Modulation of HIV transmission by Neisseria gonorrhoeae: molecular and immunological aspects.

Abstract:

:Neisseria gonorrhoeae (GC), a major cause of pelvic inflammatory disease, can facilitate HIV transmission. In response to GC infection, genital epithelial cells can produce cytokines, chemokines and defensins to modulate HIV infection and infectivity. GC can also induce the production of cytokines and chemokines in monocytes and modulate T cell activation. In vivo, an increase in the number of endocervical CD4+ T cells has been found in GC-infected women. Additionally, GC appears to modulate HIV-specific immune responses in HIV-exposed sex workers. Interestingly, in vitro, GC exhibits HIV enhancing or inhibitory effects depending on the HIV target cells. This review summarizes molecular and immunological aspects of the modulation of HIV infection and transmission by GC. Future studies using a multi-cellular system or in animal models will offer insight into the mechanisms by which GC increases HIV transmission.

journal_name

Curr HIV Res

journal_title

Current HIV research

authors

Jarvis GA,Chang TL

doi

10.2174/157016212800618138

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

211-7

issue

3

eissn

1570-162X

issn

1873-4251

pii

CHIVR-EPUB-20120229-002

journal_volume

10

pub_type

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