Reconstructing sexual divisions of labor from fingerprints on Ancestral Puebloan pottery.

abstract：:Untargeted metabolomics of environmental samples routinely detects thousands of small molecules, the vast majority of which cannot be identified. Meta-mass shift chemical (MeMSChem) profiling was developed to identify mass differences between related molecules using molecular networks. This approach illuminates metabo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Hartmann AC,Petras D,Quinn RA,Protsyuk I,Archer FI,Ransome E,Williams GJ,Bailey BA,Vermeij MJA,Alexandrov T,Dorrestein PC,Rohwer FL

更新日期：2017-10-31 00:00:00

abstract：:The immune defense against viral infections involves cytotoxic T lymphocytes that recognize viral products in the context of class I major histocompatibility complex (MHC) antigens. To evade such immune surveillance viruses may have evolved various strategies to manipulate the expression of class I antigens. Adenoviru...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Pääbo S,Nilsson T,Peterson PA

更新日期：1986-12-01 00:00:00

abstract：:The mammalian gastrointestinal tract harbors thousands of bacterial species that include symbionts as well as potential pathogens. The immune responses that limit access of these bacteria to underlying tissue remain poorly defined. Here we show that γδ intraepithelial lymphocytes (γδ IEL) of the small intestine produc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ismail AS,Severson KM,Vaishnava S,Behrendt CL,Yu X,Benjamin JL,Ruhn KA,Hou B,DeFranco AL,Yarovinsky F,Hooper LV

更新日期：2011-05-24 00:00:00

abstract：:Flowering time (FT) is the developmental transition coupling an internal genetic program with external local and seasonal climate cues. The genetic loci sensitive to predictable environmental signals underlie local adaptation. We dissected natural variation in FT across a new global diversity set of 473 unique accessi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Huang Y,Bergelson J,Nordborg M,Borevitz JO

更新日期：2010-12-07 00:00:00

abstract：:Curcumin (Cur) is a naturally occurring anticancer drug isolated from the Curcuma longa plant. It is known to exhibit anticancer properties via inhibiting the STAT3 phosphorylation process. However, its poor water solubility and low bioavailability impede its clinical application. Herein, we used organoplatinum(II) ← ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Datta S,Misra SK,Saha ML,Lahiri N,Louie J,Pan D,Stang PJ

更新日期：2018-08-07 00:00:00

abstract：:Mesothelin is a differentiation antigen present on the surface of ovarian cancers, mesotheliomas, and several other types of human cancers. Because among normal tissues, mesothelin is present only on mesothelial cells, it represents a good target for antibody-mediated delivery of cytotoxic agents. In the present study...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chowdhury PS,Viner JL,Beers R,Pastan I

更新日期：1998-01-20 00:00:00

abstract：:The 5'-phosphoinositol phosphatase SHIP negatively regulates signaling pathways triggered by antigen, cytokine and Fc receptors in both lymphocytes and myeloid cells. Mice with germ-line (null) deletion of SHIP develop a myeloproliferative-like syndrome that causes early lethality. Lymphocyte anomalies have been obser...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Tarasenko T,Kole HK,Chi AW,Mentink-Kane MM,Wynn TA,Bolland S

更新日期：2007-07-03 00:00:00

abstract：:FIP-3 (14.7K interacting protein) was discovered during a search for cell proteins that could interact with an adenovirus protein (Ad E3-14.7K) that had been shown to prevent tumor necrosis factor (TNF)-alpha-induced cytolysis. FIP-3, which contains leucine zippers and a zinc finger domain, inhibits both basal and ind...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li Y,Kang J,Friedman J,Tarassishin L,Ye J,Kovalenko A,Wallach D,Horwitz MS

更新日期：1999-02-02 00:00:00

abstract：:There is considerable interest in engineering plant cell wall components, particularly lignin, to improve forage quality and biomass properties for processing to fuels and bioproducts. However, modifying lignin content and/or composition in transgenic plants through down-regulation of lignin biosynthetic enzymes can i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gallego-Giraldo L,Liu C,Pose-Albacete S,Pattathil S,Peralta AG,Young J,Westpheling J,Hahn MG,Rao X,Knox JP,De Meester B,Boerjan W,Dixon RA

更新日期：2020-02-11 00:00:00

abstract：:We present data that demonstrate that three MR elements isolated from wild populations of Drosophila melanogaster on two continents can cause large deletions of the X chromosome in males. The deleted chromosomes, termed mini-X chromosomes, are induced at a frequency of approximately 1:4000 in chromosomes that are init...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Green MM,Yamamoto MT,Miklos GL

