Liver-specific expression of the mouse alpha-fetoprotein gene is mediated by cis-acting DNA elements.

abstract：:Replication-competent viruses, such as Vaccinia virus (VACV), are powerful tools for the development of oncolytic viral therapies and elicit superior immune responses when used as vaccine and immunotherapeutic vectors. However, severe complications from uncontrolled viral replication can occur, particularly in immunoc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Grigg P,Titong A,Jones LA,Yilma TD,Verardi PH

更新日期：2013-09-17 00:00:00

abstract：:Incommensurate charge order in hole-doped oxides is intertwined with exotic phenomena such as colossal magnetoresistance, high-temperature superconductivity, and electronic nematicity. Here, we map, at atomic resolution, the nature of incommensurate charge-lattice order in a manganite using scanning transmission elect...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： El Baggari I,Savitzky BH,Admasu AS,Kim J,Cheong SW,Hovden R,Kourkoutis LF

更新日期：2018-02-13 00:00:00

abstract：:We recently showed that culture-derived metacyclic trypomastigotes (CMT), but not epimastigotes (Epi), of the Miranda 88 strain of Trypanosoma cruzi evade lysis by the human alternative complement pathway because of inefficient binding of factor B to complement component C3b on the parasite surface. These results sugg...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rimoldi MT,Sher A,Heiny S,Lituchy A,Hammer CH,Joiner K

更新日期：1988-01-01 00:00:00

abstract：:The v-jun oncogene encodes a nuclear DNA binding protein that functions as a transcription factor and is part of the activator protein 1 complex. Oncogenic transformation by v-jun is thought to be mediated by the aberrant expression of specific target genes. To identify such Jun-regulated genes and to explore the mech...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kruse U,Iacovoni JS,Goller ME,Vogt PK

更新日期：1997-11-11 00:00:00

abstract：:Promoters whose temporal activity can be directly manipulated in transgenic animals provide a tool for the study of gene functions in vivo. We have evaluated a tetracycline-responsive binary system for its ability to temporally control gene expression in transgenic mice. In this system, a tetracycline-controlled trans...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Furth PA,St Onge L,Böger H,Gruss P,Gossen M,Kistner A,Bujard H,Hennighausen L

更新日期：1994-09-27 00:00:00

abstract：:We have shown that 3-nitropropionate, an isoelectronic analogue of succinate, is a suicide inactivator of succinate dehydrogenase [succinate:(acceptor) oxidoreductase, EC 1.3.99.1] as follows. (i) When rat liver mitochondria oxidize succinate in the presence of 3-nitropropionate carbanion, the rate of O(2) consumption...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Alston TA,Mela L,Bright HJ

更新日期：1977-09-01 00:00:00

abstract：:Commercial hydrogen production by electrocatalytic water splitting will benefit from the realization of more efficient and less expensive catalysts compared with noble metal catalysts, especially for the oxygen evolution reaction, which requires a current density of 500 mA/cm2 at an overpotential below 300 mV with lon...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou H,Yu F,Sun J,He R,Chen S,Chu CW,Ren Z

更新日期：2017-05-30 00:00:00

abstract：:Protocell models are used to investigate how cells might have first assembled on Earth. Some, like oil-in-water droplets, can be seemingly simple models, while able to exhibit complex and unpredictable behaviors. How such simple oil-in-water systems can come together to yield complex and life-like behaviors remains a ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Points LJ,Taylor JW,Grizou J,Donkers K,Cronin L

更新日期：2018-01-30 00:00:00

abstract：:We have analyzed the cell cycle regulation of human cyclin-dependent kinase 2 (CDK2), a protein closely related to the cell cycle-regulatory protein kinase CDC2. We find that CDK2 activity, like that of CDC2, oscillates during the cell cycle in cultured mammalian fibroblasts. Unlike CDC2 activity (which peaks during m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Rosenblatt J,Gu Y,Morgan DO

更新日期：1992-04-01 00:00:00

abstract：:An understanding of the division of labor in different societies, and especially how it evolved in the human species, is fundamental to most analyses of social, political, and economic systems. The ability to reconstruct how labor was organized, however, especially in ancient societies that left behind few material re...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kantner J,McKinney D,Pierson M,Wester S

