Qualitative and quantitative variables that affect the potency of Fc- mediated effector function in vitro and in vivo: considerations for passive immunization using non-neutralizing antibodies.

abstract：:Over the past 10 years substantial progress has been made in the implementation of prevention of mother-to-child transmission of HIV (PMTCT) interventions in Sub-Saharan Africa (SSA). In spite of this, new pediatric infections remain unacceptably high, contributing the majority (>90%) of the estimated 390,000 infectio...

journal_title：Current HIV research

authors： Aizire J,Fowler MG,Coovadia HM

更新日期：2013-03-01 00:00:00

abstract：:Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in mo...

journal_title：Current HIV research

authors： Jarvis GA,Chang TL

更新日期：2012-04-01 00:00:00

abstract：:Recently, a mechanism of negative regulation of immune responses by a specialized population of so-called regulatory T cells (Tregs) has become a focus of intense investigation. Through the discovery of transcription factor Foxp3 as a central molecular determinant of Tregs differentiation and function, the complex bio...

journal_title：Current HIV research

authors： Bernardes SS,Borges IK,Lima JE,Milanez Pde A,Conchon-Costa I,Felipe I,Saridakis HO,Watanabe MA

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND:Over the years, numerous studies have been carried out demonstrating the role of antibodies in HIV control leading to the development of antibody-based therapeutic and prophylactic strategies. OBJECTIVE:The objective of this review is to provide updated information on the role of antibodies in the preventio...

journal_title：Current HIV research

authors： Fabra-Garcia A,Beltran C,Sanchez-Merino V,Yuste E

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Whether HIV-positive injecting drug users (IDUs) are at higher risk of developing drug resistance mutations (DRMs) after methadone maintenance therapy (MMT) than any other HIV-positive population is unclear. OBJECTIVE:To compare the incidence of new DRMs in two population groups: antiretroviraltreatment (AR...

journal_title：Current HIV research

authors： Huang C,Ye L,Abdullah AS,Liang B,Jiang J,Ning C,Zang N,Zhang Y,Yang Y,Hu X,Yang Q,Luo C,Lao F,Liu H,Liang H,Huang J

更新日期：2020-01-01 00:00:00

abstract：:To assess the correlation between HIV-1 RNA load in blood and semen by antiretroviral therapy status and the relative penetration of antiretroviral drugs in seminal plasma. We performed a cross-sectional cohort study of 119 HIV-1 subjects divided into three groups according to treatment status. Blood and semen were co...

journal_title：Current HIV research

authors： Chan DJ,Ray JE,McNally L,Batterham M,Smith DE

更新日期：2008-09-01 00:00:00

abstract：:While significant progress has been made since 2003 when a comprehensive treatment, prevention and control program was implemented to combat the HIV/AIDS epidemic in China, new challenges are emerging. There have been limited direct case reports on profiles of HIV/AIDS patients under care at unique clinical settings i...

journal_title：Current HIV research

authors： Jiao Y,Zhang T,Wang S,Liu Q,Zhou H,Lu S,Wu H

更新日期：2010-10-01 00:00:00

abstract：:Although hepatitis B serology screening has been recommended for HIV care, it has not been routinely performed. We aimed to assess compliance and timing of hepatitis B serology screening among HIV-infected patients in a resource-limited setting. A cross-sectional study was conducted in Thailand. Compliance, timing of ...

journal_title：Current HIV research

authors： Kiertiburanakul S,Chotiprasitsakul D,Atamasirikul K,Sungkanuparph S

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:A vaccine able to elicit broadly neutralizing antibodies capable of blocking infection by global viruses has not been achieved, and remains a key public health challenge. OBJECTIVE:During infection, a robust strain-specific neutralizing response develops in most people, but only a subset of infected people ...

journal_title：Current HIV research

authors： Moore PL

更新日期：2018-01-01 00:00:00

abstract：:In HIV-1, tRNA(Lys3) serves as the primer for reverse transcriptase, and during viral assembly, the tRNA(Lys) isoacceptors, tRNA(Lys1,2) and tRNA(Lys3), are selectively packaged into the virion. In this review, we shall first discuss the evidence for the formation of a tRNA(Lys) packaging complex, whose components inc...

journal_title：Current HIV research

authors： Kleiman L,Halwani R,Javanbakht H

更新日期：2004-04-01 00:00:00

abstract：BACKGROUND:Genetic variations in Human leukocyte antigen C (HLA-C), Zinc ribbon domain containing 1 (ZNRD1) and its antisense RNA (ZNRD1-AS1) genes are known to influence the HIV-1 replication and disease progression. OBJECTIVE AND METHOD:We evaluated the distribution of HLA-C (rs10484554, rs9264942) and ZNRD1 (rs8321...