更新日期：1987-07-01 00:00:00

abstract：:The GTPase-activating protein (GAP) has been postulated to function either as a negative regulator or as a possible target protein of Ras in mammalian cells and Xenopus oocytes. Ras must be localized in the plasma membrane of vertebrate cells to function, but GAP is localized in the cytosol. To test whether Ras functi...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Gibbs JB,Schaber MD,Schofield TL,Scolnick EM,Sigal IS

更新日期：1989-09-01 00:00:00

abstract：:An acetone extract of chloroplast particles, when layered on an aqueous surface, exhibited light-dependent phosphorylation. Studies with the firefly-tail enzyme assay, as well as with (32)P-labeled inorganic phosphate, show an initial release of adenosine triphosphate (a step that is apparently only light-triggered), ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： McPhee J,Brody SS

更新日期：1973-01-01 00:00:00

abstract：:Rat liver polysomal RNA was translated in the rabbit reticulocyte lysate and in the wheat germ cell-free protein-synthesizing systems, using [(35)S]methionine as label. The catalase (hydrogen-peroxide:hydrogen-peroxide oxidoreductase, EC 1.11.1.6) that was synthesized was isolated by immunoprecipitation and characteri...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Robbi M,Lazarow PB

更新日期：1978-09-01 00:00:00

abstract：:As the most prototypical G protein-coupled receptor, beta-adrenergic receptor (betaAR) regulates the pace and strength of heart beating by enhancing and synchronizing L-type channel (LCC) Ca(2+) influx, which in turn elicits greater sarcoplasmic reticulum (SR) Ca(2+) release flux via ryanodine receptors (RyRs). Howeve...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhou P,Zhao YT,Guo YB,Xu SM,Bai SH,Lakatta EG,Cheng H,Hao XM,Wang SQ

更新日期：2009-10-20 00:00:00

abstract：:Reduced intake of nutrients [calorie restriction (CR)] extends longevity in organisms ranging from yeast to mammals. Mutations affecting somatotropic, insulin, or homologous signaling pathways can increase life span in worms, flies, and mice, and there is considerable evidence that reduced secretion of insulin-like gr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Bonkowski MS,Rocha JS,Masternak MM,Al Regaiey KA,Bartke A

更新日期：2006-05-16 00:00:00

abstract：:DG42 is one of the main mRNAs expressed during gastrulation in embryos of Xenopus laevis. Here we demonstrate that cells expressing this mRNA synthesize hyaluronan. The cloned DG42 cDNA was expressed in rabbit kidney (RK13) and human osteosarcoma (tk-) cells using a vaccinia virus system. Lysates prepared from infecte...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Meyer MF,Kreil G

更新日期：1996-05-14 00:00:00

abstract：:The p53 tumor-suppressor protein is a critical mediator of cellular growth arrest and the induction of apoptosis. To identify proteins involved in the modulation of p53 transcriptional activity, a gain-of-function cellular screen was carried out with an arrayed matrix of approximately 20,000 cDNAs. Nine genes previous...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Huang Q,Raya A,DeJesus P,Chao SH,Quon KC,Caldwell JS,Chanda SK,Izpisua-Belmonte JC,Schultz PG

更新日期：2004-03-09 00:00:00

abstract：:A cardinal symptom of major depressive disorder (MDD) is the disruption of circadian patterns. However, to date, there is no direct evidence of circadian clock dysregulation in the brains of patients who have MDD. Circadian rhythmicity of gene expression has been observed in animals and peripheral human tissues, but i...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li JZ,Bunney BG,Meng F,Hagenauer MH,Walsh DM,Vawter MP,Evans SJ,Choudary PV,Cartagena P,Barchas JD,Schatzberg AF,Jones EG,Myers RM,Watson SJ Jr,Akil H,Bunney WE

更新日期：2013-06-11 00:00:00

abstract：:Critical to the maintenance of circadian rhythmicity is the cyclic expression of at least some components of the central oscillator. High-amplitude cycling of mRNA and protein abundance, protein phosphorylation and nuclear/cytoplasmic shuttling have all been implicated in the maintenance of circadian period. Here we u...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim WY,Geng R,Somers DE

更新日期：2003-04-15 00:00:00

abstract：:Early embryos of many organisms develop outside the mother and are immediately confronted with myriads of potential colonizers. How these naive developmental stages control and shape the bacterial colonization is largely unknown. Here we show that early embryonic stages of the basal metazoan Hydra are able to control ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fraune S,Augustin R,Anton-Erxleben F,Wittlieb J,Gelhaus C,Klimovich VB,Samoilovich MP,Bosch TC

