent reports have indicated that bone marrow stromal cells (BMSCs) have the potential to improve neurological function when transplanted into models of central nervous system (CNS) disorders, including traumatic spinal cord injury. In this study, the authors aimed to clarify the underlying mechanism through...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968308315596
更新日期:2008-09-01 00:00:00
abstract::Background. Mesenchymal stem cell (MSC)-derived exosomes play a critical role in regenerative medicine. Objective. To determine the dose- and time-dependent efficacy of exosomes for treatment of traumatic brain injury (TBI). Methods. Male rats were subjected to a unilateral moderate cortical contusion. In the dose-res...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968320926164
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Several pilot studies have evoked interest in robot-assisted therapy (RAT) in children with cerebral palsy (CP). OBJECTIVE:To assess the effectiveness of RAT in children with CP through a single-blind randomized controlled trial. PATIENTS AND METHODS:Sixteen children with CP were randomized into 2 groups. ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968314541172
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Low-frequency repetitive transcranial magnetic stimulation (rTMS) over the unaffected motor cortex may improve motor function of the paretic hand after stroke. However, low-frequency rTMS might adversely affect bimanual movement by decreasing transcallosal function. OBJECTIVE:The authors investigated whethe...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968311433295
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To examine whether cerebral activity during passive movements decreases with time after stroke, and if reduced activity in the representation for the upper extremity can be reversed with training. METHODS:Brain activity was measured by functional magnetic resonance imaging (fMRI) during passive wrist flexion...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章
doi:10.1177/1545968306296965
更新日期:2007-07-01 00:00:00
abstract::The goal of the present study was to examine factors affecting motor impairment and recovery in a primate model of cortical infarction. Microelectrode stimulation techniques were used to delineate the hand representation in the primary motor cortex (M1). Microinfarcts affecting approximately 30% of the hand representa...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/154596830001400406
更新日期:2000-01-01 00:00:00
abstract::Background. Severe poststroke arm impairment is associated with greater activation of the nonlesioned hemisphere during movement of the affected arm. The circumstances under which this activation may be adaptive or maladaptive remain unclear. Objective. To identify the functional relevance of key lesioned and nonlesio...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968319876253
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:Studies have demonstrated the efficacy of functional electrical stimulation in the management of foot drop after stroke. OBJECTIVE:To compare changes in walking performance with the WalkAide (WA) foot-drop stimulator and a conventional ankle-foot orthosis (AFO). METHODS:Individuals with stroke within the p...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1177/1545968313481278
更新日期:2013-09-01 00:00:00
abstract:BACKGROUND:Our ability to sense movement is essential for motor control; however, the impact of kinesthesia deficits on functional recovery is not well monitored in the spinal cord injury (SCI) population. One problem is the lack of accurate and reliable tools to measure kinesthesia. OBJECTIVE:The purpose of this stud...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968315591703
更新日期:2016-03-01 00:00:00
abstract:BACKGROUND:A recent review showed that no existing instrument measured the entire spectrum of health-related quality of life (HRQOL) in stroke patients. However, the HRQOL in stroke patients (HRQOLISP) questionnaire is valid and exceptionally comprehensive. Founded on a holistic model of human life, it comprises both p...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究
doi:10.1177/1545968310369113
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND:Objective measures of functional walking remain scarce for individuals with incomplete spinal cord injury (ISCI). Hence, the authors developed the Spinal Cord Injury Functional Ambulation Profile (SCI-FAP), which encompasses the timed performance of 7 tasks, such as walking and negotiating obstacles, doors, ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968310381250
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:The assessment of rehabilitation efficacy in spinal cord injury (SCI) should be based on a combination of neurological and functional outcome measures. The Spinal Cord Independence Measure II (SCIM II) is an independence scale that was specifically developed for subjects with SCI. However, little is known ab...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究
doi:10.1177/1545968307306240
更新日期:2008-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This study investigated the relative effects of distributed constraint-induced therapy (CIT) and bilateral arm training (BAT) on motor performance, daily function, functional use of the affected arm, and quality of life in patients with hemiparetic stroke. METHODS:A total of 60 patients were r...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968308328719
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:Ambulating on stairs is an important aspect of daily activities for many individuals with incomplete spinal cord injury (SCI), and little is known about the effect of training for this specific task. OBJECTIVE:The goal of this study was to determine whether staircase ascent training enhances motor recovery ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968310378510
