Effects of Tongue Force Training on Bulbar Motor Function in the Female SOD1-G93A Rat Model of Amyotrophic Lateral Sclerosis.

Abstract:

BACKGROUND:The use of exercise in amyotrophic lateral sclerosis (ALS) is controversial. Although moderate exercise appears to be beneficial for limb muscles in ALS, the effects of exercise on bulbar muscles such as the tongue have not been studied. OBJECTIVE:To determine the effects of tongue force training on bulbar motor function in the SOD1-G93A rat model of ALS. METHODS:We compared the effects of tongue force training on bulbar motor function and neuromuscular junction innervation in female SOD1-G93A rats and age-matched female wild-type controls. Half of each group underwent afternoon tongue force training sessions, and all rats were tested under minimal force conditions in the mornings. RESULTS:Tongue force did not differ between the SOD1-G93A rats and healthy controls during the morning testing sessions, nor was it affected by training. Surprisingly, decreases in tongue motility, the number of licks per session, and body weight were greater in the tongue force-trained SOD1-G93A rats. Forelimb grip force, survival, and denervation of the genioglossus (GG) muscle did not differ between the trained and untrained SOD1-G93A rats. GG innervation was correlated with changes in tongue force but not tongue motility in SOD1-G93A rats at end stage. CONCLUSIONS:The results indicate a potential deleterious effect of tongue force training on tongue motility in female SOD1-G93A rats. The lack of a relationship between GG innervation and tongue motility suggests that factors other than lower-motor neuron integrity likely accounted for this effect.

authors

Ma D,Shuler JM,Kumar A,Stanford QR,Tungtur S,Nishimune H,Stanford JA

doi

10.1177/1545968316666956

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

147-156

issue

2

eissn

1545-9683

issn

1552-6844

pii

1545968316666956

journal_volume

31

pub_type

杂志文章
  • Targeted aiming movements are compromised in nonaffected limb of persons with stroke.

    abstract:BACKGROUND:Research has shown that movement impairments following stroke are typically associated with the limb contralateral to the side of the stroke. Prior studies identified ipsilateral motor declines across a variety of tasks. OBJECTIVE:Two experiments were conducted to better understand the ipsilateral contribut...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968306297872

    authors: Ketcham CJ,Rodriguez TM,Zihlman KA

    更新日期:2007-09-01 00:00:00

  • Defining the role of sensation, strength, and prehension for upper limb function in cervical spinal cord injury.

    abstract:BACKGROUND:Upper limb function plays a significant role in enhancing independence for individuals with tetraplegia. However, there is limited knowledge about the specific input of sensorimotor deficits on upper limb function. Thus the theoretical framework designed to develop the Graded Redefined Assessment of Strength...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968313490998

    authors: Kalsi-Ryan S,Beaton D,Curt A,Duff S,Jiang D,Popovic MR,Rudhe C,Fehlings MG,Verrier MC

    更新日期:2014-01-01 00:00:00

  • Does functional electrical stimulation for foot drop strengthen corticospinal connections?

    abstract:BACKGROUND:Long-term use of a foot-drop stimulator applying functional electrical stimulation (FES) to the common peroneal nerve improves walking performance even when the stimulator is off. This "therapeutic" effect might result from neuroplastic changes. OBJECTIVE:To determine the effect of long-term use of a foot-d...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 临床试验,杂志文章

    doi:10.1177/1545968309349939

    authors: Everaert DG,Thompson AK,Chong SL,Stein RB

    更新日期:2010-02-01 00:00:00

  • Upper Limb Recovery in Spinal Cord Injury: Involvement of Central and Peripheral Motor Pathways.

    abstract:BACKGROUND AND OBJECTIVE:The course of central and peripheral motor recovery after cervical spinal cord injury (SCI) may be investigated by electrophysiological measures. The goal of this study was to compare the 2 over the first year after injury in relation to motor gains. METHODS:Compound motor action potentials (C...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,多中心研究

    doi:10.1177/1545968316688796

    authors: Petersen JA,Spiess M,Curt A,Weidner N,Rupp R,Abel R,EM-SCI Study Group.,Schubert M

    更新日期:2017-05-01 00:00:00

  • Upper limb robot-assisted therapy in cerebral palsy: a single-blind randomized controlled trial.

    abstract:BACKGROUND:Several pilot studies have evoked interest in robot-assisted therapy (RAT) in children with cerebral palsy (CP). OBJECTIVE:To assess the effectiveness of RAT in children with CP through a single-blind randomized controlled trial. PATIENTS AND METHODS:Sixteen children with CP were randomized into 2 groups. ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968314541172

    authors: Gilliaux M,Renders A,Dispa D,Holvoet D,Sapin J,Dehez B,Detrembleur C,Lejeune TM,Stoquart G