journal_title：Current HIV research

authors： Celerino da Silva R,Moura RR,Victor Campos Coelho A,Arraes LC,Brandão LAC,Crovella S,Lima Guimarães R

更新日期：2017-01-01 00:00:00

abstract：:The HIV epidemic has resulted in medical, social and economic consequences. There is general agreement that a safe, effective and affordable preventive HIV vaccine is urgently needed to control the epidemic. To date, over 60 phase I/II trials of about 30 candidate vaccines have been conducted worldwide. In 1991, Thail...

journal_title：Current HIV research

authors： Pitisuttithum P

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Non-alcoholic Fatty Liver Disease (NAFLD) is common in HIV-infected individuals. Liver biopsy remains the gold-standard procedure for the diagnosis of liver fibrosis, but both Transient Elastography (TE) and Non-invasive Biomarkers (NIBMs) have emerged as alternatives. OBJECTIVES:Our study's aim was to vali...

journal_title：Current HIV research

authors： Androutsakos T,Schina M,Pouliakis A,Kontos A,Sipsas N,Hatzis G

更新日期：2019-01-01 00:00:00

abstract：:AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of terminal diseases to that of treatable chronic illnesses, its long-term therapeutic success may be co...

journal_title：Current HIV research

authors： Zeinalipour-Loizidou E,Nicolaou C,Nicolaides A,Kostrikis LG

更新日期：2007-07-01 00:00:00

abstract：:Premature immunosenescence has been reported in different HIV scenarios. However, how premature is the HIV-related immunosenescent phenotype is still unknown. Thus, the aim of this study was to analyze the immunosenescent status of young viraemic naive HIV-infected individuals, with less than four years from infection...

journal_title：Current HIV research

authors： Ferrando-Martínez S,Ruiz-Mateos E,Romero-Sánchez MC,Muñoz-Fernández MÁ,Viciana P,Genebat M,Leal M

更新日期：2011-07-01 00:00:00

abstract：:Interleukin 7 (IL7) is a critical factor for lymphocyte homeostasis. A dysfunction of the IL7/IL7R pathway has previously been described in HIV-1 infection, and promising results were observed in recent analyses of IL7 for therapeutic use in HIV infected individuals. However, further investigations are still warranted...

journal_title：Current HIV research

authors： Limou S,Melica G,Coulonges C,Lelièvre JD,Do H,McGinn S,Gut IG,Lévy Y,Zagury JF

更新日期：2012-03-01 00:00:00

abstract：BACKGROUND:China has implemented a nation-wide policy to control mother-to-child transmission (MTCT) of the human immunodeficiency virus (HIV) since 2011, yet the efficacy of the control policy is less studied. The aim of the present study was to report the data in the prevention of MTCT of HIV in Nantong city, China. ...

journal_title：Current HIV research

authors： Lou H,Ge X,Xu B,Liu W,Zhou YH

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:HIV lipodystrophy is characterised by abnormal adipose tissue distribution and metabolism, as a result of altered adipocyte function and gene expression. The protease inhibitor ritonavir is associated with the development of lipodystrophy. Quantifying changes in adipogenic gene expression in the presence of r...

journal_title：Current HIV research

authors： Loonam CR,O'Dell SD,Sharp PA,Mullen A

更新日期：2016-01-01 00:00:00

abstract：:Superinfection is defined as infection by a second virus during an immunologic steady state, following infection by a primary virus. It is now well established that superinfection with HIV-1 occurs in humans. Detection of an increasing number of circulating recombinant forms, which result from infection of a cell by t...

journal_title：Current HIV research

authors： Chan DJ

更新日期：2004-07-01 00:00:00

abstract：:Antiretroviral drug therapy has significantly improved the prognosis and life expectancy of people living with HIV over the years. But this progress comes with an important caveat that antiretroviral regimens generally require adherence to life-long, daily dosing, to keep viral multiplication under check. Non-adherenc...

journal_title：Current HIV research

authors： Labh R,Gupta R

更新日期：2020-08-23 00:00:00

abstract：:After the infusion of HIV-1 virus into a host cell, RNA is reverse transcribed to dsDNA, which persists intracellular to the infected cell in a variety of forms. Numerous in-house assays have been developed for the quantification of the different cellular HIV-1 DNA forms; these implement conventional or real-time PCR ...

