Effects of treatment intensity in upper limb robot-assisted therapy for chronic stroke: a pilot randomized controlled trial.

Abstract:

BACKGROUND AND OBJECTIVES:Robot-assisted therapy (RT) is a current promising intervention in stroke rehabilitation, but more research is warranted for examining its efficacy and the dose-benefit relation. The authors investigated the effects of higher intensity versus lower intensity RT on movements of forearm pronation-supination and wrist flexion-extension relative to conventional rehabilitation (CR) in patients poststroke for a mean of 21 months. METHODS:In this pilot study, 18 patients with initial mean Fugl-Meyer Assessment (FMA) of 37 to 44 for the upper extremity were randomized to higher intensity RT, lower intensity RT, or CR intervention for 4 weeks. The dose of the higher intensity RT was twice the number of repetitions in the lower intensity RT. Outcome measures at pretreatment and posttreatment were administered to patients to evaluate beneficial and adverse effects of interventions. Primary outcomes were the FMA and Medical Research Council scale. RESULTS:There were significant differences in motor function (P = .04) and daily performance (P = .03) among the 3 groups. The higher intensity RT group showed better improvement in motor function, muscle strength, performance of daily activities, and bimanual ability than the other 2 groups. The intensive RT intervention did not induce higher levels of an oxidative DNA biomarker. CONCLUSIONS:Higher intensity of RT that assists forearm and wrist movements may lead to greater improvement in motor ability and functional performance in stroke patients. A sample size of only 20 to 25 in each arm of a larger randomized controlled trial is needed to confirm the findings for similar subjects.

authors

Hsieh YW,Wu CY,Liao WW,Lin KC,Wu KY,Lee CY

doi

10.1177/1545968310394871

subject

Has Abstract

pub_date

2011-07-01 00:00:00

pages

503-11

issue

6

eissn

1545-9683

issn

1552-6844

pii

1545968310394871

journal_volume

25

pub_type

杂志文章,随机对照试验
  • Minimal detectable change and clinically important difference of the Stroke Impact Scale in stroke patients.

    abstract:OBJECTIVES:The purpose of this study was to establish the minimal detectable change (MDC) and clinically important differences (CIDs) of the physical domains of the Stroke Impact Scale (SIS) and to assess the proportions of patients' change scores exceeding the MDC and CIDs after stroke rehabilitation. METHODS:Seventy...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968309356295

    authors: Lin KC,Fu T,Wu CY,Wang YH,Liu JS,Hsieh CJ,Lin SF

    更新日期:2010-06-01 00:00:00

  • Does rTMS Targeting Contralesional S1 Enhance Upper Limb Somatosensory Function in Chronic Stroke? A Proof-of-Principle Study.

    abstract:BACKGROUND:Somatosensory deficits are prevalent after stroke, but effective interventions are limited. Brain stimulation of the contralesional primary somatosensory cortex (S1) is a promising adjunct to peripherally administered rehabilitation therapies. OBJECTIVE:To assess short-term effects of repetitive transcrania...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968321989338

    authors: Pundik S,Skelly M,McCabe J,Akbari H,Tatsuoka C,Plow EB

    更新日期:2021-01-29 00:00:00

  • Assessing Proprioception: A Systematic Review of Possibilities.

    abstract::Proprioception is a vital aspect of motor control and when degraded or lost can have a profound impact on function in diverse clinical populations. This systematic review aimed to identify clinically related tools to measure proprioceptive acuity, to classify the construct(s) underpinning the tools, and to report on t...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,评审

    doi:10.1177/1545968315573055

    authors: Hillier S,Immink M,Thewlis D

    更新日期:2015-11-01 00:00:00

  • Impaired Functional Connectivity Unmasked by Simple Repetitive Motor Task in Early Relapsing-Remitting Multiple Sclerosis.

    abstract:BACKGROUND:Resting brain activity can be modulated by motor tasks to adapt to function. In multiple sclerosis (MS) patients, altered resting-state functional connectivity (RS-FC) has been reported and associated with impaired function and disability; little is known on how RS-FC is modulated by a simple repetitive moto...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968314558600

    authors: Petsas N,Tomassini V,Filippini N,Sbardella E,Tona F,Piattella MC,Pozzilli C,Wise RG,Pantano P

    更新日期:2015-07-01 00:00:00

  • Cortical and spinal excitability changes after robotic gait training in healthy participants.

    abstract:BACKGROUND:Recent studies have proposed a role for robotic gait training in participants with acquired brain injury, but the effects on the excitability of cortical and spinal neurons even in healthy participants are uncertain. OBJECTIVE:To investigate changes in corticospinal excitability in healthy participants afte...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968308317973

    authors: Blicher JU,Nielsen JF

    更新日期:2009-02-01 00:00:00

  • Cerebellar ataxia rehabilitation trial in degenerative cerebellar diseases.

    abstract:OBJECTIVE:To investigate short- and long-term effects of intensive rehabilitation on ataxia, gait, and activities of daily living (ADLs) in patients with degenerative cerebellar disease. METHODS:A total of 42 patients with pure cerebellar degeneration were randomly assigned to the immediate group or the delayed-entry ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968311425918

    authors: Miyai I,Ito M,Hattori N,Mihara M,Hatakenaka M,Yagura H,Sobue G,Nishizawa M,Cerebellar Ataxia Rehabilitation Trialists Collaboration.