更新日期：2019-06-18 00:00:00

abstract：:Guanosine 3':5'-cyclic monophosphate (cGMP) increased 7-fold in rat pineal glands incubated in the presence of l-norepinephrine. This response consisted of two components-one was stereospecific and inhibited by alpha-adrenergic antagonists while the other was not stereospecific and not readily inhibited by antagonists...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Dea RF,Zatz M

更新日期：1976-10-01 00:00:00

abstract：:Adult-born granule cells in the dentate gyrus of the rodent hippocampus are important for memory formation and mood regulation, but the cellular mechanism underlying their polarized development, a process critical for their incorporation into functional circuits, remains unknown. We found that deletion of the serine-t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang W,She L,Chang XY,Yang RR,Wang L,Ji HB,Jiao JW,Poo MM

更新日期：2014-01-07 00:00:00

abstract：:We study static and dynamical properties that distinguish 2D crystals constrained to lie on a curved substrate from their flat-space counterparts. A generic mechanism of dislocation unbinding in the presence of varying Gaussian curvature is presented in the context of a model surface amenable to full analytical treatm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vitelli V,Lucks JB,Nelson DR

更新日期：2006-08-15 00:00:00

abstract：:In mammals, toxic electrolytes of endogenous and exogenous origin are excreted through the urine and bile. Before excretion, these compounds cross numerous cellular membranes in a transporter-mediated manner. However, the protein transporters involved in the final excretion step are poorly understood. Here, we show th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Otsuka M,Matsumoto T,Morimoto R,Arioka S,Omote H,Moriyama Y

更新日期：2005-12-13 00:00:00

abstract：:The four core histones (H2A, H2B, H3, and H4) and DNA were assembled into nucleosome-like particles at physiological ionic strengths either by an extract of chromatin rich in nicking-closing activity or by the purified nicking-closing enzyme itself. When histone-DNA complexes were assembled in vitro from relaxed circu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Germond JE,Rouvière-Yaniv J,Yaniv M,Brutlag D

更新日期：1979-08-01 00:00:00

abstract：:Polycomb group genes (PcGs) have been implicated in cancer based on altered levels of expression observed in certain tumors and the behavior of cultured cells containing inserted PcG transgenes. Endometrial stromal tumors provide evidence for a direct causal relationship because they contain several chromosomal transl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li H,Ma X,Wang J,Koontz J,Nucci M,Sklar J

更新日期：2007-12-11 00:00:00

abstract：:The relative importance of local ecological and larger-scale historical processes in causing differences in species richness across the globe remains keenly debated. To gain insight into these questions, we investigated the assembly of plant diversity in the Cerrado in South America, the world's most species-rich trop...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Simon MF,Grether R,de Queiroz LP,Skema C,Pennington RT,Hughes CE

更新日期：2009-12-01 00:00:00

abstract：:We have generated a transgenic mouse line by microinjection of a chimeric DNA fragment (KER-CAT) containing a hair-specific, murine ultra-high-sulfur keratin promoter (KER) fused to the coding region of the bacterial chloramphenicol acetyltransferase (CAT) gene. A 671-base pair (bp) stretch of the 5' promoter region w...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McNab AR,Andrus P,Wagner TE,Buhl AE,Waldon DJ,Kawabe TT,Rea TJ,Groppi V,Vogeli G

更新日期：1990-09-01 00:00:00

abstract：:In all but the poorest countries of South Asia and Africa, the supply and quality of food will rise to meet the demand. Biotechnology, accelerated by genomics, will create wealth for both producers and consumers by reducing the cost and increasing the quality of food. Famine and malnutrition in the poorest countries m...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Briggs SP

更新日期：1998-03-03 00:00:00

abstract：:Neural crest stem cells arise within the central nervous system but then undergo an epithelial-to-mesenchymal transition to migrate away and contribute to the peripheral nervous system and craniofacial skeleton. Here we show that DNA methyltransferase 3B (DNMT3B) is responsible for the loss of competence of dorsal neu...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hu N,Strobl-Mazzulla PH,Simoes-Costa M,Sánchez-Vásquez E,Bronner ME

更新日期：2014-12-16 00:00:00

abstract：:RNA-dependent RNA polymerases (RdRps) of the Nidovirales (Coronaviridae, Arteriviridae, and 12 other families) are linked to an amino-terminal (N-terminal) domain, called NiRAN, in a nonstructural protein (nsp) that is released from polyprotein 1ab by the viral main protease (Mpro). Previously, self-GMPylation/UMPylat...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Slanina H,Madhugiri R,Bylapudi G,Schultheiß K,Karl N,Gulyaeva A,Gorbalenya AE,Linne U,Ziebuhr J

