Abstract:
BACKGROUND:Fatigue is a debilitating symptom in multiple sclerosis (MS). Previous studies showed no association between fatigue as perceived by the patient and physiological measures of fatigability. OBJECTIVE:The authors investigated associations between perceived fatigue and measures of fatigability after correction for differences in maximal voluntary contraction (MVC). METHODS:A total of 20 people with relapsing-remitting MS with an Extended Disability Severity Score less than 5.5 and 20 healthy controls filled out the Fatigue Severity Score questionnaire of perceived fatigue. The authors obtained the MVC from the first dorsal interosseus muscle, voluntary muscle activation, and force decline during a sustained MVC (124 s, muscle fatigue). RESULTS:Patients perceived increased levels of fatigue compared with controls (P < .001). Although patients and controls developed similar amounts of muscle fatigue during the sustained contraction, a linear regression model that included both muscle fatigue and MVC was positively associated with perceived fatigue in patients only (R (2) = 0.45; P = .01). Voluntary activation during the sustained contraction was negatively associated with perceived fatigue (R (2) = 0.25; P = .02). CONCLUSION:The data indicate that fatigue perceived by MS patients is associated with measures of fatigability. This observation helps in the understanding of mechanisms underlying the increased levels of fatigue perceived by MS patients. These data also emphasize that for comparison of fatigue-related parameters between groups, correction for individual maximal force is essential.
journal_name
Neurorehabil Neural Repairjournal_title
Neurorehabilitation and neural repairauthors
Steens A,de Vries A,Hemmen J,Heersema T,Heerings M,Maurits N,Zijdewind Idoi
10.1177/1545968311416991subject
Has Abstractpub_date
2012-01-01 00:00:00pages
48-57issue
1eissn
1545-9683issn
1552-6844pii
1545968311416991journal_volume
26pub_type
杂志文章abstract:BACKGROUND:Step length asymmetry (SLA) is a common hallmark of gait poststroke. Though conventionally viewed as a spatial deficit, SLA can result from differences in where the feet are placed relative to the body (step position strategy), the timing between foot strikes (step time strategy), or the velocity of the body...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968314567149
更新日期:2015-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Poststroke functional outcome and discharge disposition are influenced by age, lesion location and size, severity of neurological insult, prior functional ability, and social support. The effect of admission ambulation velocity on length of stay and discharge disposition has not been previously r...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968304272762
更新日期:2005-03-01 00:00:00
abstract:BACKGROUND:Motor training alone or combined with transcranial direct current stimulation (tDCS) positioned over the motor cortex (M1) improves motor function in chronic stroke. Currently, understanding of how tDCS influences the process of motor skill learning after stroke is lacking. OBJECTIVE:To assess the effects o...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968318769164
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:A randomized clinical has shown the effectiveness of intramuscular electrical stimulation for the treatment of poststroke shoulder pain. OBJECTIVE:Identify predictors of treatment success and assess the impact of the strongest predictor on outcomes. METHOD:This is a secondary analysis of a multisite random...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1177/1545968306298412
更新日期:2007-11-01 00:00:00
abstract::Approximately one-third of stroke patients suffer visual field impairment as a result of their strokes. However, studies using the visual pathway as a paradigm for studying poststroke recovery are limited. In this article, we propose that the visual pathway has many features that make it an excellent model system for ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968319827569
更新日期:2019-02-01 00:00:00
abstract::Background. Concussions affect nearly 3 million people a year and are the leading cause of traumatic brain injury-related emergency department visits among youth. Evidence shows neuromotor regions are sensitive to concussive events and that motor symptoms may be the earliest clinical manifestations of neurodegenerativ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968320943578
更新日期:2020-09-01 00:00:00
abstract:BACKGROUND:Resting brain activity can be modulated by motor tasks to adapt to function. In multiple sclerosis (MS) patients, altered resting-state functional connectivity (RS-FC) has been reported and associated with impaired function and disability; little is known on how RS-FC is modulated by a simple repetitive moto...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968314558600
更新日期:2015-07-01 00:00:00
abstract::A major problem in neurorehabilitation is the lack of objective outcomes to measure movement quality. Movement quality features, such as coordination and stability, are essential for everyday motor actions. These features allow reacting to continuously changing environment or to resist external perturbations. Neurolog...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968320969936
更新日期:2020-12-01 00:00:00
abstract:OBJECTIVE:To systematically review the literature with meta-analysis to determine whether persistence of sensorimotor or physiological impairment exists between 4 weeks to 6 months post mild traumatic brain injury (mTBI), and assign level of evidence to findings. METHOD:The databases PubMed, pscyINFO, SPORTdiscus, Med...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,meta分析
doi:10.1177/1545968318760728
更新日期:2018-02-01 00:00:00
abstract:BACKGROUND:Although functional imaging and neurophysiological approaches reveal alterations in motor and premotor areas after stroke, insights into neurobiological events underlying these alterations are limited in human studies. OBJECTIVE:We tested whether cerebral metabolites related to neuronal and glial compartmen...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968312469835
更新日期:2013-06-01 00:00:00
abstract:OBJECTIVE:This study investigated the blood lactate accumulation during two wheelchair-racing protocols. During exercise, energy is required, which causes metabolism to increase and blood lactate to accumulate. Proper training can reduce the amount of blood lactate accumulation and increase tolerance to blood lactate a...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/154596830101500306
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Dysphagia diagnosis is limited by our inability to evaluate the underlying neuromuscular pathology of swallowing. A novel approach using pharyngeal surface electromyography (PsEMG) has been reported in the literature. OBJECTIVE:Three exploratory projects were undertaken to provide data toward the validation...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968306293448
更新日期:2007-05-01 00:00:00
abstract:BACKGROUND:Somatosensory deficits are prevalent after stroke, but effective interventions are limited. Brain stimulation of the contralesional primary somatosensory cortex (S1) is a promising adjunct to peripherally administered rehabilitation therapies. OBJECTIVE:To assess short-term effects of repetitive transcrania...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968321989338
