Abstract:
BACKGROUND:Hemiparetic gait following stroke requires substantial energy consumption, which would promote deconditioning and disability. Optimal modalities for decreasing this energy cost remain challenging. Excessive energy consumption, however, seems to be mainly due to extra positive muscle work to substantially lift the body's center of mass (CM) against gravity during the paretic limb swing. OBJECTIVE:The authors tested a new rehabilitation strategy in a pilot study to specifically reduce the energy cost in hemiparetic gait. METHODS:Six chronic hemiparetic patients underwent a 6-week gait training program on a treadmill with real-time feedback of their CM and were asked to reduce its increased vertical displacement. The authors assessed the walking energy cost, vertical CM displacement, kinematics, and electromyogram activity without feedback before and after treatment. RESULTS:After treatment, the vertical CM displacement decreased by 10% (P = .005), particularly when the CM vaulted over the nonparetic limb in stance, and the energy cost decreased markedly by 30% (P = .009). The paretic knee flexion in swing increased concomitantly by 45% and muscle co-contraction decreased significantly in both thigh muscles by 15%. CONCLUSIONS:The rehabilitation approach followed in this study seems remarkably effective in decreasing the walking energy cost. By treating the compensatory strategy (ie, the increased CM displacement), we also appear to treat primary deviations such as poststroke knee impairments, which is novel and complementary to current concepts in rehabilitation. This new approach is promising and merits further investigation.
journal_name
Neurorehabil Neural Repairjournal_title
Neurorehabilitation and neural repairauthors
Massaad F,Lejeune TM,Detrembleur Cdoi
10.1177/1545968309349927subject
Has Abstractpub_date
2010-05-01 00:00:00pages
338-47issue
4eissn
1545-9683issn
1552-6844pii
1545968309349927journal_volume
24pub_type
杂志文章abstract:BACKGROUND:Individuals with stroke often sustain bone loss on the hemiparetic side and are prone to fragility fractures. Exercise training may be a viable way to promote bone mineral density (BMD) and geometry in this population. OBJECTIVE:This was a pilot study to evaluate the effects of a 6-month treadmill exercise ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968309353326
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Confidence about balance may be an important factor affecting self-efficacy for daily activities after stroke. OBJECTIVE:The authors investigated whether confidence changes and the parameters that may predict changes in self-perceived balance within the first year of community reintegration. METHODS:In thi...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968312437941
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:Step length asymmetry (SLA) is a common hallmark of gait poststroke. Though conventionally viewed as a spatial deficit, SLA can result from differences in where the feet are placed relative to the body (step position strategy), the timing between foot strikes (step time strategy), or the velocity of the body...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968314567149
更新日期:2015-09-01 00:00:00
abstract::Stroke recovery research involves distinct biological and clinical targets compared to the study of acute stroke. Guidelines are proposed for the pre-clinical modeling of stroke recovery and for the alignment of pre-clinical studies to clinical trials in stroke recovery. ...