    更新日期:2012-06-01 00:00:00

  • History of and Insights Into Spinal Cord Stimulation in Parkinson Disease.

    abstract:BACKGROUND:Current available therapies for Parkinson disease (PD) have strong limitations, and patients usually present with refractory symptoms despite all efforts. Deep brain stimulation (DBS), which has been used in PD patients for decades (since 1987), has best indications for symptoms like tremor, motor fluctuatio...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968320956984

    authors: Garcia BB,Junior ER,Araújo MFP,Simplício H

    更新日期:2020-11-01 00:00:00

  • Defining the role of sensation, strength, and prehension for upper limb function in cervical spinal cord injury.

    abstract:BACKGROUND:Upper limb function plays a significant role in enhancing independence for individuals with tetraplegia. However, there is limited knowledge about the specific input of sensorimotor deficits on upper limb function. Thus the theoretical framework designed to develop the Graded Redefined Assessment of Strength...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968313490998

    authors: Kalsi-Ryan S,Beaton D,Curt A,Duff S,Jiang D,Popovic MR,Rudhe C,Fehlings MG,Verrier MC

    更新日期:2014-01-01 00:00:00

  • How long is the recovery of global aphasia? Twenty-five years of follow-up in a patient with left hemisphere stroke.

    abstract:BACKGROUND:Current knowledge regarding the time course of aphasia recovery is based on observations limited to the first years after stroke. OBJECTIVE:The authors studied long-term outcome (25 years) of language in a patient with global aphasia. METHODS:A 37-year-old man with global aphasia from a large ischemic lesi...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968310368962

    authors: Smania N,Gandolfi M,Aglioti SM,Girardi P,Fiaschi A,Girardi F

    更新日期:2010-11-01 00:00:00

  • Efficacy of short-term FK506 administration on accelerating nerve regeneration.

    abstract:BACKGROUND:The slow rate of nerve regeneration following injury can cause extended muscle denervation, leading to irreversible muscle atrophy, fibrosis, and destruction of motor endplates. The immunosuppressant FK506 (tacrolimus) has been shown to accelerate the rate of nerve regeneration and functional recovery. Howev...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968311431965

    authors: Yan Y,Sun HH,Hunter DA,Mackinnon SE,Johnson PJ

    更新日期:2012-07-01 00:00:00

  • Efficacy of early physical therapy in severe Bell's palsy: a randomized controlled trial.

    abstract:BACKGROUND:Bell's palsy (BP) is the most frequent form of peripheral palsy of the facial nerve. Prognosis for recovery is good for most patients; in the remaining cases, different grades of residual impairment persist. Physical therapy, in association with drug administration, aims to improve outcomes. OBJECTIVE:To as...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968313481280

    authors: Nicastri M,Mancini P,De Seta D,Bertoli G,Prosperini L,Toni D,Inghilleri M,Filipo R

    更新日期:2013-07-01 00:00:00

  • Physiological Cost Index as a proxy measure for the oxygen cost of gait in stroke patients.

    abstract:BACKGROUND:Stroke survivors can exhibit abnormally elevated oxygen consumption during walking. Therapeutic interventions can improve gait deficits and oxygen consumption. A practical measure of oxygen cost is not available. This study tested the usefulness of an indirect index of oxygen cost, the Physiological Cost Ind...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968307300400

    authors: Fredrickson E,Ruff RL,Daly JJ

    更新日期:2007-09-01 00:00:00

  • Interference between cognition, double-limb support, and swing during gait in community-dwelling individuals poststroke.

    abstract:BACKGROUND:Dual tasking can interfere with activity after stroke. OBJECTIVE:The authors examined the interactions between 3 different cognitive tasks and the swing and double-limb support (DLS) components of the gait cycle in community-dwelling individuals poststroke. METHODS:Acquisition of cognitive and gait data we...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968309357926

    authors: Plummer-D'Amato P,Altmann LJ,Behrman AL,Marsiske M

    更新日期:2010-07-01 00:00:00

  • The EXCITE trial: attributes of the Wolf Motor Function Test in patients with subacute stroke.