    更新日期:2015-02-01 00:00:00

  • Serum Albumin Predicts Long-Term Neurological Outcomes After Acute Spinal Cord Injury.

    abstract:BACKGROUND:There is a need to identify reliable biomarkers of spinal cord injury recovery for clinical practice and clinical trials. OBJECTIVE:Our objective was to correlate serum albumin levels with spinal cord injury neurological outcomes. METHODS:We performed a secondary analysis of patients with traumatic spinal ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968317746781

    authors: Tong B,Jutzeler CR,Cragg JJ,Grassner L,Schwab JM,Casha S,Geisler F,Kramer JLK

    更新日期:2018-01-01 00:00:00

  • Intramuscular electrical stimulation for shoulder pain in hemiplegia: does time from stroke onset predict treatment success?

    abstract:BACKGROUND:A randomized clinical has shown the effectiveness of intramuscular electrical stimulation for the treatment of poststroke shoulder pain. OBJECTIVE:Identify predictors of treatment success and assess the impact of the strongest predictor on outcomes. METHOD:This is a secondary analysis of a multisite random...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/1545968306298412

    authors: Chae J,Ng A,Yu DT,Kirsteins A,Elovic EP,Flanagan SR,Harvey RL,Zorowitz RD,Fang ZP

    更新日期:2007-11-01 00:00:00

  • Working memory training and semantic structuring improves remembering future events, not past events.

    abstract::Objectives. Memory training in combination with practice in semantic structuring and word fluency has been shown to improve memory performance. This study investigated the efficacy of a working memory training combined with exercises in semantic structuring and word fluency and examined whether training effects genera...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968314527352

    authors: Richter KM,Mödden C,Eling P,Hildebrandt H

    更新日期:2015-01-01 00:00:00

  • Auditory, Phonological, and Semantic Factors in the Recovery From Wernicke's Aphasia Poststroke: Predictive Value and Implications for Rehabilitation.

    abstract::Background. Understanding the factors that influence language recovery in aphasia is important for improving prognosis and treatment. Chronic comprehension impairments in Wernicke's aphasia (WA) are associated with impairments in auditory and phonological processing, compounded by semantic and executive difficulties. ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968319868709

    authors: Robson H,Griffiths TD,Grube M,Woollams AM

    更新日期:2019-10-01 00:00:00

  • Reassessment of the incidence of complex regional pain syndrome type 1 following stroke.

    abstract::Previous literature has suggested that reflex sympathetic dystrophy, also known as complex regional pain syndrome (CRPS) type 1, is a relatively common finding after a stroke. However, much of this data was obtained before patients routinely received early intensive inpatient rehabilitation. The purpose of this study ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/154596830001400107

    authors: Petchkrua W,Weiss DJ,Patel RR

    更新日期:2000-01-01 00:00:00

  • A Critical Evaluation of the Methodological Obstacles to Translating Cell-Based Research Into an Effective Treatment for People With Parkinson's Disease.

    abstract::The remarkable scientific and technological advances in the field of cell research have not been translated into viable restorative therapies for brain disorders. In this article, we examine the best available evidence for the clinical efficacy of reconstructive intracerebral transplantation in people with Parkinson's...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968316635277

    authors: Polgar S,Karimi L,Buultjens M,Morris ME

    更新日期:2016-10-01 00:00:00

  • Effects of constraint-induced therapy versus bilateral arm training on motor performance, daily functions, and quality of life in stroke survivors.

    abstract:BACKGROUND AND OBJECTIVE:This study investigated the relative effects of distributed constraint-induced therapy (CIT) and bilateral arm training (BAT) on motor performance, daily function, functional use of the affected arm, and quality of life in patients with hemiparetic stroke. METHODS:A total of 60 patients were r...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968308328719

    authors: Lin KC,Chang YF,Wu CY,Chen YA

    更新日期:2009-06-01 00:00:00

  • Cortical plasticity in amyotrophic lateral sclerosis: motor imagery and function.

    abstract:BACKGROUND:Cortical networks underlying motor imagery are functionally close to motor performance networks and can be activated by patients with severe motor disabilities. OBJECTIVE:The aim of the study was to examine the longitudinal effect of progressive motoneuron degeneration on cortical representation of motor im...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968307300698

    authors: Lulé D,Diekmann V,Kassubek J,Kurt A,Birbaumer N,Ludolph AC,Kraft E

    更新日期:2007-11-01 00:00:00

  • Pushing the Rehabilitation Boundaries: Hand Motor Impairment Can Be Reduced in Chronic Stroke.

    abstract::Background. Stroke is one of the most common causes of physical disability worldwide. The majority of survivors experience impairment of movement, often with lasting deficits affecting hand dexterity. To date, conventional rehabilitation primarily focuses on training compensatory maneuvers emphasizing goal completion ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968320939563

    authors: Mawase F,Cherry-Allen K,Xu J,Anaya M,Uehara S,Celnik P

    更新日期:2020-08-01 00:00:00

  • Training memory self-efficacy in the chronic stage after stroke: a randomized controlled trial.