journal_title:Neurorehabilitation and neural repair
pub_type: 共识发展会议,杂志文章,实务指引
doi:10.1177/1545968317724285
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:There is growing interest in the use of D-amphetamine (D-AMPH) as a pharmacological treatment to supplement rehabilitative therapy following stroke. Based on the success of earlier animal models, several clinical studies have demonstrated beneficial effects of applying physical rehabilitation while stroke pa...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968306290773
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:Current knowledge regarding the time course of aphasia recovery is based on observations limited to the first years after stroke. OBJECTIVE:The authors studied long-term outcome (25 years) of language in a patient with global aphasia. METHODS:A 37-year-old man with global aphasia from a large ischemic lesi...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968310368962
更新日期:2010-11-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:This study investigated the relative effects of distributed constraint-induced therapy (CIT) and bilateral arm training (BAT) on motor performance, daily function, functional use of the affected arm, and quality of life in patients with hemiparetic stroke. METHODS:A total of 60 patients were r...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968308328719
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:To investigate the individual occurrence of walking-related motor fatigue in persons with multiple sclerosis (PwMS), according to disability level and disease phenotype.Study design This was a cross-sectional, multinational study.Participants They were 208 PwMS from 11 centers with Expanded Disability Status ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究
doi:10.1177/1545968315597070
更新日期:2016-05-01 00:00:00
abstract::The remarkable scientific and technological advances in the field of cell research have not been translated into viable restorative therapies for brain disorders. In this article, we examine the best available evidence for the clinical efficacy of reconstructive intracerebral transplantation in people with Parkinson's...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968316635277
更新日期:2016-10-01 00:00:00
abstract:BACKGROUND:There is a need to identify reliable biomarkers of spinal cord injury recovery for clinical practice and clinical trials. OBJECTIVE:Our objective was to correlate serum albumin levels with spinal cord injury neurological outcomes. METHODS:We performed a secondary analysis of patients with traumatic spinal ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968317746781
更新日期:2018-01-01 00:00:00
abstract:PURPOSE:Impaired economy of gait, prevalent in chronic stroke secondary to residual gait deficits, is associated with intolerance for performing activities of daily living. Gait economy/efficiency is traditionally assessed by determining the rate of oxygen consumption during submaximal treadmill walking. However, the m...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968313497103
更新日期:2013-11-01 00:00:00
abstract:BACKGROUND:The slow rate of nerve regeneration following injury can cause extended muscle denervation, leading to irreversible muscle atrophy, fibrosis, and destruction of motor endplates. The immunosuppressant FK506 (tacrolimus) has been shown to accelerate the rate of nerve regeneration and functional recovery. Howev...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968311431965
更新日期:2012-07-01 00:00:00
abstract::Background. Motoneuron loss is a severe medical problem that can result in loss of motor control and eventually death. We have previously demonstrated that partial motoneuron loss can result in dendritic atrophy and functional deficits in nearby surviving motoneurons, and that treatment with androgens can be neuroprot...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968319860485
更新日期:2019-08-01 00:00:00
abstract:BACKGROUND:Long-term use of a foot-drop stimulator applying functional electrical stimulation (FES) to the common peroneal nerve improves walking performance even when the stimulator is off. This "therapeutic" effect might result from neuroplastic changes. OBJECTIVE:To determine the effect of long-term use of a foot-d...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章
doi:10.1177/1545968309349939
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:Peripheral axon regeneration is improved when the nerve lesion under consideration has recently been preceded by another nerve injury. This is known as the conditioning lesion effect (CLE). While the CLE is one of the most robust and well characterized means to enhance motor axon regeneration in experimental...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968318790020
更新日期:2018-08-01 00:00:00
abstract:BACKGROUND:Predicting walking outcomes poststroke is a challenge for clinicians. OBJECTIVE:To identify the extent to which exercise dose (repetitions of leg movements) in the first week of a comprehensive stroke unit stay predicts discharge mobility. METHODS:A cohort study was conducted on 200 consecutive people admi...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968312439628
更新日期:2012-10-01 00:00:00
abstract:BACKGROUND:In clinical trials, behavioral outcomes and physiological measures of activity-dependent plasticity that evolve with task-oriented therapies may fail to reach statistical significance. When significant, clinical effectiveness may not be robust enough to alter professional practices. OBJECTIVE:Provide the co...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968305281892
更新日期:2005-12-01 00:00:00
abstract:BACKGROUND:Damage to the callosal motor fibers (CMFs) may affect motor recovery in patients with stroke. However, whether the severity of CMF impairment varies with lesion locations remains unclear. OBJECTIVE:To investigate (1) whether CMF impairment occurs after stroke and whether the impairment varies with lesion lo...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968318779730
更新日期:2018-06-01 00:00:00
abstract::The Motor Status Scale (MSS) measures shoulder, elbow (maximum score = 40), wrist, hand, and finger movements (maximum score = 42), and expands the measurement of upper extremity impairment and disability provided by the Fugl-Meyer (FM) score. This work examines the interrater reliability and criterion validity of the...