    abstract::The Wolf Motor Function Test (WMFT) has been used in rehabilitation studies of chronic stroke patients, but until now its psychometric properties have not been evaluated in patients with subacute stroke. Two hundred twenty-nine participants with subacute stroke (3-9 months postinjury) at 7 research sites met inclusion...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968305276663

    authors: Wolf SL,Thompson PA,Morris DM,Rose DK,Winstein CJ,Taub E,Giuliani C,Pearson SL

    更新日期:2005-09-01 00:00:00

  • The estimated cost of managing focal spasticity: a physician practice patterns survey.

    abstract::The purpose of this study was to estimate the overall cost of managing focal spasticity after stroke (CVA) and traumatic brain injury (TBI) and the cost impact of individual treatments. Sixty physicians described management strategies over six treatment visits for four focal spasticity case studies (one upper and one ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/154596830101500108

    authors: Radensky PW,Archer JW,Dournaux SF,O'Brien CF

    更新日期:2001-01-01 00:00:00

  • Using Vision to Study Poststroke Recovery and Test Hypotheses About Neurorehabilitation.

    abstract::Approximately one-third of stroke patients suffer visual field impairment as a result of their strokes. However, studies using the visual pathway as a paradigm for studying poststroke recovery are limited. In this article, we propose that the visual pathway has many features that make it an excellent model system for ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968319827569

    authors: Busza A,Schneider CL,Williams ZR,Mahon BZ,Sahin B

    更新日期:2019-02-01 00:00:00

  • Amount of exercise in the first week after stroke predicts walking speed and unassisted walking.

    abstract:BACKGROUND:Predicting walking outcomes poststroke is a challenge for clinicians. OBJECTIVE:To identify the extent to which exercise dose (repetitions of leg movements) in the first week of a comprehensive stroke unit stay predicts discharge mobility. METHODS:A cohort study was conducted on 200 consecutive people admi...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968312439628

    authors: Scrivener K,Sherrington C,Schurr K

    更新日期:2012-10-01 00:00:00

  • Spatial and Temporal Control Contribute to Step Length Asymmetry During Split-Belt Adaptation and Hemiparetic Gait.

    abstract:BACKGROUND:Step length asymmetry (SLA) is a common hallmark of gait poststroke. Though conventionally viewed as a spatial deficit, SLA can result from differences in where the feet are placed relative to the body (step position strategy), the timing between foot strikes (step time strategy), or the velocity of the body...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968314567149

    authors: Finley JM,Long A,Bastian AJ,Torres-Oviedo G

    更新日期:2015-09-01 00:00:00

  • Effects of Tongue Force Training on Bulbar Motor Function in the Female SOD1-G93A Rat Model of Amyotrophic Lateral Sclerosis.

    abstract:BACKGROUND:The use of exercise in amyotrophic lateral sclerosis (ALS) is controversial. Although moderate exercise appears to be beneficial for limb muscles in ALS, the effects of exercise on bulbar muscles such as the tongue have not been studied. OBJECTIVE:To determine the effects of tongue force training on bulbar ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968316666956

    authors: Ma D,Shuler JM,Kumar A,Stanford QR,Tungtur S,Nishimune H,Stanford JA

    更新日期:2017-02-01 00:00:00

  • Stroke affects locomotor steering responses to changing optic flow directions.

    abstract:BACKGROUND:Stroke patients manifest steering difficulties during walking, which may arise from an altered perception of visual motion. OBJECTIVE:To examine the ability of stroke patients to control their heading direction while walking in a virtual environment (VE) describing translational optic flows (OFs) expanding ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968309355985

    authors: Lamontagne A,Fung J,McFadyen B,Faubert J,Paquette C

    更新日期:2010-06-01 00:00:00

  • Constraint-induced movement therapy during early stroke rehabilitation.

    abstract:BACKGROUND:Limited data are available about the effectiveness of early rehabilitation after stroke. OBJECTIVE:This is the 1st randomized controlled trial of constraint-induced movement therapy (CIMT) in subacute stroke to investigate neurophysiologic mechanisms and long-term outcome. METHODS:Within 2 weeks after stro...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968306291858

    authors: Boake C,Noser EA,Ro T,Baraniuk S,Gaber M,Johnson R,Salmeron ET,Tran TM,Lai JM,Taub E,Moye LA,Grotta JC,Levin HS

    更新日期:2007-01-01 00:00:00

  • Longitudinal analysis of balance confidence in individuals with stroke using a multilevel model for change.

