Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation.

abstract：:Export of LDL-derived cholesterol from lysosomes requires the cooperation of the integral membrane protein Niemann-Pick C1 (NPC1) and a soluble protein, Niemann-Pick C2 (NPC2). Mutations in the genes encoding these proteins lead to Niemann-Pick disease type C (NPC). NPC2 binds to NPC1's second (middle), lumenally orie...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Li X,Saha P,Li J,Blobel G,Pfeffer SR

更新日期：2016-09-06 00:00:00

abstract：:This work describes the rational design, synthesis, and study of a ligand that selectively complexes CUG repeats in RNA (and CTG repeats in DNA) with high nanomolar affinity. This sequence is considered a causative agent of myotonic dystrophy type 1 (DM1) because of its ability to sequester muscleblind-like (MBNL) pro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Arambula JF,Ramisetty SR,Baranger AM,Zimmerman SC

更新日期：2009-09-22 00:00:00

abstract：:Highly purified preparations of trp repressor (TrpR) protein derived from Escherichia coli strains that were engineered to overexpress this material were found to contain another protein, of 21 kDa. The second protein, designated WrbA [for tryptophan (W) repressor-binding protein] remained associated with its namesake...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Yang W,Ni L,Somerville RL

更新日期：1993-06-15 00:00:00

abstract：:The small heat-shock protein (sHSP) from Methanococcus jannaschii (Mj HSP16.5) forms a homomeric complex of 24 subunits and has an overall structure of a multiwindowed hollow sphere with an external diameter of approximately 120 A and an internal diameter of approximately 65 A with six square "windows" of approximatel...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kim R,Lai L,Lee HH,Cheong GW,Kim KK,Wu Z,Yokota H,Marqusee S,Kim SH

更新日期：2003-07-08 00:00:00

abstract：:The lipid monogalactosyl diacylglycerol (MGD) is a major structural component of photosynthetic membranes in chloroplasts. Its formation is catalyzed by the enzyme MGD synthase. In many plants, MGD derives from two different biosynthetic pathways: the prokaryotic pathway, which operates entirely within the plastid, an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jarvis P,Dörmann P,Peto CA,Lutes J,Benning C,Chory J

更新日期：2000-07-05 00:00:00

abstract：:Optimization of hydride transfer (HT) catalysts to enhance rates and selectivities of (photo)electroreduction reactions could be a crucial component of a sustainable chemical industry. Here, we analyze how ring functionalization of the adsorbed transient intermediate 2-pyridinide (2-PyH-*)-predicted to form in situ fr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu S,Carter EA

更新日期：2019-11-12 00:00:00

abstract：:Old Italian violins are routinely credited with playing qualities supposedly unobtainable in new instruments. These qualities include the ability to project their sound more effectively in a concert hall-despite seeming relatively quiet under the ear of the player-compared with new violins. Although researchers have l...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fritz C,Curtin J,Poitevineau J,Tao FC

更新日期：2017-05-23 00:00:00

abstract：:The fungus, Phycomyces blakesleeanus, shows many well-defined responses to a number of external stimuli. Genetic analysis shows that at least eight genes are involved in Phycomyces sensory transduction. As a first step toward the molecular analysis of these genes and their products, we have developed a transformation ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Revuelta JL,Jayaram M

更新日期：1986-10-01 00:00:00

abstract：:We extend and apply theories of filled foam elasticity and failure to recently available data on foods. The predictions of elastic modulus and failure mode dependence on internal pressure and on wall integrity are borne out by photographic evidence of distortion and failure under compressive loading and under the loca...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Warner M,Thiel BL,Donald AM

更新日期：2000-02-15 00:00:00

abstract：:Previous studies have shown that defective virus vectors (amplicons) derived from herpes simplex viruses could be efficiently propagated in virus stocks in the presence of trans-acting helper virus functions. The present study established that two separate cis-acting functions--a DNA replication origin and a cleavage/...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Spaete RR,Frenkel N

更新日期：1985-02-01 00:00:00

abstract：:Barth, Larsen, and others showed that complex submanifolds of complex projective space, CP(N), of small codimension strongly resemble CP(N) both homotopically and cohomologically. These results are generalized to yield analogous results for complex subspaces of arbitrary homogeneous complex manifolds. One very special...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sommese AJ