journal_title:Neurorehabilitation and neural repair
pub_type: 临床试验,杂志文章
doi:10.1177/154596830201600306
更新日期:2002-09-01 00:00:00
abstract:BACKGROUND:Motor training alone or combined with transcranial direct current stimulation (tDCS) positioned over the motor cortex (M1) improves motor function in chronic stroke. Currently, understanding of how tDCS influences the process of motor skill learning after stroke is lacking. OBJECTIVE:To assess the effects o...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968318769164
更新日期:2018-04-01 00:00:00
abstract:BACKGROUND:A randomized clinical has shown the effectiveness of intramuscular electrical stimulation for the treatment of poststroke shoulder pain. OBJECTIVE:Identify predictors of treatment success and assess the impact of the strongest predictor on outcomes. METHOD:This is a secondary analysis of a multisite random...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2007-11-01 00:00:00
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journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968316666956
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Functional neuroimaging studies show adaptive changes in areas adjacent and distant from the stroke. This longitudinal study assessed whether changes in cortical excitability in affected and unaffected motor areas after acute stroke correlates with functional and motor recovery. METHODS:We studied 13 patien...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968307313505
更新日期:2008-07-01 00:00:00
abstract:BACKGROUND:Perception of sound in the absence of an external auditory source is called tinnitus, which may negatively affect quality of life. Anodal transcranial direct current stimulation (tDCS) of the left temporoparietal area (LTA) was explored for tinnitus relief. OBJECTIVE:This pilot study examined tDCS dose (cur...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968312459908
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Community-dwelling, chronic stroke survivors are at risk of falling during turning and are more likely to sustain a hip fracture when they fall. OBJECTIVE:This study quantifies kinematic differences between stroke survivors (mean +/- SD: 38.3 +/- 31.3 months post-stroke, 59.9 +/- 10.1 years of age), with (n...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968309348508
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:. Mental practice through motor imagery improves subsequent motor performance and thus mental training is considered to be a potential tool in neuromotor rehabilitation. OBJECTIVE:. The authors investigated whether a circadian fluctuation of the motor imagery process occurs, which could be relevant in sched...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968308321775
更新日期:2009-03-01 00:00:00
abstract:BACKGROUND:Stroke patients with a low memory self-efficacy (MSE) report more memory complaints than patients with a high MSE. OBJECTIVE:The aim of this study was to examine the effect of a memory-training program on MSE in the chronic phase after stroke and to identify which patients benefit most from the MSE training...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章,随机对照试验
doi:10.1177/1545968312455222
更新日期:2013-02-01 00:00:00
abstract:BACKGROUND:Selection of patients who are most and least likely to benefit from constraint-induced therapy (CIT) for the upper extremity is uncertain. OBJECTIVE:This study investigated demographic and clinical characteristics that may predict outcomes for a distributed form of CIT. METHODS:A group of 57 patients were ...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968308321773
更新日期:2009-05-01 00:00:00
abstract::Current assessments do not provide reliable factors predictive of outcome from stroke for stroke survivors of intermediate age and severity of deficit. We sought to investigate whether early rate of functional improvement can facilitate prediction of functional outcome, length of stay, and disposition beyond that affo...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/154596830001400309
更新日期:2000-01-01 00:00:00
abstract:BACKGROUND:Conventional methods of rehabilitation in patients with chronic, severe motor impairments after stroke usually do not lessen paresis. OBJECTIVE:A novel therapeutic approach (assisted movement with enhanced sensation [AMES]) was employed in a medical device phase I clinical trial to reduce paresis and spasti...
journal_title:Neurorehabilitation and neural repair
pub_type: 杂志文章
doi:10.1177/1545968308317437
更新日期:2009-01-01 00:00:00