Abstract:
:Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in monocytes and modulate T cell activation. In vivo, an increase in the number of endocervical CD4+ T cells has been found in GC-infected women. Additionally, GC appears to modulate HIV-specific immune responses in HIV-exposed sex workers. Interestingly, in vitro, GC exhibits HIV enhancing or inhibitory effects depending on the HIV target cells. This review summarizes molecular and immunological aspects of the modulation of HIV infection and transmission by GC. Future studies using a multi-cellular system or in animal models will offer insight into the mechanisms by which GC increases HIV transmission.
journal_name
Curr HIV Resjournal_title
Current HIV researchauthors
Jarvis GA,Chang TLdoi
10.2174/157016212800618138subject
Has Abstractpub_date
2012-04-01 00:00:00pages
211-7issue
3eissn
1570-162Xissn
1873-4251pii
CHIVR-EPUB-20120229-002journal_volume
10pub_type
杂志文章,评审abstract::In this paper we report the study of tryptophan metabolism via serotonin in ventricular CSF in HIV-1 infection in order to investigate the origin of tryptophan metabolites in the human brain. The patients (n=4) were affected with non-communicating hydrocephalus. One of these also was suffering from HIV-1 infection. Th...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016207780077020
更新日期:2007-03-01 00:00:00
abstract:OBJECTIVE:The primary objective of this study was to estimate etravirine activity in a cohort of patients infected with non-B subtype HIV-1 and failing nevirapine-based therapy. MATERIALS AND METHODS:Genotypic resistance testing was performed if viral load was >OR= 1,000 copies/ml after receiving at least six months o...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016210791111098
更新日期:2010-04-01 00:00:00
abstract:OBJECTIVE:To evaluate the potential impact of the current global economic crisis (GEC) on the spread of HIV. DESIGN:To evaluate the impact of the economic downturn we studied two distinct HIV epidemics in Southeast Asia: the generalized epidemic in Cambodia where incidence is declining and the epidemic in Papua New Gu...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209789973637
更新日期:2009-11-01 00:00:00
abstract:OBJECTIVE:HIV lipodystrophy is characterised by abnormal adipose tissue distribution and metabolism, as a result of altered adipocyte function and gene expression. The protease inhibitor ritonavir is associated with the development of lipodystrophy. Quantifying changes in adipogenic gene expression in the presence of r...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x13666150806110238
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to analyze the temporal trends of HIV epidemiology in Turkey from 2011 to 2016. METHODS:Thirty-four teams from 28 centers at 17 different cities participated in this retrospective study. Participating centers were asked to complete a structured form containing questions about epidem...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200427223823
更新日期:2020-01-01 00:00:00
abstract::In the HAART era Kaposi's sarcoma (KS) remains the second most frequent tumor in HIV-infected patients worldwide, and it has become the most common cancer in Sub-Saharan Africa. In western countries the risk for KS in men having sex with men (MSM) is 5 to 10 times higher compared to other groups of individuals practic...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016209789973619
更新日期:2009-11-01 00:00:00
abstract::Immunization is an important measure to protect HIV-infected children and adults against certain vaccine preventable diseases. However, the antibody response, which is associated with the level of CD4+ T cell count, is frequently impaired in this group of patients. Certain vaccines enhance virus replication and transi...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162043351084
更新日期:2004-10-01 00:00:00
abstract:BACKGROUND:Despite decreasing rates of HIV among many populations, HIV-related health disparities among gay, bisexual and other men who have sex with men persist, with disproportional percentages of new HIV diagnoses among racial and ethnic minority men. Despite increasing awareness of HIV pre-exposure prophylaxis (PrE...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X16666180730144455
更新日期:2018-01-01 00:00:00
abstract::Two HIV-1 non B isolates, 98US_MSC5007 and 98US_MSC5016, which have been identified amongst the US Army personnel serving abroad, are known to have originated from other nations. Notwithstanding, they are categorized as American strains. This is because their countries of origin are unknown. American isolates are basi...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x113119990046
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:HIV infection induces alterations in the gut-associated lymphoid tissue (GALT) that constitutes the most important site for viral replication due to the extensive presence of effector memory T-cells. In the case of HIV-controllers, several studies have reported fewer peripheral alterations and conserved immu...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190130115113
更新日期:2018-01-01 00:00:00
abstract::Objective was to assess dietary intake and physical activity in a Canadian population sample of male patients with HIV and metabolic abnormalities and to compare the data to Canadian recommendations. Sixty-five HIV-infected men with at least one feature associated with the metabolic syndrome (insulin resistance, dysli...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016208783571973
更新日期:2008-01-01 00:00:00
abstract::One of the major obstacles to effective prolonged CD8 T cell control over HIV and other latent infections may be the intrinsic, genetically programmed barrier to unlimited proliferation that is characteristic of all normal human somatic cells. Replicative senescence, characterized extensively in cell culture for a var...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162033485348
更新日期:2003-04-01 00:00:00
abstract::The development of pre-exposure prophylactics or microbicide products for the reduction or elimination of the sexual transmission of HIV has numerous challenges or barriers to success. Historically traditional dosage forms such as gels have been developed in the field but more recently controlled release dosage forms ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212799304599
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:Manipur is one of the highest HIV prevalence states of India because of its geographical location at the international border near the golden triangle of South-East Asia, but no study on drug resistance associated mutations (DRAMs) has been reported yet. OBJECTIVE:A population-based study on DRAMs of HIV-1 ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x14666160401131426