journal_title：Current HIV research

authors： Beloukas A,Paraskevis D,Psichogiou M,Hatzakis A

更新日期：2009-05-01 00:00:00

abstract：:Enteroaggregative Escherichia coli (EAEC) have been isolated from both HIV-positive and non-HIV diarrheal samples. In this study a collection of 18 isolates from these two groups were compared for biofilm formation and antibiotic resistance and for the presence of 14 virulence-related genes. All the HIV-positive and o...

journal_title：Current HIV research

authors： Jafari A,Shafaei E,Oloomi M,Aghasadeghi MR,Bouzari S

更新日期：2013-12-01 00:00:00

abstract：PURPOSE:Switch to unboosted atazanavir (ATV) is an attractive option due to convenience and tolerability in HIV-positive patients. With limited available data we investigated the determinants of long-term efficacy and the consequences of virological failure of unboosted atazanavir-based regimens. METHODS:Retrospective...

journal_title：Current HIV research

authors： Bonora S,Calcagno A,Vigano O,Bigliano P,Marinaro L,Colella E,Orofino G,Trentini L,Tettoni MC,D'Avolio A,Mercadante S,Galli M,Di Perri G,Rusconi S

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:HIV-1+ long-term nonprogressors (LTNPs) maintain natural control of viral infection. This study sought to identify and characterize HIV- LTNPs series case, regarding the presence of possible host factors that may be associated with this status. METHODS:We evaluated the plasma levels of IP-10/IL-8 chemokines...

journal_title：Current HIV research

authors： Dos Santos JS,de Almeida SM,Ferreira GS,Bordignon J,Maia Teixeira SL,Martins Lima AC,Raboni SM

更新日期：2017-01-01 00:00:00

abstract：:Natural or experimental infection of the African sooty mangabey (SM) with the simian immunodeficiency virus (SIV) results in chronic high levels of virus replication but is associated with none of the debilitating immunopathology, including the marked CD4 T-cell depletion, persistent cell activation and acquired immun...

journal_title：Current HIV research

authors： Pereira LE,Ansari AA

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:Human immunodeficiency virus (HIV) infection is a global health burden which ultimately results in acquired immune deficiency syndrome (AIDS). There are multiple host factors which are capable of limiting HIV-1 replication. One of the most important host factors which inhibit HIV-1 DNA synthesis is the apoli...

journal_title：Current HIV research

authors： Iqbal K,Imran M,Ullah S,Jamal M,Waheed Y

更新日期：2018-01-01 00:00:00

abstract：:It has been known for decades that exogenous RNAs are able to induce cytotoxic T lymphocytes (CTLs) and immunological reactivity to a wide variety of antigens. The molecular events responsible for these effects remain unclear for more than two decades. It has been decided to revisit this phenomenon in the light of new...

journal_title：Current HIV research

authors： Watanabe MA,de Souza LR,Murad JM,De Lucca FL

更新日期：2005-10-01 00:00:00

abstract：BACKGROUND:The change in the prevalence of hypogonadism with age in men with human immunodeficiency virus (HIV) infection is subject to debate. OBJECTIVE:To address this issue, we diagnosed hypogonadism based on serum levels of free testosterone (fTST) rather than total testosterone which is thought to be an inaccurat...

journal_title：Current HIV research

authors： Yoshino Y,Koga I,Wakabayashi Y,Kitazawa T,Ota Y

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to analyze the temporal trends of HIV epidemiology in Turkey from 2011 to 2016. METHODS:Thirty-four teams from 28 centers at 17 different cities participated in this retrospective study. Participating centers were asked to complete a structured form containing questions about epidem...

journal_title：Current HIV research

authors： Erdinc FS,Dokuzoguz B,Unal S,Komur S,Inkaya AC,Inan D,Karaoglan I,Deveci A,Celen MK,Kose S,Erben N,Senturk GC,Heper Y,Kutlu SS,Hatipoglu CA,Sumer S,Kandemir B,Sirmatel F,Bayindir Y,Yilmaz E,Ersoy Y,Kazak E,Yil

更新日期：2020-01-01 00:00:00

abstract：:It has long been recognized that drug metabolism and drug toxicity may vary greatly between individuals, affecting both efficacy and toxicity. Pharmacogenetics could benefit HIV therapeutics because of the high prevalence of drug-related adverse events and the long term nature and complexity of combination therapy. In...

journal_title：Current HIV research

authors： Tozzi V,Libertone R,Liuzzi G

更新日期：2008-11-01 00:00:00