更新日期:2011-01-01 00:00:00
abstract::Objectives. Memory training in combination with practice in semantic structuring and word fluency has been shown to improve memory performance. This study investigated the efficacy of a working memory training combined with exercises in semantic structuring and word fluency and examined whether training effects genera...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968314527352
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The neural correlates of training-induced improvements of cognitive functions after brain damage remain still scarcely understood. In the specific case of aphasia, although several investigations have addressed the issue of the neural substrates of functional recovery, only a few studies have attempted to as...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章
doi:10.1177/1545968306294735
更新日期:2007-03-01 00:00:00
abstract::One in 2 Canadians is expected to acquire cancer in their lifetime. Many cancers, including breast, ovarian, and lung cancer, are treated using taxane chemotherapy with curative intent. A major adverse effect with the use of taxane chemotherapeutic agents is taxane-induced peripheral neuropathy (TIPN). Both positive (...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,评审
doi:10.1177/1545968319860486
更新日期:2019-10-01 00:00:00
abstract::The Motor Status Scale (MSS) measures shoulder, elbow (maximum score = 40), wrist, hand, and finger movements (maximum score = 42), and expands the measurement of upper extremity impairment and disability provided by the Fugl-Meyer (FM) score. This work examines the interrater reliability and criterion validity of the...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章
doi:10.1177/154596830201600306
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Individuals with stroke often sustain bone loss on the hemiparetic side and are prone to fragility fractures. Exercise training may be a viable way to promote bone mineral density (BMD) and geometry in this population. OBJECTIVE:This was a pilot study to evaluate the effects of a 6-month treadmill exercise ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968309353326
更新日期:2010-05-01 00:00:00
abstract::Objective. Stroke recovery is a multidimensional process influenced by biological and psychosocial factors. To understand the latter, we mapped the social networks of stroke patients, analyzing their changes and effects on physical function at 3 and 6 months after stroke. Methods. We used a quantitative social network...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究
doi:10.1177/1545968319872994
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVE:To systematically review the literature with meta-analysis to determine whether persistence of sensorimotor or physiological impairment exists between 4 weeks to 6 months post mild traumatic brain injury (mTBI), and assign level of evidence to findings. METHOD:The databases PubMed, pscyINFO, SPORTdiscus, Med...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,meta分析
doi:10.1177/1545968318760728
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Individuals with unilateral vestibular hypofunction (UVH) alter their movement and reduce mobility to try to stabilize their gaze and avoid symptoms of dizziness and vertigo. OBJECTIVE:To determine if individuals with UVH 6 weeks after surgery demonstrate altered head and trunk kinematics during community a...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968318770271
更新日期:2018-04-01 00:00:00
abstract:PURPOSE:Sarcopenia and increased fat infiltration in muscle may play a role in the functional impairment and high risk for diabetes in stroke. Our purpose was to compare muscle volume and muscle attenuation across 6 muscles of the paretic and nonparetic thigh and examine the relationships between intramuscular fat and ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968311408920
更新日期:2011-11-01 00:00:00
abstract:BACKGROUND:Damage to the callosal motor fibers (CMFs) may affect motor recovery in patients with stroke. However, whether the severity of CMF impairment varies with lesion locations remains unclear. OBJECTIVE:To investigate (1) whether CMF impairment occurs after stroke and whether the impairment varies with lesion lo...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968318779730
更新日期:2018-06-01 00:00:00
abstract::Background. Concussions affect nearly 3 million people a year and are the leading cause of traumatic brain injury-related emergency department visits among youth. Evidence shows neuromotor regions are sensitive to concussive events and that motor symptoms may be the earliest clinical manifestations of neurodegenerativ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968320943578
更新日期:2020-09-01 00:00:00
abstract::Approximately one-third of stroke patients suffer visual field impairment as a result of their strokes. However, studies using the visual pathway as a paradigm for studying poststroke recovery are limited. In this article, we propose that the visual pathway has many features that make it an excellent model system for ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968319827569
更新日期:2019-02-01 00:00:00
abstract:BACKGROUND:A randomized clinical has shown the effectiveness of intramuscular electrical stimulation for the treatment of poststroke shoulder pain. OBJECTIVE:Identify predictors of treatment success and assess the impact of the strongest predictor on outcomes. METHOD:This is a secondary analysis of a multisite random...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1545968306298412
更新日期:2007-11-01 00:00:00