更新日期:2016-01-01 00:00:00
abstract::AIDS has claimed the lives of 25 million people worldwide, an additional 40 million people are HIV-infected and new cases are being diagnosed every year. Despite the fact that HAART has moved AIDS from the category of terminal diseases to that of treatable chronic illnesses, its long-term therapeutic success may be co...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016207781023965
更新日期:2007-07-01 00:00:00
abstract::To promote the initiation of reverse transcription, the HIV-1 virus uses a host tRNA as a primer, tRNA(3Lys). The annealing of tRNA(3Lys) to the viral RNA requires the breaking of the 3D structure of the tRNA and RNA rearrangements, to form a stable initiation complex recognised by the reverse transcriptase. The annea...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162053506919
更新日期:2005-04-01 00:00:00
abstract:BACKGROUND:The change in the prevalence of hypogonadism with age in men with human immunodeficiency virus (HIV) infection is subject to debate. OBJECTIVE:To address this issue, we diagnosed hypogonadism based on serum levels of free testosterone (fTST) rather than total testosterone which is thought to be an inaccurat...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200720000344
更新日期:2020-01-01 00:00:00
abstract::Human immunodeficiency virus has evolved several redundant mechanisms to remove its receptor, the CD4 molecule, from the cell surface. Indeed, HIV-1 encodes three proteins, Nef, Vpu and Env, that have a profound effect on CD4 trafficking and catabolism. Given this functional convergence, it is believed that cell surfa...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/1570162043485086
更新日期:2004-01-01 00:00:00
abstract:BACKGROUND:HIV-1 CRF55_01B was first reported in 2013. At present, no report is available regarding this new clade's polymorphisms in its functionally critical regions protease and reverse transcriptase. OBJECTIVE:To identify the diversity difference in protease and reverse transcriptase between CRF55_01B and its pare...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X18666200415140652
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:We studied the clinical presentation, diagnosis, treatment outcome and survival in children with HIV and Tuberculosis (TB) co-infection. METHODS:All HIV infected children with symptoms or signs consistent with tuberculosis were screened. We studied 24 cases of culture confirmed TB from among a cohort of 213...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016207781662434
更新日期:2007-09-01 00:00:00
abstract::It has been known for decades that exogenous RNAs are able to induce cytotoxic T lymphocytes (CTLs) and immunological reactivity to a wide variety of antigens. The molecular events responsible for these effects remain unclear for more than two decades. It has been decided to revisit this phenomenon in the light of new...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016205774370447
更新日期:2005-10-01 00:00:00
abstract::Antiretroviral (ARV) prophylaxis for prevention of mother to child transmission (MTCT) of HIV could affect hemoglobin (Hb) development of infants. A cross-sectional descriptive study was conducted in 24 HIV-infected and 21 HIV-uninfected pregnancies. ARV drugs were administered to HIV-infected pregnancies at 21 weeks ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162x12666140713170800
更新日期:2014-01-01 00:00:00
abstract::It has long been recognized that drug metabolism and drug toxicity may vary greatly between individuals, affecting both efficacy and toxicity. Pharmacogenetics could benefit HIV therapeutics because of the high prevalence of drug-related adverse events and the long term nature and complexity of combination therapy. In...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016208786501535
更新日期:2008-11-01 00:00:00
abstract:BACKGROUND:Transmitted drug resistance (TDR) remains a significant threat to Human immunodeficiency virus (HIV) infected patients that are not exposed to antiretroviral treatment. Although, combined antiretroviral therapy (cART) has reduced deaths among infected individuals, emergence of drug resistance is gradually on...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666191004093433
更新日期:2019-01-01 00:00:00
abstract::Since the beginning of the AIDS pandemic, and following the discovery of the human immunodeficiency virus (HIV) as the etiological agent of the disease, it was clear that the virus gains access to the human host predominantly through the mucosal tissue after sexual exposure. As a consequence, the female genital tract ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016212799304689
更新日期:2012-01-01 00:00:00
abstract::Among HIV positive patients, Fine needle aspiration cytology (FNAC) or biopsy for diagnosis of tuberculous lymphadenopathy is often avoided due to an unspoken stigma. Earlier, we had developed a clinical scoring scale for the diagnosis of tuberculous lymphadenitis (TBLN), which had 88% sensitivity and detected no fals...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016206778560009
更新日期:2006-10-01 00:00:00
abstract::Although hepatitis B serology screening has been recommended for HIV care, it has not been routinely performed. We aimed to assess compliance and timing of hepatitis B serology screening among HIV-infected patients in a resource-limited setting. A cross-sectional study was conducted in Thailand. Compliance, timing of ...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016211794582669
更新日期:2011-01-01 00:00:00
abstract:BACKGROUND:Vaccine against HIV-1 is not currently available. In present, Virus like particles (VLPs) as effective strategy was used in several vaccine developing. Two conserved sequences; V3 loop of gp120 and the membrane-proximal external region (MPER) of gp41 are dominant sites for vaccine studies. OBJECTIVE:In this...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X15666171017122229
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:The aim of the study was to investigate if the supplementation with multistrain probiotics may be able to modulate T cell response in HIV-1 infected patients and to evaluate the anti-HIV activity of probiotic by studying fecal water (FW) samples. METHODS:Three HIV-1-positive patients (Pt1, Pt2 and Pt3) on l...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190903230622
更新日期:2019-01-01 00:00:00
abstract:BACKGROUND:Previous studies have developed methodologies for predicting the number of CD4+ cells from the total leukocyte and lymphocytes count based on mathematical methodologies, obtaining percentages of effectiveness prediction higher than 90% with a value of less than 5000 leukocytes. OBJECTIVE:To improve the meth...
journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190306125819
更新日期:2018-01-01 00:00:00