更新日期：1977-04-01 00:00:00

abstract：:The parathyroid hormone 2 (PTH2) receptor's anatomical distribution suggests that, among other functions, it may be involved in modulation of nociception. We localized PTH2 receptor protein to spinal cord lamina II and showed that it is synthesized by subpopulations of primary sensory neurons and intrinsic spinal cord...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Dobolyi A,Ueda H,Uchida H,Palkovits M,Usdin TB

更新日期：2002-02-05 00:00:00

abstract：:Cell-based therapies are attractive for revascularizing and regenerating tissues and organs, but clinical trials of endothelial progenitor cell transplantation have not resulted in consistent benefit. We propose a different approach in which a material delivery system is used to create a depot of vascular progenitor c...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Silva EA,Kim ES,Kong HJ,Mooney DJ

更新日期：2008-09-23 00:00:00

abstract：:cDNAs representing the alpha subunit of polyomavirus enhancer binding protein 2 (PEBP2; also called PEA2) were isolated. The products of the cDNAs are highly homologous to that of Drosophila segmentation gene runt (run) for an N-proximal 128-amino acid region showing 66% identity. The run homology region encompasses t...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Ogawa E,Maruyama M,Kagoshima H,Inuzuka M,Lu J,Satake M,Shigesada K,Ito Y

更新日期：1993-07-15 00:00:00

abstract：:We have synthesized 175-nucleotide-long probes for the DNA of human histocompatibility antigens HLA-DR alpha and beta by extending on poly(A)+ mRNA from B-cell lines with short synthetic deoxyribonucleotide primers complementary to the predicted nucleotide sequence of the NH2 terminus of both polypeptides. The synthes...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Das HK,Biro PA,Cohen SN,Erlich HA,von Gabain A,Lawrance SK,Lemaux PG,McDevitt HO,Peterlin BM,Schulz MF,Sood AK,Weissman SM

更新日期：1983-03-01 00:00:00

abstract：:Transcriptional repression via methylation of histone H3 lysine 27 (H3K27) by the polycomb repressive complex 2 (PRC2) is conserved in higher eukaryotes. The Arabidopsis PRC2 controls homeotic gene expression, flowering time, and gene imprinting. Although downstream target genes and the regulatory mechanism of PRC2 ar...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Jeong CW,Roh H,Dang TV,Choi YD,Fischer RL,Lee JS,Choi Y

更新日期：2011-05-10 00:00:00

abstract：:Ras is a guanine nucleotide-binding protein that cycles between inactive GDP-bound and active GTP-bound states to regulate a diverse array of cellular processes, including cell growth, apoptosis, and differentiation. The guanine nucleotide-bound state of Ras is tightly maintained by regulatory factors to promote regul...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Williams JG,Pappu K,Campbell SL

更新日期：2003-05-27 00:00:00

abstract：:Lon (or La) is a soluble, homooligomeric ATP-dependent protease. Mass determination and cryoelectron microscopy of pure mitochondrial Lon from Saccharomyces cerevisiae identify Lon as a flexible ring-shaped heptamer. In the presence of ATP or 5'-adenylylimidodiphosphate, most of the rings are symmetric and resemble ot...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Stahlberg H,Kutejová E,Suda K,Wolpensinger B,Lustig A,Schatz G,Engel A,Suzuki CK

更新日期：1999-06-08 00:00:00

abstract：:We have examined whether dissociation of the histone octamer is required for elongation of RNA transcripts through arrays of nucleosome cores in vitro. Control or dimethyl suberimidate-crosslinked histone octamers were reconstituted onto supercoiled, closed circular pT207-18 DNA, which contains tandemly repeated 207-b...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： O'Neill TE,Smith JG,Bradbury EM

更新日期：1993-07-01 00:00:00

abstract：:The prefrontal cortex (PFC) is assumed to contribute to goal-directed episodic encoding by exerting cognitive control on medial temporal lobe (MTL) memory processes. However, it is thus far unclear to what extent the contribution of PFC-MTL interactions to memory manifests at a structural anatomical level. We combined...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Schott BH,Niklas C,Kaufmann J,Bodammer NC,Machts J,Schütze H,Düzel E

更新日期：2011-03-29 00:00:00

abstract：:Herpesvirus entry into cells requires the coordinated action of multiple virus envelope glycoproteins, including gH, gL, and gB. For EBV, the gp42 protein assembles into complexes with gHgL heterodimers and binds HLA class II to activate gB-mediated membrane fusion with B cells. EBV tropism is dictated by gp42 levels ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Sathiyamoorthy K,Jiang J,Möhl BS,Chen J,Zhou ZH,Longnecker R,Jardetzky TS

