Abstract:
:In this paper we report the study of tryptophan metabolism via serotonin in ventricular CSF in HIV-1 infection in order to investigate the origin of tryptophan metabolites in the human brain. The patients (n=4) were affected with non-communicating hydrocephalus. One of these also was suffering from HIV-1 infection. The CSF was withdrawn from different sites of the cerebral cavity with a neuroendoscopic procedure which allows an accurate exploration of all the cerebral ventricles. The measurement of tryptophan, 5-hydroxytryptophan, serotonin, 5-hydroxyindoleacetic acid, and melatonin was carried out by HPLC with fluorometric detection. In HIV-1 infection the highest concentration of tryptophan is present in the CSF of the choroid plexus; however, the levels are markedly lower than those in hydrocephalic individuals (control group). 5-Hydroxytryptophan CSF content is higher in HIV-1 infection than in hydrocephalic controls in all districts examined. Regarding serotonin, a great difference appears in the choroid plexus and in the pituitary recess between the HIV-1 infected patient and the control group. The values of 5-hydroxyindoleacetic acid are much lower in the CSF of the HIV-1 infected patient than in hydrocephalic controls. Melatonin levels appear to fluctuate largely but, in the HIV-1 infection, a great variability is present among the sites of CSF withdrawal. The third ventricle contains the highest concentration of melatonin and the choroid plexus and the pituitary recess the lowest. All the melatonin concentrations in HIV-1 infection are largely different than in hydrocephalic controls. This is the first report on the measurement of tryptophan metabolites via serotonin in ventricular CSF in HIV-1 infection.
journal_name
Curr HIV Resjournal_title
Current HIV researchauthors
Longatti P,Perin A,Comai S,Bertazzo A,Rizzo V,Costa CV,Allegri Gdoi
10.2174/157016207780077020subject
Has Abstractpub_date
2007-03-01 00:00:00pages
267-72issue
2eissn
1570-162Xissn
1873-4251journal_volume
5pub_type
杂志文章abstract::Among HIV positive patients, Fine needle aspiration cytology (FNAC) or biopsy for diagnosis of tuberculous lymphadenopathy is often avoided due to an unspoken stigma. Earlier, we had developed a clinical scoring scale for the diagnosis of tuberculous lymphadenitis (TBLN), which had 88% sensitivity and detected no fals...
journal_title:Current HIV research
pub_type: 杂志文章
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abstract::Intensive antiretroviral therapy successfully suppresses viral replication but is unable to eradicate the virus. HIV persists in a small number of resting memory T cells where HIV has been transcriptionally silenced. This review will focus on recent insights into the HIV transcriptional control mechanisms that provide...
journal_title:Current HIV research
pub_type: 杂志文章
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abstract::Since the beginning of the AIDS pandemic, and following the discovery of the human immunodeficiency virus (HIV) as the etiological agent of the disease, it was clear that the virus gains access to the human host predominantly through the mucosal tissue after sexual exposure. As a consequence, the female genital tract ...
journal_title:Current HIV research
pub_type: 杂志文章,评审
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abstract::In the HAART era Kaposi's sarcoma (KS) remains the second most frequent tumor in HIV-infected patients worldwide, and it has become the most common cancer in Sub-Saharan Africa. In western countries the risk for KS in men having sex with men (MSM) is 5 to 10 times higher compared to other groups of individuals practic...
journal_title:Current HIV research
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journal_title:Current HIV research
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journal_title:Current HIV research
pub_type: 杂志文章,评审
doi:10.2174/157016210791208613
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journal_title:Current HIV research
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pub_type: 杂志文章,评审
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journal_title:Current HIV research
pub_type: 杂志文章,评审
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journal_title:Current HIV research
pub_type: 杂志文章
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journal_title:Current HIV research
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更新日期:2014-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209789973637
更新日期:2009-11-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
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journal_title:Current HIV research
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journal_title:Current HIV research
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journal_title:Current HIV research
pub_type: 杂志文章,评审
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journal_title:Current HIV research
pub_type: 杂志文章,随机对照试验
doi:10.2174/1570162x12666140526120831
更新日期:2014-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016208785132545
更新日期:2008-06-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/157016209787581382
更新日期:2009-03-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章
doi:10.2174/1570162X17666190903230622
更新日期:2019-01-01 00:00:00
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journal_title:Current HIV research
pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Current HIV research
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
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journal_title:Current HIV research
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更新日期:2013-07-01 00:00:00