    abstract:BACKGROUND:Confidence about balance may be an important factor affecting self-efficacy for daily activities after stroke. OBJECTIVE:The authors investigated whether confidence changes and the parameters that may predict changes in self-perceived balance within the first year of community reintegration. METHODS:In thi...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968312437941

    authors: Yiu J,Miller WC,Eng JJ,Liu Y

    更新日期:2012-10-01 00:00:00

  • Enhancing the Alignment of the Preclinical and Clinical Stroke Recovery Research Pipeline: Consensus-Based Core Recommendations From the Stroke Recovery and Rehabilitation Roundtable Translational Working Group.

    abstract::Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for the pre-clinical modeling of stroke recovery and for the alignment of pre-clinical studies to clinical trials in stroke recovery. ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 共识发展会议,杂志文章,实务指引

    doi:10.1177/1545968317724285

    authors: Corbett D,Carmichael ST,Murphy TH,Jones TA,Schwab ME,Jolkkonen J,Clarkson AN,Dancause N,Weiloch T,Johansen-Berg H,Nilsson M,McCullough LD,Joy MT

    更新日期:2017-08-01 00:00:00

  • Spaced Noninvasive Brain Stimulation: Prospects for Inducing Long-Lasting Human Cortical Plasticity.

    abstract::Neuroplasticity is critical for learning, memory, and recovery of lost function following neurological damage. Noninvasive brain stimulation (NIBS) techniques can induce neuroplastic changes in the human cortex that are behaviorally relevant, raising the exciting possibility that these techniques might be therapeutica...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968314562649

    authors: Goldsworthy MR,Pitcher JB,Ridding MC

    更新日期:2015-09-01 00:00:00

  • Admission ambulation velocity predicts length of stay and discharge disposition following stroke in an acute rehabilitation hospital.

    abstract:BACKGROUND AND PURPOSE:Poststroke functional outcome and discharge disposition are influenced by age, lesion location and size, severity of neurological insult, prior functional ability, and social support. The effect of admission ambulation velocity on length of stay and discharge disposition has not been previously r...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968304272762

    authors: Rabadi MH,Blau A

    更新日期:2005-03-01 00:00:00

  • The effects of treadmill exercise training on hip bone density and tibial bone geometry in stroke survivors: a pilot study.

    abstract:BACKGROUND:Individuals with stroke often sustain bone loss on the hemiparetic side and are prone to fragility fractures. Exercise training may be a viable way to promote bone mineral density (BMD) and geometry in this population. OBJECTIVE:This was a pilot study to evaluate the effects of a 6-month treadmill exercise ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968309353326

    authors: Pang MY,Lau RW

    更新日期:2010-05-01 00:00:00

  • Neuromechanical Differences Between Successful and Failed Sit-to-Stand Movements and Response to Rehabilitation Early After Stroke.

    abstract:BACKGROUND:Recovery of the sit-to-stand (StS) movement early after stroke could be improved by targeting physical therapy at the underlying movement deficits in those people likely to respond. AIM:To compare the movement characteristics of successful and failed StS movements in people early after stroke and identify w...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/1545968319846119

    authors: Kerr A,Clark A,Pomeroy VM

    更新日期:2019-05-01 00:00:00

  • Potential predictors of motor and functional outcomes after distributed constraint-induced therapy for patients with stroke.

    abstract:BACKGROUND:Selection of patients who are most and least likely to benefit from constraint-induced therapy (CIT) for the upper extremity is uncertain. OBJECTIVE:This study investigated demographic and clinical characteristics that may predict outcomes for a distributed form of CIT. METHODS:A group of 57 patients were ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968308321773

    authors: Lin KC,Huang YH,Hsieh YW,Wu CY

    更新日期:2009-05-01 00:00:00

  • Motor Imagery Training After Stroke Increases Slow-5 Oscillations and Functional Connectivity in the Ipsilesional Inferior Parietal Lobule.

    abstract::Background. Reorganization in motor areas have been suggested after motor imagery training (MIT). However, motor imagery involves a large-scale brain network, in which many regions, andnot only the motor areas, potentially constitute the neural substrate for MIT. Objective. This study aimed to identify the targets for...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968319899919

    authors: Wang X,Wang H,Xiong X,Sun C,Zhu B,Xu Y,Fan M,Tong S,Sun L,Guo X

    更新日期:2020-04-01 00:00:00

  • Abbreviated environmental enrichment enhances neurobehavioral recovery comparably to continuous exposure after traumatic brain injury.

    abstract:BACKGROUND:Environmental enrichment (EE) is a complex living milieu that has been shown to enhance functional recovery versus standard (STD) housing after experimental traumatic brain injury (TBI) and therefore may be considered a rodent correlate of rehabilitation. However, the typical EE paradigm consists of continuo...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968310390520

    authors: de Witt BW,Ehrenberg KM,McAloon RL,Panos AH,Shaw KE,Raghavan PV,Skidmore ER,Kline AE

    更新日期:2011-05-01 00:00:00