    abstract:BACKGROUND:Stroke patients with a low memory self-efficacy (MSE) report more memory complaints than patients with a high MSE. OBJECTIVE:The aim of this study was to examine the effect of a memory-training program on MSE in the chronic phase after stroke and to identify which patients benefit most from the MSE training...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,随机对照试验

    doi:10.1177/1545968312455222

    authors: Aben L,Heijenbrok-Kal MH,van Loon EM,Groet E,Ponds RW,Busschbach JJ,Ribbers GM

    更新日期:2013-02-01 00:00:00

  • Brain-computer interface with language model-electroencephalography fusion for locked-in syndrome.

    abstract:BACKGROUND:Some noninvasive brain-computer interface (BCI) systems are currently available for locked-in syndrome (LIS) but none have incorporated a statistical language model during text generation. OBJECTIVE:To begin to address the communication needs of individuals with LIS using a noninvasive BCI that involves rap...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968313516867

    authors: Oken BS,Orhan U,Roark B,Erdogmus D,Fowler A,Mooney A,Peters B,Miller M,Fried-Oken MB

    更新日期:2014-05-01 00:00:00

  • Prevalence of Walking-Related Motor Fatigue in Persons With Multiple Sclerosis: Decline in Walking Distance Induced by the 6-Minute Walk Test.

    abstract:OBJECTIVE:To investigate the individual occurrence of walking-related motor fatigue in persons with multiple sclerosis (PwMS), according to disability level and disease phenotype.Study design This was a cross-sectional, multinational study.Participants They were 208 PwMS from 11 centers with Expanded Disability Status ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,多中心研究

    doi:10.1177/1545968315597070

    authors: Leone C,Severijns D,Doležalová V,Baert I,Dalgas U,Romberg A,Bethoux F,Gebara B,Santoyo Medina C,Maamâgi H,Rasova K,Maertens de Noordhout B,Knuts K,Skjerbaek A,Jensen E,Wagner JM,Feys P

    更新日期:2016-05-01 00:00:00

  • Rehabilitation of gait speed after stroke: a critical review of intervention approaches.

    abstract:PURPOSE:Walking speed is a cardinal indicator of poststroke gait performance; however, no consensus exists regarding the optimal treatment method(s) for its enhancement. The most widely accepted criterion for establishing the contribution of treatment to walking speed is the gain in speed. The actual speed, however, at...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,评审

    doi:10.1177/1545968308315997

    authors: Dickstein R

    更新日期:2008-11-01 00:00:00

  • Effect of a foot-drop stimulator and ankle-foot orthosis on walking performance after stroke: a multicenter randomized controlled trial.

    abstract:BACKGROUND:Studies have demonstrated the efficacy of functional electrical stimulation in the management of foot drop after stroke. OBJECTIVE:To compare changes in walking performance with the WalkAide (WA) foot-drop stimulator and a conventional ankle-foot orthosis (AFO). METHODS:Individuals with stroke within the p...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1177/1545968313481278

    authors: Everaert DG,Stein RB,Abrams GM,Dromerick AW,Francisco GE,Hafner BJ,Huskey TN,Munin MC,Nolan KJ,Kufta CV

    更新日期:2013-09-01 00:00:00

  • Botulinum Toxin Conditioning Enhances Motor Axon Regeneration in Mouse and Human Preclinical Models.

    abstract:BACKGROUND:Peripheral axon regeneration is improved when the nerve lesion under consideration has recently been preceded by another nerve injury. This is known as the conditioning lesion effect (CLE). While the CLE is one of the most robust and well characterized means to enhance motor axon regeneration in experimental...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968318790020

    authors: Franz CK,Puritz A,Jordan LA,Chow J,Ortega JA,Kiskinis E,Heckman CJ

    更新日期:2018-08-01 00:00:00

  • Mismatch between investigator-determined and patient-reported independence after spinal cord injury: consequences for rehabilitation and trials.

    abstract:OBJECTIVE:This study investigated the course and relationship between investigator-determined and patient-reported level of independence within the first year after spinal cord injury (SCI). The authors examined variables that contributed to these scores. METHODS:In this observational cohort study, 73 patients with tr...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968311407518

    authors: van Hedel HJ,Dokladal P,Hotz-Boendermaker S,EM-SCI Study Group.