更新日期：2021-02-09 00:00:00

abstract：:Age-related hearing loss and noise-induced hearing loss are major causes of human morbidity. Here we used genetics and functional studies to show that a shared cause of these disorders may be loss of function of the ATP-gated P2X(2) receptor (ligand-gated ion channel, purinergic receptor 2) that is expressed in sensor...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yan D,Zhu Y,Walsh T,Xie D,Yuan H,Sirmaci A,Fujikawa T,Wong AC,Loh TL,Du L,Grati M,Vlajkovic SM,Blanton S,Ryan AF,Chen ZY,Thorne PR,Kachar B,Tekin M,Zhao HB,Housley GD,King MC,Liu XZ

更新日期：2013-02-05 00:00:00

abstract：:High-resolution mapping of cofactor-specific photochemistry in photosynthetic reaction centers (RCs) from Rhodobacter sphaeroides was achieved by polarization selective ultrafast spectroscopy in single crystals at cryogenic temperature. By exploiting the fixed orientation of cofactors within crystals, we isolated a si...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang L,Ponomarenko N,Wiederrecht GP,Tiede DM

更新日期：2012-03-27 00:00:00

abstract：:Eukaryotic transcriptional activators may function by stimulating formation of RNA polymerase II preinitiation complexes at the core promoter of genes. In this case, their mode of action will intrinsically depend on how these complexes assemble on promoters in living cells, an issue that remains largely unexplored. He...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gonzalez-Couto E,Klages N,Strubin M

更新日期：1997-07-22 00:00:00

abstract：:Teratocarcinoma is a germ-line carcinoma giving rise to an embryoid tumor with structures derived from the three embryonic layers: mesoderm, endoderm, and ectoderm. Teratocarcinoma is widely used as an in vitro model system to study regulation of cell determination and differentiation during mammalian embryogenesis. M...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Trojan J,Johnson TR,Rudin SD,Blossey BK,Kelley KM,Shevelev A,Abdul-Karim FW,Anthony DD,Tykocinski ML,Ilan J

更新日期：1994-06-21 00:00:00

abstract：:Synthesis of mouse metallothionein (MT)-I and MT-II is transcriptionally induced by the synthetic glucocorticoid, dexamethasone (DEX) or both in vivo as well as in numerous cell lines. However, the location(s) of a glucocorticoid response element (GRE) has not been described. The observation that a marked MT-I gene, a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kelly EJ,Sandgren EP,Brinster RL,Palmiter RD

更新日期：1997-09-16 00:00:00

abstract：:The Ediacara biota include macroscopic, morphologically complex soft-bodied organisms that appear globally in the late Ediacaran Period (575-542 Ma). The physiology, feeding strategies, and functional morphology of the modular Ediacara organisms (rangeomorphs and erniettomorphs) remain debated but are critical for und...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Laflamme M,Xiao S,Kowalewski M

更新日期：2009-08-25 00:00:00

abstract：:Elucidation of mechanisms that regulate hematopoietic stem cell self-renewal and differentiation would be facilitated by the identification of defined culture conditions that allow these cells to be amplified. We now demonstrate a significant net increase (3-fold, P < 0.001) in vitro of cells that are individually abl...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Miller CL,Eaves CJ

更新日期：1997-12-09 00:00:00

abstract：:Binding of carbon monoxide and oxygen to sterically protected heme model compounds (basket-handle porphyrins) was investigated in liquid toluene at temperatures from 180 to 300 K by laser flash photolysis. Only a single exponential rebinding process from the solvent could be seen in the time range of 20 nsec to millis...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tetreau C,Lavalette D,Momenteau M,Lhoste JM

更新日期：1987-04-01 00:00:00

abstract：:GLQ223 is a highly purified, formulated preparation of trichosanthin, a 26-kDa plant-derived ribosome-inactivating protein with potent inhibitory activity against human immunodeficiency virus (HIV) in vitro. The compound produced concentration-dependent inhibition of HIV replication in acutely infected cultures of T-l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McGrath MS,Hwang KM,Caldwell SE,Gaston I,Luk KC,Wu P,Ng VL,Crowe S,Daniels J,Marsh J

更新日期：1989-04-01 00:00:00