更新日期:2021-01-29 00:00:00
abstract:BACKGROUND:Recent studies have proposed a role for robotic gait training in participants with acquired brain injury, but the effects on the excitability of cortical and spinal neurons even in healthy participants are uncertain. OBJECTIVE:To investigate changes in corticospinal excitability in healthy participants afte...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968308317973
更新日期:2009-02-01 00:00:00
abstract::Objectives. Memory training in combination with practice in semantic structuring and word fluency has been shown to improve memory performance. This study investigated the efficacy of a working memory training combined with exercises in semantic structuring and word fluency and examined whether training effects genera...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968314527352
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:Functional magnetic resonance imaging (fMRI) of motor impairment after stroke strongly depends on patient effort and capacity to make a movement. Hence fMRI has had limited use in clinical management. Alternatively, resting-state fMRI (ie, with no task) can elucidate the brain's functional connections by det...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968312457827
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Individuals with stroke often sustain bone loss on the hemiparetic side and are prone to fragility fractures. Exercise training may be a viable way to promote bone mineral density (BMD) and geometry in this population. OBJECTIVE:This was a pilot study to evaluate the effects of a 6-month treadmill exercise ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968309353326
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:Sarcopenia and increased fat infiltration in muscle may play a role in the functional impairment and high risk for diabetes in stroke. Our purpose was to compare muscle volume and muscle attenuation across 6 muscles of the paretic and nonparetic thigh and examine the relationships between intramuscular fat and ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968311408920
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To examine whether cerebral activity during passive movements decreases with time after stroke, and if reduced activity in the representation for the upper extremity can be reversed with training. METHODS:Brain activity was measured by functional magnetic resonance imaging (fMRI) during passive wrist flexion...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章
doi:10.1177/1545968306296965
更新日期:2007-07-01 00:00:00
abstract::Previous literature has suggested that reflex sympathetic dystrophy, also known as complex regional pain syndrome (CRPS) type 1, is a relatively common finding after a stroke. However, much of this data was obtained before patients routinely received early intensive inpatient rehabilitation. The purpose of this study ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/154596830001400107
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:The course of central and peripheral motor recovery after cervical spinal cord injury (SCI) may be investigated by electrophysiological measures. The goal of this study was to compare the 2 over the first year after injury in relation to motor gains. METHODS:Compound motor action potentials (C...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究
doi:10.1177/1545968316688796
更新日期:2017-05-01 00:00:00
abstract:BACKGROUND:Autologous bone marrow mesenchymal cells that include stem cells (MSCs) are a clinically attractive cellular therapy option to try to treat severe spinal cord injury (SCI). OBJECTIVE:To study the possible value of MSCs injected intrathecally to enhance rehabilitation. METHODS:This case control, convenience...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968310369801
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Long-term use of a foot-drop stimulator applying functional electrical stimulation (FES) to the common peroneal nerve improves walking performance even when the stimulator is off. This "therapeutic" effect might result from neuroplastic changes. OBJECTIVE:To determine the effect of long-term use of a foot-d...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章
doi:10.1177/1545968309349939
更新日期:2010-02-01 00:00:00
abstract::Background. Stroke is one of the most common causes of physical disability worldwide. The majority of survivors experience impairment of movement, often with lasting deficits affecting hand dexterity. To date, conventional rehabilitation primarily focuses on training compensatory maneuvers emphasizing goal completion ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968320939563
更新日期:2020-08-01 00:00:00
abstract:BACKGROUND:High-intensity, variable stepping training can improve walking speed in individuals poststroke, although neuromuscular strategies used to achieve faster speeds are unclear. We evaluated changes in joint kinetics and neuromuscular coordination following such training; movement strategies consistent with intac...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968318817825
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:and purpose. Mental practice (MP), which involves cognitive rehearsal of physical movements, is a noninvasive, inexpensive method of enabling repetitive, task-specific practice (RTP). Recent, randomized controlled data suggest that MP, when combined with an RTP therapy program, increases affected arm use and...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章
doi:10.1177/1545968308326427
更新日期:2009-05-01 00:00:00
abstract::The goal of the present study was to examine factors affecting motor impairment and recovery in a primate model of cortical infarction. Microelectrode stimulation techniques were used to delineate the hand representation in the primary motor cortex (M1). Microinfarcts affecting approximately 30% of the hand representa...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/154596830001400406
更新日期:2000-01-01 00:00:00
abstract::Proprioception is a vital aspect of motor control and when degraded or lost can have a profound impact on function in diverse clinical populations. This systematic review aimed to identify clinically related tools to measure proprioceptive acuity, to classify the construct(s) underpinning the tools, and to report on t...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,评审
doi:10.1177/1545968315573055
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Stroke survivors can exhibit abnormally elevated oxygen consumption during walking. Therapeutic interventions can improve gait deficits and oxygen consumption. A practical measure of oxygen cost is not available. This study tested the usefulness of an indirect index of oxygen cost, the Physiological Cost Ind...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968307300400
更新日期:2007-09-01 00:00:00
abstract:BACKGROUND:Cortical networks underlying motor imagery are functionally close to motor performance networks and can be activated by patients with severe motor disabilities. OBJECTIVE:The aim of the study was to examine the longitudinal effect of progressive motoneuron degeneration on cortical representation of motor im...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968307300698
更新日期:2007-11-01 00:00:00