更新日期：2010-10-19 00:00:00

abstract：:Rapamycin is a potent immunosuppressant that blocks the G1/S transition in antigen-activated T cells and in yeast. The similar effects of rapamycin in animal cells and yeast suggest that the biochemical steps affected by rapamycin are conserved. Using a two-hybrid system we isolated mammalian clones that interact with...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Chiu MI,Katz H,Berlin V

更新日期：1994-12-20 00:00:00

abstract：:The mechanism by which cells recognize and complete replicated regions at their precise doubling point must be remarkably efficient, occurring thousands of times per cell division along the chromosomes of humans. However, this process remains poorly understood. Here we show that, in Escherichia coli, the completion of...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Wendel BM,Courcelle CT,Courcelle J

更新日期：2014-11-18 00:00:00

abstract：:NY-ESO-1 is a "cancer-testis" antigen frequently expressed in epithelial ovarian cancer (EOC) and is among the most immunogenic tumor antigens defined to date. In an effort to understand in vivo tolerance mechanisms, we assessed the phenotype and function of NY-ESO-1-specific CD8(+) T cells derived from peripheral blo...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Matsuzaki J,Gnjatic S,Mhawech-Fauceglia P,Beck A,Miller A,Tsuji T,Eppolito C,Qian F,Lele S,Shrikant P,Old LJ,Odunsi K

更新日期：2010-04-27 00:00:00

abstract：:Environmental cues modulate a variety of intracellular pathways whose signaling is integrated by the molecular mechanism that constitutes the circadian clock. Although the essential gears of the circadian machinery have been elucidated, very little is known about the signaling systems regulating it. Here, we report th...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yujnovsky I,Hirayama J,Doi M,Borrelli E,Sassone-Corsi P

更新日期：2006-04-18 00:00:00

abstract：:The molecular mechanism of desensitization of soluble guanylyl cyclase (sGC), the NO receptor, has long remained unresolved. Posttranslational modification and redox state have been postulated to affect sGC sensitivity to NO but evidence has been lacking. We now show that sGC can be S-nitrosylated in primary aortic sm...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sayed N,Baskaran P,Ma X,van den Akker F,Beuve A

更新日期：2007-07-24 00:00:00

abstract：:In the nervous system, glucocorticosteroid hormones play a major role during development and adult life. Myelin-forming cells are among the targets of glucocorticosteroids, which have been shown to promote myelination both in the central and peripheral nervous system. Glucocorticosteroid-stimulated gene transcription ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fonte C,Grenier J,Trousson A,Chauchereau A,Lahuna O,Baulieu EE,Schumacher M,Massaad C

更新日期：2005-10-04 00:00:00

abstract：:Glyoxalase I forms part of the glyoxalase pathway that detoxifies reactive aldehydes such as methylglyoxal, using the spontaneously formed glutathione hemithioacetal as substrate. All known eukaryotic enzymes contain zinc as their metal cofactor, whereas the Escherichia coli glyoxalase I contains nickel. Database mini...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Vickers TJ,Greig N,Fairlamb AH

更新日期：2004-09-07 00:00:00

abstract：:Major histocompatibility complex (MHC) class II molecules displayed clustered patterns at the surfaces of T (HUT-102B2) and B (JY) lymphoma cells characterized by interreceptor distances in the micrometer range as detected by scanning force microscopy of immunogold-labeled antigens. Electron microscopy revealed that a...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jenei A,Varga S,Bene L,Mátyus L,Bodnár A,Bacsó Z,Pieri C,Gáspár R Jr,Farkas T,Damjanovich S

更新日期：1997-07-08 00:00:00

abstract：:The genetic basis for virulence in influenza virus is largely unknown. To explore the mutational basis for increased virulence in the lung, the H3N2 prototype clinical isolate, A/HK/1/68, was adapted to the mouse. Genomic sequencing provided the first demonstration, to our knowledge, that a group of 11 mutations can c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Brown EG,Liu H,Kit LC,Baird S,Nesrallah M

更新日期：2001-06-05 00:00:00

abstract：:Tyr-SV40E transgenic mice are susceptible to melanoma due to simian virus 40 oncogenic sequences specifically expressed in pigment cells. Skin melanomas form relatively late. Therefore, melanocyte cell lines have been established from very young transgenic animals, when they showed no skin lesions, so that the spontan...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Larue L,Dougherty N,Mintz B

更新日期：1992-10-15 00:00:00