    更新日期:2011-11-01 00:00:00

  • Roles of Lesioned and Nonlesioned Hemispheres in Reaching Performance Poststroke.

    abstract::Background. Severe poststroke arm impairment is associated with greater activation of the nonlesioned hemisphere during movement of the affected arm. The circumstances under which this activation may be adaptive or maladaptive remain unclear. Objective. To identify the functional relevance of key lesioned and nonlesio...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968319876253

    authors: Harrington RM,Chan E,Rounds AK,Wutzke CJ,Dromerick AW,Turkeltaub PE,Harris-Love ML

    更新日期:2020-01-01 00:00:00

  • Using Vision to Study Poststroke Recovery and Test Hypotheses About Neurorehabilitation.

    abstract::Approximately one-third of stroke patients suffer visual field impairment as a result of their strokes. However, studies using the visual pathway as a paradigm for studying poststroke recovery are limited. In this article, we propose that the visual pathway has many features that make it an excellent model system for ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968319827569

    authors: Busza A,Schneider CL,Williams ZR,Mahon BZ,Sahin B

    更新日期:2019-02-01 00:00:00

  • Severe degeneration of peripheral motor axons after spinal cord injury: a European multicenter study in 345 patients.

    abstract:OBJECTIVE:There are indications that perilesional and remote peripheral motor axons may degenerate after spinal cord injury (SCI). The authors investigated the magnitude and dependence on severity of SCI of this degeneration as well as whether motor axons so affected can recover. METHODS:The function of the peripheral...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,多中心研究

    doi:10.1177/1545968310368534

    authors: Van De Meent H,Hosman AJ,Hendriks J,Zwarts M,EM-SCI Study Group.,Schubert M

    更新日期:2010-09-01 00:00:00

  • Compensation or Recovery? Altered Kinetics and Neuromuscular Synergies Following High-Intensity Stepping Training Poststroke.

    abstract:BACKGROUND:High-intensity, variable stepping training can improve walking speed in individuals poststroke, although neuromuscular strategies used to achieve faster speeds are unclear. We evaluated changes in joint kinetics and neuromuscular coordination following such training; movement strategies consistent with intac...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968318817825

    authors: Ardestani MM,Kinnaird CR,Henderson CE,Hornby TG

    更新日期:2019-01-01 00:00:00

  • The effects of treadmill exercise training on hip bone density and tibial bone geometry in stroke survivors: a pilot study.

    abstract:BACKGROUND:Individuals with stroke often sustain bone loss on the hemiparetic side and are prone to fragility fractures. Exercise training may be a viable way to promote bone mineral density (BMD) and geometry in this population. OBJECTIVE:This was a pilot study to evaluate the effects of a 6-month treadmill exercise ...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968309353326

    authors: Pang MY,Lau RW

    更新日期:2010-05-01 00:00:00

  • Quantification of Lower Extremity Kinesthesia Deficits Using a Robotic Exoskeleton in People With a Spinal Cord Injury.

    abstract:BACKGROUND:Our ability to sense movement is essential for motor control; however, the impact of kinesthesia deficits on functional recovery is not well monitored in the spinal cord injury (SCI) population. One problem is the lack of accurate and reliable tools to measure kinesthesia. OBJECTIVE:The purpose of this stud...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968315591703

    authors: Chisholm AE,Domingo A,Jeyasurya J,Lam T

    更新日期:2016-03-01 00:00:00

  • How long is the recovery of global aphasia? Twenty-five years of follow-up in a patient with left hemisphere stroke.

    abstract:BACKGROUND:Current knowledge regarding the time course of aphasia recovery is based on observations limited to the first years after stroke. OBJECTIVE:The authors studied long-term outcome (25 years) of language in a patient with global aphasia. METHODS:A 37-year-old man with global aphasia from a large ischemic lesi...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968310368962

    authors: Smania N,Gandolfi M,Aglioti SM,Girardi P,Fiaschi A,Girardi F

    更新日期:2010-11-01 00:00:00

  • Clinical measurement of pharyngeal surface electromyography: exploratory research.

    abstract:BACKGROUND:Dysphagia diagnosis is limited by our inability to evaluate the underlying neuromuscular pathology of swallowing. A novel approach using pharyngeal surface electromyography (PsEMG) has been reported in the literature. OBJECTIVE:Three exploratory projects were undertaken to provide data toward the validation...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章

    doi:10.1177/1545968306293448

    authors: Doeltgen SH,Hofmayer A,Gumbley F,Witte U,Moran C,Carroll G,Huckabee ML

    更新日期:2007-05-01 00:00:00

  • Caregiver-mediated intervention can improve physical functional recovery of patients with chronic stroke: a randomized controlled trial.

    abstract::Background and Purpose. Patients with chronic stroke may benefit from continuing rehabilitation training after hospital discharge. This study examined whether caregiver-mediated, home-based intervention (CHI) could improve physical functioning and social participation in these patients. Methods. A single-blind, random...

    journal_title:Neurorehabilitation and neural repair

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1177/1545968314532030

    authors: Wang TC,Tsai AC,Wang JY,Lin YT,Lin KL,Chen JJ,Lin BY,Lin TC

    更新日期:2015-01-01 00:00:00