更新日期：2017-10-10 00:00:00

abstract：:Vibrational modes in mechanical resonators provide a promising candidate to interface and manipulate classical and quantum information. The observation of coherent dynamics between distant mechanical resonators can be a key step toward scalable phonon-based applications. Here we report tunable coherent phonon dynamics...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Zhang ZZ,Song XX,Luo G,Su ZJ,Wang KL,Cao G,Li HO,Xiao M,Guo GC,Tian L,Deng GW,Guo GP

更新日期：2020-03-17 00:00:00

abstract：:Carney-Stratakis syndrome, an inherited condition predisposing affected individuals to gastrointestinal stromal tumor (GIST) and paraganglioma, is caused by germline mutations in succinate dehydrogenase (SDH) subunits B, C, or D, leading to dysfunction of complex II of the electron transport chain. We evaluated the ro...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Janeway KA,Kim SY,Lodish M,Nosé V,Rustin P,Gaal J,Dahia PL,Liegl B,Ball ER,Raygada M,Lai AH,Kelly L,Hornick JL,NIH Pediatric and Wild-Type GIST Clinic.,O'Sullivan M,de Krijger RR,Dinjens WN,Demetri GD,Antonescu CR,F

更新日期：2011-01-04 00:00:00

abstract：:The amyloid beta-protein precursor (AbetaPP) is best known as the parent molecule to the amyloid beta-peptide that accumulates in the brains of patients with Alzheimer's disease. Secreted isoforms of AbetaPP that contain the Kunitz proteinase inhibitor domain are analogous to the previously identified cell-secreted pr...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Xu F,Davis J,Miao J,Previti ML,Romanov G,Ziegler K,Van Nostrand WE

更新日期：2005-12-13 00:00:00

abstract：:Food avoidance learning in the mollusc Pleurobranchaea entails reduction in the responsiveness of key brain interneurons in the feeding neural circuitry, the paracerebral feeding command interneurons (PCNs), to the neurotransmitter acetylcholine (AcCho). Food stimuli applied to the oral veil of an untrained animal dep...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Morielli AD,Matera EM,Kovac MP,Shrum RG,McCormack KJ,Davis WJ

更新日期：1986-06-01 00:00:00

abstract：:In response to hypoxia the hypoxia-inducible factor-1 (HIF-1) mediates transcriptional activation of a network of genes encoding erythropoietin, vascular endothelial growth factor, and several glycolytic enzymes. HIF-1 consists of a heterodimer of two basic helix-loop-helix PAS (Per/Arnt/Sim) proteins, HIF-1alpha and ...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Kallio PJ,Pongratz I,Gradin K,McGuire J,Poellinger L

更新日期：1997-05-27 00:00:00

abstract：:Protein database searches frequently can reveal biologically significant sequence relationships useful in understanding structure and function. Weak but meaningful sequence patterns can be obscured, however, by other similarities due only to chance. By searching a database for multiple as opposed to pairwise alignment...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Altschul SF,Lipman DJ

更新日期：1990-07-01 00:00:00

abstract：:Bacteriophage Mu replicates as a transposable element, exploiting host enzymes to promote initiation of DNA synthesis. The phage-encoded transposase MuA, assembled into an oligomeric transpososome, promotes transfer of Mu ends to target DNA, creating a fork at each end, and then remains tightly bound to both forks. In...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Nakai H,Doseeva V,Jones JM

更新日期：2001-07-17 00:00:00

abstract：:A coarse-grained model for protein-folding dynamics is introduced based on a discretized representation of torsional modes. The model, based on the Ramachandran map of the local torsional potential surface and the class (hydrophobic/polar/neutral) of each residue, recognizes patterns of both torsional conformations an...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Fernández A,Kostov K,Berry RS

更新日期：1999-11-09 00:00:00

abstract：:Mycobacterium abscessus (Mabs) is a rapidly growing Mycobacterium and an emerging pathogen in humans. Transitioning from a smooth (S) high-glycopeptidolipid (GPL) producer to a rough (R) low-GPL producer is associated with increased virulence in zebrafish, which involves the formation of massive serpentine cords, absc...

journal_title：Proceedings of the National Academy of Sciences of the United States of America

authors： Halloum I,Carrère-Kremer S,Blaise M,Viljoen A,Bernut A,Le Moigne V,Vilchèze C,Guérardel Y,Lutfalla G,Herrmann JL,Jacobs WR Jr,Kremer L

更新日期：2016-07-19 00:00:00